Navigation On Topic Complete Directory About Us Add-site Link to Us MerchantStore Shopping	Advertisement 207 Health - Double Helix - DNA - Genes - Genetics - Genome Resources A Family Mystery, Solved by a Genome Physicians can now use DNA sequencing to uncover the causes of rare genetic disorders. View Source August 25, 2010 Provides Information A fingerprint for genes Cells may not have a mouth, but they still need to ingest substances from the external environment. If this process - known as endocytosis - is affected, it can lead to infectious diseases or cardio-vascular diseases, cancer, Huntington’s and diabetes. In cooperation with the Center for Information Services and High Performance Computing (ZIH) at the Dresden University of Technology, scientists from the Max Planck Institute of Molecular Cell Biology and Genetics therefore applied a new strategy to identify and characterize genes involved in endocytosis. View Source March 5, 2010 Provides Information A mutation that frustrates DNA repair likely contributes to Fanconi anemia After more than a century of technological refinements, zippers still get stuck. So do the molecular machines that routinely unzip the double helix of DNA in our cells after billions of years of evolution, and the results can be lethal. View Source July 21, 2010 Provides Information AIGISRx Anti-Bacterial Patch Helps Prevent Post-Surgery Infection in Soft Tissue8 The FDA has given New Jersey based TYRX, Inc. 510(k) clearance for its AIGISRx ST anti-bacterial patch for soft tissue repair. The material was previously FDA cleared for use in an envelope which reduces risk of infection following implantation of a pacemaker or cardioverter-defibrillator, and in its newly approved use it will help prevent post-operative infections in soft tissue. View Source April 28, 2010 Provides Information Akonni Biosystems Awarded Patent for its Method of Rapidly Extracting Nucleic Acids Frederick, MD based Akonni Biosystems has announced issuance of a patent titled "Apparatus, system, and method for purifying nucleic acids." The method described by the patent utilizes the company's TruTip kits, which consist of pipette tips that contain a nucleic acid binding matrix in order to speed up the process of extracting DNA or RNA samples for PCR. View Source August 6, 2010 Provides Information Algorithms for Searching Among Chinese Characters Could Provide Effective Genome Search Engine As scientists decode more and more genomes, the tree of life gets pretty complicated. It makes tough work for geneticists or other researchers who want to understand which organisms share which genes -- there are just so many comparisons. So there's a growing need for a better, easily searchable bioinformatics database. View Source June 30, 2010 Provides Information An ultrasensitive electronic DNA sensor array speeds up disease diagnostics A novel electronic sensor array for the rapid, accurate and cost-efficient testing of DNA for disease diagnosis has been designed by A*STAR researchers ("Mass-Produced Nanogap Sensor Arrays for Ultrasensitive Detection of DNA"). View Source March 31, 2010 Provides Information Ancient DNA sequences within human cells can help cancer cells survive: Study A new study in the journal Nature Medicine, part-funded by Cancer Research UK, has discovered that ancient DNA sequences within human cells can actually help cancer cells survive - at least in one type of the disease. View Source May 7, 2010 Provides Information APDN, H.W. Sands to Market DNA Security-Based Products Applied DNA Sciences, Inc. a provider of DNA-based security solutions, and H.W. Sands Corp., a trusted leader in the global market for advancing security, chemical and card industries, announced the signing of an Agreement to jointly market and sell DNA security-based solutions to clients that are dedicated to protecting their products, supply chains and end consumers from counterfeiting and gray market diversion. View Source July 7, 2010 Provides Information Applied DNA Sciences and H.W. Sands Corp. Sign Agreement to Jointly Market Security Technologies Applied DNA Sciences, Inc., a provider of DNA-based security solutions, and H.W. Sands Corp., a trusted leader in the global market for advancing security, chemical and card industries, announced the signing of an Agreement to jointly market and sell DNA security-based solutions to clients that are dedicated to protecting their products, supply chains and end consumers from counterfeiting and gray market diversion. View Source July 6, 2010 Provides Information Architecture of Mitochondrial Complex I at Nanoscale Level Scientists of the University of Freiburg and the University of Frankfurt have elucidated the architecture of the largest protein complex of the cellular respiratory chain. They discovered an unknown mechanism of energy conversion in this molecular complex. The mechanism is required to utilize the energy contained in food. View Source July 2, 2010 Provides Information 'Artificial life' breakthrough announced by scientists Scientists in the US have succeeded in developing the first synthetic living cell. View Source May 20, 2010 Provides Information ASU Regents Professor Honored for Research on Low-Cost DNA Sequencing On behalf of the White House, ASU Regents Professor and Biodesign Institute researcher Stuart Lindsay, PhD, was honored for his innovative efforts to bring low-cost DNA sequencing to the masses. View Source August 27, 2010 Provides Information B 'Biocomputing' advance demonstrates DNA computing circuits with rtificial catalytic nucleic acids EU-funded scientists have succeeded in demonstrating the feasibility of components for a kind of 'biocomputer', paving the way for new advances in the field of bioengineering. The scientists, from the Chemistry Department at the University of Liège in Belgium and the Institute of Chemistry at the Hebrew University of Jerusalem in Israel, set out the details of their work in an article in the journal Nature Nanotechnology ("DNA computing circuits using libraries of DNAzyme subunits"). View Source June 1, 2010 Provides Information Biomarkers can help predict prostate cancer progression, say Johns Hopkins scientists A blood test for certain forms of prostate specific antigen (PSA) and measurement of DNA content in biopsy tissue accurately predict which men with potentially non-lethal prostate cancers may eventually need treatment, say Johns Hopkins scientists. View Source April 20, 2010 Provides Information Biophotonic Technique Probes Cell Death in Technicolor Researchers from the University of Buffalo have created a hybrid method of monitoring apoptosis. The technique should help us to understand the programmed cell death process and to perhaps aid in the development of techniques that will allow clinicians to program self annihilation of cancer cells. View Source July 22, 2010 Provides Information Boffins demo one-molecule DNA 'walker' nano-bot American boffins say that they have created tiny robot spiders or "walkers", each one of which is a single complicated molecule fashioned out of DNA. They have managed to get the molecular nanorobospiders to follow a trail of DNA "breadcrumbs". View Source May 14, 2010 Provides Information Breakthrough in DNA Nanotube Research Researchers at the McGill University Chemistry Department have achieved a major breakthrough in the development of DNA nanotubes. The team has been able to create nanotubes that can be loaded with a cargo which is released when a specific strand of DNA is added. DNA nanotubes are hollow tubes formed of strands of DNA that are a few nanometers wide. View Source March 22, 2010 Provides Information BYU undergrad publishes better DNA sequencing method in medical journal Nathan Clement is still a few courses away from earning a bachelor's degree, but he's already credited with a significant advance in the field of DNA sequencing. View Source March 3, 2010 Provides Information C 'Capture Technique' Enables Researchers to Study 49,000-Year-Old DNA to Study How Similar and Different Neandertals Were to Us Researchers from the Max Planck Institute (MPI), Cold Spring Harbor Laboratory (CSHL), Agilent Technologies Inc., and other prestigious institutions worldwide have shown that DNA capture techniques can greatly enable the sequencing of ancient Neandertal DNA, providing new insight into the nature of these prehistoric hominids. View Source May 6, 2010 Provides Information Cell signaling classification system gives researchers new tool Using ever-growing genome data, scientists with the Department of Energy's (DOE) Oak Ridge National Laboratory and the University of Tennessee are tracing the evolution of the bacterial regulatory system that controls cellular motility, potentially giving researchers a method for predicting important cellular functions that will impact both medical and biotechnology research. View Source July 2, 2010 Provides Information Certain Laboratory Technique Allows Rapid Detection of Eye Pathogens A laboratory technique using real-time polymerase chain reaction (PCR) that copies DNA segments may allow clinicians to accurately identify pathogens infecting the cornea more quickly than standard methods, according to a report in the May issue of Archives of Ophthalmology, one of the JAMA/Archives journals. View Source May 14, 2010 Provides Information Chemical competition: Research identifies new mechanism regulating embryonic development A Princeton University-led research team has discovered that protein competition over an important enzyme provides a mechanism to integrate different signals that direct early embryonic development. The work suggests that these signals are combined long before they interact with the organism's DNA, as was previously believed, and also may inform new therapeutic strategies to fight cancer. View Source March 9, 2010 Provides Information Chemical engineers discover an enhanced delivery method of DNA payloads into cells Chang Lu and his chemical engineering research group at Virginia Tech have discovered how to "greatly enhance" the delivery of DNA payloads into cells. The description of their work will be featured on the cover of Lab on a Chip, the premier journal for researchers in microfluidics ("Vortex-assisted DNA delivery"). View Source July 9, 2010 Provides Information Chemists Create DNA Assembly Line Chemists at New York University and China's Nanjing University have created a DNA assembly line that has the potential to create novel materials efficiently on the nanoscale. View Source May 14, 2010 Provides Information Chromosomal abnormality found for inherited clubfoot Although clubfoot is one of the most common congenital birth defects, few genetic causes have been found. Now, researchers at Washington University School of Medicine in St. Louis have found what they believe to be the most common cause of inherited clubfoot yet discovered. View Source July 1, 2010 Provides Information Clean Genes: Chemists