A new study found that the recommended blood test may not be enough to catch type 2 diabetes in overweight children, missing more than two-thirds of children at high-risk for the condition. Researchers from Children's Mercy Hospital and Clinics found that performing two tests -- both the recommended hemoglobin A1C test and an oral glucose tolerance test -- could dramatically reduce the risk of delayed diagnosis in overweight children.
A team led by researchers from University of Cambridge showed that closed loop insulin delivery was effective in controlling overnight blood glucose levels in patients with type 1 diabetes. The system took readings every fifteen minutes and automatically titrated a proper amount of insulin.
Diabetes type 2 is caused by insufficient levels of insulin to keep blood glucose under control. Excessive levels of another hormone, glucagon, can also contribute to diabetes type 2 by causing the liver to flood the body with stored glucose. Diabetes type 2 does not arise overnight, but slowly progresses for many years as a condition known as prediabetes. In prediabetes, blood sugar rises to excessive levels after a meal, but is normal or nearly normal after an overnight fast. Researchers are seeking ways to prevent prediabetes from progressing to diabetes. Besides diet and exercise, the diabetic drug metformin can slow the onset of diabetes.
A daily dose of safflower oil, a common cooking oil, for 16 weeks can improve such health measures as good cholesterol, blood sugar, insulin sensitivity and inflammation in obese postmenopausal women who have Type 2 diabetes, according to new research.
Obese teenagers who don't get the proper amount of sleep may have disruptions in insulin secretion and blood sugar (glucose) levels, say pediatric researchers. Their study suggests that getting a good night's sleep may stave off the development of type 2 diabetes in these adolescents.
Over the past 10 years, Americans drank more sugar-sweetened beverages than ever--as much as 13 billion gallons a year--making these drinks the largest source of added sugar and excess calories in the American diet and, arguably, the single largest dietary factor in the current obesity epidemic. While many states have a sales tax on soda, experts believe they are too low to impact consumption.
Researchers from Harvard Medical School and MIT have developed a new approach for identifying the "self" proteins targeted in autoimmune diseases such as multiple sclerosis, diabetes and rheumatoid arthritis.
The American Academy of Neurology has issued a new guideline on the most effective treatments for diabetic nerve pain, the burning or tingling pain in the hands and feet that affects millions of people with diabetes. The guideline is published in the April 11, 2011, online issue of Neurology, the medical journal of the American Academy of Neurology, and will be presented April 11, 2011, at the American Academy of Neurology's Annual Meeting in Honolulu.
Abbott has received CE approval for its FreeStyle InsuLinx Blood Glucose Monitoring System, which, in addition to measuring blood glucose, calculates suggested insulin doses.
Findings from a recent University of Cincinnati (UC) and Cincinnati Department of Veterans Affairs (VA) Medical Center study show that multiple episodes of acute kidney injury during hospital stays for patients with diabetes are associated with a risk for developing chronic kidney disease.
Linagliptin (trade name: Trajenta) has been approved since August 2011 to improve blood glucose control ("glycaemic control") in adults with type 2 diabetes mellitus whose elevated blood glucose levels are inadequately controlled by diet and exercise. It is an option for patients who do not tolerate or should not take the usual treatment with the drug metformin.
Individuals with diabetes who adhere to their medication had lower risk of hospitalization by one-third when compared to patients who do not adhere to their medication, according to a new study. The results of the study by Prime Therapeutics (Prime), a thought leader in pharmacy benefit management, are being presented the last week in April at the Academy of Managed Care Pharmacy's 23rd Annual Meeting and Showcase in Minneapolis, Minn.
Up to 30 percent of all patients develop diabetes mellitus within the first year after a kidney transplantation. This high rate could soon fall rapidly. A Medical University of Vienna research team at Vienna General Hospital's University Department of Internal Medicine III has discovered in the context of a study that preemptive insulin therapy drastically reduces this rate.
Researchers from Harvard-affiliated Dana-Farber Cancer Institute and the Scripps Research Institute in Jupiter, Fla., report they have created prototype drugs having powerful anti-diabetic effects, yet apparently free -- at least in mice -- of dangerous side effects plaguing some current diabetes medications.
Walking on a treadmill for one hour a day may slow the progression of nonalcoholic fatty liver disease in obese people with prediabetes by jump-starting their metabolism and slowing the oxidative damage wrought by the condition, say researchers at the Cleveland Clinic. A study of 15 obese people with nonalcoholic fatty liver disease revealed that the daily walks not only increase insulin sensitivity, but improve the liver's polyunsaturated lipid index (PUI), which is thought to be a marker of liver health.
Aetna, a leading global diversified health care benefits company, announced that it is participating in a diabetes prevention program in India led by non-profit Arogya World that strives to reach one million consumers via mobile text messages. This mobile health (mHealth) initiative, which is being supported by a consortium of organisations, aims to raise awareness about diabetes and its prevention through text messages in 12 languages over two years.
African American women who develop gestational diabetes mellitus during pregnancy face a 52 percent increased risk of developing diabetes in the future compared to white women who develop GDM during pregnancy, according to a Kaiser Permanente study published online in the journal Diabetologia.
Age and body mass index (BMI) are important risk factors for gestational diabetes mellitus (GDM) particularly amongst South Asian and Black African women finds new research published today in BJOG: An International Journal of Obstetrics and Gynaecology.
Surgeons from Boston Medical Center (BMC) have found that in diabetic patients undergoing coronary artery bypass graft (CABG) surgery, aggressive glycemic control does not result in any significant improvement of clinical outcomes as compared with moderate control. The findings, which appear in this month's issue of Annals of Surgery, also found the incidence of hypoglycemic events increased with aggressive glycemic control.
Chronic pain affects an estimated 116 million adults in the U.S.--more than the number affected by heart disease, diabetes, and cancer combined, according to a recent report by the Institute of Medicine. At the same time, prescriptions for opioids have increased over the last ten years by 48%, contributing to the nation's growing battle with prescription drug abuse, according to a report by the U.S. Food and Drug Administration.
Akebia Therapeutics, Inc., a small molecule discovery and development company focused on anemia and vascular disorders, today announced that it has dosed the first subjects in a first-in-man Phase 1 study of AKB-9778, a first-in-class human protein tyrosine phosphatase beta inhibitor in development for diabetic macular edema and diabetic retinopathy.
Fifty years ago, adult-onset diabetes was relatively rare, affecting less than one percent of the adult population in the United States. Today, more than 25 million Americans over the age of 20 battle the disease - an alarming 11 percent of the population. The condition has been renamed type 2 diabetes because nearly a quarter of a million children also have it. The Bronx has been especially hard hit, with approximately 150,000 adults and children affected.
In 2009, the American Diabetes Association recommended that Hemoglobin A1c be exclusively used for the diagnosis of diabetes in children. The simple test measures longer-term blood sugar levels -- without requiring patients to fast overnight.
The Juvenile Diabetes Research Foundation and Amylin Pharmaceuticals, Inc. announced today that they have entered into a research collaboration agreement to provide financial support for a series of clinical studies to investigate the feasibility of mixing pramlintide, an analog of the human hormone amylin, with insulin to treat type 1 diabetes.
Amylin Pharmaceuticals, Inc., Eli Lilly and Company and Alkermes, Inc. today announced that the companies have submitted their reply to a complete response letter issued in October 2010 by the U.S. Food and Drug Administration (FDA) regarding BYDUREON™ (exenatide extended-release for injectable suspension), an investigational medication for type 2 diabetes.
Amylin Pharmaceuticals won approval Friday for its long-delayed diabetes drug Bydureon, a next-generation treatment that requires fewer injections than the company's 7-year old diabetes medicine, Byetta.
Patients who consumed only 600 calories a day for two months were able to reverse their Type 2 diabetes, according to a groundbreaking British study. The research, involving just 11 patients, suggests a very low-calorie diet can remove fat that clogs the pancreas, allowing normal insulin secretion to be restored, according to Newcastle University.
Over the past decade, much progress has been made regarding the understanding and promise of personalized medicine. Scientists are just beginning to consider the impact of gene-diet interactions in different populations in regards to disease prevention and treatment.
Nearly two years after the FDA issued what became the first of two rejections, the agency has finally approved the Bydureon diabetes treatment, setting up what is going to be heated battle between Amylin Pharmaceuticals and Novo Nordisk, which sells a rival medicine called Victoza.
Pediatric researchers who tested newborn animals with an existing human drug used in adults with diabetes report that this drug, when given very early in life, prevents diabetes from developing in adult animals. If this finding can be repeated in humans, it may become a way to prevent at-risk infants from developing type 2 diabetes.
American Podiatric Medical Association Encourages Hispanic Health Awareness with "Knock Your Socks Off" Foot Care Campaign, Promotes Regular Foot Exams by Podiatrist to End Diabetes Complications
Two small randomised trials published in the British Medical Journal today suggest that closed loop insulin delivery (also known as an artificial pancreas) may improve overnight blood glucose control and reduce the risk of nocturnal hypoglycaemia (a sudden drop in blood glucose levels during the night) in adults with type 1 diabetes.
While the continuous delivery provided by an insulin pump allows for better control of blood sugar levels than multiple daily injections, currently available insulin pumps use a reservoir that requires frequent refilling. Sunnyvale, CA based Asante Solutions, Inc. hopes that its Pearl Insulin Pump will solve this problem, while still providing the same advantages as existing insulin pumps. The Pearl uses an insulin cartridge instead of the traditional reservoir, which the company claims will make refilling much quicker and more convenient for patients. The Pearl Insulin Pump received the CE mark this week, and is currently awaiting 510(k) clearance from the FDA.
Reducing cardiovascular risk factors like high blood pressure, smoking, diabetes and being overweight could potentially reduce more than half of all cases of atrial fibrillation, according to research reported in Circulation: Journal of the American Heart Association.
Normally you wouldn’t want your test strips to get into contact with bacteria; you’d want to store the strips in a safe and clean place. But what if the bacteria were part of the test strip? Students from Missouri Science and Technology have made a system in which they use segments of DNA embedded in bacteria to detect glucose.
Bariatric surgery is an especially cost-effective therapy for managing Type 2 diabetes in moderately and severely obese patients. These findings and others were presented today at the 2nd World Congress on Interventional Therapies for Type 2 Diabetes, hosted by NewYork-Presbyterian Hospital and Weill Cornell Medical College.
In the longest study of its kind, bariatric surgery has been shown to reduce the risk of heart attack and stroke in patients with diabetes. These results and other groundbreaking research were presented at the 2nd World Congress on Interventional Therapies for Type 2 Diabetes, hosted by NewYork-Presbyterian Hospital and Weill Cornell Medical College.
Whether patients with type 2 diabetes mellitus benefit from attempts to lower their blood glucose levels to near-normal levels through treatment ("intensive blood glucose control") remains an unanswered question. The studies currently available provide indications of a benefit but also of potential harm. This is the result of a report published by the German Institute for Quality and Efficiency in Health Care (IQWiG).
Boehringer Ingelheim and Eli Lilly and Company today announced that the U.S. Food and Drug Administration has approved linagliptin tablets, a prescription medication used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.
Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company today announced the U.S. Food and Drug Administration has approved Jentadueto™ tablets, a new tablet combining the dipeptidyl peptidase-4 inhibitor, linagliptin, and metformin. JENTADUETO provides a new, single-tablet treatment option, taken twice-daily, for patients who need to control their blood sugar. Linagliptin is marketed in the U.S. as Tradjenta™ tablets.
Sleeping disorders have been known for some years to increase the risk of diabetes. A French-British team coordinated by Philippe Froguel from the Genomics and Metabolic Diseases Laboratory working with Ralf Jockers' team, has just linked a gene that plays a key role in synchronising biological rhythms to type 2 diabetes. Researchers in Lille and Paris demonstrated that mutations in the melatonin receptor gene lead to an almost sevenfold increase in the risk of developing diabetes.
Biomaterials may prove key to healing chronic wounds in Diabetic patients, delegates will hear September 6 at the 24th European Conference on Biomaterials. Over 950 delegates are at the event in Dublin, which is jointly hosted by NUI Galway's Network of Excellence for Functional Biomaterials and the University of Ulster, Jordanstown.
Security analyst Jerome Radcliffe had good reason to research the vulnerability of insulin pumps and similar medical devices to remote attack -- he's a diabetic. What he found out is pretty scary.
For type 2 diabetics who are not on insulin, monitoring their blood sugar does little to control blood sugar levels over time and may not be worth the effort or expense, according to a new evidence review.
Today, Zealand Pharma, a Copenhagen based biopharmaceutical company, and Boehringer Ingelheim, one of the world's leading pharmaceutical companies, jointly announced an exclusive global licence and collaboration agreement for dual-acting glucagon and GLP-1 receptor agonists for the treatment of patients with Type-2 diabetes and patients with obesity.
Boston Therapeutics, Inc., a public company registered with the SEC and a developer of diabetes therapeutics, today announced that it has submitted an Abbreviated New Drug Application (ANDA) for chewable metformin with the U.S. Food and Drug Administration (FDA). The Reference Listed Drug at the FDA is Bristol-Myers Squibb's Glucophage® product ([metformin hydrochloride] Tablets).
Researchers at the University of Florida and Metagenics Inc. today announced that a program consisting of a breakthrough medical food combined with a low-glycemic, Mediterranean-style diet is almost twice as effective as one of the best diets alone for lowering risk factors for cardiovascular disease, the leading cause of death in the U.S.
