| 77 Health - Arthritis Resources |
| 2 in 5 Rheumatoid Arthritis Patients Sedentary |
| Many RA Patients Who Avoid Exercise Unaware That Physical Activity Can Ease Symptoms |
| January 26, 2012 |
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| A promising new approach to autoimmune diseases |
| Researchers from Harvard Medical School and MIT have developed a new approach for identifying the "self" proteins targeted in autoimmune diseases such as multiple sclerosis, diabetes and rheumatoid arthritis. |
| June 2, 2011 |
| A wise man's treatment for arthritis -- frankincense? |
| The answer to treating painful arthritis could lie in an age old herbal remedy - frankincense, according to Cardiff University scientists. |
| June 21, 2011 |
| Abbott announces results from HUMIRA Phase 3 study on axSpA |
| Abbott today announced results from the Phase 3 ABILITY-1 study of HUMIRA® (adalimumab) in patients with active non-radiographic axial spondyloarthritis (axSpA). AxSpA is a debilitating condition that primarily presents with inflammatory low back pain and can be accompanied by the presence of the HLA-B27 gene, arthritis, and inflammation in the eye and/or gastrointestinal tract. |
| November 7, 2011 |
| Achieving Realistic Physical Activity Goals Benefits Rheumatoid Arthritis Patients |
| Researchers from The Netherlands report that patients with rheumatoid arthritis (RA) who have higher levels of self-efficacy for physical activity are more likely to achieve their physical activity goals. According to the study now available in Arthritis Care & Research, a journal of the American College of Rheumatology (ACR), achievement of physical activity goals is associated with lower self-reported arthritis pain and increased health-related quality of life (HRQOL). |
| August 25, 2011 |
| Adults with arthritis suffer with poorer health related quality of life |
| A new study reports that the health-related quality of life (HRQOL) for U.S. adults with arthritis is much worse than for those without this condition. Both physical and mental health are affected by arthritis, which poses a significant health and economic burden as the number of those diagnosed continues to climb. Details of this study are now online in Arthritis Care & Research, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR). |
| April 28, 2011 |
| Are You Chained to Your Pillbox? |
| What to do to curb your need for drugs that treat high blood pressure, cholesterol, diabetes, and osteoarthritis. |
| May 10, 2011 |
| Arthritis drug could help beat melanoma skin cancer |
| A breakthrough discovery by the University of East Anglia (UEA) and Children's Hospital Boston promises an effective new treatment for one of the deadliest forms of cancer. |
| March 23, 2011 |
| Arthritis patients taking newer treatments do not have an overall increased cancer risk |
| Only three percent (n=181) of patients in the study cohort receiving anti-tumour necrosis factor agents (anti-TNFs) for treatment of their arthritis developed a first cancer within nine years and overall risk was not dependent on the type of arthritis. |
| May 27, 2011 |
| Arthritis sufferers are not engaging in physical activity critical to their health |
| Being physically active is one of best ways people with arthritis can improve their health, but a new study from Northwestern University Feinberg School of Medicine shows that more than half of women and 40 percent of men with arthritis are virtually couch potatoes. |
| August 10, 2011 |
| Arthritis sufferers at increased risk of heart disease |
| Rheumatoid arthritis (RA) sufferers are at an increased risk of dying due to cardiovascular disease. A new five year study published in BioMed Central's open access journal Arthritis Research & Therapy showed that the risk of cardiovascular disease for people with RA is due to disease-related inflammation as well as the risk factors which affect the general population. Treatment of arthritis with disease modifying antirheumatic drugs (DMARDs) also reduced the patient's risk of heart disease. |
| August 15, 2011 |
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| Bilateral oophorectomy associated with higher prevalence of low bone mineral density and arthritis in younger women |
| Women who underwent surgery to remove their ovaries before the age of 45 years were more likely to have arthritis and low bone mineral density compared with women with intact ovaries, researchers found. |
| December 8, 2011 |
| Biological agents for rheumatoid arthritis associated with increased skin cancer risk |