Cull the Good Synthetic DNA from the Bad Birds do it, bees do it. Even scientists in labs do it. But the scientists can't hold a candle to the birds and the bees, who can make gobs of primo DNA without even thinking about it. View Source July 23, 2010 Provides Information 'Copy and Paste DNA' More Common Than Previously Thought Researchers at the University of Leicester have demonstrated that movable sequences of DNA, which give rise to genetic variability and sometimes cause specific diseases, are far more common than previously thought. View Source June 28, 2010 Provides Information Chronix Biomedical expands biomarker development capabilities with installation of DNA mass sequencer Chronix Biomedical today reported that it has significantly expanded and accelerated its biomarker development capabilities with the installation of Germany's first state-of-the-art high-throughput DNA mass sequencer at the University of Göttingen, Chronix's long-time collaborator. Chronix is developing disease-specific biomarkers based on DNA fragments that are released into the bloodstream by damaged and dying (apoptotic) cells. Chronix's serum DNA biomarkers are applicable to a wide range of cancers and other chronic diseases. View Source August 17, 2010 Provides Information D Dangerous bacterium hosts genetic remnant of life's distant past Within a dangerous stomach bacterium, Yale University researchers have discovered an ancient but functioning genetic remnant from a time before DNA existed, they report in the August 13 issue of the journal Science. View Source August 12, 2010 Provides Information Deficiencies in DNA loop formation can cause multiple diseases: Research The genes that are responsible for maintaining each cell type form DNA loops that link control elements for these genes. This surprising genome structure is generated and reinforced by two essential protein complexes that bridge the loops and contribute to proper gene regulation. View Source August 19, 2010 Provides Information Deficiency of frataxin protein causes Friedreich's ataxia The defective gene responsible for Friedreich's ataxia was identified over 20 years ago, but so far our ideas of how this gene causes the disease have been merely speculative. View Source May 4, 2010 Provides Information Developmental problems: Some exist in the genes Everyone is special in their own unique way. From a genetic point of view, no two humans are genetically identical. This means that DNA for each individual contains variants that are more or less comm. on in the overall population. View Source August 17, 2010 Provides Information Discovered gene causes Kabuki syndrome NHGRI-supported researchers streamlined DNA sequencing strategies to find rare disease genes quickly View Source August 16, 2010 Provides Information DNA and its complexes Throughout life, DNA repair mechanisms go to work during exposure (UV radiation, etc.) in order to protect the human genetic code. This role is assured by the NER complex. View Source April 13, 2010 Provides Information DNA barcoding exposes fake ferns in international plant trade DNA testing of garden ferns sold at plant nurseries in North Carolina, Texas, and California has found that plants marketed as American natives may actually be exotic species from other parts of the globe. View Source May 4, 2010 Provides Information DNA check on remains from grave of Romania's Ceausescu Scientists in Romania have exhumed what are thought to be the remains of former dictator Nicolae Ceausescu and his wife in order to check their identity. View Source July 21, 2010 Provides Information DNA construction kit for nanoengines There is fresh buzz in nanomechanics. Scientists at the University of Bonn have succeeded for the first time in making, out of DNA double stands, an interlocked molecule (rotaxane) with freely moveable components. As the researchers wrote in the latest edition of the science journal Nature Nanotechnology, this opens up exciting possibilities for nanorobotics and synthetic biology. View Source April 30, 2010 Provides Information DNA Medicine Institute awarded Grand Challenges Explorations grant to develop finger scanner for malaria The DNA Medicine Institute announced today that it has received a US$100,000 Grand Challenges Explorations grant from the Bill & Melinda Gates Foundation. The grant will support an innovative global health research project conducted by Eugene Y. Chan, M.D. titled "Optomagnetic Finger Scanner for Malaria." View Source May 11, 2010 Provides Information DNA nanotechnology breakthrough offers promising applications in medicine A team of McGill Chemistry Department researchers led by Dr. Hanadi Sleiman has achieved a major breakthrough in the development of nanotubes - tiny "magic bullets" that could one day deliver drugs to specific diseased cells. Sleiman explains that the research involves taking DNA out of its biological context. So rather than being used as the genetic code for life, it becomes a kind of building block for tiny nanometre-scale objects. View Source March 17, 2010 Provides Information DNA nanotubes carry and selectively release materials A team of McGill Chemistry Department researchers led by Dr. Hanadi Sleiman has achieved a major breakthrough in the development of nanotubes - tiny "magic bullets" that could one day deliver drugs to specific diseased cells. Sleiman explains that the research involves taking DNA out of its biological context. So rather than being used as the genetic code for life, it becomes a kind of building block for tiny nanometre-scale objects. View Source March 17, 2010 Provides Information DNA patent case: US District Judge rules in favor of AMP The Association for Molecular Pathology (AMP) is an international medical and professional association representing approximately 1,800 physicians, doctoral scientists, and medical laboratory scientists who perform laboratory testing based on knowledge derived from molecular biology, genetics, and genomics. AMP applauds US District Judge Robert Sweet's ruling in favor of the plaintiffs in the lawsuit, Association for Molecular Pathology, et al. v. U.S. Patent and Trademark Office, et al. "This is a landmark decision that has the potential to dramatically improve patient access to genetic testing. View Source April 2, 2010 Provides Information DNA puts Stanford chemists on scent of better artificial nose A new approach to building an "artificial nose" -- using fluorescent compounds and DNA -- could accelerate the use of sniffing sensors into the realm of mass production and widespread use, say Stanford chemists. If their method lives up to its promise, it could one day detect everything from incipiently souring milk to high explosives. View Source August 20, 2010 Provides Information DNA repair changes with the flip of a switch The DNA blueprint in each human cell undergoes about 100,000 damaging events every day. Because a cell's survival depends on the repair of these damaged molecules, each injury signals a team of proteins to work together to fix the mutated DNA. View Source August 26, 2010 Provides Information DNA robots spin gold in molecular factory If you thought nanobots might give us cause for concern when the singularity occurs, how about nanobots made from DNA? U.S. scientists have developed microscopic robots composed of DNA that can follow instructions and work together like an assembly line to make products such as particles of gold. View Source May 14, 2010 Provides Information DNA Sequence Itself Influences Mutation Rate, New Research Indicates Genetic variation due to DNA mutation is a driving force of adaptation and evolution, as well as a contributing factor to disease. However, the mechanisms governing DNA mutation rate are not well understood. In a report published online in Genome Research, researchers have identified intrinsic properties of DNA that influence mutation rate, shedding light on mechanisms involved in genome maintenance and potentially disease. View Source May 24, 2010 Provides Information DNA tests give bogus results, U.S. probe finds Government investigators find little or no useful information in predicting disease risk View Source July 22, 2010 Provides Information DNA test to help find family roots A DNA test could pinpoint the roots of a person's family to within a few miles, according to a new study. View Source July 6, 2010 Provides Information DNA through graphene nanopores A team of researchers from Delft University of Technology (The Netherlands) announces a new type of nanopore devices that may significantly impact the way we screen DNA molecules, for example to read off their sequence. In a paper entitled 'DNA Translocation through Graphene Nanopores' (published online in Nano Letters), they report a novel technique to fabricate tiny holes in a layer of graphene and they managed to detect the motion of individual DNA molecules that travel through such a hole. View Source July 12, 2010 Provides Information DNAzymes and substrates constitute a platform for logic operations essential to computational processes New perspectives are opening up in bio-engineering thanks to research jointly carried out by teams of chemists at the University of Liège and the Hebrew University of Jerusalem within the framework of the European MOLOC project (Molecular Logic Circuits). This work has led to the publication of two important publications, one straight after the other, in the Nature Nanotechnology journal. View Source May 31, 2010 Provides Information Doctors use gene scan to predict health risks Mapping DNA could spot warning signs for heart disease, cancer View Source April 30, 2010 Provides Information E Electron cryomicroscopy helps observe molecules in hydrated state close to natural state Gene expression takes place in two stages: the transcription of DNA to RNA by an enzyme called RNA polymerase, followed by the translation of this RNA into proteins, whose behaviour affects the characteristics of each individual. View Source June 21, 2010 Provides Information Electronic medical records may accelerate genome-driven diagnoses and treatments A new study reveals an exciting potential benefit of the rapidly accumulating databases of health care information, the ability to make unprecedented links between genomic data and clinical medicine. The research, published by Cell Press in the April issue of the American Journal of Human Genetics, supports the idea that large scale DNA databanks linked to electronic medical record (EMR) systems provide a valuable platform for discovering, assessing and validating associations between genes and diseases. View Source April 1, 2010 Provides Information Embedded DNA Commands Let Nanomachines Follow Instructions, Assemble Components Nanotech has opened the door to some serious sci-fi possibilities: tiny robots -- built by other tiny robots -- that swim in our bloodstreams eradicating infection or hunting tumors, or perhaps assembling miniscule electronic