Patients simultaneously treated for both Type 2 diabetes and depression improve medication compliance and significantly improve blood sugar and depression levels compared to patients receiving usual care, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Researchers at McMaster University have found that brief high intensity workouts, as little as six sessions over two weeks, rapidly lower blood sugar levels in type 2 diabetics, offering a potential fix for patients who struggle to meet exercise guidelines.
Diabetes is a major risk factor for cardiovascular disease and can reduce blood supply to the heart tissue and damage cardiac cells, resulting in heart failure. New research has investigated if nerve growth factor (NGF) gene therapy can prevent diabetic heart failure and small vascular disease in mice.
Cardium Therapeutics announced today that it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market and sell the Company's new Excellagen™ professional-use, sterile, syringe-based advanced wound care product for the management of diabetic foot ulcers and other dermal wounds. Directions for use indicate the application of Excellagen immediately following surgical debridement, which is routinely practiced in the treatment of diabetic foot ulcers and other dermal wounds.
Foot and leg amputations were once a fairly common fate for diabetics, but new government research shows a dramatic decline in limbs lost to the disease, probably due to better treatments.
It is widely suspected that the current wave of obesity among children will result in greater rates of cardiovascular disease and diabetes over the next few decades. But a second systematic review of research into childhood obesity and metabolic disease in adult life has shown there is little evidence of a direct link and suggests that treating obesity during childhood will remove any risk of lasting harm.
Tianyin Pharmaceutical Co., Inc., a pharmaceutical company that specializes in patented biopharmaceutical medicine, modernized traditional Chinese medicine, branded generics and other pharmaceuticals today announced that TPI has received the China's SFDA's approval for its anti-diabetic drug Gliclazide Tablets (80 mg formulation).
Tianyin Pharmaceutical Co., Inc., a pharmaceutical company that specializes in patented biopharmaceutical medicine, modernized traditional Chinese medicine, branded generics and other pharmaceuticals today announced TPI has received the production license for its anti-diabetic drug Gliclazide Tablets (80 mg formulation) from China's State Food and Drug Administration (SFDA). The national pharmaceutical certificate number for TPI's new Gliclazide Tablets is also issued: H20113233.
A chemical produced by the same cells that make insulin in the pancreas prevented and even reversed Type 1 diabetes in mice, researchers at St. Michael's Hospital have found.
Clot-busting drugs given to patients who have diabetes and previously suffered a stroke aid their recovery from a second stroke a new study has revealed.
In most cases of diabetes, various genes and environmental factors are involved. Not in monogenic diabetes, where the causes are mutations in just a single gene. Between 25% and 45% of family members or patients with monogenic diabetes do not present alterations in any of the genes that have been put forward to date as possible causes, and so new candidate genes have had to be identified.
Researchers at the Joslin Diabetes Center have identified for the first time two molecular pathways that are critical to activating a type of "good" fat found in the body, a discovery that could play an important role in the fight against obesity and diabetes.
Kinesiology researcher Barry Braun of the University of Massachusetts Amherst and colleagues recently reported unexpected results of a study suggests that exercise and one of the most commonly prescribed drugs for diabetes, metformin, each improves insulin resistance when used alone, but when used together, metformin blunted the full effect of a 12-week exercise program in pre-diabetic men and women.
Many people with type 2 diabetes can manage blood sugar levels effectively on oral diabetes medications and lifestyle changes alone. Others will need to combine oral diabetes medications with injectable diabetes drugs in order to bring their blood glucose levels into a healthy range. Finding the right combination is the key to managing diabetes successfully.
Concert Pharmaceuticals, Inc. today announced it has made significant progress advancing CTP-499, its novel anti-inflammatory, anti-oxidant, and anti-fibrotic agent for diabetic nephropathy and other forms of chronic kidney disease, into clinical development. Based on encouraging preclinical results and successful formulation assessment in healthy volunteers, Concert has initiated a Phase 1 single ascending dose study of CTP-499 in healthy volunteers.
Concert Pharmaceuticals, Inc. today announced data from a Phase 1 clinical trial of CTP-499, a novel agent for the potential treatment of diabetic nephropathy. The results demonstrated that a controlled-release formulation of CTP-499 was well-tolerated at single doses up to and including 1800 mg.
Type 1 diabetes is a lifelong disease characterized by high levels of sugar (glucose) in the blood. It is caused by the patient's immune system attacking and destroying the cells in their pancreas that produce the hormone insulin, which regulates blood glucose levels.
Speaking Thursday at an informal civil society hearing that is a precursor to the first-ever high-level meeting on non-communicable diseases (NCDs), top U.N. officials "stressed the need for governments, the private sector and civil society to work together and more effectively to address cancers, diabetes and other non-communicable diseases, which account for nearly two thirds of global deaths each year," the U.N. News Centre reports.
Australian researchers have isolated a 'master gene' that controls Type 2 diabetes and say drugs that prevent or reverse the condition by switching off the gene may be as little as five years away
Robert Winkler says he limped around on his painful left foot for six months, suffering unnecessarily from a misdiagnosis by a physician who didn't know about the symptoms and treatments for Charcot foot, a form of localized osteoporosis linked to diabetes that causes the bones to soften and break, often resulting in amputation.
Investigators at Case Western Reserve University School of Medicine received a $6.75 million Program Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to study the role of innate immunity in inflammatory bowel disease.
Concert Pharmaceuticals, Inc. today announced that three abstracts relating to CTP-499, its clinical candidate for the potential treatment of diabetic nephropathy, have been accepted for poster presentations at the American Society of Nephrology's (ASN) Kidney Week 2011.
Researchers from Mount Sinai School of Medicine have discovered that decaffeinated coffee may improve brain energy metabolism associated with type 2 diabetes. This brain dysfunction is a known risk factor for dementia and other neurodegenerative disorders like Alzheimer's disease.
Confronted with a high blood pressure value in a diabetic patient, most doctors would treat aggressively with medications. According to new research, however, delaying drug treatment for up to a year is unlikely to be harmful. The delay allows doctors and their patients to focus on lifestyle changes such as salt restriction, weight management, and exercise.
In a study, Identification of unrecognized diabetes and pre-diabetes in a dental setting, published in the July 2011 issue of the Journal of Dental Research, researchers at Columbia University College of Dental Medicine found that dental visits represented a chance to intervene in the diabetes epidemic by identifying individuals with diabetes or pre-diabetes who are unaware of their condition. The study sought to develop and evaluate an identification protocol for high blood sugar levels in dental patients and was supported by a research grant from Colgate-Palmolive. The authors report no potential financial or other conflicts.
Depression in patients with diabetes is associated with a substantively increased risk of development of dementia compared to those with diabetes alone.
In the 1960s, a group of U.S. states with high age-adjusted stroke mortality defined a "stroke belt." Until recently, geographic patterns of diabetes had not been specifically characterized in the same manner. In an article published in the April 2011 issue of the American Journal of Preventive Medicine, researchers were able to identify clustered high prevalence areas, or a "diabetes belt" of 644 counties in 15 mostly southeastern states using data compiled for the first time of estimates of the prevalence of diagnosed diabetes for every U.S. county.
For better or worse, a popular class of anti-diabetic drugs does more than lower blood sugar. One known as rosiglitazone (trade name Avandia) has been in the spotlight for its possible link to increased cardiovascular events, but it also seems to come with unexplained vascular benefits and an unwelcome tendency for weight gain. Now, two separate studies in the July Cell Metabolism, a Cell Press publication, explore those other effects of the drugs known collectively as thiazolidinediones (TZDs), both of which stem from their activity in fat.
Canadian Inuit are not protected from the health consequences of obesity, contrary to previous knowledge, and their diabetes levels are similar to those in the general population, according to an article in CMAJ (Canadian Medical Association Journal).
People with diabetes appear to be at a significantly increased risk of developing dementia, according to a study published in the September 20, 2011, print issue of Neurology, the medical journal of the American Academy of Neurology.
Diabetes rate increases in status Aboriginal adults in Alberta appear to be slowing compared with the general population, although diabetes is more common in status Aboriginals and death rates for this group are significantly higher than the general population, states an article in CMAJ (Canadian Medical Association Journal). Death rates have in fact remained unchanged for status Aboriginals who do not have diabetes.
A survey of federally funded diabetes prevention and control programs in 57 U.S. states and territories has highlighted the need for better diabetes treatment guidelines that are specifically adapted to different populations. Such guidelines do not currently exist.
Private companies and hospital researchers are increasingly making strides toward developing an artificial pancreas, supplanting insulin injections and pinpricks for patients with diabetes. Such a system would mimic the functions of a healthy pancreas, delivering insulin and monitoring blood sugar according to a computer's careful calculations.
An inexpensive, culturally sensitive diabetes prevention program created by researchers at the University of Massachusetts Medical School reduced pre-diabetes indicators in a Latino population at risk for developing diabetes.
An Emory University study published in the January issue of Health Affairs assesses real-world lifestyle interventions to help delay or prevent the costly chronic disease that affects nearly 26 million Americans.
Research led by Warwick Medical School at the University of Warwick has found that Metformin, a drug treatment used to treat diabetes and also in women with Polycystic vary syndrome (PCOS), may potentially provide protection against endometrial cancer.
The Alberta Diabetes Surveillance System was created in 2006 in partnership between Alberta Health and Wellness and the Institute of Health Economics. Led by Jeff Johnson in the University of Alberta's School of Public Health, the group has been identifying trends in diabetes, its associated health conditions and monitoring trends in accessing health-care services and has published a comprehensive report called a Diabetes Atlas every two years.
Over time, diabetes can wreak havoc on the body's eyes, cardiovascular system, kidneys and nerves. A major study by Joslin Diabetes Center researchers, however, has found that some people who have survived diabetes for many decades exhibit remarkably few complications--a discovery that points toward the presence of protective factors that guard against the disease's effects.
No matter how small or superficial a wound is, you should not ignore it if you have diabetes, says Daniel Cohen, DPM, a podiatrist with Medical Associates of Brevard in Brevard County, Fla. If you stub your toe, get a blister from tight shoes, or nick your chin while shaving, you probably give it little thought. But if you have diabetes, you should seek proper treatment.
Diabetic kidney disease has become more prevalent in the United States over the past 20 years, despite a substantial increase in the use of medications for the treatment of people with diabetes, according to a study to be published June 22 in JAMA, the Journal of the American Medical Association.
People with diabetes have a three to five times higher risk of contracting tuberculosis (TB) than non-diabetics, according to researchers at The University of Texas Health Science Center at Houston (UTHealth).
Three dialysis patients have received the world's first blood vessels grown in a lab from donated skin cells. It's a key step toward creating a supply of ready-to-use arteries and veins that could be used to treat diabetics, soldiers with damaged limbs, people having heart bypass surgery and others.
Women with diabetes are less likely than women without chronic diseases to get contraceptive counseling or use reversible contraceptives, according to a study led by a University of Pittsburgh School of Medicine researcher that was published online in the Journal of General Internal Medicine. The study's authors say family planning services are critical for diabetic women because diabetics who become pregnant when their blood sugar is uncontrolled have an increased risk of birth defects.
Notable levels of calcium buildup in coronary arteries can be strong predictors of heart attacks and strokes in people with diabetes and metabolic syndrome, according to a study led by UC Irvine's Heart Disease Prevention Program.
A Newcastle University team has discovered that Type 2 diabetes can be reversed by an extreme low calorie diet alone. Affecting two and half million people in the UK -- and on the increase -- Type 2 diabetes is a long-term condition caused by too much glucose, a type of sugar, in the blood.
New research from academics at the University of Bristol shows that, in patients with recently diagnosed type 2 diabetes, 6.5 hours of additional dietary advice sessions leads to improvement in blood sugar control compared with patients who receive usual care. However, increased activity conferred no additional benefit when combined with the diet intervention.
A study led by researchers at the Joslin Diabetes Center suggests that adding the amino acid leucine to their diets may help those with pre-diabetes or metabolic syndrome.
Lifestyle changes that include dieting to lose weight and exercise can help prevent type 2 diabetes, but researchers were uncertain which element contributes more. A new study suggests that, in postmenopausal women at least, dietary weight loss alone is effective while exercise alone is not effective, and both together are best of all.
Johns Hopkins researchers believe they have uncovered the molecular switch for the secretion of insulin -- the hormone that regulates blood sugar -- providing for the first time an explanation of this process. In a report published online March 1 in Cell Metabolism, the researchers say the work solves a longtime mystery and may lead to better treatments for type 2 diabetes, the most common form of the disease.
By 2012, an estimated 14 million people will serve as distance caregivers to family members who live across the state, across the region, even across the country.
Leading medical specialists, public health researchers and nutritionists warn that not enough is being done to prevent the rapidly increasing diabetes rates, largely caused by significant increases in obesity in adults and children in recent years.
Doctors who used a free iPhone application provided by the UK Resuscitation Council performed significantly better in a simulated medical emergency than those who did not, according to a study in the April issue of Anaesthesia.
A new anti-inflammatory drug used by patients with type 2 diabetes improved their kidney function during a year-long study involving researchers from UT Southwestern Medical Center.
Results of a small, observational study conducted at the University at Buffalo suggest that liraglutide, an injectable medication used to treat type 2 diabetes, also helps type 1 diabetics on insulin achieve optimal control of their blood glucose levels.
