Navigation On Topic Complete Directory About Us Add-site Link to Us	328 Health - Double Helix - DNA - Genes - Genetics - Genome Resources 3D Nano-Porous Optical Biosensor Receives Most Innovative Product (MIP) Award SKi Pro™ 3D biomolecular interaction analysis platform by Silicon Kinetics Inc., a privately-held life sciences tool company, has been recognized as the Most Innovative Product in the "Diagnostics and Research Tools" category in the 21st Annual Most Innovative New Product (MIP) Awards by CONNECT, a non-profit organization dedicated to creating and sustaining the growth of innovative technology and life science businesses in San Diego. Open Open Tab December 17, 2008 Provides Information A A novel method of isolating high quality RNA from Kupffer cells Kupffer cells, resident tissue macrophages that line the liver sinusoids, play a key role in modulating inflammation in a number of experimental models of liver injury. Since Kupffer cells represent only a small portion of the entire liver cell population, greatly outnumbered by the parenchymal cells, Kupffer cell isolation faces major technical obstacles. Open Open Tab April 17, 2009 Provides Information Affymetrix and Genisphere Announce Launch of New, Best-in-Class Solution for microRNA Research Studies Affymetrix, Inc. and Genisphere Inc. today announced the launch of a new, best-in-class solution for microRNA (miRNA) research studies. Encompassing assay, array, and software, the solution offers comprehensive miRNA coverage for 71 organisms on a single array. Open Open Tab March 16, 2009 Provides Information Africans have world's greatest genetic variation Africans have more genetic variation than anyone else on Earth, according to a new study that helps narrow the location where humans first evolved, probably near the South Africa-Namibia border. Open Open Tab April 30, 2009 Provides Information Agilent Technologies to Manufacture Unique Array for Invitrogen Invitrogen Corporation, a provider of essential life science technologies for research, production and diagnostics, today announced the launch of the first high-density microarray for the profiling of non-coding RNAs. Open Open Tab November 7, 2008 Provides Information ALN-VSP Represents Industry's First Dual Targeting RNAi Therapeutic to Advance to Clinical Studies Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today that its investigational new drug (IND) application for ALN-VSP has been cleared by the U.S. Food and Drug Administration (FDA) to begin enrolling patients. ALN-VSP, an RNAi therapeutic for the treatment of liver cancers including hepatocellular carcinoma and other solid tumors with liver involvement, contains two small interfering RNAs (siRNAs, the molecules that mediate RNAi), formulated in a lipid nanoparticle developed by Tekmira Pharmaceuticals Corporation. Open Open Tab January 23, 2009 Provides Information Alnylam Publishes In Vivo Research on Systemic Delivery of RNAi Therapeutics Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, today announced the publication of new data in the journal Molecular Therapy by Alnylam scientists and collaborators from the David H. Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology (MIT). Open Open Tab March 6, 2009 Provides Information Alnylam, Cenix and IMM Discover New Targets in Malaria Infection with RNAi Technology Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, and Cenix BioScience GmbH, a leading RNAi-focused contract research organization, today announced the publication of a new study in the journal PLoS Pathogens demonstrating in vitro and in vivo RNAi-mediated silencing of novel host factors involved in malaria infection. Open Open Tab November 12, 2008 Provides Information Altogen Announces Launch of Novel Nanoparticle-Based Transfection Reagent Altogen Biosystems announced the launch of a novel Nanoparticle-based transfection reagent for use in laboratories and research facilities for animal testing. Transfection is one of the major laboratory methods used to introduce DNA and RNA molecules into cells and tissues. This technique makes it possible to cross the cellular barriers and deliver a gene or a small interfering RNA (siRNA) into the cells for research or therapeutic purposes. Open Open Tab November 3, 2008 Provides Information Aluminum-oxide nanopore beats other materials for DNA analysis Fast and affordable genome sequencing has moved a step closer with a new solid-state nanopore sensor being developed by researchers at the University of Illinois. Open Open Tab June 2, 2009 Provides Information An Efficient System for Delivering siRNA into Primary Cells In technology that promises to one day allow drug delivery to be tailored to an individual patient and a particular cancer tumor, researchers at the University of California, San Diego School of Medicine, have developed an efficient system for delivering siRNA into primary cells. Open Open Tab May 17, 2009 Provides Information Applied Biosystems Establishes Global Service Provider Program for RNA Expression Analysis Applied Biosystems Inc. today announced that it has established a global service provider program for RNA expression analysis. The TaqMan® Service Provider Program was created for research scientists who do not have laboratories equipped for performing TaqMan assays, or who choose to outsource their experiments to obtain accurate, sensitive, and reproducible data, generated by authorized third parties using Applied Biosystems' TaqMan RNA expression analysis reagents. Open Open Tab September 16, 2008 Provides Information Applied DNA Sciences Completes Pilot Study for IIMAK Applied DNA Sciences, Inc., a provider of DNA-based security solutions, announced today that it has successfully completed its pilot study of SigNature® DNA in IIMAK thermal transfer ink and ribbons. APDN and IIMAK will officially launch this at IMI's 20th Annual Thermal Printing Conference in Orlando, Florida on May 11, 2009. Open Open Tab May 7, 2009 Provides Information Are DNA barcodes always accurate? DNA barcoding is a movement to catalog all life on earth by a simple standardized genetic tag, similar to stores labeling products with unique barcodes. The effort promises foolproof food inspection, improved border security and better defenses against disease-causing insects, among many other applications. Open Open Tab August 25, 2008 Provides Information Artificial Genetics: New Type Of DNA Has 12 Chemical Letters Instead Of Usual 4 In a dramatic rewrite of the recipe for life, scientists from Florida are describing the design of a new type of DNA with 12 chemical letters instead of the usual four.     March 23, 2009 Provides Information Australia leads world first global effort to improve diagnosis of genetic disorders An Australian-led global initiative to improve the diagnosis of genetic disorders and reduce errors in the reporting of genetic variations has been published today in the prestigious scientific journal Science. Open Open Tab November 6, 2008 Provides Information Australian-led global initiative to improve diagnosis of genetic disorders An Australian-led global initiative to improve the diagnosis of genetic disorders and reduce errors in the reporting of genetic variations has been published today in the prestigious scientific journal Science. Open Open Tab November 7, 2008 Provides Information B Baby Olympian? DNA test screens sports ability But some worry about mental toll the results of at-home test may bring Open Open Tab March 4, 2009 Provides Information Better sequence searches of genes and proteins Since the sequencing of the human genome eight years ago, enormous progress has been made in analyzing and understanding it. Nevertheless, the function of most human genes is still barely understood. Open Open Tab February 23, 2009 Provides Information Biologist Enhances Use Of Bioinformatic Tools And Achieves Precision In Genetic Annotation In concrete, for his PhD thesis, “Strategies for the comparative genomic study of microorganisms with various levels of pregenomic information and genic complexity”, Dr Lavin used an emerging discipline: bioinformatics. By using informatics tools for studying sequences of DNA and proteins, he managed to generate databases for the genetic diversity of various organisms. Open Open Tab January 16, 2009 Provides Information Biologists Discover Link Between CGG Repeats In DNA And Neurological Disorders Researchers have long known that some repetitive DNA sequences can make human chromosomes "fragile," i.e. appearing constricted or even broken during cell divisions. Scientists at Tufts University have found that one such DNA repeat not only stalls the cell's replication process but also thwarts the cell's capacity to repair and restart it. The researchers focused on this CGG repeat because it is associated with hereditary neurological disorders such as fragile X syndrome and FRAXE mental impairment. Open Open Tab January 13, 2009 Provides Information Biologists Discover New Motor Proteins that "Rewind" DNA Molecule Two biologists at the University of California, San Diego have discovered the first of a new class of cellular motor proteins that "rewind" sections of the double-stranded DNA molecule that become unwound, like the tangled ribbons from a cassette tape, in "bubbles" that prevent critical genes from being expressed. Open Open Tab October 31, 2008 Provides Information Biologists find gene network that gave rise to first tooth A paper in this week's PLoS Biology reports that a common gene regulatory circuit controls the development of all dentitions, from the first teeth in the throats of jawless fishes that lived half a billion years ago, to the incisors and molars of modern vertebrates, including you and me. Open Open Tab February 10, 2009 Provides Information Biologists identify genes that prevent changes in physical traits due to environmental changes New York University biologists have identified genes that prevent physical traits from being affected by environmental changes. The research, which studied the genetic makeup of baker's yeast, appears in the latest issue of the Public Library of Science's journal, PloS Biology. Open Open Tab November 4, 2008 Provides Information BioNanomatrix awarded phase II NIH grant to support development of single-molecule nanoscale whole genome analyzer BioNanomatrix, Inc. has announced receipt of a Phase II grant from the National Human Genome Research Institute (NHGRI) of the U.S. National Institutes of Health (NIH). Open Open Tab March 19, 2009 Provides Information BioServe introduces customizable DNA panels for genetic research BioServe has announced a more affordable pricing plan for its vast bank of DNA with comprehensive, de-identified, covariate data that includes age, gender, diet, body mass index (BMI), and race. In addition, each sample has data on the complete diagnostic and treatment history of the donor. Open Open Tab September 14, 2008 Provides Information Britain to remove some DNA profiles from database Britain said Thursday it will set up a system to remove details about the DNA of innocent people from its nationwide registry of genetic information - but it could take up to 12 years for some of that information to be erased. Open Open Tab May 7, 2009 Provides Information British company could deeply cut DNA scans' cost A British company's new technique for reading DNA could move medicine a step closer to an affordable