components. But programming such tiny objects to do what we want presents a problem: commands need space to exist, and space is limited aboard a nanobot. But two papers just published in the journal Nature today highlight an interesting and promising approach to this problem: embedding the commands in the nanobots' environments. View Source May 12, 2010 Provides Information Enabling easy access to DNA sequence information The European Nucleotide Archive (ENA) is launched today, consolidating three major sequence resources to become Europe's primary access point to globally comprehensive DNA and RNA sequence information. The ENA is freely available from the European Bioinformatics Institute (EMBL-EBI), a part of European Molecular Biology Laboratory. View Source May 10, 2010 Provides Information Experiments decipher key piece of the ‘histone code’ in cell division Reproduce or perish. That’s the bottom line for genes. Because nothing lives forever, reproduction is how life sustains itself, and it happens most fundamentally in the division and replication of the cell, known as mitosis. Now new research at Rockefeller University has detailed a key role in mitosis for a chemical modification to histone proteins that package lengthy strings of DNA into compact chromosomes. View Source August 16, 2010 Provides Information Expression Analysis agrees to purchase PacBio RS DNA sequencing system from Pacific Biosciences Expression Analysis, a leading provider of genomic services for clinical trials and research, announced today that it has agreed to purchase a PacBio RS DNA sequencing system from northern-California based Pacific Biosciences, whose third-generation DNA sequencing technology is expected to revolutionize the field of genetic analysis through the use of single molecule real time detection of biological events. View Source May 24, 2010 Provides Information F Family Finder DNA Test Matches up to Five Generations of Family Family Tree DNA out of Houston, Texas has announced the launch of the Family Finder DNA test. It uses several hundred thousand genetic markers to determine ancestry and family relations up to five generations back in time. Results can be compared between two individuals, but are also compared against a database of people who previously took the test. View Source May 4, 2010 Provides Information Faster DNA analysis at room temperature DNA microarrays are one of the most powerful tools in molecular biology today. The devices, which can be used to probe biological samples and detect particular genes or genetic sequences, are employed in everything from forensic analysis to disease detection to drug development. View Source August 3, 2010 Provides Information FDA cracking down on genetic tests Issues letters to 5 companies that devices must be approved View Source June 11, 2010 Provides Information First ever high resolution observations of DNA unfolding The separation of the two DNA strands occurs in millionths of a second. Consequently, it is extremely difficult to study this phenomenon experimentally and researchers must rely on computational simulations. After four years of fine-tuning an effective physical model and massive use of the supercomputer Mare Nostrum, researchers at IRB Barcelona and the Barcelona Supercomputing Center (BSC) have managed to produce the first realistic simulation of DNA opening at high resolution. View Source May 20, 2010 Provides Information First step toward electronic DNA sequencing: Translocation through graphene nanopores Researchers at the University of Pennsylvania have developed a new, carbon-based nanoscale platform to electrically detect single DNA molecules. View Source July 26, 2010 Provides Information Fluorescence Microscope Used to Analyze DNA Delivery into Cells Chang Lu and his chemical engineering research group at Virginia Tech have discovered how to "greatly enhance" the delivery of DNA payloads into cells. View Source July 12, 2010 Provides Information Fluidigm Releases 5kb and 10kb Long-Range PCR Protocol for Access Array Systems Fluidigm Corporation today announced the release of 5kb and 10kb long-range PCR protocols for its Access Array™ System. Researchers interested in targeted re-sequencing projects for large cohort studies can use these new protocols and the Fluidigm Access Array System to amplify up to 48 samples per array. Long-range PCR enables new applications on the Access Array System by allowing researchers to enrich significantly more sequence per sample. View Source March 8, 2010 Provides Information Fluidigm, SABiosciences to Create Gene Expression Panels for Real-Time PCR Analysis Fluidigm Corporation and SABiosciences (a QIAGEN Company) today announced that they have teamed up to create over 100 pathway-focused gene expression panels validated for real-time PCR analysis on the Fluidigm BioMark™ System for Genetic Analysis. These kits are named the RT2 Profiler™ PCR Arrays for the Fluidigm BioMark system. View Source March 25, 2010 Provides Information FNA Cell Block Samples Now Analyzed Using Rosetta’s MicroRNA-Based Diagnostic Tests Rosetta Genomics, Ltd., a leading developer and provider of microRNA-based molecular diagnostics, announced today that starting April 1, 2010 physicians are able to send FNA cell block samples to Rosetta Genomics’ CLIA-certified and CAP-accredited laboratory in Philadelphia for analysis using Rosetta’s miRview squamous test. View Source April 6, 2010 Provides Information Four hours for forensic DNA test Forensic scientists have developed a test that can match a suspect's DNA to crime scene samples in just four hours. View Source August 5, 2010 Provides Information G GEN reports on the promise of DNA vaccines Laboratory research and clinical studies are beginning to demonstrate that DNA vaccines can be as effective as traditional vaccines, reports Genetic Engineering & Biotechnology News (GEN). A number of factors are driving the growth of the field, especially new approaches to electroporation, vaccine formulation, and vector design, according to the April 15 issue of GEN. View Source April 19, 2010 Provides Information Gene that allows growing a new head identified British boffins say they have identified the key "smed-prop" gene which allows Planarian flatworms to regenerate any part of their body following an injury - even their brains. View Source April 25, 2010 Provides Information Gene variations likely to have important effects on gene function: Study Everyone is special in their own unique way. From a genetic point of view, no two humans are genetically identical. This means that DNA for each individual contains variants that are more or less comm. on in the overall population. View Source August 17, 2010 Provides Information Genetic inspiration could show the way to revolutionise information technology Chemists at the University of Reading have created a synthetic form of DNA that could transform how digital information is processed and stored. View Source June 28, 2010 Provides Information Genetic instability in people with Fanconi anemia: New proteins in FA DNA repair pathway may help explain Identification of two new proteins in the Fanconi anemia DNA repair pathway may help explain genetic instability in people with Fanconi anemia and how otherwise healthy people are susceptible to cancer from environmentally triggered DNA damage. View Source March 26, 2010 Provides Information GENEWIZ Adds Gene Synthesis Service to Molecular Biology Service Portfolio GENEWIZ, Inc., a leading provider of DNA services, announced the expansion of its molecular biology portfolio with the addition of Gene Synthesis services. Gene synthesis provides researchers with a time- and cost-saving alternative to molecular cloning, DNA engineering, protein engineering and directed evolution for custom construct production. View Source March 8, 2010 Provides Information Genome comparison tools found to be susceptible to slip-ups You might call it comparing apples and oranges, but lining up different species' genomes is common practice in evolutionary research. Scientists can see how species have evolved, pinpoint which sections of DNA are similar between species, meaning they probably are crucial to the animals' survival, or sketch out evolutionary trees in places where the fossil record is spotty. View Source May 26, 2010 Provides Information German-Japanese team develops world's first DNA-based revolutionary biosensor technology Fujitsu Laboratories Ltd. and the Technische Universität München ("TUM", Technical University Munich) today announced the joint development of a completely novel bio-sensor technology. The new technology, the first of its kind in the world, works by inducing a cyclical motion in negatively charged DNA(1) and measuring its movement, to enable quick detection of proteins. View Source April 22, 2010 Provides Information Gold Nanoparticles to Asses Trace Protein Concentration in Blood Scottish scientists were able to detect sub-femtomolar (10-12) concentrations of thrombin in human serum by using gold nanoparticles and lasers. This could eventually be used to detect blood clots and other disorders in-vivo by injecting patients with the gold nanoparticles, which bind to thrombin in the blood, and then using non-invasive laser sensors on the skin to asses concentration changes. View Source April 12, 2010 Provides Information Graphene-DNA biosensor selective, simple to create Graphene and DNA can combine to create a stable and accurate biosensor, reports a study published in the nanotechnology journal Small. The tiny biosensor might eventually help doctors and researchers better understand and diagnose disease. View Source May 14, 2010 Provides Information H Harvard Scientists Develop Centrifuge Force Microscope to Manipulate Molecules Scientists have developed a new massively-parallel approach for manipulating single DNA and protein molecules and studying their interactions under force. The finding appears in the June 2 issue of Biophysical Journal. View Source June 2, 2010 Provides Information High-performance computing reveals missing genes Scientists at the Virginia Bioinformatics Institute (VBI) and the Department of Computer Science at Virginia Tech have used high-performance computing to locate small genes that have been missed by scientists in their quest to define the microbial DNA sequences of life. Using an ephemeral supercomputer made up of computers from across the world, the mpiBLAST computational tool used by the researchers took only 12 hours instead of the 90 years it would have required if the work were performed on a standard personal computer. View Source April 13, 2010 Provides Information Histone H1 regulates gene activity throughout the cell cycle A protein that helps pack DNA into the cell nucleus has an important role in regulating gene activity, scientists report. The researchers found that the protein, histone H1, also takes part in the formation of ribosomes, the cellular