Engineers at Brown University have designed a biological device that can measure glucose concentrations in human saliva. The technique could eliminate the need for diabetics to draw blood to check their glucose levels. The biochip uses plasmonic interferometers and could be used to measure a range of biological and environmental substances.
Eating nuts every day could help control Type 2 diabetes and prevent its complications, according to new research from St. Michael's Hospital and the University of Toronto.
Echo Therapeutics, Inc., a company developing the Symphony® tCGM System as a non-invasive, wireless, transdermal continuous glucose monitoring (tCGM) system and the Prelude® SkinPrep System for transdermal drug delivery, today announced that it is initiating a clinical study of its Symphony tCGM System in patients with Type 1 and Type 2 diabetes. The company expects to complete and announce the results of the study in the fourth quarter, and plans to subsequently begin a separate study in critical care patients.
Three randomized controlled trials published Online First today in Archives of Internal Medicine examine the effectiveness of behavioral and educational interventions for patients with poorly controlled diabetes. All three reports are part of the journal's Health Care Reform series.
Use of electronic health records shows promise for improving care and outcomes in patients with type 2 diabetes, but still has considerable room for improvement.
Measuring the levels of small molecules in the blood may be able to identify individuals at elevated risk of developing type 2 diabetes as much as a decade before symptoms of the disorder appear. In a report receiving advance online release in Nature Medicine, a team led by Massachusetts General Hospital (MGH) researchers describes finding that levels of five amino acids not only indicated increased diabetes risk in a general population but also could differentiate, among individuals with traditional risk factors such as obesity, those most likely to actually develop diabetes.
Engineering researchers at Rensselaer Polytechnic Institute are combining automation techniques from oil refining and other diverse areas to help create a closed-loop artificial pancreas. The device will automatically monitor blood sugar levels and administer insulin to patients with Type 1 diabetes, and aims to remove much of the guesswork for those living with the chronic disease.
In a new study, scientists report that they substantially curbed weight gain, improved metabolism, and improved the efficacy of insulin in mice by engineering them to express a specific human enzyme in their fat tissue.
It's not estrogen produced by body fat that causes low levels of testosterone in type 2 diabetic men, according to a University at Buffalo study published last month in Diabetes Care.
Exenatide, a drug commonly prescribed to help patients with type 2 diabetes improve blood sugar control, also has a powerful and rapid anti-inflammatory effect, a University at Buffalo study has shown.
One of the toughest things about Type 1 diabetes -- a chronic, incurable autoimmune disease -- is that once it begins to develop, there's no way to stop it. Slowly but surely, your immune system will kill off the cells in your pancreas that produce insulin, a crucial hormone that allows you to absorb the energy (in the form of glucose) from your food. The process can take years, but the end result is always the same: you'll be entirely dependent on injections of artificial insulin to stay alive. Even though it's now possible to predict with more than 75 percent accuracy whether someone will develop Type 1 within the next five years, there's nothing to do with that information but wait.
A medicine designed to improve levels of "good" cholesterol may also help control blood sugar in people with diabetes who are taking cholesterol-lowering drugs, according to a new analysis in Circulation: Journal of the American Heart Association.
A team of scientists at the Gladstone Institutes and Yale University have begun to unravel the complex process by which cells take in and store microscopic fat molecules, suggesting new directions for further research into solutions for obesity and its related conditions, such as heart disease, type 2 diabetes and fatty liver disease.
Patients with diabetes face daily challenges in managing their blood glucose levels, and it has been postulated that patients could benefit from a system providing continuous real-time glucose readings. Today, The Endocrine Society released a clinical practice guideline (CPG) providing recommendations on settings where patients are most likely to benefit from continuous glucose monitoring (CGM).
A uniquely collaborative study by researchers at the Salk Institute for Biological Studies uncovered a novel mechanism that turns up glucose production in the liver when blood sugar levels drop, pointing towards a new class of drugs for the treatment of metabolic disease.
Electronic medical records (EMRs) have been in use for more than 30 years, but have only increased in utilization in recent years, due in part to research supporting the benefits of EMRs and federal legislation. As EMRs have become a standard in medical care, there is a need for additional research of how the system and usage can be refined. A group of researchers from Brigham and Women's Hospital have done just that, and discovered that one way false information can make its way into EMRs is due to users' reliance on copying and pasting material within the patient's record. These findings are published in the May 23 issue of Archives of Internal Medicine.
A major risk factor for cardiovascular disease, type 2 diabetes and other health- and life-threatening conditions, obesity is epidemic in the United States and other developed nations where it's fueled in large part by excessive consumption of a fat-rich "Western diet."
Takeda Pharmaceutical Company Limited and its wholly-owned subsidiary, Takeda Global Research & Development Center, Inc., U.S., today announced that the company received notification from the U.S. Food and Drug Administration (FDA) that its review of investigational type 2 diabetes therapy alogliptin, and thus the fixed-dose combination therapy alogliptin/pioglitazone, will be delayed.
King of Prussia, PA based Devon Medical Devices has announced FDA 510(k) clearance of its new ArterioFlow 7500 sequential pneumatic compression device. The ArterioFlow 7500 utilizes a set of compression sleeves which cyclically squeeze the patient's feet and calves. This application of pressure can be used to treat diabetic foot ulcers and peripheral arterial disease by emptying the veins in the lower extremities.
Asante Solutions, Inc. (Asante), a medical device company focused on diabetes care, announced that the U.S. Food and Drug Administration has granted 510(k) clearance for the company's Pearl Insulin Pump. Last month, the Pearl also received the CE Mark, a European proof of conformity that certifies the product meets EU safety, health and environmental requirements.
SweetSpot Diabetes Care, Inc. announced today it has received 510(k) clearance from the United States Food & Drug Administration for the SweetSpot Diabetes Data Management Service which helps health care providers and patients see, understand and use blood glucose meter data to diagnose and manage diabetes.
Federal health regulators have concerns about bladder and breast cancer seen in patients taking an experimental diabetes pill from Bristol-Myers Squibb and AstraZeneca.
Federal regulators have warned Johnson & Johnson that it could face fines and other sanctions for selling faulty insulin pumps and delaying disclosures of serious injuries to diabetics who were using its OneTouch Ping and 2020 pumps.
The burning, tingling pain of neuropathy may affect feet and hands before other body parts because the powerhouses of nerve cells that supply the extremities age and become dysfunctional as they complete the long journey to these areas, Johns Hopkins scientists suggest in a new study. The finding may eventually lead to new ways to fight neuropathy, a condition that often accompanies other diseases including HIV/AIDS, diabetes and circulatory disorders.
Research introduced at SNM's 58th Annual Meeting reveals the extent to which an ongoing study can help save life and limb for patients with diabetes-related foot infections. Diabetes can cause nerve damage and reduced blood flow to the bones and tissues of the feet, leaving diabetics vulnerable to infection. This study shows that combining two imaging agents with molecular imaging techniques provides diabetic patients an excellent infection screening method that has already spared a number of patients from aggressive amputation of infected feet.
Activating a specialized type of fat, known as brown adipose tissue, may help combat obesity as well as result in better glucose control for type 2 diabetes, according to new research conducted by scientists at the UC Metabolic Diseases Institute.
Scientists at the National Institutes of Health have uncovered a pathway in mice that allows white fat -- a contributor to obesity and type 2 diabetes -- to burn calories in a way that's normally found in brown fat and muscle. The findings are in the July 6 edition of Cell Metabolism.
The mechanisms by which obesity leads towards metabolic co-morbidities, such as diabetes mellitus, are poorly understood and of great public health interest. A study led by Matej Oresic from VTT Technical Research Centre of Finland suggests that adaptation of fat cell membranes to obesity may play a key role in the early stages of inflammatory disorders.
Scientists today reported the first strong evidence implicating nicotine as the main culprit responsible for persistently elevated blood sugar levels -- and the resulting increased risk of serious health complications -- in people who have diabetes and smoke.
A recent study from scientists at the Salk Institute for Biological Studies suggests that a strawberry a day (or more accurately, 37 of them) could keep not just one doctor away, but an entire fleet of them, including the neurologist, the endocrinologist, and maybe even the oncologist.
Diabetes and high blood pressure are the two leading causes of chronic kidney disease (CKD), a health problem that is growing at an alarming rate in the United States. There are 26 million Americans who have CKD, and millions more are at increased risk and may not even know it. On World Kidney Day, Fresenius Medical Care North America (FMCNA), the nation's leading network of dialysis facilities, encourages those at risk for CKD to diagnose and treat high blood pressure and diabetes, because these conditions can lead to life-threatening kidney failure.
For type 2 diabetics who are not on insulin, monitoring their blood sugar does little to control blood sugar levels over time and may not be worth the effort or expense, according to a new evidence review.
Part of managing diabetes involves piercing a finger several times daily to monitor blood sugar levels. Raman spectroscopy could let diabetics monitor glucose without those daily pinpricks. In the past, this would have required a tabletop's worth of equipment. Two former graduate students at MIT's George R. Harrison Spectroscopy Laboratory, Chae-Ryon Kong and Ishan Barman, detail in the AIP's journal AIP Advances how to potentially reduce the overall size of this sensor by making an important part of this equipment smaller.
Despite the disappointing results in trying to treat children suffering from type 1 diabetes with the GAD vaccine, the treatment has not been written off entirely. DIAPREV-IT, the study in which healthy high-risk children are vaccinated, is continuing as planned, and now with more money behind it. "I am still hopeful that the GAD vaccine will work", says Helena Elding Larsson.
An experimental cure for Type 1 diabetes has a nearly 80 percent success rate in curing diabetic mice. The results, to be presented Saturday at The Endocrine Society's 93rd Annual Meeting in Boston, offer possible hope of curing a disease that affects 3 million Americans.
An experimental cure for Type 1 diabetes has a nearly 80 percent success rate in curing diabetic mice. The results, being presented at The Endocrine Society's 93rd Annual Meeting in Boston, offer possible hope of curing a disease that affects 3 million Americans.
Increasing a specific protein in areas of the pancreas that produce insulin blocks the immune attack that causes type 1 diabetes, researchers reported in the August issue of the Journal of Clinical Investigation, published early online.
Researchers from ETH Zurich have fitted human cells with a synthetic signaling cascade that can be used to switch on and regulate genes via blue light. This "gene light switch" makes interesting therapies possible, which could be used to treat type 2 diabetes, for instance.
A new study uncovers a previously unrecognized link between tobacco smoking and a gene known to influence the cardiovascular system, possibly identifying an early stage of smoking-associated cardiovascular pathology. The research, published by Cell Press in the April issue of The American Journal of Human Genetics, may serve to guide future research strategies aimed at identifying and counteracting mechanisms of smoking-induced pathology.
Researchers at Case Western Reserve University School of Medicine have discovered a genetic factor that can regulate obesity-induced inflammation that contributes to chronic health problems.
Researchers have found a genetic variation predisposing children to six-times greater risk of developing metabolic syndrome when taking second-generation anti-psychotic medications. Metabolic syndrome is a cluster of conditions that are risk factors for cardiovascular disease.
Researchers at Washington University School of Medicine in St. Louis have identified the first genetic variant associated with severity of coronary artery disease in patients with type 2 diabetes.
Who would have thought that Gila monster saliva would be the inspiration for a blockbuster new drug for Type 2 diabetes? Or that medicines for chronic pain, heart attacks, high blood pressure and stroke would emerge from venom of the Magician's cone snail, the saw-scaled viper, the Brazilian lancehead snake and the Southeastern pygmy rattlesnake? These are just some of the sources contributing to the emergence of potential new drugs based on "peptides" that is the topic of the cover story in the current edition of Chemical & Engineering News (C&EN), ACS' weekly newsmagazine. Peptides are short sequences of amino acids that are the building blocks of proteins.
Allowing those at the highest risk of developing diabetes to select the lifestyle intervention that will benefit them offers the best results in well-being and functionality when compared to other methods.
Diabetes is running rampant in the U. S., and treatment for the disease is evolving. Glucose meters and insulin pumps are now wireless, allowing hands-free operation 24/7.
Eating a fatty fast food meal is never good for you, but washing that meal down with a coffee is even worse, according to a new University of Guelph study.
The gold standard long-term glucose monitoring test for patients with diabetes proved to be of limited value in dialysis patients, according to a new study at Wake Forest Baptist Medical Center.
A health-care delivery model called patient-centered medical home (PCMH) increased the percentage of diabetes patients who achieved goals that reduced their sickness and death rates, according to health researchers.
Evidence of cardiovascular disease and diabetes risk is present in the blood of adolescents who consume a lot of fructose, a scenario that worsens in the face of excess belly fat, researchers report.
Evidence of cardiovascular disease and diabetes risk is present in the blood of adolescents who consume a lot of fructose, a scenario that worsens in the face of excess belly fat.
According to a new report the rate of Type 1 diabetes in Australian children will leap by 10 per cent in the five years to 2013, cementing Australia's position in the top 10 OECD nations for the condition's prevalence. Currently the prevalence of diabetes in Australia ranks seventh-highest among the 30 OECD nations.
A high-fat diet during pregnancy may program a woman's baby for future diabetes, even if she herself is not obese or diabetic, says a new University of Illinois study published in the Journal of Physiology.