gene scan for every patient. Open Open Tab February 25, 2009 Provides Information Broken DNA Must Find Right Partners Quickly Amid Repairs Just as square dance partners join hands at a particular point in the music, so broken pieces of DNA in our cells reunite as they are repaired. Precisely and quickly, these DNA pieces identify each other and tether together. A tumor-suppressor gene called ATM choreographs this fast-paced, but reliable, reassembly operation. Open Open Tab July 25, 2008 Provides Information C Can genetic information be controlled by light? DNA, the molecule that acts as the carrier of genetic information in all forms of life, is highly resistant against alteration by ultraviolet light, but understanding the mechanism for its photostability presents some puzzling problems. Open Open Tab October 13, 2008 Provides Information Carbon Nanotubes Used to Detect Toxins That Damage DNA MIT researchers used DNA coated carbon nanotubes to detect the presence of chemicals that can modify the structure of DNA. The technique, described as a single-molecule sensor to monitor chemotherapy and detect toxins intracellularly, can have a variety of clinical applications. Open Open Tab December 15, 2008 Provides Information CEO to Give Industrial Keynote Address on the Field of Targeting RNA RXi Pharmaceuticals Corporation (Nasdaq: RXII), a biopharmaceutical company pursuing the development and commercialization of proprietary therapeutics based on RNA interference (RNAi), today announced that the Company's President and Chief Executive Officer, Tod Woolf, Ph.D., will present an industry keynote address at the seventh annual RNAi, MicroRNAs - 2009 - Boston Meeting on Wednesday, April 1, 2009. Open Open Tab March 30, 2009 Provides Information Challenges and Opportunities in Pesticides Market Such as Biotechnology and Nanotechnology Reportlinker.com announces that a new market research report related to the Agricultural chemicals industry is available in its catalogue. Open Open Tab October 31, 2008 Provides Information China launches DNA database to track trafficked kids China's Ministry of Public Security is to use DNA testing to help police identify kidnapped children and return them to their homes. Open Open Tab May 1, 2009 Provides Information Chronic stress alters our genetic immune response Most people would agree that stress increases your risk for illness and this is particularly true for severe long-term stresses, such as caring for a family member with a chronic medical illness. However, we still have a relatively limited understanding of exactly how stress contributes to the risk for illness. Open Open Tab August 27, 2008 Provides Information Closing The Gaps In The Human Genome Sequence gaps in human chromosome 15 have been closed by the application of 454 technology. Researchers have described a simple and scalable method for finishing non-structural gaps in genome assemblies. Open Open Tab June 15, 2009 Provides Information Cold Virus Found To Manipulate Genes Sneezing, runny nose and chills? You might blame the human rhinovirus (HRV), which causes 30 to 50 percent of common colds. But in reality, it's not the virus itself but HRV's ability to manipulate your genes that is the true cause of some of the most annoying cold symptoms. Open Open Tab October 27, 2008 Provides Information Collaboration to Explore Therapeutic Potential of microRNAs Mirna Therapeutics ("Mirna"), a wholly owned subsidiary of Asuragen, Inc. and the University of California, San Francisco announce that they have entered into a collaboration agreement to evaluate the capacity of specific microRNAs to reduce or eliminate tumors in mouse models of cancer. The collaboration will include studies of cancer-related microRNAs that were discovered at both Mirna and UCSF as well as small RNAs that will be identified in research using mouse and cell models from UCSF. Open Open Tab February 3, 2009 Provides Information Colloids twist like DNA French scientists have used magnetic colloids to make self-assembling, helical structures reminiscent of DNA. Similar methods could be used to make tiny, self-propelling objects and colloidal models that mimic the assembly of complex, naturally occurring molecules ("Chiral colloidal clusters"). Open Open Tab September 18, 2008 Provides Information Combined stem cell-gene therapy approach cures human genetic disease in vitro A study led by researchers at the Salk Institute for Biological Studies, has catapulted the field of regenerative medicine significantly forward, proving in principle that a human genetic disease can be cured using a combination of gene therapy and induced pluripotent stem (iPS) cell technology. Open Open Tab May 31, 2009 Provides Information Complete Genomics Announces Partnership to Conduct First Human Genome Population Study Complete Genomics, Inc., a newly-launched, third-generation human genome sequencing company, and the Institute for Systems Biology (ISB) today announced their partnership to conduct population-wide human genome studies. Open Open Tab October 7, 2008 Provides Information Complete Genomics Releases Proof-of-Concept Data for its Sequencing Technology Complete Genomics, Inc. released proof-of-concept (PoC) data for its human genome sequencing technology for the first time yesterday evening. The analysis results were reviewed by Dr. Clifford Reid, Complete Genomics chairman, president and CEO, during his presentation at the annual Advances in Genome Biology and Technology Meeting held at the Marco Island Marriott Beach Resort, Marco Island, Fla. Open Open Tab February 6, 2009 Provides Information Computer simulations help explain the photostability of DNA Complex computer simulations have, for the first time, allowed scientists to examine in detail the processes that help to ensure the stability of DNA when exposed to UV light. Open Open Tab February 23, 2009 Provides Information D Data Corroborate Company's Promise to Deliver High-Quality Commercial Human DNA Sequencing at Low Cost Complete Genomics, Inc. released proof-of-concept (PoC) data for its human genome sequencing technology for the first time yesterday evening. The analysis results were reviewed by Dr. Clifford Reid, Complete Genomics chairman, president and CEO, during his presentation at the annual Advances in Genome Biology and Technology Meeting held at the Marco Island Marriott Beach Resort, Marco Island, Fla. Open Open Tab February 6, 2009 Provides Information Defining DNA Differences To Track And Tackle Typhoid For the first time, next-generation DNA sequencing technologies have been turned on typhoid fever - a disease that kills 600,000 people each year. The results will help to improve diagnosis, tracking of disease spread and could help to design new strategies for vaccination. Open Open Tab July 30, 2008 Provides Information Designer RNA fights high cholesterol, medical researchers find Small, specially designed bits of ribonucleic acid (RNA) can interfere with cholesterol metabolism, reducing harmful cholesterol by two-thirds in pre-clinical tests, according to a new study by researchers at UT Southwestern Medical Center in collaboration with Alnylam Pharmaceuticals and the Massachusetts Institute of Technology. Open Open Tab August 11, 2008 Provides Information Detecting Protein-DNA Interactions Using Photonic Crystal Biosensors Scientists at the University of Illinois have developed a new class of disposable, microplate-based optical biosensors capable of detecting protein-DNA interactions. Based on the properties of photonic crystals, the biosensors are suitable for the rapid identification of inhibitors of protein-nucleic acid and protein-protein interactions. Open Open Tab September 24, 2008 Provides Information Device Marks Step Toward More Complex Synthetic Molecular Motor Systems Chemists at New York University and Harvard University have created a bipedal, autonomous DNA "walker" that can mimic a cell's transportation system. The device, which marks a step toward more complex synthetic molecular motor systems, is described in the most recent issue of the journal Science. Open Open Tab April 3, 2009 Provides Information Diamond Biosensor for Specific Sequence of DNA with Ultra-high Sensitivity Hiroshi Uetsuka and Nianjun Yang, the Diamond Research Center of the National Institute of Advanced Industrial Science and Technology (AIST) have fabricated vertically aligned nanowire structure with 10 nm lateral spacing on conductive diamond surfaces, and succeeded in highly sensitive detection of DNA (2 pM) using an electrochemical sensor with the nanowire-structured diamond electrodes. Open Open Tab March 6, 2009 Provides Information Discovery of gene associated with epilepsy A University of Iowa-led international research team has found a new gene associated with the brain disorder epilepsy. Open Open Tab November 18, 2008 Provides Information Discovery of new biochemical pathway which controls DNA repair From the sun's UVA rays to tobacco smoke, our environment is chock-full of DNA-damaging agents that can lead to cancer. Open Open Tab November 7, 2008 Provides Information Discovery of obesity genes A study of 228 women has revealed genetic variants responsible for body shape. Based on work in the fruit fly Drosophila melanogaster, research published in the open access journal BMC Genetics identifies natural variation in the human LAMA5 gene as a key determinant of weight. Open Open Tab August 10, 2008 Provides Information DNA Acts as Smart Glue for Nanostructures Brookhaven physicists have developed a way to use DNA to guide nanoparticles to stick together in a very specific way. Conveniently, the DNA strands themselves act as the binding glue to keep the particles together. Open Open Tab March 31, 2009 Provides Information DNA component can stimulate and suppress the immune response A component of DNA that can both stimulate and suppress the immune system, depending on the dosage, may hold hope for treating cancer and infection, Medical College of Georgia researchers say. Open Open Tab January 27, 2009 Provides Information DNA convictions fall as database doubles in size The number of crimes solved thanks to the DNA database is actually falling despite the ever-growing number of people it contains. Open Open Tab November 11, 2008 Provides Information DNA database breach of rights Two British men should not have had their DNA and fingerprints retained by police, the European Court of Human Rights has ruled. Open Open Tab December 4, 2008 Provides Information DNA database costs soar Home Office figures show that the cost of running the national DNA database has more than doubled since 2002-03. Open Open Tab September 5, 2008 Provides Information DNA database grows faster than forecast 14m profiles, despite removal of under-10s Open Open Tab March 31, 2009 Provides Information DNA database includes nipper and nonagenarian Jacqui Smith yesterday showed how the DNA database presents a truly wideview snapshot of Britain when she revealed the youngest subject on the database is under one year while the oldest is over 90. Open Open Tab March 10, 2009 Provides Information DNA Editing Tool Flips Its Target Imagine having to copy an entire book by hand without missing a comma. Our cells face a similar task every time they divide. They must duplicate both their DNA and a subtle pattern of punctuation-like modifications on the DNA known as methylation. Open