workbenches on which all proteins are made. View Source July 1, 2010 Provides Information House votes to expand national DNA arrest database Millions of Americans arrested for but not convicted of crimes will likely have their DNA forcibly extracted and added to a national database, according to a bill that the U.S. House of Representatives approved on Tuesday. View Source May 19, 2010 Provides Information How ATP, Molecule Bearing 'the Fuel of Life,' Is Broken Down in Cells Researchers at the Louisiana State University Health Sciences Center have figured out how ATP is broken down in cells, providing for the first time a clear picture of the key reaction that allows cells in all living things to function and flourish. View Source March 1, 2010 Provides Information Human cells can copy not only DNA, but also RNA Single-molecule sequencing technology has detected and quantified novel small RNAs in human cells that represent entirely new classes of the gene-translating molecules, confirming a long-held but unproven hypothesis that mammalian cells are capable of synthesizing RNA by copying RNA molecules directly. The findings were reported in Nature by researchers from the University of Pittsburgh School of Medicine, Helicos Biosciences Corp., Integromics Inc., and the University of Geneva Medical School. View Source August 10, 2010 Provides Information Human Genome Project is 10: Where are we now? "It's hard to think back and remember how we worked then. We were scrabbling around in the dark," says Professor Mark McCarthy of the Oxford Centre for Diabetes, Endocrinology and Metabolism [OCDEM], recalling how research on the genetic causes of disease had to be carried out before the human genome was sequenced. View Source March 2, 2010 Provides Information I Identification of Molecules Using Nanopore-Based Single-Molecule Mass Spectrometry Scientists at National Institute of Standards and Technology (NIST) are using nanopores (membrane gates less than 2 nanometers wide) to identify the type of molecules that are passing through the openings. The method measures the electrical change of the ionic fluid that is pumped through the nanopores along with the molecules in question. Because each molecule reduces the amount of the ionic fluid passing through based on its size and shape, the electrical measurements reveal which molecule is traversing the gate. Once developed, nanopore based technology may allow for all kinds of new diagnostic devices that can identify pathogens, proteins, and other reagents. View Source June 30, 2010 Provides Information iGEM team helps prevent rogue use of synthetic biology A team of students from ENSIMAG, an engineering school in Grenoble, France, and Virginia Tech is using bioinformatics to implement federal guidance on synthetic genomics. The students' work will help gene synthesis companies and their customers better detect the possible use of manufactured DNA as harmful agents for bioterrorism. View Source July 19, 2010 Provides Information Illuminating the genetic alphabet The development of fluorescent tags—small, light-emitting molecules attached to DNA strands—has revolutionized cell biology over the past two decades, allowing precise tracking of labeled segments in living systems. Because fluorescent tags project outwards from the nucleic acid chains, they can interfere with the mobility and geometry of their targets, skewing the view of critical biological actions. View Source June 25, 2010 Provides Information Inovio Biomedical introduces new CELLECTRA-SP series of hand-held, cordless electroporation devices Inovio Biomedical Corporation, a leader in DNA vaccine design, development and delivery, has unveiled its new CELLECTRA®-SP series of hand-held, cordless electroporation devices at the DNA Vaccines 2010 conference being held in New Orleans, LA. View Source March 3, 2010 Provides Information Instant testing for sore throats with DNA nanobarcodes Imagine finding out before you leave the pediatrician's office if your child has strep throat, or even something more serious requiring a different treatment. A novel application for applying DNA "nanobarcodes" in a clinical assay could help primary-care physicians quickly and more accurately determine what's causing a patient's acute pharyngitis from an easy throat swab. View Source July 8, 2010 Provides Information International research team discovers novel genes influencing kidney disease risk A team of researchers from the United States and Europe has identified more than a dozen genes that may play a role in the etiology of common forms of kidney disease. The team, known as the CKDGen Consortium, examined common variations in DNA sequences in more than 65,000 individuals of European descent. Common variations in several genes were found to be more frequent among people with poor kidney function or chronic kidney disease than in those with normal kidney function. View Source April 12, 2010 Provides Information Is DNA evidence enough? An interview with David Kaye Law professor David H. Kaye shares his insights into how the the use of DNA evidence has impacted our legal system. While its use has far-reaching implications, Kaye points out that "DNA is only a tool. View Source July 30, 2010 Provides Information J Jell-O lab-on-a-chip devices to spark interest in science careers With "hands-on" experiences in childhood and adolescence having sparked so many science careers, scientists in Canada are describing a quick, simple, safe, and inexpensive way for kids to participate in making microfluidic devices. Those devices are at the heart of lab-on-a chip, inkjet printing, DNA chip, and other technologies. View Source June 16, 2010 Provides Information K Kinked nanopores slow DNA passage for easier sequencing In an innovation critical to improved DNA sequencing, a markedly slower transmission of DNA through nanopores has been achieved by a team led by Sandia National Laboratories researchers. View Source July 30, 2010 Provides Information Kylin Therapeutics Announces New Patent Surrounding pRNAi Technology Officials of Kylin Therapeutics Inc., a leading RNAi company, announced this week that they received an issued patent from the U.S. Patent and Trademark Office (USPTO). View Source April 6, 2010 Provides Information L Life Technologies Unveils Single Molecule Sequencing Technology Life Technologies Corporationhas announced early stage results from its single molecule sequencing (SMS) technology. The technology promises to combine virtually unlimited continuous long read lengths with unmatched accuracy to deliver targeted genomic sequence data in a matter of hours, paving the way for sequencing to become a commonplace tool in research laboratories and clinical settings worldwide. View Source March 2, 2010 Provides Information Light, circadian rhythms affect vast range of physiological, behavioral functions A new study of the genetic basis of circadian rhythms - the biological responses related to daily light exposure - has found that a few minutes of light exposure in a fungus directly affects a huge range of its biological functions, everything from reproduction to coloring and DNA repair. View Source August 26, 2010 Provides Information Low-cost, ultra-fast DNA sequencing brings diagnostic use closer Sequencing DNA could get a lot faster and cheaper -- and thus closer to routine use in clinical diagnostics - thanks to a new method developed by a research team based at Boston University. The team has demonstrated the first use of solid state nanopores -- tiny holes in silicon chips that detect DNA molecules as they pass through the pore -- to read the identity of the four nucleotides that encode each DNA molecule. In addition, the researchers have shown the viability of a novel, more efficient method to detect single DNA molecules in nanopores. View Source May 19, 2010 Provides Information M Make Your Own DNA Nanostructures with caDNAno Scientists have been working on folding DNA into nano scale shapes for a few years now. They've made maps of the world in 2D, spelled out "DNA", and have recently been playing around with self assembling 3D oligonucleotide structures. View Source April 8, 2010 Provides Information Magnetically guided nanoparticles for delivering DNA, cells and drugs Scientists and engineers have used uniform magnetic fields to drive iron-bearing nanoparticles to metal stents in injured blood vessels, where the particles deliver a drug payload that successfully prevents blockages in those vessels. In this animal study, the novel technique achieved better results at a lower dose than conventional non-magnetic stent therapy. View Source April 20, 2010 Provides Information Marina Biotech Acquires RNA Delivery Assets of Novosom AG Marina Biotech, Inc. has announced that the Company has acquired the intellectual property of Novosom AG of Halle, Germany for its SMARTICLES® liposomal-based delivery system in an all-stock transaction. The transaction further expands Marina's RNA delivery platform IP estate, which now includes DiLA2 delivery platform, tkRNAi (bacterial delivery platform), peptide nanoparticle delivery platform, and the SMARTICLES® liposomal delivery platform. View Source July 29, 2010 Provides Information McGill researchers pioneer major breakthrough in DNA nanotechnology A team of McGill Chemistry Department researchers led by Dr. Hanadi Sleiman has achieved a major breakthrough in the development of nanotubes - tiny "magic bullets" that could one day deliver drugs to specific diseased cells. Sleiman explains that the research involves taking DNA out of its biological context. So rather than being used as the genetic code for life, it becomes a kind of building block for tiny nanometre-scale objects. View Source March 18, 2010 Provides Information MDRNA, Inc. Announces Patent Allowance Covering siRNA and Delivery Systems MDRNA, Inc., a leading RNAi-based drug discovery and development company, today announced that the Intellectual Property Office of New Zealand (IPONZ) has issued a Notice of Acceptance for patent application 553828, titled"Methods of Treating an Inflammatory Disease by Double-Stranded Ribonucleic Acid." Allowed claims cover small interfering RNAs (siRNA) directed against the tumor necrosis factor (TNF) gene as well as several of the Company's key nucleic acid condensing and delivery peptide motifs in combination with a siRNA directed against TNF. View Source April 19, 2010 Provides Information Melting DNA into a barcode A completely new method for producing an image of individual DNA molecules' genetic make-up has been developed by researchers in Sweden and Denmark. The results are published in the latest issue of the journal Proceedings of the National Academy of Sciences ("Single-molecule denaturation mapping of DNA in nanofluidic channels"). View Source July 19, 2010 Provides Information Messenger RNAs are regulated in far more ways than previously appreciated, study finds One way of regulating protein