Researchers at McMaster University have found that brief high intensity workouts, as little as six sessions over two weeks, rapidly lower blood sugar levels in type 2 diabetics, offering a potential fix for patients who struggle to meet exercise guidelines.
A research team led by Baker IDI Heart and Diabetes Institute has for the first time demonstrated that the effect of obesity on the risk of premature death is seriously underestimated unless a person's hip circumference is taken into account.
Each year, the holiday season brings good tidings and cheer along with an abundance of sweet treats, from tasty eggnog to candy canes. The holiday food frenzy actually begins with Halloween candy and lingers all the way until the big game, offering a steady stream of tempting goodies that can be a real hazard for the millions of people living with diabetes or at risk for diabetes.
Researchers at Mount Sinai School of Medicine have identified how a gene for a protein that can cause Type 2 diabetes, also possibly kills nerve cells in the brain, thereby contributing to Alzheimer's disease.
The number of people who suffer from one or more of the adverse complications of obesity, including type 2 diabetes and heart disease is rapidly increasing.
Researchers have shown one way in which poor nutrition in the womb can put a person at greater risk of developing type 2 diabetes and other age-related diseases in later life. This finding could lead to new ways of identifying people who are at a higher risk of developing these diseases and might open up targets for treatment.
While infectious diseases tend to grab media headlines and public attention, non-communicable diseases such as diabetes, cancer, cardiovascular disease, and chronic respiratory diseases together comprise the number one killer in the world and represent a serious social and economic burden to developed and developing countries alike.
When normal proteins form protein clumps in the body, then alarm bells start ringing. Such clumps, called "amyloids," are closely associated with Alzheimer's disease and type 2 diabetes, formerly called adult-onset diabetes. If doctors knew how these proteins form clumps, then they might be able to treat such diseases more efficiently. The physicist Adrian Keller and his colleagues at the Helmholtz-Zentrum Dresden-Rossendorf and the university in Aarhus, Denmark, have succeeded in taking a major step in that direction.
A recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) found that the greater an individual's total muscle mass, the lower the person's risk of having insulin resistance, the major precursor of type 2 diabetes.
Ischemic stroke hospitalization rates in adolescents and young adults aged 15 to 44 increased up to 37% between 1995 and 2008 according to a study conducted by researchers at the Centers for Disease Control and Prevention (CDC). The findings available today in Annals of Neurology, a journal of the American Neurological Association and the Child Neurology Society, report an increase in the prevalence of hypertension, diabetes, obesity, lipid disorders, and tobacco use among this age group during the 14-year study period.
India is facing a twin epidemic of diabetes and high blood pressure, doctors have warned, after the results of a countrywide study suggested that one in five people had both conditions.
Obesity is a known risk factor for developing type 2 diabetes. But it hasn't been clear whether the "dose" of obesity--how much excess weight a person has, and for how long--affects the risk of diabetes.
Research carried out at the Hebrew University of Jerusalem has provided the first proof of molecular risk factors leading to type 2 diabetes, providing an “early warning” sign that could lead to new approaches to treating this and other human disease conditions.
It's a dream of medical science that looks tantalizingly within reach: the artificial pancreas, a potential breakthrough treatment for the scourge of type 1 diabetes.
A new signal pathway that renders the insulin-releasing beta cell more sensitive to high levels of blood glucose has been discovered by researchers at the Swedish medical university Karolinska Institutet. A second new study reveals a possible way to delay the disease by inhibiting a lipoprotein.
In the largest study of it kind to establish a link between sleep and diabetes, researchers found that people with diabetes who sleep poorly have higher insulin resistance, and a harder time controlling the disease.
You need insulin to control your diabetes. That seems pretty straightforward. Yet there are a few decisions you and your doctor still need to make -- including how that insulin is delivered.
When Jay Radcliffe revealed three weeks ago that he'd found serious security holes in a popular type of insulin pump that diabetics wear, he kept two important details secret: the pump maker's name, and the specific technique he used to hack the device.
New research from Uppsala University shows that reduced insulin sensitivity is linked to smaller brain size and deteriorated language skills in seniors.
Now a team of Johns Hopkins Children's Center scientists has uncovered what they consider surprising evidence that insulin resistance, long considered a prime suspect, has little to do with infertility in women with type-2 diabetes, polycystic ovary syndrome and metabolic syndrome, all obesity-related conditions in which the body becomes desensitized to insulin and loses the ability to regulate blood sugar.
Insulin signaling is altered in the pancreas, a new study shows for the first time in humans. The errant signals disrupt both the number and quality of beta cells -- the cells that produce insulin.
New research reveals that insulin applied in therapeutic doses selectively stimulates the formation of new elastic fibers in cultures of human aortic smooth muscle cells. These results advance the understanding of the molecular and cellular mechanisms of diabetic vascular disease.
Controlling blood glucose early in the course of type 1 diabetes yields huge dividends, preserving kidney function for decades. The new finding from a study funded by the National Institutes of Health was published online in the New England Journal of Medicine Nov. 12 to coincide with presentation at a scientific meeting.
Intermittent exercise with and without low oxygen concentrations (or hypoxia) can improve insulin sensitivity in type 2 diabetics, however exercise while under hypoxic conditions provides greater improvements in glycemic control than intermittent exercise alone.
A new study from University of California, Berkeley, researchers demonstrates that adult stem cells can reshape our organs in response to changes in the body and the environment, a finding that could have implications for diabetes and obesity.
IRIDEX Corporation today announced that data from a clinical study compiled over 10 years demonstrates the safety and efficacy of MicroPulse laser therapy for treating diabetic macular edema without the retina tissue damage associated with conventional laser therapy. According to the United States Centers for Disease Control and Prevention, DME, a swelling of retinal tissue, is the leading cause of new cases of blindness amongst adults aged 20-74 in the US.
Isis Pharmaceuticals, Inc. announced today that it has initiated Phase 1 clinical studies for ISIS-GCGRRx and ISIS-GCCRRx, antisense drugs Isis is developing for the treatment of type 2 diabetes. Isis will develop both ISIS-GCGRRx and ISIS-GCCRRx to treat a broad population of diabetic patients. The unique mechanism of action of these new drugs could allow each drug to be used in combination with other therapies for type 2 diabetes.
Isis Pharmaceuticals, Inc. announced today that it has initiated a Phase 1 clinical study for ISIS-PTP1BRx, an antisense drug for the treatment of type 2 diabetes targeting protein tyrosine phosphatase-1B, PTP-1B. ISIS-PTP1BRx is designed to increase the body's sensitivity to the natural hormone insulin, resulting in better glucose control for patients with type 2 diabetes. Because of its unique mechanism ISIS-PTP1BRx has the potential to contribute to the treatment of type 2 diabetes without causing weight gain or hypoglycemia. The reductions in LDL-C produced by PTP-1B inhibition should also provide an added benefit to patients.
Joslin Diabetes Center has received a $3.9 million DP3 grant from the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health, to identify protective factors that enable many Joslin 50-Year Medalists to remain free of commonly occurring diabetes complications.
The Juvenile Diabetes Research Foundation (JDRF) and Selecta Biosciences, Inc. announced today that they have established a research collaboration to support Selecta's development of a vaccine technology, which may subsequently help to better treat and potentially prevent type 1 diabetes.
Johns Hopkins University has chosen Unbound Medicine as the official electronic publisher of its Antibiotic (ABX), Diabetes, and HIV POC-IT Guides. The guides provide evidenced-based information that is regularly updated so they stay on top of the latest clinical knowledge.
Researchers at the Hebrew University of Jerusalem have identified the key signal that prompts production of insulin-producing beta cells in the pancreas -- a breakthrough discovery that may ultimately help researchers find ways to restore or increase beta cell function in people with type 1 diabetes.
By knocking out a key regulatory protein, scientists at the University of California, San Diego School of Medicine and the Ecole Polytechnique Federale de Lausanne (EPFL) in Switzerland dramatically boosted insulin sensitivity in lab mice, an achievement that opens a new door for drug development and the treatment of diabetes.
Sanofi announced today data that demonstrates that initiating Lantus® (insulin glargine [rDNA origin] injection) in type 2 diabetes patients leads to better glycemic control and comparable and modest weight gain versus a comparator group consisting of other insulins, oral antidiabetics (OADs) and dietary changes. The lowest weight gain was seen in patients initiating treatment with baseline A1C levels below eight percent and in patients aged 65 and older. This data is being presented at the European Association for the Study of Diabetes (EASD) 47th Annual Meeting in Lisbon, Portugal.
The largest-ever analysis of genetic data related to type 1 diabetes has uncovered new genes associated with the common metabolic disease, which affects 200 million people worldwide. The findings add to knowledge of gene networks involved in the origin of this complex disorder, in which patients depend on frequent insulin injections to control their blood sugar levels.
A natural product called DLPC (dilauroyl phosphatidylcholine) increases sensitivity to insulin and reduces fatty liver in mice, leading Baylor College of Medicine researchers to believe it may provide a treatment for prediabetic patients. DLPC is an unusual phospholipid and a trace component of the dietary supplement lecithin.
Having a lower percentage of body fat may not always lower your risk for heart disease and diabetes, according to a study by an international consortium of investigators, including two scientists from the Institute for Aging Research of Hebrew SeniorLife, an affiliate of Harvard Medical School (HMS).
Electronic medical records (EMRs) have been in use for more than 30 years, but have only increased in utilization in recent years, due in part to research supporting the benefits of EMRs and federal legislation. As EMRs have become a standard in medical care, there is a need for additional research of how the system and usage can be refined. A group of researchers from Brigham and Women's Hospital have done just that, and discovered that one way false information can make its way into EMRs is due to users' reliance on copying and pasting material within the patient's record. These findings are published in the May 23 issue of Archives of Internal Medicine.
Obesity is a known risk factor for developing type 2 diabetes. But it hasn't been clear whether the "dose" of obesity -- how much excess weight a person has, and for how long -- affects the risk of diabetes.
Six months after a bitter dispute led to an unusual court battle, Eli Lilly and Amylin Pharmaceuticals are getting divorced. The two drugmakers announced they are ending their venture to develop and market diabetes meds, and Amylin will take control of the twice-a-day Byetta drug, as well as Bydureon, a once-weekly injectable that is designed to supplant the older drug.
Studying the genetic make-up of different varieties of lipids (fatty molecules) in the blood plasma of an individual can lead to a better and earlier prediction of diseases such as diabetes, atherosclerosis, and heart disease, two researchers will tell the annual conference of the European Society of Human Genetics today (Monday 30 May). In the first study, Dr. Joanne Curran from the Texas Biomedical Research Institute, San Antonio, USA, will tell the conference that lipidomic profiling will become a more reliable early indicator of individuals likely to develop diabetes than the more commonly used predictors such as blood glucose and insulin levels.
Our liver could be a major springboard for determining life-changing diabetes diagnosis and treatment thanks to a world-first discovery by an Australian-Chinese research team.
Researchers from Mount Sinai School of Medicine have for the first time determined that the ketogenic diet, a specialized high-fat, low carbohydrate diet, may reverse impaired kidney function in people with Type 1 and Type 2 diabetes. They also identified a previously unreported panel of genes associated with diabetes-related kidney failure, whose expression was reversed by the diet. The findings were published in the current issue of PLoS ONE.
according to a study underwritten by National Starch LLC, a business unit of Corn Products International. The American Diabetes Association defines prediabetes as a non-disease state where blood sugar (glucose) levels are higher than normal, but not yet high enough to be diagnosed as diabetes.
In observance of National Diabetes Month and World Diabetes Day on Nov. 14, the National Institutes of Health urges people to set goals and make plans to prevent diabetes and diabetes-related complications.
UC Irvine researchers have uncovered an important source of inflammation seen in people with chronic kidney disease, which is increasingly common due to the epidemic of obesity-related diabetes and hypertension.
There's more good news about pure maple syrup from the University of Rhode Island (URI). Researchers there have now identified 54 compounds in maple syrup from Canada, double the amount previously reported, and many with antioxidant activity and potential health benefits. In laboratory studies, they acted as anti-cancer and anti-inflammatory agents. Initial studies also suggest that maple compounds may inhibit enzymes relevant in Type 2 diabetes management.
The 25.8 million Americans who have diabetes may soon be free of finger pricks and daily insulin dosing. Mayo Clinic endocrinologists Yogish Kudva, M.B.B.S., and Ananda Basu, M.B.B.S., M.D., are developing an artificial pancreas that will deliver insulin automatically and with an individualized precision never before possible.
Medtronic just announced US FDA approval and market launch of CareLink® Pro 3.0 Therapy Management Software, an analytical data crunching program that provides advanced decision support to clinicians managing diabetes.
Medtronic, Inc. and Bayer HealthCare have expanded their international alliance to now include the United States and will work exclusively to develop innovative next generation diabetes management solutions for patients, state-of-the-art, wireless blood glucose meters worldwide.
A Yale University-led research team has discovered how reduced expression of a particular gene protects against obesity and type 2 diabetes, possibly prolonging lifespan by mimicking the effects of calorie restriction. The study appears in the August 3 issue of Cell Metabolism.
Researchers at the University of California, San Diego School of Medicine and Rady Children's Hospital-San Diego say an evolutionary gene mutation that occurred in humans millions of years ago and our subsequent inability to produce a specific kind of sialic acid molecule appears to make people more vulnerable to developing type 2 diabetes, especially if they're overweight.