Open Tab September 5, 2008 Provides Information DNA founder attacks database The inventor of the genetic technology behind the national DNA database says it risks losing support because it holds the records of innocent people. Open Open Tab April 15, 2009 Provides Information DNA gripped in nanopores - Researchers analyse forces on DNA in gel Molecular biologists, including the cool dudes from CSI, use gel electrophoresis to separate DNA fragments from each other in order to analyse the DNA. Open Open Tab May 14, 2009 Provides Information DNA Makes for Great Network Cable Scientists at Chalmers University of Technology in Sweden found that DNA molecules can be used as miniature optical fibers, a discovery that might allow the development of future photonic optical microprocessors made out of webs of DNA strands. Open Open Tab November 14, 2008 Provides Information DNA nanotechnology symposium at Duke A one day symposium on using DNA to build structures and machinery on millionths and billionths of a meter scales will bring leading experts from Denmark and throughout the United States to Duke University on Friday, March 20, 2009. Open Open Tab March 19, 2009 Provides Information DNA Nanotubes Controlled by Gold Particles Arizona State University researchers Hao Yan and Yan Liu harnessed the natural qualities of DNA and gold to manipulate the size and shape of nanotube structures. Open Open Tab January 5, 2009 Provides Information DNA Nanotubes Spark Interest Arizona State University researchers Hao Yan and Yan Liu imagine and assemble intricate structures on a scale almost unfathomably small. Their medium is the double-helical DNA molecule, a versatile building material offering near limitless construction potential. Open Open Tab February 12, 2009 Provides Information DNA origami could be forerunner to smart nanodelivery systems By combining the art of origami with nanotechnology, Dana-Farber Cancer Institute researchers have folded sheets of DNA into multilayered objects with dimensions thousands of times smaller than the thickness of a human hair. Open Open Tab May 20, 2009 Provides Information DNA Origami Seeds Control Complex Nucleation Processes The construction of complex man-made objects--a car, for example, or even a pizza--almost invariably entails what are known as "top-down" processes, in which the structure and order of the thing being built is imposed from the outside (say, by an automobile assembly line, or the hands of the pizza maker). Open Open Tab April 9, 2009 Provides Information DNA Profiling For Tracing Parental Ancestry Becomes More Accurate And Reliable Anyone who has watched crime dramas on TV knows that forensic scientists can use DNA “profiling” to identify people from evidence gathered at a crime scene, establish a paternity link or help free an innocent person who has been wrongly jailed. A lesser known but rapidly growing application of DNA profiling is tracing a person’s paternal ancestry—a process known as genetic genealogy. Open Open Tab December 29, 2008 Provides Information DNA Proven Softer than Previously Thought The DNA's double helix--the sub-microscopic core of our life--has been the subject of intense study and scrutiny for decades. Open Open Tab October 17, 2008 Provides Information DNA Quantification Kits Offer Rapid Solutions for Quantification of Global DNA Methylation Sigma-Aldrich today introduced its Imprint(TM) Methylated DNA Quantification Kit (MDQ1) for epigenetic research . The Methylated DNA Quantification Kit employs a familiar ELISA-like procedure, with no radioactivity or chromatography, to measure global methylation in less than four hours. Open Open Tab October 30, 2008 Provides Information DNA Repair Mechanisms Relocate In Response To Stress Like doctors making house calls, some DNA repair enzymes can relocate to the part of the cell that needs their help, a collaborative team of scientists at Emory University School of Medicine has found. Open Open Tab April 1, 2009 Provides Information DNA Repair: Structure Of The Mre11 Protein Bound To DNA Repairing breaks in the two strands of the DNA double helix is critical for avoiding cancer. In humans and other organisms, a molecular machine called the MRN complex is responsible for finding and signaling double-strand breaks (DSBs), then launching the error-free method of DNA repair called homologous recombination. Open Open Tab October 27, 2008 Provides Information DNA Research Taking Guesswork Out Of Finding The 'Therapeutic Window' It's only spit, but what's inside your saliva may help solve a dosing dilemma facing doctors and patients. By using DNA to customize prescriptions, researchers at Temple University's School of Pharmacy are working to prevent adverse drug reactions before you even take the first dose. Open Open Tab October 28, 2008 Provides Information DNA sewing machine Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The work published in the Royal Society of Chemistry journal Lab on a Chip demonstrates a unique way to manipulate delicate DNA chains without breaking them. Open Open Tab July 10, 2008 Provides Information DNA Shape Is Constrained By Evolution: Structural Approach To Exploring DNA A team led by researchers from Boston University and the National Institutes of Health has developed a new method for uncovering functional areas of the human genome by studying DNA's three-dimensional structure -- a topographical approach that extends the more familiar analysis of the sequence of the four-letter alphabet of the DNA bases. Open Open Tab March 19, 2009 Provides Information DNA Spotted Microarray Reduces Time to Detect Dangerous Disease Dangerous disease often spreads faster than it takes to diagnose it in the lab. To remedy that, researchers at Kansas State University have developed a test to bring that time from days down to hours. Open Open Tab August 23, 2008 Provides Information DNA template could explain evolutionary shifts Rearrangements of all sizes in genomes, genes and exons can result from a glitch in DNA copying that occurs when the process stalls at a critical point and then shifts to a different genetic template, duplicating and even triplicating genes or just shuffling or deleting part of the code within them, said researchers from Baylor College of Medicine in a recent report in the journal Nature Genetics. Open Open Tab June 22, 2009 Provides Information DNA tricked to act as nano-building blocks McGill researchers have succeeded in finding a new way to manufacture nanotubes, one of the important building blocks of the nanotechnology of the future. Their building material? Biological DNA. Open Open Tab April 13, 2009 Provides Information Do-it-yourself DNA testing: Helpful or harmful? Dozens of companies want to predict your medical future Open Open Tab April 9, 2009 Provides Information Does HBV infection induce acute cellular DNA damage? Eukaryotic cells employ multiple strategies of checkpoint signaling and DNA repair mechanisms to monitor and repair damaged DNA. Open Open Tab November 12, 2008 Provides Information Don't delay: Delete your DNA today Now that a European Court has decided that the retention of the DNA of innocent people is illegal - what should you do now? Open Open Tab December 17, 2008 Provides Information Drug From Genetically Altered Goats Approved The Food and Drug Administration made history Friday as it approved the first drug made with materials from genetically engineered animals, clearing the way for a new class of medical therapies. Open Open Tab February 6, 2009 Provides Information Duke University To Host DNA Nanotechnology Symposium A one day symposium on using DNA to build structures and machinery on millionths and billionths of a meter scales will bring leading experts from Denmark and throughout the United States to Duke University on Friday, March 20, 2009. Open Open Tab March 17, 2009 Provides Information E Early-stage Gene Transcription Creates Access To DNA A gene contained in laboratory yeast has helped an international team of researchers uncover new findings about the process by which protein molecules bind to control sequences in genes in order to initiate gene expression, according to findings reported in the journal Nature. Open Open Tab October 15, 2008 Provides Information Engineers Build First-ever Multi-input 'Plug-and-play' Synthetic RNA Device Engineers from the California Institute of Technology (Caltech) have created a "plug-and-play" synthetic RNA device--a sort of eminently customizable biological computer--that is capable of taking in and responding to more than one biological or environmental signal at a time. Open Open Tab October 20, 2008 Provides Information Enzyme Key To 'Sister Act' That Maintains Genome Stability Keeping the genome stable is a "sister act" of matched chromatids -- the pairs of the double helix DNA molecule that exist during the chromosome duplication in the S phase of the cell cycle. Open Open Tab July 14, 2008 Provides Information Enzyme Necessary For DNA Synthesis Can Also Erase DNA In this week's edition of Proceedings of the National Academy of Sciences, PNAS, Uppsala University scientists describe a new mechanism behind an important process that causes a rapid reduction of DNA in the chromosomes of bacteria. The findings advance our knowledge of how DNA content has been reduced, which is something that has occurred in bacteria that live as parasites inside the cells of other organisms. Open Open Tab June 9, 2009 Provides Information Examining the DNA Patterns of Microbes The genomes or DNA of microbes contain defined DNA patterns called genome signatures. Such signatures may be used to establish relationships and to search for DNA from viruses or other organisms in the microbes' genomes. Foreign DNA in bacteria has often been associated with disease-causing abilities. Open Open Tab June 25, 2009 Provides Information Experienced Pilots May Be At Risk Of DNA Damage From Ionizing Radiation Airline pilots who have flown for many years may be at risk of DNA damage from prolonged exposure to cosmic ionising radiation, suggests a study published ahead of print in Occupational and Environmental Medicine. Open Open Tab December 16, 2008 Provides Information Even In Our Genome, Good Fences Make Good Neighbors Our genome is a patchwork of neighborhoods that couldn't be more different: Some areas are hustling and bustling with gene activity, while others are sparsely populated and in perpetual lock-down. Open Open Tab May 15, 2009 Provides Information F Fast and Affordable Genome Sequencing Moved a Step Closer with New Solid-State Nanopore Sensor The nanopore sensor, made by drilling a tiny hole through a thin film of aluminum oxide, could ultimately prove capable of performing DNA analysis with a single molecule, offering tremendous possibilities for personalized medicine and advanced diagnostics. Open Open Tab June 2, 2009 Provides Information First DNA molecule made almost entirely of artificial parts Chemists in Japan report development of the world's first DNA molecule made almost entirely of artificial parts. The finding could lead to improvements in gene therapy, futuristic nano-sized computers, and other high-tech advances, they say. Open Open Tab July 2, 2008 Provides Information First DNA Molecule Made Almost Entirely Of Artificial Parts Chemists in Japan report development of the world's first DNA molecule made almost entirely of artificial