levels in cells is to shorten the lifespan of messenger RNAs (mRNAs). These are intermediary molecules that are first copied from DNA in the cell's nucleus via a process called transcription and then transported into the cell's body to be translated into protein. View Source June 25, 2010 Provides Information Mitochondria: New Functions of Mitochondrial Fusion Uncovered A typical human cell contains hundreds of mitochondria -- energy-producing organelles -- that continually fuse and divide. Relatively little is known, however, about why mitochondria undergo this behavior. View Source April 15, 2010 Provides Information Molecular gauge to disclose function of new medications Luminescent markers are an indispensable tool for researchers working with DNA. But the markers are troublesome. Some tend to destroy the function and structure of DNA when inserted. Others emit so little light, that they can barely be detected in the hereditary material. So researchers have been asking for alternative markers. View Source April 6, 2010 Provides Information Molecular methods are not sufficient in systematics and evolution Modern evolutionary systematists often use molecular methods, such like mitochondrial DNA analysis, to differentiate between species and subspecies. These molecular methods are a flashy symbol of modern science cleverly exploited by media to draw interest of public and by laboratory scientists to draw attention of government funding agencies. However, current research indicates that the picture painted by these methods may be false, and only a creative combination of classical field-based ecology, museum-based systematics and DNA-based phylogenetics, can lead to right conclusions. View Source June 7, 2010 Provides Information Moving polymers through pores The movement of long chain polymers through nanopores is a key part of many biological processes, including the transport of RNA, DNA, and proteins. New research reported in The Journal of Chemical Physics, which is published by the American Institute of Physics, describes an improved theoretical model for this type of motion. View Source July 14, 2010 Provides Information N Nanoblasts from laser-activated nanoparticles move molecules, proteins and DNA into cells Using chemical "nanoblasts" that punch tiny holes in the protective membranes of cells, researchers have demonstrated a new technique for getting therapeutic small molecules, proteins and DNA directly into living cells. View Source July 27, 2010 Provides Information Nanobotmodels Company Made Detail Animation of DNA-Repair Process Human DNA is under constant assault from harmful agents such as ultraviolet sunlight, tobacco smoke and a myriad of chemicals, both natural and man-made. Because damage can lead to cancer, cell death and mutations, an army of proteins and enzymes are mobilized into action whenever it occurs. Therefore there is a system of DNA repair in a cell. View Source March 22, 2010 Provides Information Nanofluidics Identify Epigenetic Changes One Molecule at a Time Using a system of nanofluidic channels and multicolor fluorescence microscopy, a team of investigators at Cornell University has developed a method that analyzes the binding of DNA and DNA-binding proteins known as histones at specific locations along individual DNA molecules. The data generated using this method provides information on the so-called epigenetic state of a cell, which reflect differences in the genes that a given cell is expressing at any one time. View Source March 30, 2010 Provides Information Nanoparticles Increase Intensity of Quantum Dots' Glow Demonstration of precision DNA-based nanoassembly method for making light-emitting particle clusters could lead to advances in solar cells, optoelectronics, and biosensors View Source July 26, 2010 Provides Information Nanoscale DNA sequencing could spur revolution in personal health care In experiments with potentially broad health care implications, a research team led by a University of Washington physicist has devised a method that works at a very small scale to sequence DNA quickly and relatively inexpensively. View Source August 16, 2010 Provides Information Nanoscale Light Mill Spins a Motor with a Beam of Light Whether wielded by Egyptian sun gods, Luke Skywalker, or your run of the mill solar-thermal power plant, light has the potential to do big things. Thanks to a breakthrough by UC Berkeley and the DOE’s Lawrence Berkeley National Lab, we can now make light do very small things as well. Researchers there have created the first nano-sized light mill motor that can be manipulated in both speed and direction by tuning the frequency of the light waves that serve as its power source. View Source July 7, 2010 Provides Information New Detection Technique Screens Cells for DNA Damage A team of MIT and Harvard researchers has developed a new way to screen cells for signs of DNA damage. The hope is that this new technology may become quite popular for testing the effectiveness of cancer drugs or for identifying environmental or metabolic factors responsible for genetic damage. The technique is an advancement on the "comet assay", also known as Single Cell Gel Electrophoresis assay. View Source May 7, 2010 Provides Information New detection technique used in analysis of vaccines An analysis of vaccines undertaken by researchers from 5 institutions has found that 7 of the vaccines' DNA content was pretty much as expected, but surprisingly, one also contained DNA of an apparently benign pig virus. This finding is reported in a paper written by lead author Eric Delwart of Blood Systems Research Institute and 6 co-authors, including three researchers from LLNL. View Source April 9, 2010 Provides Information New Device Will Slash Time for DNA Analysis The University of Arizona Center for Applied Nanobioscience and Medicine is developing technology to revolutionize procedures in law enforcement and medicine. View Source August 18, 2010 Provides Information New DNA Assembly Line to Create Nanomaterials Efficiently Chemists at New York University and China's Nanjing University have created a DNA assembly line that has the potential to create novel materials efficiently on the nanoscale. Their work is reported in the latest issue of the journal Nature. View Source May 13, 2010 Provides Information New evidence that smokeless tobacco damages DNA and key enzymes Far from having adverse effects limited to the mouth, smokeless tobacco affects the normal function of a key family of enzymes found in almost every organ in the body, according to the first report on the topic in ACS' monthly journal Chemical Research in Toxicology. The enzymes play important roles in production of hormones, including the sex hormones estrogen and testosterone; production of cholesterol and vitamin D; and help the body breakdown prescription drugs and potentially toxic substances. Smokeless tobacco also damages genetic material in the liver, kidney and lungs. View Source June 16, 2010 Provides Information New genetic analysis reveals principles of phenotypic expression The Human Genome Project, along with numerous parallel efforts to solve the DNA sequences of hundreds of animal, plant, fungal, and microbe genomes in the last few decades, has produced enormous amounts of genetic data with which researchers are struggling to keep pace. Knowing gene sequences, after all, may not directly reveal what roles that genes play in the actual manifestation of physical traits (or phenotypes) of an organism -- including their roles in human diseases. To help navigate the new genomic landscape, researchers are developing experimental approaches and analysis tools to help prioritize and organize complex genetic information with respect to phenotypic effects. View Source June 22, 2010 Provides Information New Hope Exists in Treating Inherited Disease by Suppressing DNA Mutations Genetic mutation can disrupt the way human cells make proteins, which in turn leads to inherited disease. David Bedwell, a professor in the University of Alabama at Birmingham (UAB) Department of Microbiology, says scientists are closer than ever to producing drugs that fix this disrupted-protein pathway and drastically improving treatment of genetic disease. View Source April 26, 2010 Provides Information New measurement of DNA could help identify most viable embryos for IVF Scientists from the University of Warwick and University Hospitals Coventry and Warwickshire NHS Trust, are the first to directly measure a specific region of DNA in human embryos. The length of this region could be a quality marker for embryonic development. View Source June 28, 2010 Provides Information New methods identify thousands of new DNA sequences missing from reference map of human genome A person can have one or more copies, or no copy at all, of a particular DNA sequence, which may account for why these sequences were absent from the reference genome. View Source April 20, 2010 Provides Information New Nanopore Based DNA Sequencing Method Scientists from University of Washington are reporting the development of a new method of DNA sequencing that utilizes a nanopore harvested from a bacteria. By watching the electrical changes within the ion flow within the pore, it is possible to identify which nucleotides are passing by. View Source August 19, 2010 Provides Information New nanopore method for DNA sequencing Sequencing DNA could get a lot faster and cheaper – and thus closer to routine use in clinical diagnostics – thanks to a new method developed by a research team based at Boston University. The team has demonstrated the first use of solid state nanopores — tiny holes in silicon chips that detect DNA molecules as they pass through the pore — to read the identity of the four nucleotides that encode each DNA molecule. View Source May 19, 2010 Provides Information New research indicates that DNA sequence itself influences mutation rate Genetic variation due to DNA mutation is a driving force of adaptation and evolution, as well as a contributing factor to disease. However, the mechanisms governing DNA mutation rate are not well understood. In a report published online today in Genome Research, researchers have identified intrinsic properties of DNA that influence mutation rate, shedding light on mechanisms involved in genome maintenance and potentially disease. View Source May 24, 2010 Provides Information New, Robust Test for Extended Group Typing of Donated Blood French scientists recently reported on a new method to quickly provide extended blood group typing for donated blood, an advance that should help us better match donors with recipients. The new test, called HiFi-Blood 96, is being commercialized by AXO Science, a spin-off company of the Institut de Chimie et Biochimie Moléculaires et Supramoléculaires ICBMS. View Source July 15, 2010 Provides Information New tool developed for DNA research: Molecular gauge to disclose function of new medications