Fifty years after participating in studies of pentosuria, an inherited disorder once mistaken for diabetes, 15 families again welcomed medical geneticists into their lives. Their willingness to have their DNA analyzed with advanced genomics technologies has solved a mystery more than a hundred years old.
Research introduced at SNM's 58th Annual Meeting may lead to much-needed cardiovascular disease screening for diabetic patients at risk of ischemic heart disease, a disorder marked by significantly reduced blood flow in the heart. Ischemia of the myocardium, or cardiac muscle, can signal diminished oxygenation of the heart tissue and trigger a heart attack if left untreated.
Developing type 2 diabetes is a lengthy process. An early sign that it has begun is high levels of insulin in the blood. As long as the insulin-producing beta cells are able to compensate for the increased demand, for example when the individual is overweight, the blood sugar levels remain normal.
Developing type 2 diabetes is a lengthy process. An early sign that it has begun is high levels of insulin in the blood. As long as the insulin-producing beta cells are able to compensate for the increased demand, for example when the individual is overweight, the blood sugar levels remain normal.
The liver normally makes and stores fat, which is required in moderation for normal body function. However, if the process goes awry, excess fat in the liver can cause major liver damage. In fact, fatty liver is a leading cause of liver failure in the United States, and is often brought on by obesity and diabetes. In turn, the increasing prevalence of these diseases has brought with it an epidemic of liver disease.
MonoSol Rx LLC, the developer of PharmFilm® drug delivery technology, and Midatech Ltd., the developer of MidaForm™ nanoparticle excipients and a global leader and center of excellence for the design, development, synthesis and manufacture of nanomedicines, today announced the launch of their strategic joint venture, MidaSol Therapeutics LP. The launch will focus on the commercialization, via partnering or licensing, of products that have combined the IP of the companies' respective technologies in the primary treatment of diabetes.
One of the more fascinating ways that medical researchers are looking in to fighting antibiotic resistant bacteria is through the use of Manuka honey. Last year, some research was published evidencing some effectiveness against MRSA. Now a team from the Cardiff School of Health Sciences has demonstrated the effectiveness of this honey against Streptococcus pyogenes, an antibiotic resistant bacteria that often infects wounds and can prevent skin grafts from forming.
Despite recent concerns that changes in atmospheric pressure during airplane travel may affect the amount of insulin delivered via pump devices, the current evidence is limited and it would be unwise to overreact until more data are available, according to an insightful editorial in Diabetes Technology & Therapeutics, a peer-reviewed journal published by Mary Ann Liebert, Inc. The editorial is available free online.
A diet high in fiber -- but not necessarily one low in saturated fat or cholesterol -- is tied to a lower risk of heart disease and type-2 diabetes in teenagers, according to new findings from Michigan State University.
Low-income women with children who move from high-poverty to lower-poverty neighborhoods experience notable long-term improvements in some aspects of their health, namely reductions in diabetes and extreme obesity, according to a new study by researchers at the University of Chicago and partner institutions.
Studies show the incidence of diabetes in dogs has increased 200 percent over the past 30 years. Now, University of Missouri veterinarians have changed the way veterinarians treat diabetes in animals by adapting a device used to monitor glucose in humans.
VIVUS, Inc. today announced that multiple abstracts have been accepted for presentation at the upcoming American Diabetes Association (ADA) meeting to be held June 24th to June 28th, 2011, at the San Diego Convention Center, San Diego, CA. Timothy Garvey, MD, Professor of Medicine and Chair of the Department of Nutrition Sciences at UAB, will present his findings on the impact of QNEXA treatment on metabolic syndrome.
The New York Cardiac Diagnostic Center announced today Dr. Steven Reisman, a New York City cardiologist, will be featured on an upcoming episode of The Jeremy Kyle Show. Dr. Reisman will be discussing the increased risk for heart disease, type 2 diabetes and metabolic syndrome for individuals who are overweight or obese.
A research collaboration between the Wyss Institute for Biologically Inspired Engineering at Harvard University and Children's Hospital Boston has developed "smart" injectable nanotherapeutics that can be programmed to selectively deliver drugs to the cells of the pancreas. Although this nanotechnology will need significant additional testing and development before being ready for clinical use, it could potentially improve treatment for Type I diabetes by increasing therapeutic efficacy and reducing side effects.
Researchers at Washington University School of Medicine in St. Louis have restored normal blood sugar metabolism in diabetic mice using a compound the body makes naturally. The finding suggests that it may one day be possible for people to take the compound much like a daily vitamin as a way to treat or even prevent type 2 diabetes.
The holidays have come and gone, but many of us may still be battling intense sweet cravings leftover from the season's festivities. Excessive sugar cravings can be a sign that your blood glucose levels are out of balance which, if left unchecked, can lead to insulin resistance and Metabolic Syndrome, also known as "Pre-Diabetes."
New survey data released today at the American Association of Clinical Endocrinologists (AACE) 20th Annual Meeting and Clinical Congress reveal that more than half (55%) of people with type 2 diabetes across the country report they have experienced hypoglycemia, or low blood sugar. What's more, many experienced it during typical daily activities such as working (42%), exercising (26%) and driving (19%), according to the survey, designed by the American College of Endocrinology (ACE) and supported by Merck. Recognizing symptoms like nervousness, sweating or shakiness before engaging in common activities is important to help reduce the risk of serious consequences, such as fainting or loss of consciousness.
Amsterdam, The Netherlands: Studying the genetic make-up of different varieties of lipids (fatty molecules) in the blood plasma of an individual can lead to a better and earlier prediction of diseases such as diabetes, atherosclerosis, and heart disease, two researchers will tell the annual conference of the European Society of Human Genetics today (Monday 30 May). In the first study, Dr. Joanne Curran from the Texas Biomedical Research Institute, San Antonio, USA, will tell the conference that lipidomic profiling will become a more reliable early indicator of individuals likely to develop diabetes than the more commonly used predictors such as blood glucose and insulin levels.
Scientists at Joslin Diabetes Center have identified two novel markers that, when elevated in the blood stream, can predict accurately the risk of renal (kidney) failure in patients with Type 1 and Type 2 diabetes. The findings have immediate diagnostic implications and can be used for the development of new therapies to prevent or postpone the progression of renal disease in diabetes.
For those who suffer from diabetes, the pain that comes with pricking one's finger often discourages consistent blood glucose monitoring. However, with a new sensor from engineers at Arizona State University and Mayo Clinic, the days of painful finger pricks may be numbered.
In a new post-hoc analysis based on the American Association of Clinical Endocrinologists (AACE/ACE) diabetes algorithm presented at the American Diabetes Association (ADA) 71st Annual Scientific Sessions, significantly more patients with type 2 diabetes treated with JANUMET- (sitagliptin/metformin HCl) tablets achieved blood sugar goals after 18 weeks compared to metformin as initial therapy.
People with diabetes could be helped by a new type of self-monitoring blood glucose sensor being developed by Arizona State University engineers and clinicians at Mayo Clinic in Arizona.
A new signal pathway that renders the insulin-releasing beta cell more sensitive to high levels of blood glucose has been discovered by researchers at the Swedish medical university Karolinska Institutet. A second new study reveals a possible way to delay the disease by inhibiting a lipoprotein.
A team of engineers and scientists at the University of British Columbia has developed a device that can be implanted behind the eye for controlled and on-demand release of drugs to treat retinal damage caused by diabetes.
A new anti-inflammatory drug used by patients with type 2 diabetes improved their kidney function during a year-long study involving researchers from UT Southwestern Medical Center.
Researchers at the Stanford University School of Medicine have identified a key molecular pathway responsible for the natural decrease in the proliferation of insulin-producing cells that occurs as a person ages. Artificially activating this pathway, which is normally not functional in adults, may be a new way to combat diabetes.
A new fact sheet from the National Institutes of Health explains the A1C test, a widely used and important test to diagnose type 2 diabetes and prediabetes, and to monitor blood glucose levels of people with type 1 and type 2 diabetes.
An international research team has discovered that a pervasive human RNA modification provides the physiological underpinning of the genetic regulatory process that contributes to obesity and type II diabetes.
Research by a team of Michigan State University scientists has shed new light on why some body parts are more sensitive to environmental change than others, work that could someday lead to better ways of treating a variety of diseases, including type 2 diabetes.
Blood vessels and supporting cells appear to be pivotal partners in repairing nerves ravaged by diabetic neuropathy, and nurturing their partnership with nerve cells might make the difference between success and failure in experimental efforts to regrow damaged nerves, Johns Hopkins researchers report in a new study.
Researchers at Joslin Diabetes Center have determined key differences between Type 1 and Type 2 diabetes in the Asian American population. This study, identified ways to differentiate the types of diabetes, which can be clinically similar in young Asian Americans.
The results from a new CIGNA study support that there is a potential association between treated periodontal (gum) disease and reduced medical costs for patients with diabetes. The findings of the three-year claims study were presented during a recent meeting of the International Association for Dental Research (IADR) in San Diego.
Researchers from The Australian National University have discovered a new treatment for Type-1 diabetes -- an autoimmune disease which currently affects some 130,000 Australians.
Researchers at the Joslin Diabetes Center have shown that an enzyme found in the mitochondria of cells is decreased in the skeletal muscle of those with diabetes, a finding that could lead to the development of drugs to boost the activity of this enzyme in an effort to fight the disease.
The work of a team of scientists at Cold Spring Harbor Laboratory (CSHL) led by Professor Nicholas Tonks FRS, suggests a way to overcome one of the major technical obstacles preventing a leading therapeutic target for diabetes and obesity from being addressed successfully by novel drugs.
UC Davis investigators have shown that blocking a specific receptor pathway could slow or even prevent diabetic nephropathy -- an often fatal complication of diabetes for which there are few good treatment options. Published online today (May 26) in the journal Arteriosclerosis, Thrombosis and Vascular Biology, the study is the first to clarify the role of the receptor -- toll-like receptor 2, or TLR2 -- in diabetes-associated kidney disease.
A new strategic plan to guide diabetes-related research over the next decade was announced today by the National Institutes of Health. The plan, developed by a federal work group led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), identifies research opportunities with the greatest potential to benefit the millions of Americans who are living with or at risk for diabetes and its complications.
A scientist at The Scripps Research Institute has been awarded $4.2 million from the National Institutes of Health in a program to advance what the agency calls "bold and creative research" into Type I diabetes.
Diabetic retinopathy is one of the most common and debilitating complications of diabetes. During National Diabetes Month, the National Eye Institute (NEI), a part of the National Institutes of Health, is encouraging people with diabetes to get annual dilated eye exams and take steps to avoid vision loss.
Scientists at the National Institutes of Health have uncovered a pathway in mice that allows white fat -- a contributor to obesity and type 2 diabetes -- to burn calories in a way that's normally found in brown fat and muscle. The findings are in the July 6 edition of Cell Metabolism.
A high level of a hormone that regulates phosphate is associated with an increased risk of kidney failure and death among chronic kidney disease (CKD) patients, according to a recent study led by researchers at the University of Miami and funded by the National Institute of Diabetes and Digestive Diseases and Kidney Diseases (NIDDK) at the National Institutes of Health. Results are in the June 15 issue of the Journal of the American Medical Association.
In observance of National Diabetes Month and World Diabetes Day on Nov. 14, the National Institutes of Health urges people to set goals and make plans to prevent diabetes and diabetes-related complications.
Diabetes is often called the "silent killer" because people who have it are often unaware they are affected. According to the American Diabetes Association, diabetes affects 26 million people -- including children -- in the United States. Approximately one-quarter of those people do not know they're living with the disease.
Type 2 diabetes patients, who face higher risk of cardiovascular disease, often take a combination of medications designed to lower their LDL or "bad" cholesterol and triglyceride levels while raising their HDL or "good" cholesterol because doctors long have thought that taken together, the drugs offer protection from heart attacks and improve survival.
Today, Novo Nordisk, a world leader in diabetes care, launched a free 5-volume diabetes educational e-book series, designed to help patients work with their health care team to better manage their diabetes.
Novo Nordisk announced today that the company will establish a type 1 diabetes research and development center in Seattle, Wash., U.S. The new center will combine Novo Nordisk's history of innovation and leadership in diabetes treatment with the company's growing expertise in immunotherapy.
Ultra-long-acting insulin degludec, an investigational basal insulin being developed by Novo Nordisk, showed significant blood sugar reductions in patients with type 2 diabetes. A study demonstrated that changes in the injection time of insulin degludec from day to day (up to 40 hours apart) did not affect overall glycaemic control or risk of hypoglycaemia when compared to insulin glargine given at the same time each day. Data were presented today at the 47th meeting of the European Association for the Study of Diabetes (EASD) in Lisbon. The clinical investigation of insulin degludec is ongoing and regulatory submission has not been filed.
The number of adults with type 2 diabetes has doubled worldwide over the last three decades, rising from 153 million in 1980 to 347 million, "a sign that the epidemic will impose an ever-greater cost burden on health systems," according to a study published on Saturday in the Lancet, the Wall Street Journal reports.
Nonalcoholic steatohepatitis (NASH) occurs when fat builds up in the liver. This accumulation of fat damages the liver and leads to cirrhosis. NASH is rapidly increasing in the U.S. mainly related to the epidemics of obesity and diabetes.