parts. The finding could lead to improvements in gene therapy, futuristic nano-sized computers, and other high-tech advances. Open Open Tab July 7, 2008 Provides Information First glimpse of a key DNA repair protein at work Repairing breaks in the two strands of the DNA double helix is critical for avoiding cancer. In humans and other organisms, a molecular machine called the MRN complex is responsible for finding and signaling double-strand breaks (DSBs), then launching the error-free method of DNA repair called homologous recombination. Open Open Tab October 3, 2008 Provides Information First Large-scale Computer Simulation Of Gene Therapy A group of researchers at the University of California, Berkeley and Los Alamos National Laboratory have completed the first comprehensive, molecular-level numerical study of gene therapy. Their work should help scientists design new experimental gene therapies and possibly solve some of the problems associated with this promising technique. Open Open Tab April 30, 2009 Provides Information Fluidigm Developing Quantification System Allowing Sequencing of Rare Samples Fluidigm Corporation today announced a sample quantification system that allows researchers to sequence their libraries of rare samples and also dramatically lower costs, improve data quality and speed up time-to-results for scientists performing next-generation DNA sequencing. Open Open Tab March 30, 2009 Provides Information Fluidigm’s New Digital Array Delivers Peak Levels of Throughput for Digital PCR This IFC is capable of testing up to 48 individual samples at a time and automatically partitioning each of the samples into separate sets of 770 reaction chambers - delivering a total of 36,960 simultaneous digital PCR reactions. Open Open Tab March 16, 2009 Provides Information Free Online Toolkit Provides Standard Measures For Genome and Population Studies New Measures Will Allow Integration of Multiple Research Studies Open Open Tab April 20, 2009 Provides Information Future Of Personalized Cancer Treatment: An Entirely New Direction For RNAi Delivery In technology that promises to one day allow drug delivery to be tailored to an individual patient and a particular cancer tumor, researchers at the University of California, San Diego School of Medicine, have developed an efficient system for delivering siRNA into primary cells. Open Open Tab May 17, 2009 Provides Information G Gates Foundation grant for nanopatch delivery of DNA-based malaria vaccines to skin Professor Kendall's project is one of 104 grants selected from nearly 4000 proposals —announced by the Gates Foundation for the first funding round of Grand Challenges Explorations, an initiative to help scientists around the world explore bold, new solutions for health challenges in developing countries. The grants were provided to all levels of scientists in 22 countries and five continents. Open Open Tab October 29, 2008 Provides Information Gene Associated With Epilepsy Discovered A University of Iowa-led international research team has found a new gene associated with the brain disorder epilepsy. While the PRICKLE1 gene mutation was specific to a rare form of epilepsy, the study results could help lead to new ideas for overall epilepsy treatment. Open Open Tab November 19, 2008 Provides Information Gene Associated With Reduced Mortality From Acute Lung Injury Researchers at National Jewish Health and the University of Colorado Denver have discovered a gene that is associated with improved survival among patients with acute lung injury. Acute lung injury (ALI) is often caused by a respiratory infection and results in low oxygen levels in the blood, and fluid in the lungs. Open Open Tab January 21, 2009 Provides Information Gene by gene, scientists dig for the triggers James Thomson knew that to send a cell back to its past was no trivial matter. Like generations of biologists, the University of Wisconsin-Madison stem cell pioneer had been taught that development was a one-way street; it began with an embryo and finished with all the mature cells that make up the body. Yet in the summer of 2007, Thomson and scientists around the globe were racing to do what once had been thought impossible: to reverse the natural process and return old cells to their embryonic origin. They sought the healing potential of embryonic stem cells - immortal in a lab dish, able to become any cell in the body - but without the controversial destruction of human embryos. Open Open Tab January 2, 2009 Provides Information Gene Chips Help Uncover Causes of Genetic Disorders Researchers from the University of Washington have identified a region in the 1q21.1 chromosome, the aberrations of which causes a wide range of genetic disorders in children. The journal Nature has a short article that profiles the business and clinical implications of microarrays, devices that can detect the variations of the sequence of DNA. Open Open Tab September 17, 2008 Provides Information Gene could allow lab-grown teeth Scientists believe they have found a way to grow teeth in the laboratory, a discovery that could put an end to fillings and dentures. Open Open Tab February 24, 2009 Provides Information Gene mutations linked to lung cancer found 2 variants associated with increased risk in women, research suggests.     December 22, 2008 Provides Information Gene research sheds light on T-cell production New research, just published by researchers from the University of Georgia, provides the first evidence that a key gene may be crucial to maintaining the production of the thymus and its disease-fighting T-cells after an animal's birth. Open Open Tab November 7, 2008 Provides Information Gene silencer and quantum dots reduce protein production to a whisper More than 15 years ago, scientists discovered a way to stop a particular gene in its tracks. The Nobel Prize-winning finding holds tantalizing promise for medical science, but so far it has been difficult to apply the technique, known as RNA interference, in living cells. Open Open Tab July 9, 2008 Provides Information Gene Switch Sites Found Mainly On 'Shores,' Not Just 'Islands' Of The Human Genome Scientists who study how human chemistry can permanently turn off genes have typically focused on small islands of DNA believed to contain most of the chemical alterations involved in those switches. But after an epic tour of so-called DNA methylation sites across the human genome in normal and cancer cells, Johns Hopkins scientists have found that the vast majority of the sites aren't grouped in those islands at all, but on nearby regions that they've named "shores." Open Open Tab January 20, 2009 Provides Information Gene That Helps Control Production Of Stomach Acid Discovered University of Cincinnati (UC) researchers have discovered a gene that helps control the secretion of acid in the stomach—information that could one day aid scientists in creating more efficient treatment options for conditions such as acid reflux or peptic ulcers. Open Open Tab November 4, 2008 Provides Information Gene That Regulates Mold's Resistance To Drugs Identified Montana State University scientists concerned about lethal mold infections have found a gene that regulates the mold's resistance to drugs. Open Open Tab November 20, 2008 Provides Information Gene Therapy Cures Eight Children With Potentially Fatal 'Bubble Boy Disease' Gene therapy seems to have cured eight of 10 children who had potentially fatal "bubble boy disease," according to a study that followed their progress for about four years after treatment. Open Open Tab January 28, 2009 Provides Information Gene transfer with the aid of magnetic nanoparticles Magnetic nanoparticles are applied today routinely as a contrast agent for magnetic resonance imaging. In addition to medical diagnostics, there are also approaches to utilize magnetic nanoparticles for therapy. In these applications, the interaction of these nanometer sized particles with external magnetic fields is designed to give rise to a therapeutic effect on the surrounding tissue. Open Open Tab March 5, 2009 Provides Information Genes for 9 health indicators A new genome-wide study examines genetic variants associated with nine metabolic traits and is the first to draw out novel variants from a population unselected for current disease. The traits are indicators for common disease such as cardiovascular disease, type 2 diabetes, blood pressure, inflammation and lipid levels. Open Open Tab December 7, 2008 Provides Information Genes May Make Some People More Prone To Anxiety Inborn differences may help explain why trauma gives some people bad memories and others the nightmare of post-traumatic stress. Scientists in Germany and the United States have reported evidence linking genes to anxious behavior. Open Open Tab August 11, 2008 Provides Information Genetic 'bearded lady' syndrome uncovered New research provides exciting genetic insight into a rare syndrome that first appeared in the medical literature in the mid 1800s with the case of Julia Pastrana, the world's most notorious bearded lady. Open Open Tab May 21, 2009 Provides Information Genetic Data Pose Ethical Dilemmas New legislation in the United States and elsewhere has banned the use of genetic testing to deny health insurance or job opportunities. Open Open Tab July 27, 2008 Provides Information Genetic Immunity to Attend CLINAM European Conference for Clinical Nanomedicine Genetic Immunity has announced that Julianna Lisziewicz, Chief Executive Officer of the Company will be presenting at the European Conference for Clinical Nanomedicine, to be held from April 26-29, 2009 at the Basel Convention Center in Basel, Switzerland. Open Open Tab April 23, 2009 Provides Information Genetic Link Between Immune And Nerve Systems Found For some time, researchers have theorized a direct link between the nervous and immune systems, such as stress messages that override the protective effects of antibodies, but the exact connection was unknown. Open Open Tab September 22, 2008 Provides Information Genetic mutation linked to seasonal affective disorder With the days shortening toward winter, many people will begin to experience the winter blahs. Open Open Tab November 4, 2008 Provides Information Genetic risk for anxiety does not have to be destiny A growing body of basic animal research and studies of abused and neglected children provide a strong basis of support for the hypothesis that individuals with particular genotypes are at greater risk for depression, anxiety disorders, and problems with the abuse of alcohol and other substances. Open Open Tab April 30, 2009 Provides Information Genetic testing: Do you really want to know? Once impenetrable, the individual genetic code is becoming an open book thanks to kits that scan for genes linked to scores of traits and diseases, from bladder cancer and baldness to male infertility and memory loss. Open Open Tab January 15, 2009 Provides Information Genetic Tests on the Horizon The latest in genetic testing from the Consumer Genomics Conference. Open Open Tab June 9, 2009 Provides Information Genetically engineered mice don't get obese Obesity and gallstones often go hand in hand. But not in mice developed at Washington University School of Medicine in St. Louis. Even when these mice eat high-fat diets, they don't get fat, but they do develop gallstones. Open Open Tab May 7, 2009 Provides Information Genetics