| Biological agents used to treat rheumatoid arthritis seem to be associated with an increased risk of skin cancer, indicates a systematic review of published research in the Annals of the Rheumatic Diseases. |
| September 8, 2011 |
| Blood biomarker associated with prevalence, severity of Alzheimer's, but not risk of development |
| Higher levels in blood of the protein clusterin, also known as apolipoprotein J, are significantly associated with the prevalence and severity of Alzheimer's disease, but not with the risk of onset of new disease, according to a study in the April 6 issue of JAMA. |
| April 5, 2011 |
| Blue-collar workers with arthritis in much worse health than all other workers |
| While more Americans are working past age 65 by choice, a growing segment of the population must continue to work well into their sixties out of financial necessity. Research conducted by the Columbia University's Mailman School of Public Health and the University of Miami Miller School of Medicine looked at aging, social class and labor force participation rates to illustrate the challenges that lower income workers face in the global marketplace. |
| July 22, 2011 |
| Botulism toxins could be re-engineered for treating RA, asthma, psoriasis |
| The most poisonous substance on Earth - already used medically in small doses to treat certain nerve disorders and facial wrinkles - could be re-engineered for an expanded role in helping millions of people with rheumatoid arthritis, asthma, psoriasis and other diseases, scientists are reporting. |
| December 1, 2011 |
| Brain Scans Spot Alzheimer's Changes Years Before Symptoms |
| Study: People With Brain Shrinkage in Key Areas Are More Likely to Develop Memory Loss, Other Alzheimer's Symptoms |
| December 21, 2011 |
| Brain size may predict risk for early Alzheimer's disease |
| New research suggests that, in people who don't currently have memory problems, those with smaller regions of the brain's cortex may be more likely to develop symptoms consistent with very early Alzheimer's disease. |
| December 21, 2011 |
| Bring the feet when diagnosing, treating rheumatoid arthritis |
| When diagnosing and treating patients with rheumatoid arthritis, clinical research focuses primarily on the joints in the upper body. However, research carried out by rheumatologist Hetty Baan at the University of Twente reveals the importance of including the feet and ankles when examining and treating RA patients. |
| December 7, 2011 |
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| CDC Links Obesity, Arthritis, and Lack of Exercise |
| Study Shows Obese Adults Who Have Arthritis Are More Likely to Skip Exercise |
| May 19, 2011 |
| Clinical trial seeks to determine whether platelet-rich plasma can ease the pain of osteoarthritis |
| For years, doctors have used platelet-rich plasma, or PRP, to promote healing after surgery. Now, Rush University Medical Center is studying whether PRP can help relieve knee pain in patients with mild to moderate osteoarthritis. |
| March 22, 2011 |
| Coping With Psoriatic Arthritis |
| Cope with the emotional and physical demands of psoriatic arthritis with these management tips. |
| January 9, 2012 |
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| Deer tick bacteria DNA in joint fluid not reliable marker of active lyme arthritis |
| New research shows that polymerase chain reaction (PCR) testing for Borrelia burgdorferi DNA—the spirochetal bacteria transmitted by deer ticks—in joint fluid may confirm the diagnosis of Lyme arthritis, but is not a reliable indicator for active joint infection in patients whose arthritis persists after antibiotic therapy. |
| May 17, 2011 |
| Defect in A20 gene expression causes rheumatoid arthritis |
| Researchers from VIB (Flanders Institute for Biotechnology) and Ghent University have shown that a defective gene can contribute to the onset of rheumatoid arthritis, an often-crippling inflammation of the joints that afflicts about 1% of the world's population. Until now, the underlying molecular mechanism of the disease was largely unclear. In the study, published in Nature Genetics, the researchers demonstrate that a cell-specific defect in the expression of the A20 gene (TNFAIP3) can contribute to the development of rheumatoid arthritis in mice, thereby identifying A20 as a possible target for the generation of new drugs. |
| August 16, 2011 |
| Delays in specialist assessment of rheumatoid arthritis are too long |