Luminescent markers are an indispensable tool for researchers working with DNA. But the markers are troublesome. Some tend to destroy the function and structure of DNA when inserted. Others emit so little light, that they can barely be detected in the hereditary material. So researchers have been asking for alternative markers. View Source April 6, 2010 Provides Information Newly Developed Molecular Gauge Helps to Study Workings of DNA Luminescent markers are an indispensable tool for researchers working with DNA. But the markers are troublesome. Some tend to destroy the function and structure of DNA when inserted. Others emit so little light, that they can barely be detected in the hereditary material. So researchers have been asking for alternative markers. View Source April 7, 2010 Provides Information Newly discovered RNA steers brain development How does the brain work? This question is one of the greatest scientific mysteries, and neurobiologists have only recently begun to piece together the molecular building blocks that enable human beings to be "thinking" animals. View Source April 14, 2010 Provides Information Newly identified RNA sequence is key in microRNA processing Researchers at Tufts University School of Medicine and Tufts Medical Center have identified an RNA sequence that promotes increased numbers of specific microRNAs (miRNAs), molecules that regulate cell growth, development, and stress response. The discovery helps researchers understand the links between miRNA expression and disease, including heart disease and cancer. The findings are published in the August 13 issue of Molecular Cell. View Source August 16, 2010 Provides Information Next-Generation Real-Time PCR System Launched by WaferGen WaferGen Biosystems, Inc., a leading developer of state-of-the-art genomic analysis systems, today announced it has launched the breakthrough WaferGen SmartChip Real-Time PCR System, the next-generation Real-Time PCR system for discovery and validation of biomarkers, or gene expression patterns, on a single platform. View Source August 6, 2010 Provides Information NIH and Wellcome Trust Announce Partnership To Support Population-based Genome Studies in Africa Effort Uses Gene-Screening and Clinical Tools, Builds Research Capacity on Continent View Source June 22, 2010 Provides Information O Orchid Cellmark acquires paternity and immigration DNA testing business unit of Strand Analytical Laboratories Orchid Cellmark Inc., a leading international provider of identity DNA testing services, today announced it has acquired the paternity and immigration DNA testing business unit of Strand Analytical Laboratories, LLC. View Source April 7, 2010 Provides Information Orchid Cellmark awarded two-year extensions to forensic testing contracts Orchid Cellmark Inc., a leading international provider of identity DNA testing and other forensic services, today announced it has been awarded two-year extensions to contracts previously awarded under the North West/South West and Wales regional forensic tender process in the U.K. Total estimated annual value of the combined contracts is approximately (U.S.) $10 million (at the current foreign exchange rate). View Source August 17, 2010 Provides Information Our genes can be set on pause New evidence in embryonic stem cells shows that mammalian genes may all have a layer of control that acts essentially like the pause button on your DVR. The researchers say the results show that the pausing phenomenon, previously thought to be a peculiarity of particular genes, is actually a much more general feature of the genome. View Source April 29, 2010 Provides Information P Personal DNA Tests Unreliable, Investigators Say A U.S. government investigator told members of Congress on Thursday that personalized DNA tests claiming to predict certain inheritable diseases are misleading and offer little or no useful information. View Source July 23, 2010 Provides Information Phase 1 CALAA-001 Clinical Trial Shows Systemic siRNA Delivery via Targeted Nanoparticles Arrowhead Research Corporation today announced that interim data from the phase 1 clinical trial conducted by its majority-owned subsidiary, Calando Pharmaceuticals, will be presented at the 2010 American Society of Clinical Oncology Annual Meeting. View Source June 1, 2010 Provides Information Polymer passage takes time: New theory aids researchers studying DNA, protein transport Polymer strands wriggle their way through nanometer-sized pores in a membrane to get from here to there and do their jobs. New theoretical research by Rice University scientists quantifies precisely how long the journey takes. View Source July 29, 2010 Provides Information Powerful genome barcoding system reveals large-scale variation in human DNA Genetic abnormalities are most often discussed in terms of differences so miniscule they are actually called "snips" — changes in a single unit along the 3 billion that make up the entire string of human DNA. View Source May 31, 2010 Provides Information Powerful new method allows scientists to probe gene activation NYU Langone Medical Center researchers have developed a powerful new method to investigate the discrete steps necessary to turn on individual genes and examine how the process goes wrong in cancer and other diseases. The finding, based on seven years of research and described in the April 9 issue of Molecular Cell, allows scientists to investigate the unfolding of DNA, a process required for gene activation. View Source April 8, 2010 Provides Information Preventing Cells from Getting the Kinks out of DNA Many standard antibiotics and anti-cancer drugs block the enzymes that snip the kinks and knots out of DNA -- DNA tangles are lethal to cells -- but the drugs are increasingly encountering resistant bacteria and tumors. View Source May 25, 2010 Provides Information Q Quantum Entanglement May Hold DNA Together, New Study Says A new research paper brings new meaning to the joke that all science is just physics. A team of scientists at the National University of Singapore suggests that it is quantum entanglement that holds our DNA together. View Source June 28, 2010 Provides Information R Rapid analysis of DNA damage now possible Our DNA is under constant siege from a variety of damaging agents. Damage to DNA and the ability of cells to repair that damage has broad health implications, from aging and heritable diseases to cancer. Unfortunately, the tools used to study DNA damage are quite limited, but MIT researchers have developed a new tool for rapid DNA damage analysis that promises to make an impact on human health. View Source May 3, 2010 Provides Information Rare gene variants linked to high risk of broad range of seizure disorders Scientists at Duke University Medical Center have uncovered evidence suggesting that people missing large chunks of DNA on chromosome 16 are much more likely than others to develop a chronic seizure disorder during their lifetime. View Source April 15, 2010 Provides Information Redundant genetic instructions in 'junk DNA' support healthy development Seemingly redundant portions of the fruit fly genome may not be so redundant after all. View Source July 16, 2010 Provides Information Refined tools help pinpoint disease-causing genes In findings that may speed the search for disease-causing genes, a new study challenges the prevailing view that common diseases are usually caused by common gene variants (mutations). Instead, say genetics researchers, the culprits may be numerous rare variants, located in DNA sequences farther away from the original "hot spots" than scientists have been accustomed to look. View Source April 29, 2010 Provides Information Researchers advance understanding of enzyme that regulates DNA Thanks to a single-molecule imaging technique developed by a University of Illinois professor, researchers have revealed the mechanisms of an important DNA-regulating enzyme. View Source August 20, 2010 Provides Information Researchers create atlas of transcription factor combinations In a significant leap forward in the understanding of how specific types of tissue are determined to develop in mammals, an international team of scientists has succeeded in mapping the entire network of DNA-binding transcription factors and their interactions. View Source March 4, 2010 Provides Information Researchers create self-assembling nanodevices that move and change shape on demand By emulating nature's design principles, a team at Harvard's Wyss Institute for Biologically Inspired Engineering, Harvard Medical School and Dana-Farber Cancer Institute has created nanodevices made of DNA that self-assemble and can be programmed to move and change shape on demand. In contrast to existing nanotechnologies, these programmable nanodevices are highly suitable for medical applications because DNA is both biocompatible and biodegradable. View Source June 22, 2010 Provides Information Researchers develop hybrid protein tools for gene cutting and editing An Iowa State University team of researchers has developed a type of hybrid proteins that can make double-strand DNA breaks at specific sites in living cells, possibly leading to better gene replacement and gene editing therapies. View Source August 30, 2010 Provides Information Researchers Develop New Barcode Method to Produce Shaper Image of Genome A completely new method for producing an image of individual DNA molecules’ genetic make-up has been developed by researchers in Sweden and Denmark. The results are published in the latest issue of the journal Proceedings of the National Academy of Sciences of the USA (PNAS). View Source July 19, 2010 Provides Information Researchers discover key protein involved in DNA repair In a groundbreaking study, University of Toronto researchers including Professors Daniel Durocher, Anne-?Claude Gingras and Frank Sicheri have uncovered a protein called OTUB1 that blocks DNA damage in the cell -- a discovery that may lead to the development of strategies to improve some cancer therapies. View Source August 23, 2010 Provides Information Researchers Find 95 Genes Affecting Cholesterol A scan of all the human DNA has turned up 95 genes that affect blood cholesterol, including a few affected by drugs on the market and others that might be the basis of new drugs, researchers said on Wednesday. View Source August 5, 2010 Provides Information Researchers find a way to make drops on a surface move in just one direction Controlling the way liquids spread across a surface is important for a wide variety of technologies, including DNA microarrays for medical research, inkjet printers and digital lab-on-a-chip systems. But until now, the designers of such devices could only control how much the liquid would spread out over a surface, not which way it would go. View Source March 29, 2010 Provides Information Researchers find new translocation; weak spots in DNA lead to genetic disease A genetics research team based at The