testing with lab-on-chip device Using new "lab on a chip" technology, James Landers hopes to create a hand-held device that may eventually allow physicians, crime scene investigators, pharmacists, even the general public to quickly and inexpensively conduct DNA tests from almost anywhere, without need for a complex and expensive central laboratory. Open Open Tab September 19, 2008 Provides Information Genome fanatics share their DNA sequences 'Personal Genome Project' designed to serve as a resource for researchers. Open Open Tab October 21, 2008 Provides Information Genome-wide map shows precisely where microRNAs do their work MicroRNAs are the newest kid on the genetic block. By regulating the unzipping of genetic information, these tiny molecules have set the scientific world alight with such wide-ranging applications as onions that can’t make you cry and therapeutic potential for new treatments for viral infections, cancer and degenerative diseases. But the question remains: How do they work? Open Open Tab June 17, 2009 Provides Information Genome-Wide Platform to Study How Specialized Proteins Regulate RNA in Living Cells DNA, it has turned out, isn't all it was cracked up to be. In recent years we learned that the molecule of life, the discovery of the 20th century, did not -- could not -- by itself explain the huge differences in complexity between a human and a worm. Forced to look elsewhere, scientists turned to RNA, a direct yet more complex transcript of DNA. But methodological problems have historically plagued the study of RNA regulation in living cells, limiting not only the accuracy of results but also our understanding of RNA's role in human disease. Open Open Tab November 3, 2008 Provides Information Grant Program to Inspire Genomic, Epigenomic and Transcriptome Studies on the SOLiD System As part of its commitment to promote basic research in the life sciences, Applied Biosystems Inc. today announced the creation of a grant program for genomic, epigenomic and transcriptome studies. The $10K Genome Grant Program is based on the concept of sequencing an entire genome for $10,000. Applied Biosystems is launching this program to inspire new genomic sequencing studies on next-generation sequencing technology. Open Open Tab October 27, 2008 Provides Information H How A Well-known Protein Repairs Broken DNA Ends During the life cycle of our cells, a minefield of environmental and biological assaults can lead to double-stranded DNA breaks, the most lethal and dangerous form of DNA damage. Now, in research published online in Nature, Rockefeller University scientists reveal that when these breaks occur, a protein called 53BP1 helps repair them by mobilizing their dangly DNA ends — findings that uncover a previously unknown aspect of how double-stranded breaks can get fixed. Open Open Tab November 13, 2008 Provides Information How Cells Handle Broken Chromosomes Scientists from the Max Planck Institute of Biochemistry discovered a novel cellular response towards persistent DNA damage: After being recognized and initially processed by the cellular machinery, the broken chromosome is extensively scanned for homology and the break itself is later tethered to the nuclear envelope. Open Open Tab February 17, 2009 Provides Information How Defective DNA Repair Triggers Two Neurological Diseases Both disorders arise from defects in a central component of the cell's machinery that repairs damaged DNA, but each disease presents with distinct pathologies. Defects in DNA repair dramatically increase the risk of cancer, which is found in NBS. However, NBS is also characterized by the occurrence of small brain size, or microcephaly, while in contrast, ATLD causes predominantly neurodegeneration Open Open Tab January 18, 2009 Provides Information How DNA Is Unwound So That Its Code Can Be Read Researchers at The Scripps Research Institute have figured out how a macromolecular machine is able to unwind the long and twisted tangles of DNA within a cell's nucleus so that genetic information can be "read" and used to direct the synthesis of proteins, which have many specific functions in the body. Open Open Tab November 28, 2008 Provides Information Human DNA Repair Process Recorded In Action A key phase in the repair process of damaged human DNA has been observed and visually recorded by a team of researchers at the University of California, Davis. The recordings provide new information about the role played by a protein known as Rad51, which is linked to breast cancer, in this complex and critical process. Open Open Tab February 6, 2009 Provides Information Humans And Chimpanzees Genetically More Similar Than One Yeast Variety Is To Another There may be greater genetic variation between different yeasts of the same species than between humans and chimpanzees. This is one of the findings of a study from the University of Gothenburg that is being published in the scientific journal Nature. This study heralds a new era in evolutionary genetics research -- the mapping of an individual's DNA. Open Open Tab February 13, 2009 Provides Information How DNA Repairs Can Reshape Genome, Spawn New Species Researchers at Duke University Medical Center and at the National Institute of Environmental Health Sciences (NIEHS) have shown how broken sections of chromosomes can recombine to change genomes and spawn new species. Open Open Tab August 14, 2008 Provides Information How Proteins Find The Right DNA Sequences Researchers at Uppsala University and Harvard University have collaboratively developed a new theoretical model to explain how proteins can rapidly find specific DNA sequences, even though there are many obstacles in the way on the chromosomes. Open Open Tab March 23, 2009 Provides Information How short RNAs influence many proteins During the last decade, microRNAs have emerged somewhat surprisingly as key players in the way genes are regulated. These short snippets of RNA do their work by interacting with messenger RNAs, which act as blueprints for protein creation. Open Open Tab August 6, 2008 Provides Information Human rights court rules UK DNA grab illegal The European Court of Human Rights has ruled that it is illegal for the government to retain DNA profiles and fingerprints belonging to two men never convicted of any crime. Open Open Tab December 4, 2008 Provides Information I Identigene expands sales of OTC DNA paternity test kit Identigene today announced the Identigene DNA Paternity Test Kit is now available in select discount stores and supercenters in central Texas, bringing the total number of retail locations in which the kit is sold to nearly 15,500. Open Open Tab November 18, 2008 Provides Information Illumina To Distribute Oxford Nanopore DNA Sequencing Products Illumina and Oxford Nanopore Technologies ("Oxford Nanopore") today announced a strategic alliance including a commercialization agreement and equity investment. Under the terms of the commercialization agreement, Illumina will exclusively market, sell, distribute, and service BASE" Technology products developed by Oxford Nanopore for DNA sequencing into the research and diagnostic markets on a worldwide basis. Illumina and Oxford Nanopore will share profits generated from sales. Open Open Tab January 12, 2009 Provides Information Improving Diagnosis Of Genetic Disorders An Australian-led global initiative to improve the diagnosis of genetic disorders and reduce errors in the reporting of genetic variations has been published today in the journal Science. Open Open Tab November 15, 2008 Provides Information Industry's Fastest Real-Time PCR Genotyping Solution Applied Biosystems Inc. today announced the worldwide availability of a new universal genotyping reagent solution that accelerates the generation of high-quality genotyping data for a host of life science applications. Open Open Tab October 28, 2008 Provides Information Inhibiting microRNAs Through ANTAGOMIRs The answer is: trying to prevent/limit the action of damaging agents and promote the growth of new blood vessels that could help the recovery of damaged sites. With this question (and answer) in mind, Stefanie Dimmeler Professor of Experimental Medicine and Head of the Molecular Cardiology at the University of Frankfurt and colleagues, set up their investigation on so-called microRNAs (miRNAs), small molecules involved in a number of critical processes including cardiovascular development, angiogenesis and inflammation. Open Open Tab November 28, 2008 Provides Information Integrated Fluidic Circuits Bring New Levels of Efficiency and Flexibility for High-Throughput Genotyping Fluidigm Corporation and BIOKE, a licensed distributor for the company, today announced that Enza Zaden, one of the world's leading suppliers of high-quality vegetable seeds for agriculture, has chosen the Fluidigm's BioMark(TM) System for Genetic Engineering and the new 96.96 Dynamic Array to help assure the quality of its seed supply. Open Open Tab October 7, 2008 Provides Information Intel bets millions on speedy DNA sequencing chips Intel is among several investors pumping $100m into a biotech start-up that wants to make mapping an individual's genome as routine as taking an X-ray. Open Open Tab July 15, 2008 Provides Information InteRNA Technologies Joins SIROCCO Research Consortium to Study RNA Silencing InteRNA Technologies B.V. is pleased to announce that it has joined the SIROCCO research consortium consisting of 25 world-class laboratories and companies from 10 countries for studying how RNA silencing could be used to treat life-threatening diseases, including cancer. Open Open Tab November 7, 2008 Provides Information Intradigm issued RNA interference (RNAi) patent covering potent siRNA sequence Intradigm Corporation has announced the issuance of United States patent 7,534,878, titled "Composition and Methods of RNAi Therapeutics for Treatment of Cancer and Other Neovascularization Diseases." Open Open Tab May 19, 2009 Provides Information J Johns Hopkins Medical Institute Acquires Powerful Tool for Microarray Gene Expression Analysis BioDiscovery Inc., the leading developer of integrated software solutions for microarray-based research, announced today that the Johns Hopkins Medical Institute has acquired a multi-seat license of Nexus Expression, a new intuitive and powerful tool for microarray gene expression analysis. Open Open Tab October 27, 2008 Provides Information Journey into the Sub-Microscopic World of Molecular Machines Imagine that we had some way to look directly at the molecules in a living organism....Think of the wonders we could witness firsthand: antibodies attacking a virus, electrical signals racing down nerve fibers, proteins building new strands of DNA... Open Open Tab May 8, 2009 Provides Information Just A Little Squeeze Lets Proteins Assess DNA To find its target, all a protein needs to do is give quick squeezes as it moves along the DNA strand, suggests new research from The University of Arizona in Tucson. Open Open Tab December 27, 2008 Provides Information K Kiel University Researchers Report Sequence-Dependent Effects of Light on DNA DNA, the molecule that acts as the carrier of genetic information in all forms of life, is highly resistant against alteration by ultraviolet light, but understanding the mechanism for its photostability presents some puzzling problems. Open Open Tab October 13, 2008 Provides Information L Laboratory Evolution