| Delays in the specialist assessment of patients with suspected rheumatoid arthritis (RA) are "unacceptably long," finds a study carried out in eight European countries led by the University of Birmingham, published online today in the Annals of the Rheumatic Diseases. |
| August 8, 2011 |
| Diclofenac in Nano-Formulations Offers Better Pain Relief at Lower-Than-Normal Doses |
| According to the data of a Phase II clinical trial reported at the 2011 World Congress on Osteoarthritis, nano-formulations of diclofenac offer pain relief at lower-than-normal doses. |
| September 19, 2011 |
| Does Knuckle Cracking Cause Arthritis? |
| Conventional wisdom says cracking knuckles does cause problems, but a researcher who studied the question says no. |
| October 06, 2011 |
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| Exercise eases arthritis in obese mice even without weight loss |
| Adding another incentive to exercise, scientists at Duke University Medical Center have found that physical activity improves arthritis symptoms even among obese mice that continue to chow down on a high-fat diet. |
| September 27, 2011 |
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| FDA panel backs new labels for osteoporosis drugs |
| Fractures and possible increase in cancer rates have been tied to medications |
| September 9, 2011 |
| Ferring reports on FDA approval of labeling supplement for EUFLEXXA to treat knee osteoarthritis |
| On Oct. 11, 2011, the FDA approved a labeling supplement for EUFLEXXA (1% sodium hyaluronate) that provides 26-week efficacy data from the FLEXX trial, as well as, 52-week safety data to demonstrate the safety of repeated injection cycles. |
| October 22, 2011 |
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| Humira |
| HUMIRA is approved for reducing the signs and symptoms, inducing major clinical response, improving physical function, and helping to keep the joint damage from getting worse in adult patients with moderate to severe rheumatoid arthritis. |
| Provides Products |
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| Illusion can halve the pain of osteoarthritis, scientists say (w/ video) |
| A serendipitous discovery by academics at The University of Nottingham has shown that a simple illusion can significantly reduce -- and in some cases even temporarily eradicate -- arthritic pain in the hand. |
| April 14, 2011 |
| Injectable Gel Could Spell Relief for Arthritis Sufferers |
| Some 25 million people in the United States alone suffer from rheumatoid arthritis or its cousin osteoarthritis, diseases characterized by often debilitating pain in the joints. Now researchers at Brigham and Women's Hospital (BWH) report an injectable gel that could spell the future for treating these diseases and others. |
| April 13, 2011 |
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| Knee Arthritis: Very Low-Calorie Diet May Help |
| Patients on Formula Diet Achieved Dramatic Weight Loss |
| December 22, 2011 |
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| 'Mindfulness' exercises help curb stress and fatigue associated with arthritis |
| "Mindfulness" exercises, which focus on experiencing the present moment, no matter how difficult, can help curb the stress and fatigue associated with painful rheumatoid joint disease. |
| December 20, 2011 |
| Moderate Drinking May Protect Against Alzheimer's and Cognitive Impairment, Study Suggests |
| Moderate social drinking may significantly reduce the risk of dementia and cognitive impairment, suggests an analysis of 143 studies by Loyola University Chicago Stritch School of Medicine researchers. |
| August 16, 2011 |
| MRI Techniques Can Detect Early Osteoarthritis |
| Researchers from NYU Langone Medical Center's Departments of Orthopaedic Surgery and Radiology found that advanced MRI techniques can be used to detect subtle changes in joint cartilage microstructure -- and provide physicians a diagnostic tool for finding key markers of early osteoarthritis (OA). By using these techniques during patient exams to identify OA earlier, clinicians can shift the management of the disease from eventual joint reconstruction to long-term preservation. |
| August 15, 2011 |
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| Nanoparticles Could Help Pain-Relieving Osteoarthritis Drugs Last Longer, Study Indicates |
| A novel study demonstrates that using nanoparticles to deliver osteoarthritis drugs to the knee joint could help increase the retention of the drug in the knee cavity, and therefore reduce the frequency of injections patients must receive. |