Children's Hospital of Philadelphia continues to discover recurrent translocations—places in which two chromosomes exchange pieces of themselves. As many as 1 in 600 persons carry balanced chromosome translocations, which involve no loss or gain of DNA. Most such people appear healthy, but may have a child with abnormal chromosome composition and disabilities resulting from disrupted, extra or missing copies of genes. View Source July 29, 2010 Provides Information Researchers identify key enzyme in DNA repair pathway Researchers have discovered an enzyme crucial to a type of DNA repair that also causes resistance to a class of cancer drugs most commonly used against ovarian cancer. View Source July 29, 2010 Provides Information Researchers share insights into RNA Investigators from around the country came to Sanford-Burnham Medical Research Institute (Sanford-Burnham) on Friday, May 7, to share their knowledge of the burgeoning young field of microRNAs. These small non-coding nucleic acids turn off proteins and have been implicated in viral infection, cancer, cardiovascular disease, HIV and numerous other conditions. View Source May 11, 2010 Provides Information Researchers Use Simple Reaction Chamber with 254-nm Photon Source to Study RNA Building Blocks For scientists attempting to understand how the building blocks of RNA originated on Earth, guanine -- the G in the four-letter code of life -- has proven to be a particular challenge. While the other three bases of RNA -- adenine (A), cytosine (C) and uracil (U) -- could be created by heating a simple precursor compound in the presence of certain naturally occurring catalysts, guanine had not been observed as a product of the same reactions. View Source June 16, 2010 Provides Information Rewiring of gene regulation across 300 million years of evolution As published today in Science, researchers from Cambridge, Glasgow and Greece have discovered a remarkable amount of plasticity in how transcription factors, the proteins that bind to DNA to control the activation of genes, maintain their function over large evolutionary distances. View Source April 9, 2010 Provides Information RNA Offers a Safer Way to Reprogram Cells In recent years, scientists have shown that they can reprogram human skin cells to an immature state that allows the cells to become any type of cell. This ability, known as pluripotency, holds the promise of treating diseases such as diabetes and Parkinson's disease by transforming the patients' own cells into replacements for the nonfunctioning tissue. View Source July 29, 2010 Provides Information Road signs and traffic signals on DNA The DNA genomes of organisms whose cells possess nuclei are packaged in a highly characteristic fashion. Most of the DNA is tightly wrapped around protein particles called nucleosomes, which are connected to each other by flexible DNA segments, like pearls on a necklace. This arrangement plays a major role in deciding which genes are actively expressed, and thus which proteins can be synthesized in a given cell. View Source August 23, 2010 Provides Information Roche Partners with IBM for Developing Nanopore-Based Sequencer Roche and IBM announced today an agreement to develop a nanopore-based sequencer that will directly read and decode human DNA quickly and efficiently. View Source July 1, 2010 Provides Information Rosetta Genomics Identifies 49 Novel microRNAs with Potential to Provide Novel Molecular Biomarkers and Drug Target Candidates Rosetta Genomics, Ltd., a leading developer and provider of microRNA-based molecular diagnostic tests, announces the publication of a study entitled "Discovery of microRNAs and other small RNAs in solid tumors" in the online edition of Nucleic Acid Research. View Source May 18, 2010 Provides Information Rotaxane Molecules of Genetic Material Open Up New Possibilities in the Field of Nanorobotics Scientists at the University Bonn have succeeded in producing a molecule consisting of a double-stranded DNA - the so-called rotaxane - whose individual parts are movable For years, biochemists have been puzzling over rotaxanes. View Source May 3, 2010 Provides Information S SAIC-Frederick Utilizes Fluidigm’s System for EBV Genome Sequencing SAIC-Frederick, Inc. and Fluidigm Corporation are collaborating to decode the entire genome of the Epstein-Barr virus (EBV) using technology that can speed up research on the genetic basis of cancer and other diseases. View Source July 2, 2010 Provides Information Scientists Design Nanoparticle for microRNA Delivery Researchers at the University of California, San Diego School of Medicine have identified a new way to regulate the uncontrolled growth of blood vessels, a major problem in a broad range of diseases and conditions. View Source August 2, 2010 Provides Information Scientists develop DNA-vaccine that restricts supply of blood to tumours A DNA-vaccine that restricts the supply of blood to tumours has been developed by scientists at the Swedish medical university Karolinska Institutet. The vaccine slows the growth of breast cancer tumours in mice. View Source May 24, 2010 Provides Information Scientists develop the first atomic view of key genetic processes (Video: 24 Seconds) In a landmark study to be published in the journal Nature, scientists have been able to create the first picture of genetic processes that happen inside every cell of our bodies. Using a 3-D visualization method called X-ray crystallography, Song Tan, an associate professor of biochemistry and molecular biology at Penn State University, has built the first-ever image of a protein interacting with the nucleosome -- DNA packed tightly into space-saving bundles organized around a protein core. The research is expected to aid future investigations into diseases such as cancer. View Source August 25, 2010 Provides Information Scientists discover new genetic sub-code In a multidisciplinary approach, Professor Yves Barral, from the Biology Department at ETH Zurich and the computer scientists Dr. Gina Cannarozzi and Professor Gaston Gonnet, from the Computer Science Department of ETH Zurich and the SIB Swiss Institute of Bioinformatics, joined forces to chase possible sub-codes in genomic information. The study, which will be published in today's issue of the journal Cell, led to the identification of novel sequence biases and their role in the control of genomic expression. View Source April 16, 2010 Provides Information Scientists find link between estrogen metabolism pathway and breast cancer risk Scientists at the Genome Institute of Singapore (GIS), a biomedical research institute of the Agency for Science, Technology and Research (A*STAR), and the Karolinska Institutet, Sweden, recently discovered that DNA polymorphisms related to the production of estrogen play an important role in the development of hormone-sensitive breast and endometrial cancer. The knowledge gained may help develop better measures for the prevention and treatment of breast cancer. View Source July 6, 2010 Provides Information Scientists identify DNA that may contribute to each person's uniqueness Building on a tool that they developed in yeast four years ago, researchers at the Johns Hopkins University School of Medicine scanned the human genome and discovered what they believe is the reason people have such a variety of physical traits and disease risks. View Source August 11, 2010 Provides Information Scientists Uncover Transfer of Genetic Material Between Blood-Sucking Insect and Mammals Researchers at The University of Texas at Arlington have found the first solid evidence of horizontal DNA transfer, the movement of genetic material among non-mating species, between parasitic invertebrates and some of their vertebrate hosts. View Source April 30, 2010 Provides Information Second Protective Role for Tumor-Suppressor: DNA Damage Sensor Also Responds to Oxidative Harm Outside Nucleus ATM, a protein that reacts to DNA damage by ordering repairs or the suicide of the defective cell, plays a similar, previously unknown role in response to oxidative damage outside of the nucleus, researchers report in the online version of the Proceedings of the National Academy of Sciences. View Source March 2, 2010 Provides Information Self-assembling DNA Nanodevices Researchers at Harvard have created programmable self-assembling DNA nanodevices. The devices consist of a single-stranded DNA molecule that together with pieces of complementary DNA self-assembles into a 3D nanodevice. View Source June 24, 2010 Provides Information Sequencing of first frog genome sheds light on treating disease A pair of University of Houston researchers contributed to the assembly of the first comprehensive DNA sequence of an amphibian genome, which will shed light on the study of embryonic development, with implications for preventing birth defects and more effectively treating many human diseases. View Source May 6, 2010 Provides Information Single-molecule manipulation for the masses Scientists have developed a new massively-parallel approach for manipulating single DNA and protein molecules and studying their interactions under force. The finding appears in the June 2 issue of Biophysical Journal. The team of researchers from the Rowland Institute at Harvard University claim that their technique, which they call "single molecule centrifugation", offers dramatic improvements in throughput and cost compared with more established techniques. View Source June 2, 2010 Provides Information Size Matters - When it Comes to DNA A new study at the University of Leicester is examining a sequence of DNA- known as telomeres - that varies in length between individual. View Source June 9, 2010 Provides Information Slitrk5 gene linked to development of OCD-like behaviors Researchers at the Ansary Stem Cell Institute and the Department of Psychiatry at Weill Cornell Medical College discovered that mice missing a single gene developed repetitive obsessive-compulsive-like behaviors. The genetically altered mice, which behaved much like people with a certain type of obsessive-compulsive disorder (OCD), could help scientists design new therapies for this debilitating condition. View Source April 27, 2010 Provides Information Solid-State Systems Could Sequence a Genome For $100 Drawing individual strands of DNA through nanoscopic pores in a chip could do in a matter of minutes what the human genome project took more than a decade to achieve – sequence an entire human genome. View Source July 7, 2010 Provides Information SurModics And EGEN Partner For Feasibility Study of Controlled Release of siRNA Nanocomplexes SurModics, Inc., a leading provider of drug delivery and surface modification technologies to the healthcare industry and EGEN, Inc., a privately held biopharmaceutical company focused on developing nucleic acid (DNA and RNAi) therapeutics for the treatment of human diseases, are pleased to announce they have executed a continuation of their feasibility