Sped Up With a New Machine Genetic bioengineering can be a slow process, as forcing evolution onto organisms typically requires splicing and dicing of individual genes. Now George Church of Harvard and colleagues developed a system to rapidly speed up the process using a parallel approach. Open Open Tab March 20, 2009 Provides Information Laboratory Manual to Gene Transfer, Delivery and Expression of DNA and RNA Research and Markets has announced the addition of the "Gene Transfer: Delivery and Expression of DNA and RNA, A Laboratory Manual" report to their offering. Open Open Tab October 29, 2008 Provides Information Landmark Study Reveals Significant Genetic Variation Between Mexico's Population And World's Other Known Genetic Subgroups Could genetic differences explain why some people and not others have died of H1N1 Influenza A? That is among the questions raised by a landmark Mexican study showing significant genetic variation between Mestizos (Latin Americans of mixed European and Amerindian ancestry) and the world's other known genetic subgroups. Open Open Tab May 12, 2009 Provides Information Large DNA stretches, not single genes, shut off as cells mature Experiments at Johns Hopkins have found that the gradual maturing of embryonic cells into cells as varied as brain, liver and immune system cells is apparently due to the shut off of several genes at once rather than in individual smatterings as previous studies have implied. Open Open Tab January 20, 2009 Provides Information Large Reservoir Of Mitochondrial DNA Mutations Identified In Humans Researchers at the University of Newcastle, England, and the Virginia Bioinformatics Institute at Virginia Tech in the United States have revealed a large reservoir of mitochondrial DNA mutations present in the general population. Clinical analysis of blood samples from almost 3,000 infants born in north Cumbria, England, showed that at least 1 in 200 individuals in the general public harbor mitochondrial DNA mutations that may lead to disease. Open Open Tab August 12, 2008 Provides Information Light Switches Regulate Formation and Separation of DNA Duplex Japanese scientists from Advanced Science Institute in Wako have designed a method to control DNA duplex formation, something that can hopefully be used in the future to control nanomechanical devices. Open Open Tab February 17, 2009 Provides Information Link Between Control Of Chromosome Duplication And Segregation Discovered Before a cell can divide into two, first it must duplicate its genetic material--the DNA packed in its chromosomes. The two new sets of chromosomes then have to be separated from one another and correctly distributed to the resulting "daughter" cells, so that both daughter cells are genetically identical to the original, or "parent," cell. Open Open Tab February 17, 2009 Provides Information Link between DNA palindromes and disease discovered In the past 10 years, researchers in genome stability have observed that many kinds of cancers are associated with areas where human chromosomes break. More recently, scientists have discovered that slow or altered replication causes chromosomal breaking. But why does DNA replication stall? Open Open Tab July 14, 2008 Provides Information Linking microRNAs with cells that regulate the immune system could lead to new disease therapies Linking genetic material microRNAs with cells that regulate the immune system could one day lead to new therapies for treating cancer, infections and autoimmune diseases, according to a Henry Ford Hospital study. Open Open Tab June 1, 2009 Provides Information Liquidia Technologies Announces Collaboration with Abbott to Develop siRNA Therapeutics Liquidia Technologies, Inc. announced today that it has entered into a collaboration and license agreement with Abbott to develop PRINT® nanoparticles for the delivery of siRNA-based therapeutics. Liquidia’s PRINT technology offers the ability to fabricate nanoparticles of precisely defined size, shape, surface chemistry, and composition, which offers the potential to develop safer and more effective therapies. Open Open Tab January 7, 2009 Provides Information M Mathematical models reveal how organisms transcend the sum of their genes Molecular and cellular biologists have made tremendous scientific advances by dissecting apart the functions of individual genes, proteins, and pathways. Researchers at the University of Wisconsin-Madison College of Engineering are looking to expand that understanding by putting the pieces back together, mathematically. Open Open Tab February 6, 2009 Provides Information McKusick, medical genetics pioneer, dies at 86 Award-winning scientist was a key architect of the Human Genome Project. Open Open Tab July 24, 2008 Provides Information MDRNA Advances RNAi Pipeline Toward Human Clinical Development MDRNA, Inc. announced today that it has advanced its RNAi pipeline with the selection of a Lead Candidate in its hypercholesterolemia program targeting Apolipoprotein B (ApoB). The compound, designated MDR-04227, was developed using MDRNA's propriety drug discovery engine, which is built on a broad and enabling intellectual property estate and an in-house novel and proprietary delivery technology. Open Open Tab October 8, 2008 Provides Information MDRNA Announces Worldwide Non-Exclusive Licensing Agreement for RNAi Delivery Technology MDRNA, Inc. announced today that it has entered into a licensing agreement with Novartis for MDRNA's liposomal technology platform for siRNA delivery. MDRNA will receive $7.25 million in upfront fees for the non-exclusive license. Open Open Tab March 23, 2009 Provides Information Mean new microRNA data analysis method gives sharper results Our understanding of the importance of microRNAs in regulating gene expression is expanding, and with it our requirement for robust methods to measure their expression levels. Open Open Tab June 16, 2009 Provides Information Measuring distances between multicolor quantum dots with true nanometer resolution In a recent Nanowerk Spotlight we reported on a single molecule approach to directly visualize and map protein binding sites on DNA using fluorescent quantum dots (Quantum dots light up individual DNA binding proteins). Open Open Tab May 27, 2009 Provides Information Measuring The Strength Needed To Move Chromosomes It’s about as long as the width of a human hair and only half that length across. So it’s tiny — measured in millionths of a meter — and extremely tricky to manipulate. But the meiotic spindle plays so irresistibly important a role in separating our chromosomes during cell division that scientists are compelled to try to study it. Open Open Tab March 17, 2009 Provides Information Mechanisms That Regulate DNA Damage Control And Replication Illuminated Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating replication following DNA repair. Open Open Tab January 5, 2009 Provides Information Micro-Sized Sewing Machine to Sew Long Threads of DNA into Shape Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The work published in the Royal Society of Chemistry journal Lab on a Chip demonstrates a unique way to manipulate delicate DNA chains without breaking them. Open Open Tab July 11, 2008 Provides Information microRNA Expert Joins CombiMatrix Scientific Advisory Board CombiMatrix Corporation announced today that microRNA expert Dr. Muneesh Tewari has joined the Scientific Advisory Board of CombiMatrix. Dr. Tewari is in the Human Biology division at the Fred Hutchinson Cancer Research Center. Open Open Tab October 15, 2008 Provides Information MicroRNA Markets Estimates Reach $98.6 Million in 2015 Despite growing competition from new entrants, microRNA tool providers are witnessing extraordinary growth in their research product portfolios. Open Open Tab May 4, 2009 Provides Information MicroRNAs Found in Animals that Appeared a Billion Years Ago MicroRNAs, the tiny molecules that fine-tune gene expression, were first discovered in 1993. But it turns out they've been around for a billion years. Open Open Tab October 2, 2008 Provides Information microRNAs Have Roles That Go Well Beyond What Was Previously Thought In a paper published today online in the journal Nature, IBM and the Genome Institute of Singapore reported findings from a joint research study that provides new information on how stem cell differentiation is controlled by microRNAs. Open Open Tab September 18, 2008 Provides Information Miniaturized DNA sewing machines They've designed these laser-directed microdevices to pick up and manipulate individual molecules of DNA. The scientists have used optical tweezers to catch and move these microdevices, which could be used in the future to detect genetic disorders such as Down's syndrome. Open Open Tab July 13, 2008 Provides Information Modified DNA helps scientists understand secrets of DNA repair mechanisms A modified DNA is helping scientists to understand the sophisticated DNA repair mechanisms that allow dormant bacteria to come 'back to life'. Open Open Tab August 19, 2008 Provides Information Molecular Machine Turns Packaged Messenger RNA Into A Linear Transcript For RNA, the gateway to a productive life outside the nucleus is the nuclear pore complex, an amalgamation of 30 kinds of proteins that regulates all traffic passing through the nuclear membrane. New research from Rockefeller University shows that one of these proteins magnetically couples with a special molecule — a helicase — to form a machine that unpacks balled-up messenger RNA particles so that they can be translated. Open Open Tab February 13, 2009 Provides Information Molecule Stops DNA Replication In Its Tracks When a dividing cell duplicates its genetic material, a molecular machine called a sliding clamp travels along the DNA double helix, tethering the proteins that perform the replication. Researchers from the laboratory of Rockefeller University’s Michael O'Donnell, a Howard Hughes Medical Institute investigator, have discovered a small molecule that stops the sliding clamp in its tracks. Open Open Tab November 6, 2008 Provides Information N Nano Device Providing New Methods of Characterizing Torque-Generating Molecules and DNA Strands Researchers at Boston University working with collaborators in Germany, France and Korea have developed a nanoscale torsion resonator that measures miniscule amounts of twisting or torque in a metallic nanowire. This device, the size of a speck of dust, might enable measurements of the untwisting of DNA and have applications in spintronics, fundamental physics, chemistry and biology. Open Open Tab November 3, 2008 Provides Information Nano tractor beam traps DNA Using a beam of light shunted through a tiny silicon channel, researchers have created a nanoscale trap that can stop free floating DNA molecules and nanoparticles in their tracks. By holding the nanoscale material steady while the fluid around it flows freely, the trap may allow researchers to boost the accuracy of biological sensors and create a range of new 'lab on a chip' diagnostic tools. Open Open Tab December 31, 2008 Provides Information Nano-boxes from DNA origami Danish researchers have made a nano-sized box out of DNA that can be locked or opened in response to 'keys' made from short strands of DNA. Open Open Tab May 6, 2009 Provides Information Nanogen Signs Licensing and Supply Agreement with Scandinavian Gene Synthesis Nanogen, Inc., developer of