| October 26, 2011 |
| New 'bouncer' molecule halts rheumatoid arthritis |
| Researchers at Northwestern University Feinberg School of Medicine have discovered why the immune cells of people with rheumatoid arthritis become hyperactive and attack the joints and bones. The immune cells have lost their bouncer, the burly protein that keeps them in line the same way a bouncer in a nightclub controls rowdy patrons. |
| September 7, 2011 |
| New clinical practice guidelines developed for juvenile idiopathic arthritis |
| The American College of Rheumatology has developed new guidelines for starting and monitoring treatments for children with juvenile idiopathic arthritis. These are the first JIA guidelines endorsed by the ACR, with the goal of broad acceptance within the rheumatology community. |
| March 30, 2011 |
| New genetic clue in the development of rheumatoid arthritis |
| Scientists at Mount Sinai Hospital, in collaboration with researchers at the University of Toronto, University Health Network and McGill University have obtained significant new insights into the causes of rheumatoid arthritis (RA) and other autoimmune disorders including type 1 diabetes, lupus and Graves disease. |
| August 14, 2011 |
| New medication, surgery may offer relief for patients with psoriatic arthritis |
| Medications or biologic agents that target T-cells, white blood cells involved in the body's immune system, appear to offer significant benefit to patients suffering from psoriatic arthritis (PsA), a type of arthritis that affects up to 48 percent of patients with the skin disease psoriasis. |
| January 18, 2012 |
| New Method Delivers Alzheimer's Drug to the Brain |
| Oxford University scientists have developed a new method for delivering complex drugs directly to the brain, a necessary step for treating diseases like Alzheimer's, Parkinson's, Motor Neuron Disease and Muscular Dystrophy. |
| April 5, 2011 |
| New technique yields troves of information from nanoscale bone samples |
| Along with adding important new insights into the fight against osteoporosis, this innovation opens up an entirely new proteomics-based approach to analyzing bone quality. It could even aid the archeological and forensic study of human skeletons. |
| June 22, 2011 |
| New Treatment Approach for Alzheimer's Disease: Researchers Plan to Use Specialized Cells of the Immune System |
| A research team at Charité -- Universitätsmedizin Berlin and Universitätsklinik Freiburg has documented how the immune system can counteract the advancement of Alzheimer's disease. In a newly published paper, they showed that certain scavenger cells in the immune system, called macrophages, play a key role in this context. Furthermore, they were able to demonstrate how special cell-signaling proteins, called chemokines, mediate the defense process. |
| August 16, 2011 |
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| Omega-3 fatty acids shown to prevent or slow progression of osteoarthritis |
| New research has shown for the first time that omega-3 in fish oil could "substantially and significantly" reduce the signs and symptoms of osteoarthritis. |
| October 17, 2011 |
| Osteoarthritis Incidence Significantly Higher Among U.S. Military Personnel Compared to General Population |
| New research shows significantly higher osteoarthritis (OA) incidence rates in military populations than among comparable age groups in the general population. The magnitude of the difference in OA rates between military service members and the general population also increased with advancing age category. Black service members had higher OA rates than white military personnel or those in other race categories according to the study findings published in Arthritis & Rheumatism. |
| June 29, 2011 |
| Osteoarthritis results from inflammatory processes, not just wear and tear, study suggests |
| In a study to be published online Nov. 6 in Nature Medicine, investigators at the Stanford University School of Medicine have shown that the development of osteoarthritis is in great part driven by low-grade inflammatory processes. This is at odds with the prevailing view attributing the condition to a lifetime of wear and tear on long-suffering joints. |
| November 7, 2011 |
| Ovary removal in younger women may lead to low-bone mineral density, arthritis |
| Having both ovaries removed before age 45 is strongly associated with low-bone mineral density and arthritis in later years, according to a new study by Johns Hopkins oncologists and epidemiologists. The analysis covered several thousand women who took part in a U.S. government-sponsored, multiyear national health study, and excluded women whose ovaries were removed due to cancer. |