Obese individuals typically suffer more medical problems than their leaner counterparts. They are more likely to be diagnosed with insulin resistance, diabetes, increased stress hormones, hypothyroidism, and sleep apnea. Researchers at the Georgia Health Sciences University in Augusta have also found the potential for something else, using an animal model. They have found that a master clock gene -- which regulates the cardiovascular system -- does not fluctuate regularly as it does in non-obese animals. This means that a key gene clock of the cardiovascular system does not work properly when obesity is present. The findings are believed to be the first of their kind.
Obese patients with high blood pressure and diabetes are at much higher risk for major complications following non-cardiac surgery compared to otherwise healthy obese patients and patients of normal weight.
Eli Lilly and Company today announced it is conducting the first major international, prospective observational study designed to understand the real-world obstacles that people with type 2 diabetes face that prevent them from reaching their ultimate treatment goals.
Approximately one in five Canadians has metabolic syndrome -- a combination of risk factors for diabetes and heart disease -- according to a study in CMAJ (Canadian Medical Association Journal).
Even in a society that lives for the quick fix, a daily pill that could help prevent Type II diabetes sounds too good to be true. But a team of researchers at Washington University School of Medicine claims to be taking the first steps to making such a compound a reality.
Bristol-Myers Squibb Company and AstraZeneca today announced results from an investigational Phase 3b clinical study in which the addition of ONGLYZA™ (saxagliptin) 5 mg to ongoing insulin therapy (with or without metformin) maintained reductions of blood sugar levels (glycosylated hemoglobin levels, or HbA1c) in adult patients with type 2 diabetes compared to the addition of placebo (with or without metformin) from 24 to 52 weeks.
Tolerx, Inc. and GlaxoSmithKline today announced that the Phase 3 DEFEND-1 study of otelixizumab, an investigational humanized anti-CD3 monoclonal antibody, did not meet the primary efficacy endpoint of change in C-peptide at month 12 in patients with new-onset autoimmune type 1 diabetes.
Despite living in the countryside, where open space is plentiful and there is often significant agricultural production, California's more than half a million rural elders are far more likely to be overweight or obese, physically inactive and food insecure than their suburban counterparts, according to a new policy brief from the UCLA Center for Health Policy Research.
A somewhat mysterious soft tissue found in the fetus during early development in the womb plays a pivotal role in the formation of mature beta cells the sole source of the body's insulin. This discovery, made by scientists at University of California, San Francisco (UCSF) and Texas A&M University, may lead to new ways of addressing Type 1 and Type 2 diabetes.
Three randomized controlled trials published Online First today in Archives of Internal Medicine examine the effectiveness of behavioral and educational interventions for patients with poorly controlled diabetes. All three reports are part of the journal's Health Care Reform series.
Celebrity chef Paula Deen on Wednesday pledged a portion of her earnings from a lucrative endorsement deal with a diabetes drugmaker to the nonprofit American Diabetes Association.
Celebrity chef and Food Network star Paula Deen is teaming with drug maker Novo Nordisk to launch a program that aims to help people live with Type 2 diabetes and promote a Novo diabetes drug.
Obesity and insulin resistance are almost inevitably associated with increases in lipid accumulation in the liver, a serious disease that can deteriorate to hepatitis and liver failure. A real paradox in understanding insulin resistance is figuring out why insulin-resistant livers make more fat. Insulin resistance occurs when the body does a poor job of lowering blood sugars.
Scientists at the Helmholtz Zentrum München have shown that people with a good vitamin D supply are at lower risk of developing Type 2 diabetes mellitus. The study, which was conducted in cooperation with the German Diabetes Center and the University of Ulm, will be published in the October edition of the renowned scientific journal Diabetes Care.
By consuming fewer calories, ageing can be slowed down and the development of age-related diseases such as cancer and type 2 diabetes can be delayed. The earlier calorie intake is reduced, the greater the effect. Researchers at the University of Gothenburg have now identified one of the enzymes that hold the key to the ageing process.
Perrigo Company today announced that it has signed a definitive agreement to acquire substantially all of the assets of CanAm Care, a privately-held, Alpharetta, Georgia-based distributor of diabetes care products for approximately $36 million in cash. The acquisition is expected to be immediately accretive to adjusted earnings per share.
Scientists exploring a potential cure for diabetes have shown that transplanting insulin-producing cells from embryonic pigs into diabetic monkeys can dramatically lower blood sugar levels, though not quite to normal levels.
The road to type 2 diabetes is paved with insulin resistance, a condition often associated with obesity in which the hormone begins to fail at its job helping to convert sugars to energy. Researchers at Joslin Diabetes Center have now identified an enzyme called PKC-delta as an important molecular modifier for development of insulin resistance, diabetes and fatty liver in mice. They also have found evidence suggesting a similar role for the enzyme in humans, making PKC-delta a promising new target for drugs for diabetes and related ailments.
For the 26 million Americans with diabetes, drawing blood is the most prevalent way to check glucose levels. It is invasive and at least minimally painful. Researchers at Brown University are working on a new sensor that can check blood sugar levels by measuring glucose concentrations in saliva instead.
Fero Industries, Inc. is pleased to announce that it has contracted PNP Pharmaceuticals Inc. as the exclusive global manufacturer of Sucanon®, an oral treatment for type-2 diabetes.
Drugs known as thiazolidinediones, or TZDs for short, are widely used in diabetes treatment, but they come with a downside. The drugs have effects on the kidneys that lead to fluid retention as the volume of plasma in the bloodstream expands.
Genentech, a member of the Roche Group, today announced 24-month results from the two pivotal Phase III trials assessing the efficacy and safety of Lucentis® (ranibizumab injection) in people with diabetic macular edema (DME). The data showed patients who received Lucentis experienced significant, rapid and sustained improvement in vision compared to those who received placebo (sham) injections. Additional analyses showed patients who received Lucentis were significantly more likely to achieve 20/40 vision and experience less progression of the underlying diabetic retinopathy disease.
PositiveID Corporation out of Delray Beach, Florida won clearance from the FDA for its wireless iglucose diabetes management system. The device is essentially a black box that has a USB port outside and a cellular chip inside.
Newly published research from the Bruce Hammock lab at the University of California, Davis, and colleagues indicates a possible breakthrough in reducing the severity of complications associated with diabetes, including kidney, pain, inflammation and cardiac issues. The research, done with rodents, could lead to improved treatment of type 2 diabetes, a disease affecting nearly 30 million people in the United States alone.
Lower potassium levels in the blood may help explain why African-Americans are twice as likely to be diagnosed with type 2 diabetes as whites, according to a new study by Johns Hopkins researchers.
The work of a team of scientists at Cold Spring Harbor Laboratory (CSHL) led by Professor Nicholas Tonks FRS, suggests a way to overcome one of the major technical obstacles preventing a leading therapeutic target for diabetes and obesity from being addressed successfully by novel drugs.
Researchers in the Faculty of Medicine & Dentistry at the University of Alberta have discovered that resveratrol, a powerful antioxidant found in common foods, prevents a syndrome in some offspring that could lead to later health issues such as diabetes.
Spherix Incorporated -- an innovator in biotechnology for therapy in diabetes, metabolic syndrome and atherosclerosis, and providers of technical and regulatory consulting services to food, supplement, biotechnology and pharmaceutical companies -- today announced that its drug candidate, SPX-106, achieved statistically significant reductions in triglycerides and cholesterol when administered in combination with D-tagatose for nine weeks to genetically engineered mice prone to dyslipidemia.
Watching television is the most common daily activity apart from work and sleep in many parts of the world, but it is time for people to change their viewing habits. According to a new study from Harvard School of Public Health (HSPH) researchers, prolonged TV viewing was associated with increased risk of type 2 diabetes, cardiovascular disease, and premature death.
Though it generally is known that obesity dramatically increases the risk for type 2 diabetes, the biological mechanisms for that connection still are unclear.
Decreasing blood levels of a protein that helps control inflammation may be a red flag that could help children avoid type 1 diabetes, researchers say.
Increasing levels of high-density lipoproteins, better known as HDL or "good" cholesterol, reduced the risk for heart attack and stroke among patients with diabetes. That's according to a new study appearing online today in The American Journal of Cardiology.
A new study by Harvard School of Public Health (HSPH) researchers finds a strong association between the consumption of red meat--particularly when the meat is processed--and an increased risk of type 2 diabetes. The study also shows that replacing red meat with healthier proteins, such as low-fat dairy, nuts, or whole grains, can significantly lower the risk.
A highly renowned obstetrician, professor and researcher who showed that babies born to obese and diabetic women have a higher risk of becoming overweight and developing diabetes or other metabolic health problems later in life, received the March of Dimes 2011 Agnes Higgins award for outstanding achievement in the field of maternal-fetal nutrition.
New research from Warwick Medical School indicates some of your risk of developing obesity, diabetes and heart conditions is pre-determined whilst in the womb and by improving the pregnant mother’s diet and vitamins intake you can shape your baby’s future metabolism for the better.
A review of the genetic and biochemical abnormalities associated with autism reveals a possible link between the widely diagnosed neurological disorder and Type 2 diabetes, another medical disorder on the rise in recent decades.
Research carried out at the Hebrew University of Jerusalem has provided the first proof of molecular risk factors leading to type 2 diabetes, providing an "early warning" sign that could lead to new approaches to treating this and other human disease conditions.
New research identifies a distinctive population of immune cells that may play a key role in the pathogenesis of diabetes. The research, published by Cell Press and available online in the April 21st issue of Immunity, sheds new light on the pathogenesis of diabetes and may lead to the development of new more selective therapeutic strategies for diabetes and other autoimmune diseases of the accessory organs of the digestive system.
New research led by the twins Daniel and Shawn Winer, both of the University of Toronto, in conjunction with Lei Shen, research assistant at Stanford, has shown, in a paper published in Nature Medicine, a possible link between immune cell attacks and fat cell insulin resistance, the underlying cause of type-2 diabetes.
In the fast-paced world of health care, doctors are often pressed for time during patient visits. Researchers at the University of Missouri developed a tool that allows doctors to view electronic information about patients' health conditions related to diabetes on a single computer screen.
Researchers from Children’s Hospital, Boston and Harvard University-based Wyss Institute for Biologically Inspired Engineering have discovered "smart" injectable nanotherapeutics that can be selectively programmed to transmit drugs to pancreatic cells.
Simply put, people develop diabetes because they don't have enough pancreatic beta cells to produce the insulin necessary to regulate their blood sugar levels.
Researchers at the Stanford University School of Medicine have identified a key molecular pathway responsible for the natural decrease in the proliferation of insulin-producing cells that occurs as a person ages. Artificially activating this pathway, which is normally not functional in adults, may be a new way to combat diabetes.
Hormone researchers at the University of Houston (UH) have their sights set on providing long-term treatment options for diabetes, obesity and cardiovascular diseases by better understanding estradiol, the most potent naturally occurring estrogen.
The brain's hypothalamus plays a key role in obesity and one of its major complications -- type 2 diabetes. Nerve cells in the hypothalamus detect nutrients and hormones circulating in the blood and then coordinate a complex series of behavioral and physiological responses to maintain a balance between calories eaten and calories burned. Obesity and diabetes can result when this regulatory mechanism goes awry.
Lower potassium levels in the blood may help explain why African-Americans are twice as likely to be diagnosed with type 2 diabetes as whites, according to a new study by Johns Hopkins researchers.
Researchers at the University of Colorado School of Medicine have found a specific molecule that can prevent the development of type 1 diabetes in mice and has a similar effect on human cells from diabetic patients.
Researchers at UT Southwestern Medical Center have discovered a hormone pathway that potentially could lead to new ways of treating type 1 diabetes independent of insulin, long thought to be the sole regulator of carbohydrates in the liver. Results of this new study will be published March 25 in Science.
Human arteries — some smaller than a strand of hair — stiffen as a person ages. This stiffening is a factor in cardiovascular disease, the leading cause of death in the United States, because it contributes to the circulatory complications in disorders such as high blood pressure and diabetes. University of Missouri researchers have now used advanced 3-D microscopic imaging technology to identify and monitor the proteins involved in this stiffening process.
Many complications of diabetes, including kidney disease, foot problems and vision problems are generally well recognized. But the disease's impact on the brain is often overlooked.
Researchers at the Hebrew University of Jerusalem have identified the key signal that prompts production of insulin-producing beta cells in the pancreas -- a breakthrough discovery that may ultimately help researchers find ways to restore or increase beta cell function in people with type 1 diabetes.
Researchers at the La Jolla Institute for Allergy & Immunology have proven – for the first time in human tissues -- the specific immune system T cells which trigger the destruction of type 1 diabetes in the pancreas. The finding is an important advance that verifies in humans several important disease characteristics shown in mouse studies and provides a key focal point for interrupting the disease process.
Researchers at the University of Saskatchewan have discovered, after a two-year investigation, that diets high in carbohydrates are a probable mechanism for the skyrocketing rates of Type 2 diabetes.
A war is being waged in the pancreases of millions of people throughout the world. The siege leads to the development of type 1 diabetes and has been a battlefield largely hidden from view-- until now. Researchers at the La Jolla Institute for Allergy & Immunology have created the first cellular movies showing the destruction underlying type 1 diabetes in real-time in mouse models. This detailed, dynamic view will provide the worldwide scientific community insights into this disease process as never before possible and may profoundly affect future directions in type 1 diabetes research.