collaboration focused on long-term controlled release of siRNA complexes. View Source July 28, 2010 Provides Information Spiders at the nanoscale: Molecules that behave like robots A team of scientists from Columbia University, Arizona State University, the University of Michigan, and the California Institute of Technology (Caltech) have programmed an autonomous molecular "robot" made out of DNA to start, move, turn, and stop while following a DNA track. View Source May 12, 2010 Provides Information State roundup: Genetic testing on campus, Texas docs in Mass., and more Associated Press/Arizona Republic: "A plan by the University of California, Berkeley to voluntarily test the DNA of incoming freshman has come under fire from critics who said the school was pushing an unproven technology on impressionable students. The university has said it will send test kits to 5,500 new students to analyze genes that help control the body's responses to alcohol, dairy products and folic acid". View Source May 24, 2010 Provides Information Stickleback Genomes Shining Bright Light on Evolution Twenty billion pieces of DNA in 100 small fish have opened the eyes of biologists studying evolution. After combining new technologies, researchers now know many of the genomic regions that allowed an ocean-dwelling fish to adapt to fresh water in several independently evolved populations. View Source March 8, 2010 Provides Information Study Claims First In-Vivo Gene Delivery While gene therapy has seemed always just on the verge of being right around the corner, the limitation has always been delivery of the gene. How do you get the new gene to the right cells and activated? An in-vivo mice study in PNAS may take us closer to a usable delivery system. Rui Maeda-Mamiya of the University of Tokyo and others were able to get diabetic mice to increase their insulin levels after delivery of a insulin 2 gene by a water-soluble fullerene. View Source March 19, 2010 Provides Information Study: 'Jumping Genes' Make Each Person Unique Stretches of DNA known as "jumping" genes are far more common than anyone thought, and almost everyone has a unique pattern of them, U.S. researchers reported on Thursday. View Source June 25, 2010 Provides Information Study links microRNA to shut-down of DNA-repair genes New research shows for the first time that molecules called microRNA can silence genes that protect the genome from cancer-causing mutations. View Source April 30, 2010 Provides Information Study Results Reveal Key Mechanisms for Delivery of LNP-Encapsulated iRNAs Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today the publication of pre-clinical research in the journal Molecular Therapy revealing key mechanisms related to the systemic delivery of RNAi therapeutics using lipid nanoparticles (LNPs). View Source May 12, 2010 Provides Information Study shows infectious prions can arise spontaneously in normal brain tissue In a startling new study that involved research on both sides of the Atlantic, scientists from The Scripps Research Institute in Florida and the University College London (UCL) Institute of Neurology in England have shown for the first time that abnormal prions, bits of infectious protein devoid of DNA or RNA that can cause fatal neurodegenerative disease, can suddenly erupt from healthy brain tissue. View Source July 26, 2010 Provides Information Study validates Chronix Biomedical’s serum DNA blood tests for early, accurate detection of breast cancer Chronix Biomedical today announced publication of a study that supports the utility of its serum DNA blood tests for the early and accurate detection of breast cancer. The Chronix tests detect the circulating DNA that is released into the blood stream by damaged and dying cells. View Source March 9, 2010 Provides Information SUMO works with replication protein A complex to repair DNA A team of investigators led by a physician-scientist at The University of Texas MD Anderson Cancer Center has shown for the first time that the small protein SUMO can team up with the replication protein A (RPA) complex to facilitate DNA repair. View Source August 12, 2010 Provides Information T The 3-dimensional transcription film Gene expression takes place in two stages: the transcription of DNA to RNA by an enzyme called RNA polymerase, followed by the translation of this RNA into proteins, whose behaviour affects the characteristics of each individual. View Source June 17, 2010 Provides Information Three-person IVF 'may prevent inherited disease' Embryos containing DNA from a man and two women have been created by scientists at Newcastle University. View Source April 14, 2010 Provides Information Tibetans Evolved to Survive High Life, Study Says Locals carry unique versions of genes tied to blood oxygen levels. View Source May 13, 2010 Provides Information Transformation optics make a U-turn for the better Powerful new microscopes able to resolve DNA molecules with visible light, superfast computers that use light rather than electronic signals to process information, and Harry Potteresque invisibility cloaks are just some of the many thrilling promises of transformation optics. In this burgeoning field of science, light waves can be controlled at all lengths of scale through the unique structuring of metamaterials, composites typically made from metals and dielectrics – insulators that become polarized in the presence of an electromagnetic field. View Source July 1, 2010 Provides Information Twelve type 2 diabetes susceptibility loci identified An international team co-led by scientists from the University of Michigan have discovered 12 more regions on the genome with DNA variants that are associated with increased risk of type 2 diabetes, bringing the number to 38. View Source July 2, 2010 Provides Information U U.K. Launches a Largest-Ever Effort to Turn Genetic Info Into Better Medical Treatments Every day for the past three years, 600 or so additional British citizens file into medical offices around the country. They are responding to a letter, stamped “BioBank” in blue letters, that begins: “We are writing to ask for your help in studying the prevention and treatment of cancer, heart attacks, strokes, diabetes, dementia, and many other serious diseases.” The British government wants to collect peoples’ blood, urine and saliva; measure their waistlines and heart rates; sequence their DNA; and ask them questions like “How hot do you drink your tea?” View Source April 20, 2010 Provides Information UC Berkeley plan to test freshmen DNA criticized A plan by the University of California, Berkeley to voluntarily test the DNA of incoming freshman has come under fire from critics who said the school was pushing an unproven technology on impressionable students. View Source May 21, 2010 Provides Information UC Berkeley Requesting DNA Samples from Incoming Students First universities started using RFID chips to track students' attendance. Now they want their DNA. The University of California-Berkeley, that bastion of hippiedom and experimentation, is replacing its summer reading list with a call for incoming students to voluntarily provide DNA samples. View Source May 19, 2010 Provides Information UK.gov urged to slash DNA retention plan Government plans designed to bring the National DNA Database in line with human rights legislation have been criticised today by an influential group of MPs as not going far enough. View Source March 8, 2010 Provides Information UM scientists demonstrate role of RNA polymerase in gene transcription In all organisms, RNA synthesis is carried out by proteins - known as RNA polymerases (RNAPs) - that transcribe the genetic information from DNA in a highly-regulated, multi-stage process. RNAP is the key enzyme involved in creating an equivalent RNA copy of a sequence of DNA. This transcription is the first step leading to gene expression. While the major steps in RNA synthesis have been known for several decades, scientists have only recently begun to decipher the detailed molecular steps of the complex transcription process. View Source July 15, 2010 Provides Information USPTO Issues Patent Allowance for Cell Specific siRNAs Delivery Methods MDRNA, Inc. a leading RNAi-based drug discovery and development company, today announced that the U.S. Patent and Trademark Office (USPTO) has issued a Notice of Allowance for patent application U.S. 12/701,397 covering methods for the delivery of siRNAs as well as a broad array of compounds with pharmacological activity. View Source March 30, 2010 Provides Information W Walgreens postpones plans to sell personal genetic tests Walgreens has postponed its plans to sell personal genetic test kits after the Food and Drug Administration intervened. View Source May 13, 2010 Provides Information V Venter Institute's Synthetic Cell Genome Contains Hidden Messages When the J. Craig Venter Institute announced last week that it had created the first "synthetic cell," whose genome had been synthesized artificially one base pair at a time, Venter himself mentioned that the genetic code had been tagged throughout with watermarks that identify it as man-made rather than natural code. Now we're hearing that those watermarks weren't arbitrary. The code carries four hidden messages, little Easter eggs for genetics wonks to find and decipher. View Source May 25, 2010 Provides Information Vical's prophylactic Vaxfectin-formulated pDNA vaccine effective against HSV-2 in animal model Vical Incorporated today announced that its prophylactic Vaxfectin®-formulated plasmid DNA vaccine against herpes simplex virus type 2 (HSV-2) protected mice against lethal challenge, provided sterilizing immunity and inhibited viral counts at both the primary and latent infection sites. View Source July 26, 2010 Provides Information Z Zombie DNA Long Thought Dormant Can Rise to Cause Health Problems Perhaps the only thing scarier than the living dead is finding out that they're already inside the house. Geneticists recently found that non-coding genes -- some of the many dotting the human genome -- can rise from the dead. When they do they can cause problems, including one of the most common forms of muscular dystrophy. View Source August 20, 2010 Provides Information ZyGEM announces acquisition of MicroLab Diagnostics ZyGEM Corp. Ltd., today announced that it has acquired MicroLab Diagnostics Inc., a private company developing microfluidic devices for rapid DNA testing. ZyGEM intends to market products integrating its unique DNA extraction and reagents and detection assays with the breakthrough microfluidic chip technology developed by MicroLab, which will operate as a business unit of the new company. These integrated new products will dramatically decrease the time, complexity and cost of conducting DNA testing and have transformational potential in a broad range of applications. View Source May 24, 2010 Provides Information
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