| December 9, 2011 |
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| PCR testing for B. burgdorferi bacteria in joint fluid may confirm Lyme arthritis diagnosis |
| New research shows that polymerase chain reaction (PCR) testing for Borrelia burgdorferi DNA—the spirochetal bacteria transmitted by deer ticks—in joint fluid may confirm the diagnosis of Lyme arthritis, but is not a reliable indicator for active joint infection in patients whose arthritis persists after antibiotic therapy. Findings of this study are published in Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR). |
| May 13, 2011 |
| PENNSAID Viscous Solution Phase 2 clinical trial for osteoarthritis pain meets primary endpoint |
| Nuvo Research Inc., a specialty pharmaceutical company dedicated to building a portfolio of products primarily for the treatment of pain, today announced receipt from Mallinckrodt Inc., a Covidien company (Covidien), of top-line results from a Phase 2 study conducted by Covidien, of twice-daily administration of PENNSAID® Viscous Solution (topical diclofenac sodium viscous solution) 2% w/w, previously referred to as PENNSAID Gel. The study met its primary endpoint of reducing osteoarthritis (OA) pain greater than a placebo vehicle control. |
| June 30, 2011 |
| Progranulin-Derived Protein Could Provide New Treatment Strategies for Rheumatoid Arthritis |
| According to a report published in March 10, 2011 issue of Science, scientists at NYU Langone Medical Center have developed a protein molecule from the growth factor progranulin that could offer cures for inflammatory diseases including rheumatoid arthritis. |
| March 16, 2011 |
| Progress in tissue engineering to repair joint damage in osteoarthritis |
| Medical scientists now have "clear" evidence that the damaged cartilage tissue in osteoarthritis and other painful joint disorders can be encouraged to regrow and regenerate, and are developing tissue engineering technology that could help millions of patients with those disorders. That's the conclusion of a new analysis of almost 100 scientific studies on the topic, published in ACS's journal Molecular Pharmaceutics. |
| June 8, 2011 |
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| RA, Smoking, and Alcohol |
| The potential risks smoking and drinking pose to people with rheumatoid arthritis. |
| June 24, 2011 |
| Recent rituximab trial with TNF inhibitors reports no new safety risks in patients with RA |
| A recent trial of rituximab in combination with a tumor necrosis factor (TNF) inhibitor and methotrexate (MTX) in patients with active rheumatoid arthritis (RA) found the safety profile to be consistent with other RA trials with TNF inhibitors. While the trial reported no new safety risks, clear evidence of an efficacy advantage in RA patients receiving the combination therapy was not observed in this study sample. Results of the trial are published in the March issue of Arthritis & Rheumatism, a peer-reviewed journal of the American College of Rheumatology. |
| March 8, 2011 |
| Rheumatoid Arthritis Sufferers Armed With Kitchen Safety Tool |
| For sufferers of rheumatoid arthritis (RA), cooking tasks can be both difficult and dangerous. However, a new assistive technology invented by a Queensland University of Technology (QUT) student offers a safe way for people to lift cookware, relying on the strength of their forearms. |
| March 7, 2011 |
| Rituximab Combined With a TNF Inhibitor and Methotrexate Shows No Safety Signal in Rheumatoid Arthritis Treatment, Study Finds |
| A recent trial of rituximab in combination with a tumor necrosis factor (TNF) inhibitor and methotrexate (MTX) in patients with active rheumatoid arthritis (RA) found the safety profile to be consistent with other RA trials with TNF inhibitors. While the trial reported no new safety risks, clear evidence of an efficacy advantage in RA patients receiving the combination therapy was not observed in this study sample. |
| March 8, 2011 |
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| Simcere receives Chinese SFDA approval for Iremod to treat active rheumatoid arthritis |
| Simcere Pharmaceutical Group , a leading pharmaceutical company specializing in the development, manufacturing, and marketing of branded generic and proprietary pharmaceuticals in China, today announced that it has received the new drug approval from the State Food and Drug Administration ("SFDA") for Iremod. |