University of Louisville researchers have replicated the inflammatory gene changes of a human kidney as it progresses from mild to severe diabetic nephropathy, using a mouse model developed by a UofL researcher, according to an article published today in the journal Experimental Nephrology. Diabetic nephropathy is the foremost cause of kidney failure.
Researchers at the Joslin Diabetes Center have shown that an enzyme found in the mitochondria of cells is decreased in the skeletal muscle of those with diabetes, a finding that could lead to the development of drugs to boost the activity of this enzyme in an effort to fight the disease.
Kinesiology researcher Barry Braun of the University of Massachusetts Amherst and colleagues recently reported unexpected results of a study suggesting that exercise and one of the most commonly prescribed drugs for diabetes, metformin, each improves insulin resistance when used alone, but when used together, metformin blunted the full effect of a 12-week exercise program in pre-diabetic men and women.
Pediatric researchers who tested newborn animals with an existing human drug used in adults with diabetes report that this drug, when given very early in life, prevents diabetes from developing in adult animals. If this finding can be repeated in humans, it may become a way to prevent at-risk infants from developing type 2 diabetes.
At the recent Interscience Conference on Anti-Microbial Agents and Chemotherapy, Dr. Lawrence Eron from the University of Hawaii presented his results on the use of maggots to heal diabetic wounds. The small trial treated 37 diabetic patients with 27 showing successful outcomes.
A low-calorie diet eliminates insulin dependence and leads to improved heart function in obese patients with type 2 diabetes, according to a study presented November 28 at the annual meeting of the Radiological Society of North America (RSNA).
World citizen number 7 billion is less likely to die from infectious diseases like measles or even AIDS, and more likely to contract diabetes or other non-communicable diseases (NCDs), as they are now the leading causes of deaths globally.
According to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM), exposure to electrical light between dusk and bedtime strongly suppresses melatonin levels and may impact physiologic processes regulated by melatonin signaling, such as sleepiness, thermoregulation, blood pressure and glucose homeostasis.
Women who work a rotating (irregular) schedule that includes three or more night shifts per month, in addition to day and evening working hours in that month, may have an increased risk of developing type 2 diabetes when compared with women who only worked days or evenings.
A simpler form of testing individuals with risk factors for diabetes could improve diabetes prevention efforts by substantially increasing the number of individuals who complete testing and learn whether or not they are likely to develop diabetes.
For South Asians, time spent sitting down is a risk factor for diabetes which is not counteracted by time spent exercising or decreased waist size. These are the findings of a new study funded by the National Prevention Research Initiative (NPRI), which is led by the Medical Research Council.
Sangamo BioSciences, Inc. today announced that its Phase 2b study (SB-509-901) did not meet its primary or secondary clinical endpoints in subjects with moderate severity diabetic neuropathy (DN) as compared to placebo.
Excessive levels of certain saturated fatty acids cause mitochondria to fragment, leading to insulin resistance in skeletal muscle, a precursor of type 2 diabetes. This is the first time mitochondrial fragmentation has been implicated in insulin resistance.
Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), jointly with colleagues in the United States, have found out that inflammations of the heart muscle are caused by attacks of a specific type of immune cells. These immune cells attack the body's own tissue because during their maturation they did not have the chance to develop tolerance against a protein that is only found in the heart muscle.
New evidence has emerged from studies in mice that short telomeres or "caps" at the ends of chromosomes may predispose people to age-related diabetes, according to Johns Hopkins scientists.
Like a magician employing sleight of hand, the protein mitoNEET -- a mysterious but important player in diabetes, cancer and aging -- draws the eye with a flurry of movement in one location while the subtle, more crucial action takes place somewhere else.
Newly diagnosed type 2 diabetics tend to have one thing in common: obesity. Exactly how diet and obesity trigger diabetes has long been the subject of intense scientific research. A new study led by Jamey D. Marth, Ph.D., director of the Center for Nanomedicine, a collaboration between the University of California, Santa Barbara and Sanford-Burnham Medical Research Institute (Sanford-Burnham), has revealed a pathway that links high-fat diets to a sequence of molecular events responsible for the onset and severity of diabetes. These findings were published online August 14 in Nature Medicine.
Controlling diabetes may someday involve mining stem cells from the lining of the uterus, Yale School of Medicine researchers report in a new study published in the journal Molecular Therapy. The team treated diabetes in mice by converting cells from the uterine lining into insulin-producing cells.
The development of a medicine for patients with type 1 diabetes mellitus, based on autoantigen GAD65, received a setback following crucial clinical phase 3 trials that failed to show significant effects. One possible explanation may be seasonal variations in the immune system.
A simple finger prick test during routine eye examinations at high street opticians could help to identify millions of people with previously undiagnosed Type 2 diabetes, according to new research.
Researchers at King's College London have developed a test to screen patients for a range of genetic and acquired illnesses from a single spot of dried blood. The test uses mass spectrometry to analyze diagnostic peptides and metabolites in the blood and overcomes the need for larger liquid blood samples which are currently used.
Insulin pumps can be an easier way to deal with type 1 diabetes, but only 20 to 30 percent of the country who rely on insulin use them because they're usually not very discreet. The t:slim, however, looks as sleek as a smartphone, and even features a touchscreen UI so it's easier to carry and less conspicuous to use in public.
The number of people who are obese and suffer one or more of its associated health problems (including type 2 diabetes) is escalating dramatically. Researchers are seeking to identify new targets for therapeutics that could limit appetite and thereby obesity. A team of researchers, led by Scott Waldman, at Thomas Jefferson University, Philadelphia, has now uncovered one such potential target by studying the molecular control of appetite in mice.
Sugar should be controlled like alcohol and tobacco to protect public health, according to a team of UCSF researchers, who maintain in a new report that sugar is fueling a global obesity pandemic, contributing to 35 million deaths annually worldwide from non-communicable diseases like diabetes, heart disease and cancer.
In 2005, news first broke that researchers in Scotland found unexpectedly low rates of cancer among diabetics taking metformin, a drug commonly prescribed to patients with Type II diabetes. Many follow-up studies reported similar findings, some suggesting as much as a 50-per-cent reduction in risk.
Among individuals in the U.S. with diabetes, non-Latino whites tend to better control the cardiovascular risk factors blood glucose, blood pressure, and cholesterol, while African-Americans, Mexican-Americans, and those with little or no college education are at higher risk for complications of the disease.
Supreme Court Justice Sonia Sotomayor was seven years old and living in the South Bronx when she found she was thirsty all the time. Soon after, she started wetting her bed at night.
But researchers note statins address the cardiovascular consequences of diabetes and current American Diabetes Association guidelines for primary and secondary prevention should not change. Likewise, researchers write that guidelines for statin use in nondiabetic populations also should not change.
Despite the disappointing results in trying to treat children suffering from type 1 diabetes with the GAD vaccine, the treatment has not been written off entirely. DIAPREV-IT, the study in which healthy high-risk children are vaccinated, is continuing as planned, and now with more money behind it.
UC Davis Vascular Center researchers have embarked on a highly anticipated study that involves using a patient's own stem cells to increase blood circulation to the lower leg with the hope of preventing amputation due to severe arterial disease or diabetes.
Type 1 diabetes is caused by the body's own immune system attacking its pancreatic islet beta cells and requires daily injections of insulin to regulate the patient's blood glucose levels. A new method described in BioMed Central's open access journal BMC Medicine uses stem cells from cord blood to re-educate a diabetic's own T cells and consequently restart pancreatic function reducing the need for insulin.
A recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) found that shift work at a young age is associated with elevated long-term cortisol levels and increased BMI. Previous studies have shown that long-term elevated cortisol levels lead to increased abdominal obesity, hypertension, diabetes and cardiovascular risk.
Implementing structured exercise training, including aerobic, resistance or both, was associated with a greater reduction in hemoglobin A1c levels (a marker of glucose control) for patients with diabetes compared to patients in the control group, and longer weekly exercise duration was also associated with a greater decrease in these levels, according to results of an analysis of previous studies, published in the May 4 issue of JAMA.
Engineering students at Brigham Young University have developed a computer setup that can be controlled with a person's eye movements. The system measures 2 inches thick, 10 inches long and 14 inches wide, runs the Windows 7 operating system, and costs under $1,500.
People with diabetes may one day have a less expensive resource for monitoring their blood glucose levels, if research by a group of Missouri University of Science and Technology students becomes reality.
IRIDEX Corporation today announced that leading clinicians have performed and published the results of a new study that compares the benefits of MicroPulse photocoagulation technology, similar to that used in the new generation IRIDEX lasers, over the standard-of-care protocol for the treatment of eyes with diabetic macular edema (DME).
Surgeons from Boston Medical Center (BMC) have found that in diabetic patients undergoing coronary artery bypass graft (CABG) surgery, aggressive glycemic control does not result in any significant improvement of clinical outcomes as compared with moderate control. The findings, which appear in this month's issue of Annals of Surgery, also found the incidence of hypoglycemic events increased with aggressive glycemic control.
In a paper published today in Diabetologia, a team at Joslin Diabetes Center, headed by Mary R. Loeken, PhD, has identified the enzyme AMP kinase (AMPK) as key to the molecular mechanism that significantly increases the risk of neural tube defects such as spina bifida and some heart defects among babies born to women with diabetes.
A special Medicare program that stresses home health visits for patients with chronic diseases helped keep diabetes patients out of the hospital and may have lowered costs using time-honored prevention methods, researchers reported on Monday.
A Mayo Clinic study finds no correlation between the use of shock waves to break up kidney stones and the long-term development of diabetes. The study was released Friday during a meeting of the North Central Section of the American Urological Association in Rancho Mirage, Calif.
A diet high in saturated fat is a key contributor to type 2 diabetes, a major health threat worldwide. Several decades ago scientists noticed that people with type 2 diabetes have overly active immune responses, leaving their bodies rife with inflammatory chemicals.
Scientists at Joslin Diabetes Center have identified two novel markers that, when elevated in the blood stream, can predict accurately the risk of renal (kidney) failure in patients with Type 1 and Type 2 diabetes. The findings have immediate diagnostic implications and can be used for the development of new therapies to prevent or postpone the progression of renal disease in diabetes.
A study led by Matej Oresic from VTT Technical Research Centre of Finland suggests that autoimmune diabetes is preceded by diminished gut microbial diversity of the Clostridium leptum subgroup, elevated plasma leptin and enhanced glucose-stimulated insulin secretion.
Joslin researchers find critical diagnostic marker for differentiating type 1 and type 2 diabetes in young Asian Americans plus basis for changes to treatment approaches for type 2 Asian Patients.
A new study finds that decreasing the disparities in rates of type 2 diabetes among Whites, Blacks and Hispanics could eliminate some racial and ethnic disparities in the development of cognitive impairment or dementia. Prior research has shown that type 2 diabetes is a risk factor for all forms of major cognitive impairment, including Alzheimer's disease.
Researchers at Albert Einstein College of Medicine of Yeshiva University have demonstrated for the first time that the brain is a key player in regulating glucose (sugar) metabolism in humans. The findings, published today in the online edition of the Journal of Clinical Investigation, suggest that drugs targeting the brain and central nervous system could be a novel approach to treating diabetes.
79 million American adults have prediabetes and will likely develop diabetes later in life, according to the Centers for Disease Control and Prevention. As the number of people diagnosed with diabetes continues to grow, researchers are focusing on discovering why the prevalence of the disease is increasing. John Thyfault, an assistant professor in MU's departments of Nutrition and Exercise Physiology and Internal Medicine, has found that ceasing regular physical activity impairs glycemic control (control of blood sugar levels), suggesting that inactivity may play a key role in the development of type 2 diabetes.
Reducing cardiovascular risk factors like high blood pressure, smoking, diabetes and being overweight could potentially reduce more than half of all cases of atrial fibrillation, according to research reported in Circulation: Journal of the American Heart Association.
JDRF-funded researchers have begun enrolling adult patients with type 1 diabetes (T1D) in the REMOVAL study, to test whether metformin—a drug commonly used to treat type 2 diabetes—could help prevent or reduce the risk of cardiovascular complications in people with T1D.
Researchers at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) have shown that the quality -- not just the quantity -- of adipose, or fat, tissue is a significant contributing factor in the development of inflammation and vascular disease in obese individuals. The study, which is a special feature on the iPAD version of the Journal of the American College of Cardiology, provides compelling evidence that the answer to treating cardiovascular disease and other obesity-related disorders, such as type 2 diabetes and cancer, might be found in the adipose tissue itself.
Results of a small, observational study conducted at the University at Buffalo suggest that liraglutide, an injectable medication used to treat type 2 diabetes, also helps type 1 diabetics on insulin achieve optimal control of their blood glucose levels.
A Case Western Reserve University study has found electronic health records could help keep patients healthier -; at least those with diabetes -; and that clinical quality improvement is greater at practices that use EHRs.
Sixty-six percent of publicly-insured children were unable to get a doctor's appointment for medical conditions requiring outpatient specialty care including diabetes and seizures, while children with identical symptoms and private insurance were turned away only 11 percent of the time, according to an audit study of specialty physician practices in Cook County, Ill. conducted by researchers from the Perelman School of Medicine and the School of Social Policy and Practice at the University of Pennsylvania. The findings are published in the June 16 issue of the New England Journal of Medicine.