| August 25, 2011 |
| Sonography Complements Physical Exam in Identifying Juvenile Inflammatory Arthritis in Children |
| Juvenile Inflammatory Arthritis (JIA) is a potentially debilitating childhood disease. Early detection and treatment of active arthritis may avert long term joint damage and disability. Research has shown that sonography with power Doppler can facilitate making assessments in joint activity and sub-clinical disease, according to research being presented at the 2011 American Roentgen Ray Society's annual meeting. |
| May 5, 2011 |
| Steroids prevent protein changes seen in the joints of people with rheumatoid arthritis |
| Rheumatoid arthritis (RA) is a chronic inflammatory disease where the body begins to attack the joints and organs of the body. Proteins within inflamed joints are often modified by citrullination, a process that converts the protein building block arginine into citrulline. These two amino acids have very different physical properties and consequently conversion can result in aberrant changes in the three-dimensional structure of an affected protein. |
| January 27, 2012 |
| Stopping arthritis before it starts |
| About 27 million Americans suffer from arthritis, and more than three million of those cases result from a joint injury, often in the knee, that provokes slow and steady cartilage deterioration. |
| September 2, 2011 |
| Study confirms link between rheumatoid arthritis and COPD |
| Patients with rheumatoid arthritis are two times more likely to have concurrent chronic obstructive pulmonary disease (COPD) than healthy controls -- an association which was sustained even when variables such as age, gender, smoking and obesity were controlled for, according to a study presented today at the EULAR 2011 Annual Congress. |
| May 26, 2011 |
| Study finds more gut reaction to arthritis drugs |
| Patients often take drugs to lower stomach acid and reduce the chances they will develop ulcers from taking their anti-inflammatory drugs for conditions such as arthritis, but the combination may be causing major problems for their small intestines, McMaster researchers have found. |
| September 1, 2011 |
| Study identifies factors linked with better medication response for treatment of juvenile arthritis |
| Among patients with juvenile idiopathic arthritis (JIA) who initiated treatment with the drug etanercept, one-third achieved an excellent response, and this response was associated with low measures of disability at study entry, younger age at the onset of JIA, and fewer disease-modifying antirheumatic drugs used before initiating etanercept, according to a study appearing in JAMA. The study is being released early online to coincide with its presentation at the American College of Rheumatology/Association of Rheumatology Health Professionals Annual Scientific Meeting. |
| November 7, 2011 |
| Study indicates nanoparticles could help pain-relieving osteoarthritis drugs last longer |
| A novel study demonstrates that using nanoparticles to deliver osteoarthritis drugs to the knee joint could help increase the retention of the drug in the knee cavity, and therefore reduce the frequency of injections patients must receive. This research is being presented Oct. 23 -- 27 at the 2011 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Washington, D.C. |
| October 26, 2011 |
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| Targeted Adalimumab Treatment Can Optimize Long-Term Outcomes for Patients With Early Rheumatoid Arthritis, Study Suggests |
| Data presented May 25 at the EULAR 2011 Annual Congress demonstrated that initial treatment with adalimumab (Humira, ADA) plus methotrexate in early RA patients can provide high levels of disease control in many patients, and may also offer the opportunity to change future treatment options for some. |
| May 25, 2011 |
| The use of placebo in rheumatoid arthritis clinical trials may negatively impact patients |
| The results of this study, conducted in Germany, re-open the debate on whether it is ethical to conduct placebo-controlled studies where patients in the placebo-group are at a serious disadvantage compared to patients taking the new treatments. The study analysed current study designs, for new therapies such as abatacept (Orencia®), golimumab (Simponi®) or tocilizumab (Actemra®), and showed that patients in the placebo group experienced no change in medication, having to continue with their former, ineffective treatment plus placebo. |
| May 27, 2011 |
| Third Genetic Link to Osteoarthritis Discovered |
| Researchers have just revealed a new gene associated with osteoarthritis. This is only the third gene to be identified for this painful and debilitating disease that affects more than 40 per cent of people aged more than 70 years. |
| August 25, 2011 |
| Third scientific Meeting of NanoDiaRA concluded |
| The third scientific Meeting of NanoDiaRA took place in Fribourg in Switzerland, a historic University city at which one of the research groups of NanoDiaRA is located. Around 40 principal investigators, trainees and collaborators from the 15 partner institutions attended this very successful meeting. They came together to network, share and discuss their progress in research during the first year of operation. The first day was dedicated to a discussion of the management of the network, ethical issues and strategic aspects of the ongoing research. |
| March 9, 2011 |
| Trial to test laser acupuncture treatment for osteoarthritis |
| The potential for laser acupuncture to provide painless and effective treatment for osteoarthritis knee pain is being put to the test in a clinical trial beginning in Sydney. |
| March 31, 2011 |
| Two Novartis ACZ885 Phase III trial data in severe gouty arthritis to be presented at EULAR 2011 |
| Novartis announced today results of two pivotal Phase III trials in patients with severe gouty arthritis, showing that ACZ885 (canakinumab) provided superior pain relief and reduced the risk of suffering new attacks by up to 68% compared to an injectable steroid (triamcinolone acetonide, TA) used to treat gouty arthritis attacks. ACZ885 is an investigational fully human monoclonal antibody. |
| May 25, 2011 |
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| US Study Suggests That Tofacitinib Is an Efficacious Treatment for Active Rheumatoid Arthritis |
| Results of a Phase III study presented May 25 at the EULAR 2011 Annual Congress show that at 6 months, 58.3 percent of patients who had previously not responded to treatment with DMARDs, achieved ACR20 response (a 20 percent improvement in symptoms) when treated with the novel oral Janus kinase inhibitor tofacitinib at 10mg BID compared to 31.2 percent in the placebo group. Significant improvements were also observed in the 5 mg BID dose. |
| May 25, 2011 |
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| Vejthani Hospital Bangkok offers High Tibial Osteotomy Surgery for osteoarthritis |
| Vejthani Hospital Bangkok offers a High Tibial Osteotomy Surgery for osteoarthritis at TJR Center. The procedure prolongs the life of a damaged knee, helps relieve pain in the knee and delays the need for a total knee replacement. |
| December 28, 2011 |
| Vertex VX-509 12-week Phase 2a study on RA meets two primary endpoints |
| Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced that treatment with the investigational selective oral JAK3 inhibitor VX-509 in a Phase 2a trial resulted in substantial and statistically significant improvements in multiple measurements of rheumatoid arthritis (RA) activity. |
| September 6, 2011 |
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| Vitamin D insufficiency prevalent among psoriatic arthritis suffers |
| New research reports a high prevalence of vitamin D insufficiency and deficiency among patients with psoriatic arthritis. Seasonal variation in vitamin D levels was not observed in patients in southern or northern locations. The findings published today in Arthritis Care & Research, a journal of the American College of Rheumatology (ACR), also show no association between disease activity and vitamin D level. |
| July 11, 2011 |
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| When Men Get Rheumatoid Arthritis |
| For a few years, Andrew Ellis tried to tough out the pain, which started in his thumb. A boxer and football player in college, Ellis, 58, was used to aches and pains. He'd even broken his thumb once, so he told himself the new pain was from the old break. Then his other thumb began to hurt. Soon, he had pain in his toes and the balls of his feet. When his neck began to hurt, he finally admitted to himself that it was time to see a doctor. |
| July 29, 2011 |
| Why Knee Osteoarthritis Afflicts More Women Than Men |
| A Mayo Clinic orthopedic surgeon suspects that the nagging pain and inflammation that women can experience in their knees may be different from what men encounter, and she has been chosen to lead a novel U.S.-Canadian study to explore the question. |
| August 3, 2011 |