New research identifies a distinctive population of immune cells that may play a key role in the pathogenesis of diabetes. The research, available online in the April 21st issue of Immunity, sheds new light on the pathogenesis of diabetes and may lead to the development of new more selective therapeutic strategies for diabetes and other autoimmune diseases of the accessory organs of the digestive system.
Though most would agree that the digitization of our daily lives has overall been positive, there remains the persistent danger posed by hackers. This risk has ranged from the fairly innocuous (e-mail or Facebook spammers) to the financially ruinous (online bank account and credit card theft), and sometimes even to seizure inducing. However, with the digitization of medical devices -- a trend that often awes us by its potential to improve healthcare delivery -- the danger associated with hacking may now even be deadly.
One holy grail of medical technology research has been the possibility of measuring patients’ blood glucose levels indirectly, avoiding the universally hated needle pricks. Not only will this make millions of diabetics jump with joy, it will certainly increase their testing compliance, leading to better management of the disease.
SweetSpot Diabetes Care, Inc. today announced an initiative to remotely monitor blood glucose levels in veterans with diabetes, which will be funded by an award from The U.S. Department of Veteran Affair's industry innovation competition known as VAi2. Aimed at improving care and reducing complications in patients with diabetes, the SweetSpot initiative will begin with a trial in Dayton, OH.
Takeda Pharmaceutical Company Limited and its wholly-owned subsidiaries, Takeda Global Research & Development Center, Inc., and Takeda Global Research & Development Centre, Ltd., announced today the initiation of the Company's Phase 3 clinical trial program for TAK-875, an investigational therapy for type 2 diabetes. The program will be conducted across the United States, Latin America, and Europe. TAK-875 is the first GPR40 agonist to reach late stage clinical development.
People living with diabetes can help change the lives of others with diabetes in need as they do something in unison -- exercise. Every time someone participates in the Big Blue Test and shares the experience on BigBlueTest.org, a donation of life-saving supplies will be made on their behalf to someone with diabetes in need.
A new study in the journal Health Services Research shows that diabetes patients who do a better job of taking their medication have slightly lower health care costs.
The road to type 2 diabetes is paved with insulin resistance, a condition often associated with obesity in which the hormone begins to fail at its job helping to convert sugars to energy. Researchers at Joslin Diabetes Center have now identified an enzyme called PKC-delta as an important molecular modifier for development of insulin resistance, diabetes and fatty liver in mice. They also have found evidence suggesting a similar role for the enzyme in humans, making PKC-delta a promising new target for drugs for diabetes and related ailments.
Tandem Diabetes Care out of San Diego, CA will soon be marketing in the U.S. its t:slim insulin pump thanks to a newly issued FDA approval. The t:slim looks more like an iPhone 4 than a critical medical device, including a color touchscreen and USB connectivity for syncing with a computer and for recharging the internal battery.
University of Arizona researchers have received a prestigious grant to develop indicator molecules to track the onset of diabetes in patients before the disease develops -- potentially paving the way to developing treatments.
Tammy Williams was no stranger to diabetes. The North Carolina children's librarian, now on disability, had originally been diagnosed with Type II diabetes in her mid-20s. For years, she had been managing her diabetes through diet modification and oral medications. But about six years ago, she entered a new area in the world of diabetes: insulin therapy.
A research team from China investigated the effects of the Chinese herbal decoction, Yi-Qi-Zeng-Min-Tang (YQZMT), on insulin resistance in Type 2 diabetic rats. The results showed that YQZMT, which ameliorates insulin resistance and does not cause increase in body weight, may be a suitable therapeutic adjunct for the treatment of Type 2 diabetes.
Researchers at the John G. Rangos Sr. Research Center at Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine have identified a powerful molecular pathway that regulates the liver's management of insulin and new glucose production, which could lead to new therapies for diabetes. The findings were published online this week in Diabetes, a journal of the American Diabetes Association.
A research team, led by La Jolla Institute scientist Joel Linden, Ph.D., has shed new light on the problem of insulin resistance, and identified the key participants in a molecular pathway that holds therapeutic promise for reducing the severity of type 2 diabetes.
Scientists are reporting development and successful laboratory testing of an electrochemical sensor device that has the potential to measure blood sugar levels from tears instead of blood -- an advance that could save the world's 350 million diabetes patients the discomfort of pricking their fingers for droplets of blood used in traditional blood sugar tests. Their report appears in ACS' journal Analytical Chemistry.
Although clearly more comforting than pricking fingers, we’ll have to see if we want type 1 kids and type 2 demented elderly sticking pipettes into their eyeballs.
Heart function may be affected in people with Type 2 diabetes as early as adolescence, according to a new study that will be presented Sunday at The Endocrine Society's 93rd Annual Meeting in Boston.
Telcare is a Bethesda, Maryland firm that has developed blood glucose monitoring technology that combines a glucose meter with wireless connectivity to Telcare's cloud server. The package is designed to keep an open two-way communication between a patient and an ecosystem of caregivers that may include the doctor, diabetes nurse educators, and family members.
The Academy of Nutrition and Dietetics has prepared a request to submit to the Centers for Medicare and Medicaid Services to expand coverage of medical nutrition therapy for specific diseases, including hypertension, obesity, and cancer, as part of the CMS National Coverage Determination Process.
Professor Ulf Ahlgren and associates at Umeå University in Sweden are a leading research team in the world in the development of optical projection tomography. With the aid of this imaging technology, they have now described aspects of how the pancreas develops during embryonic development and how the so-called islets of Langerhans are distributed in the adult organ. The findings are important for the interpretation of modeling systems for diabetes.
Blood vessels and supporting cells appear to be pivotal partners in repairing nerves ravaged by diabetic neuropathy, and nurturing their partnership with nerve cells might make the difference between success and failure in experimental efforts to regrow damaged nerves, Johns Hopkins researchers report in a new study.
University of Manchester scientists have led an international team to discover new treatments for a rare and potentially lethal childhood disease that is the clinical opposite of diabetes mellitus.
People with type 1 diabetes, whose insulin-producing cells have been destroyed by the body's own immune system, are particularly vulnerable to a form of inflammatory heart disease (myocarditis) caused by a different autoimmune reaction. Scientists at Joslin Diabetes Center have revealed the exact target of this other onslaught, taking a large step toward potential diagnostic and therapeutic tools for the heart condition.
TWi Biotechnology Inc. announced today that the company has enrolled over 50% of the total 240 patients for the Phase IIb clinical trial of AC-201 for the treatment of Type II Diabetes. The randomized, double-blind, placebo-controlled, dose-ranging, multi-center study is primarily designed to evaluate the glycated hemoglglobin A1c (HbA1c) lowering effects of AC-201 in patients with Type II Diabetes Mellitus.
The debate over air pollution and, more specifically, the regulation of air pollution, raged on this week as the Environmental Protection Agency (EPA) watered down its cross-state pollution rule and House Republicans moved to delay new rules on toxic air pollution from cement plants, solid waste incinerators, and industrial boilers.
In the constant battle to lose inches or at least stay the same, we reach for the diet soda. Two studies presented June 25 and 27 at the American Diabetes Association's Scientific Sessions in San Diego suggest this might be self-defeating behavior.
A new computerised prescribing decision support tool -- designed to assist in the implementation of NICE guidance1,2 for the management of type 2 diabetes in adults in primary care -- is now available free to UK healthcare professionals.
Among patients who have had an ischemic stroke or transient ischemic attack (TIA), type 2 diabetes was associated with an increased risk of recurrent stroke or cardiovascular events, but metabolic syndrome was not, according to a report published Online First today by Archives of Neurology.
Scientists from the University of Warwick have discovered why a newly found form of cholesterol seems to be 'ultra-bad', leading to increased risk of heart disease. The discovery could lead to new treatments to prevent heart disease particularly in people with type 2 diabetes and the elderly.
A new study published by the American Physiological Society offers the strongest evidence yet that vulnerability to type 2 diabetes can begin in the womb, giving new insight into the mechanisms that underlie a potentially devastating disease at the center of a worldwide epidemic. The study, conducted in baboon primates, finds that when mothers are even moderately undernourished while pregnant and breastfeeding, their offspring are consistently found to be prediabetic before adolescence. It is the first time that diabetes has been shown to have prenatal origins in a primate model.
The overall poor quality of outpatient healthcare in both the formal private and public sector in low and middle income countries is worrying--especially given the increasing volume of chronic conditions, such as diabetes and heart disease, which require relatively sophisticated, long-term outpatient medical care.
It seems intuitive (at least to Medgadgeteers) that mobile technology can be used to improve health outcomes, but we still need studies to actually put data behind this idea. A recent study of the DiabetesManager mobile health platform from WellDoc is a step in this direction. We last reported about WellDoc's mobile diabetes application in 2010, and since that time it has been tested in a clinical trial and was shown to reduce HgbA1c by 1.9%.
Physicians at The University of Texas Health Science Center at Houston (UTHealth) have begun enrollment for a pilot study on a promising surgical approach for the management of Type 2 diabetes.
Ultradian Diagnostics LLC today announced the successful completion of a human pilot study for its minimally invasive, continuous glucose monitor, as well as the launch of advanced research and pilot prototyping in partnership with the College of Nanoscale Science and Engineering of the University at Albany -- critical steps toward commercializing its innovative technology to deliver improved, pain-free treatment to individuals with diabetes.
New research shows that following a vegetarian diet and exercising at least three times a week significantly reduced the risk of diabetes in African Americans, who are twice as likely to be diagnosed with diabetes when compared to non-Hispanic whites.
People with diabetes are known to have an increased risk of heart disease. New research published in BioMed Central's open access journal BMC Medicine shows that regular consumption of a vitamin D-fortified yoghurt drink improves cholesterol levels and biomarkers of endothelial dysfunction, a precursor of heart disease, in diabetics.
University researchers have found that people with Type 2 diabetes from an affluent background had the same risk of dying as someone without the condition from a deprived area.
A new study published in The Journal of Sexual Medicine reveals that in obese men with type 2 diabetes, weight loss improves erectile function, sexual desire and lowers urinary tract symptoms.
Johns Hopkins scientists say that a newly discovered "survival protein" protects the brain against the effects of stroke in rodent brain tissue by interfering with a particular kind of cell death that's also implicated in complications from diabetes and heart attack.
Cytokines, a varied group of signaling chemicals in the body, have been described as the software that runs the immune system, but when that software malfunctions, dysregulation of the immune system can result in debilitating autoimmune diseases such as lupus, arthritis, and diabetes. Leading experts in the field of cytokine research present their most up-to-date findings and unique perspectives on the role of cytokines in autoimmune diseases in a special issue of Journal of Interferon & Cytokine Research.
Diabetes mellitus is one of the most common secondary diseases in modern society. And because it is on the rise, it is also one of the greatest challenges facing medicine today. Diabetes patients do not die as a direct result of the increase in blood sugar, but from the long-term complications of their disease, in which the increase in blood sugar causes damage to blood vessels and organs. Kidneys are particularly susceptible to damage, and this can lead to a loss in kidney function and the need to begin a dialysis treatment.
Some blood-sugar-lowering drugs have caused kidney problems in patients with type 2 diabetes, so physicians are especially cautious when prescribing these agents to diabetics who also have chronic kidney disease.
The scene at the European Association for the Study of Diabetes being held in Lisbon this week has included a heated debate over the extent to which a particular type of diabetes medicine called GLP-1 therapies can increase the risk of pancreatic and thyroid cancer. These include Byetta, which is sold by Eli Lilly and its partner, Amylin Pharmaceuticals, and Victoza, which is marketed by Novo Nordisk.
Why do heavy coffee drinkers have a lower risk of developing Type 2 diabetes, a disease on the increase around the world that can lead to serious health problems?
With the trend in healthcare moving toward an era of personalized medicine, there is much anticipation and hope that customized approaches to prevention and treatment based on a person's genetic make-up will result in better health outcomes. Some advances, most notably with prevention and treatment of breast and colon cancer, have been widely heralded, raising questions about the potential for personalized medicine for other common diseases, such as diabetes.
The company hopes that its technology will make routine diabetics' tasks and decisions more mobile, intuitive, and socially friendly, by integrating its insulin pump, as well as the touch-screen mobile-connected device, into a social network-like environment.
A Madison-based clinic is trying to track down hundreds of patients after a nurse apparently spent years improperly using diabetic injection devices on them, potentially exposing them to blood-borne diseases such as HIV.
Patients with diabetes who also suffer from depression are more likely to develop a serious complication known as diabetic retinopathy, a disease that damages the eye's retina, a five-year study finds.
New research finds that gestational diabetes, or pregnancy-related diabetes, may not raise the risk of heart disease independent of other cardiovascular risk factors except in certain high-risk populations, such as Hispanics.
The lowly and simple roundworm may be the ideal laboratory model to learn more about the complex processes involved in repairing wounds and could eventually allow scientists to improve the body's response to healing skin wounds, a serious problem in diabetics and the elderly.
An interdisciplinary research team at Worcester Polytechnic Institute (WPI) has received a $1.2 million award from the National Science Foundation to develop a smart phone application that will help people with advanced diabetes and foot ulcers better manage their disease. The four-year project will be organized through WPI's Healthcare Delivery Institute (HDI) in collaboration with diabetes and wound care specialists at the University of Massachusetts Medical School.