molecular and rapid diagnostic products, announced today that it has signed a licensing and supply agreement with Scandinavian Gene Synthesis (SGS) for use of the Company's proprietary MGB Probe technology and synthetic nucleic acid chemistries including dyes and quenchers for use in human in vitro diagnostic testing. Open Open Tab February 4, 2009 Provides Information Nanoparticle Targets Melanoma With siRNA Specially designed small RNA molecules have proven very effective in decreasing the expression of specific genes that cancer cells need to survive; however, getting these RNA molecules inside cancer cells in living animals is difficult. Open Open Tab December 18, 2008 Provides Information Nanoparticles to be used in genic therapy Genic therapy can be used both with rare diseases, such as cystic fibrosis and disorders of the retina, as well as with more common illnesses, such as AIDS, cancer and neurodegenerative diseases (for example, Parkinson’s or Alzheimer’s). Open Open Tab May 18, 2009 Provides Information Nanopore sequencing could slash DNA analysis costs Over the past 5 years, researchers have been exploring the use of nanoscale pores as nucleic acid sequencing tools. In theory, such pores should generate a unique response characteristic of each of the four nucleotide bases as a piece of DNA moves through the pore. Open Open Tab March 26, 2009 Provides Information Nanopores Accurately Identify Normal and Methylated DNA Bases Oxford Nanopore Technologies ("Oxford Nanopore") today announced the publication of new research in Nature Nanotechnology, demonstrating accurate and continuous identification of DNA bases using nanopores. The system can also directly identify methylated cytosine, important in the study of epigenetics. Open Open Tab February 23, 2009 Provides Information Nanoscopic static electricity generates chiral patterns In the tiny world of amino acids and proteins and in the helical shape of DNA, a biological phenomenon abounds. Open Open Tab February 2, 2009 Provides Information Nanosensors Detecting Possible Mutations in DNA Researchers at the Cidetec-IK4 technological centre have developed electrochemical sensors that, amongst other functions, enable the detection of possible mutations in DNA in a more rapid manner that has been achieved to date. Open Open Tab March 2, 2009 Provides Information Nanosensors Quickly Detect Possible DNA Mutations Researchers at the Cidetec-IK4 technological centre have developed electrochemical sensors that, amongst other functions, enable the detection of possible mutations in DNA in a more rapid manner that has been achieved to date. Open Open Tab March 10, 2009 Provides Information Nanosilver used in food storage materials found to interfere with DNA replication Silver has long been recognized for its infection-fighting properties and it has a long and intriguing history as an antibiotic in human health care. In ancient Greece and Rome, silver was used to fight infections and control spoilage. Open Open Tab February 19, 2009 Provides Information Nanosys License Facilitates Development of DNA-activated Carbon Nanotube Transistor Sensors Evolved Machines, Inc. and Nanosys Inc. today announced that Evolved Machines has entered into a sublicense agreement with Nanosys for a portfolio of patents and patent applications related to the use of nanotubes and nanowires for artificial olfaction and chemical sensing. Open Open Tab December 3, 2008 Provides Information Nanotechnology applications could benefit from DNA tubes with programmable sizes Scientists at the California Institute of Technology (Caltech) have developed a simple process for mass producing molecular tubes of identical — and precisely programmable — circumferences. The technological feat may allow the use of the molecular tubes in a number of nanotechnology applications. Open Open Tab August 29, 2008 Provides Information Nanotechnology cell factories to make DNA based structures inside a living cell In the tiny realm of nanotechnology, scientists have used a wide variety of materials to build atomic scale structures. But just as in the construction business, nanotechnology researchers can often be limited by the amount of raw materials. Open Open Tab October 8, 2008 Provides Information Nanotechnology: Self-assembly Of Building Blocks Of DNA Can Now Be Easily Controlled Nature has long perfected the construction of nanomachines, but David González and his fellow researchers from Eindhoven University of Technology and Utrecht University under the leadership of Spinoza Award winner Bert Meijer, have brought the construction of artificial supramolecular structures a step closer. Open Open Tab May 14, 2009 Provides Information Nanotubes, Magnets and Electrically Charged Particles Leading to Quicker DNA Sequencing Research at Oak Ridge National Laboratory is exploring how a system of nanotubes, magnets and electrically charged particles could lead to a quicker, cheaper way to conduct DNA sequencing. Open Open Tab September 13, 2008 Provides Information Nanowires from DNA For millions of years nature has been optimizing DNA - in all living creatures this biomolecule is responsible for storing genetic information. Open Open Tab August 10, 2008 Provides Information Nanowires from DNA - new possibilities for modified chain molecules For millions of years nature has been optimizing DNA — in all living creatures this biomolecule is responsible for storing genetic information. Now a research project supervised by Dr. Jens Müller from the Chair of Bioinorganic Chemistry at TU Dortmund, puts the long chain molecule into a new context. Open Open Tab August 8, 2008 Provides Information National DNA database grows on the genes of the innocent Almost 600,000 genetic profiles taken from innocent people have helped swell the National DNA Database to cover about seven per cent of the UK population. Open Open Tab August 18, 2008 Provides Information New Biochemical Pathway That Triggers Critical Repairs In DNA Replication Process Discovered A Scripps Research team has unraveled a new biochemical pathway that triggers a critical repair response to correct errors in the DNA replication process that could otherwise lead to harmful or fatal mutations in cells. Open Open Tab August 8, 2008 Provides Information New Chemical System Could Answer Questions About How Life Could Emerge A team of Scripps Research scientists has created a new analog to DNA that assembles and disassembles itself without the need for enzymes. Open Open Tab June 12, 2009 Provides Information New DNA Tool Probes Rice Genome A new tool for investigating the rice genome has been developed by researchers at UC Davis led by Pamela Ronald, professor of plant pathology. The inexpensive, publicly-available rice DNA microarray covers nearly all the 45,000 genes in the rice genome. Details are published this week in the journal PLoS (Public Library of Science) One. Open Open Tab October 21, 2008 Provides Information New Drug Bypasses Gene Mutations A compound that helps cells produce normal proteins from wonky genes could have a broad impact on genetic diseases. Open Open Tab November 14, 2008 Provides Information New Findings Demonstrate Therapeutic Benefit of Anti-MicroRNA-21 Regulus Therapeutics LLC, a joint venture between Alnylam Pharmaceuticals, Inc. and Isis Pharmaceuticals, Inc. formed to discover, develop, and commercialize microRNA-based therapeutics, announced today the publication of new research in the journal Nature on the role of a microRNA, known as miR-21, in heart failure. Open Open Tab November 30, 2008 Provides Information New funding for gene therapy for human degenerative retinal diseases A Canadian and American research group including the team of Dr. Robert Koenekoop from the Research Institute at the Montreal Children's Hospital of the MUHC has just been awarded $2.4 million from the Canadian Institutes of Health Research (CIHR) and the Foundation Fighting Blindness Canada (FFB). This five-year grant will fund an ambitious research project to develop innovative gene therapies for a number of human degenerative retinal diseases. Open Open Tab December 3, 2008 Provides Information New Gene Expression Analysis Platform Invented by Australian Scientists Launched in the U.S. A new gene expression analysis platform invented by Australian scientists to help other researchers understand fundamental aspects of human development has been launched in the U.S. market overnight. Open Open Tab November 7, 2008 Provides Information New Genetic Markers For Ulcerative Colitis Identified An international team led by University of Pittsburgh School of Medicine researchers has identified genetic markers associated with risk for ulcerative colitis. The findings, which appear today as an advance online publication of the journal Nature Genetics, bring researchers closer to understanding the biological pathways involved in the disease and may lead to the development of new treatments that specifically target them. Open Open Tab January 4, 2009 Provides Information New HD BeadChip Offers Enhanced Coverage in Human Genome Illumina, Inc. today unveiled a new product for DNA Analysis: the Infinium® HD Human660W-Quad BeadChip. This four-sample BeadChip features 2.6 million genetics markers and was developed in collaboration with The Centre for Applied Genomics at the Hospital for Sick Children in Toronto, Canada and the Wellcome Trust Sanger Institute in the United Kingdom. Open Open Tab November 12, 2008 Provides Information New imaging tool helps identify DNA patterns of cancer, genetic disorders A new tool will help researchers identify the minute changes in DNA patterns that lead to cancer, Huntington's disease and a host of other genetic disorders. Open Open Tab May 19, 2009 Provides Information New Method Enabling Routine Targeted Gene Modification Developed A multi-institutional team led by Massachusetts General Hospital (MGH) investigators has developed a powerful new tool for genomic research and medicine -- a robust method for generating synthetic enzymes that can target particular DNA sequences for inactivation or repair. Open Open Tab July 26, 2008 Provides Information New miRNA Market Research Report from Percepta Associates Today Percepta Associates Inc. announced the release of MicroRNA Analysis in North America: A research market report for life science tool providers. This report presents an overview of current technologies in use, supplier audits, product indexes, detailed end-user perspectives, miRNA market size and growth estimates and concludes with a supplier opportunity analysis. Open Open Tab October 27, 2008 Provides Information New Piece Found In The Puzzle Of Epigenetics: Mechanism Of Fine Regulation Of RNA Synthesis Elucidated A team of scientists led by Professor Dirk Eick of Helmholtz Zentrum München has identified the enzyme TFIIH kinase as an important factor in the epigenetic regulation of the cell nucleus enzyme RNA polymerase II. The findings, recently published in the journal Molecular Cell, constitute a further building block for understanding the pathomechanisms of cancer and other diseases. Open Open Tab June 26, 2009 Provides Information New Platform Enables Rapid Cost-Effective Analysis of Entire Genomes Applied Biosystems today announced a new genomic analysis platform, the SOLiD(TM) 3 System, that is expected to enable scientists to sequence a human genome for approximately $10,000. Significant cost-reduction and productivity enhancements have been built into the company's latest ultra-high-throughput genomic analysis platform, enabling researchers to dramatically drive down the cost of sequencing entire genomes of all organisms, and expand applications for RNA and epigenetic analysis. Open Open Tab October 1, 2008 Provides Information New probe allows observation of single RNA molecules inside living cells Biomedical engineers have developed a new type of probe that allows them to visualize single ribonucleic acid (RNA) molecules within live cells more easily than existing methods. The tool will help scientists learn more about how RNA operates within living cells. Open Open Tab April 7, 2009 Provides Information New Product to Measure MicroRNA HTG, Inc., provider of the quantitative Nuclease Protection Assay (qNPA™) system and service partner for the life sciences industry, today announced the availability of a customizable qNPA™ ArrayPlate to measure microRNA (miRNA) or other small RNA molecules. Open Open Tab January 6, 2009 Provides Information New Role For Critical DNA Repair Molecule In Immune System The human immune system is a brilliantly adaptable weapon against foreign invaders. But it all depends on the work of specialized cells called lymphocytes that have made a risky evolutionary gambit to mutate their own DNA. New research published in Nature shows for the first time that a molecule devoted to DNA repair plays a broader role in this genetic reshuffling — called recombination — than scientists had thought. Open Open Tab November 9, 2008 Provides Information New Service Enables Researchers to Take Full Advantage of "Next-Generation" High Throughput Sequencing Technologies LC Sciences has announced the availability of a custom target enrichment service for next-generation sequencing applications. LC Sciences now provides a service for Target-Specific Selection of a defined genomic region (such as Mbp region at a specific location, suspected cancer regions, SNP regions, regions for genomic comparisons) or RNA sequences (such as sets of transcriptome sequences known from previous screening experiments, mRNAs, and miRNAs). Open Open Tab February 28, 2009 Provides Information New Step In DNA Damage Response In Neurons Discovered Researchers have identified a biochemical switch required for nerve cells to respond to DNA damage. Open Open Tab January 21, 2009 Provides Information New technique provides closer look at DNA and mRNA In a study in the advance online edition of Nature Structural and Molecular Biology, researchers from Albert Einstein College of Medicine describe a technique for looking more precisely at a fundamental step of a cell's life - a gene, DNA, being read into a message, mRNA. Open Open Tab December 3, 2008 Provides Information New understanding of RNA and evolution With the aid of a straightforward experiment, researchers have provided some clues to one of biology's most complex questions: how ancient organic molecules came together to form the basis of life. Open Open Tab December 19, 2008 Provides Information New Way Epigenetic Information is Inherited: Small RNAs Inherited From Mother Determines Offspring’s Fertility Trait Hereditary information flows from parents to offspring not just through DNA but also through the millions of proteins and other molecules that cling to it. These modifications of DNA, known as "epigenetic marks," act both as a switch and a dial – they can determine which genes should be turned on or off, and how much message an "on" gene should produce. Open Open Tab December 1, 2008 Provides Information New Way That Cells Fix Damage To DNA Discovered A team of researchers at The Scripps Research Institute and other institutions has discovered a new way by which DNA repairs itself, a process that is critical to the protection of the genome, and integral to prevention of cancer development. Open Open Tab June 10, 2009 Provides Information New, more sensitive nanotechnology test for chemical DNA modifications Researchers at The Johns Hopkins University School of Medicine in Baltimore have developed a novel test to screen for chemical modifications to DNA known as methylation. The technology potentially could be used both for early cancer diagnoses and for assessing patients' response to cancer therapies. Open Open Tab September 23, 2008 Provides Information New, non-viral technology could lead to safer gene therapy EU-funded scientists have developed a new, non-viral way of getting genes into a cell. The technique appears to avoid the side-effects, such as cancer, which can occur when viruses are used to smuggle genes into a cell. The scientists hope their discovery will 'simplify the way gene therapy is conducted, improve its overall safety and reduce the costs'. Open Open Tab May 4, 2009 Provides Information No need for RNA Not all enzymes that are assumed to require an RNA component in order to function do actually contain RNA. This surprising discovery was made during a project supported by the Austrian Science Fund FWF that focussed on the enzyme RNase P. Open Open Tab November 3, 2008 Provides Information Non-Coding RNAs Play A Role in Regulating Expression of Genes in Yeast Much debate has surrounded the mostly unknown function of non-coding RNAs, which have recently been shown to constitute a surprisingly large proportion of gene transcripts, rather than encoding proteins. Now, as reported in Nature*, a research team led by Kunihiro Ohta of the RIKEN Advanced Science Institute, Wako, has discovered a new role for such non-coding RNAs in gene expression in the fission yeast, Schizosaccharomyces pombe. Open Open Tab January 29, 2009 Provides Information Novel class of disposable protein/DNA biosensosrs is based on photonic crystals Scientists at the University of Illinois have developed a new class of disposable, microplate-based optical biosensors capable of detecting protein-DNA interactions. Based on the properties of photonic crystals, the biosensors are suitable for the rapid identification of inhibitors of protein-nucleic acid and protein-protein interactions. Open Open Tab September 23, 2008 Provides Information Novel nanopore technique to sequence human genome Since the human genome was sequenced six years ago, the cost of producing a high-quality genome sequence has dropped precipitously. More recently, the National Institutes of Health called for cutting the cost to $1,000 or less, which may enable sequencing as part of routine medical care. Open Open Tab April 15, 2009 Provides Information Nuclear Hormone Receptors, MicroRNAs Form Developmental Switch A particular nuclear hormone receptor called DAF-12 and molecules called microRNAs in the let-7 family form a molecular switch that encourages cells in the larvae of a model worm to shift to a more developed state, said a consortium led by researchers from Baylor College of Medicine in a report that appears in the journal Science. Open Open Tab April 9, 2009 Provides Information O Ocimum Biosolutions awarded two U.S. patents for gene expression technology Ocimum Biosolutions has announced issuance of United States Patent No. 7,428,554 which covers the company's proprietary system and method for determining matching patterns within gene expression data and US Patent No. 7426441, which covers methods for determining renal toxins. Open Open Tab October 15, 2008 Provides Information On-the-spot DNA analysis to test tolerance to prescription drugs gets closer A handheld device to predict whether patients will respond adversely to medication is one step closer to the market, thanks to a new partnership announced today. Open Open Tab February 16, 2009 Provides Information Oxford Nanopore Announces Publication of Landmark DNA Analysis Paper Oxford Nanopore Technologies today announced the publication of new research in Nature Nanotechnology, demonstrating accurate and continuous identification of DNA bases using nanopores. The system can also directly identify methylated cytosine, important in the study of epigenetics. This research marks significant progress towards Oxford Nanopore’s goal of developing the first label-free, single molecule DNA sequencing technology. Open Open Tab February 23, 2009 Provides Information P Photon-fueled single-molecule DNA nanomotor Molecular-size motors have evolved in nature, where they are used in virtually every important biological process. In contrast, the development of synthetic nanomotors that mimic the function of these amazing natural systems and that could be used in man-made nanodevices is in its infancy. Open Open Tab June 10, 2009 Provides Information Pioneer in High Throughput SNP Discovery Brings Expertise in Human Genome Haplotyping BioNanomatrix, Inc., a developer of breakthrough nanoscale platforms for genetic diagnostics, personalized medicine and biomedical research, today announced the appointment of noted medical genomics researcher Pui-Yan Kwok, M.D., Ph.D., to its Scientific Advisory Board (SAB). Dr. Kwok is Henry Bachrach Distinguished Professor at the University of California, San Francisco. Open Open Tab October 14, 2008 Provides Information Political Participation Is Partially Rooted In Genetic Inheritance The research, by James H. Fowler and Christopher T. Dawes, of the University of California, San Diego and Laura A. Baker, of the University of Southern California, is the first to show that genes influence participation in elections and in a wide range of political activities. Open Open Tab July 3, 2008 Provides Information Precision Biomarker Resources Offering microRNA Profiling using New GeneChip miRNA Arrays Precision Biomarker Resources, a contract research organization based in Evanston, Illinois, is the first Service Provider to offer microRNA Profiling using the new GeneChip® miRNA Arrays recently released by Affymetrix, Inc. Precision Biomarker provides RNA and microRNA (miRNA) profiling and data analysis services for pharmaceutical, biotechnology and academic researchers who use microarray methods for discovering biomarkers in their research. Open Open Tab April 13, 2009 Provides Information Products to Simplify and Enable Research on All Sequencing Platforms Invitrogen Corporation, a provider of essential life science technologies for research, production and diagnostics, today announced the introduction of its Invivofectamine(TM) delivery reagent which enables short interference ribonucleic acid (siRNA) experiments in vivo. Open Open Tab November 20, 2008 Provides Information Promising Gene Target For Neuroblastoma Therapy Identified Researchers at Dana-Farber Cancer Institute have identified a set of previously unknown mutations in a single gene in 8 percent of neuroblastomas, tumors of the nervous system that occur in young children and account for approximately 15 percent of all childhood cancer deaths. Open Open Tab October 15, 2008 Provides Information Provider of DNA-Based Security Solutions Files Patent for Embedment of DNA in Cyanoacrylate Applied DNA Sciences, Inc., a provider of DNA-based security solutions, announced today that it has filed a patent for the embedment of DNA in cyanoacrylate, adding to its extensive intellectual property portfolio, and SigNature® DNA product line. Open Open Tab May 14, 2009 Provides Information Providing a Quick and Precise View of Cell Development and Gene Expression A team of University of Oregon biologists, using fruit flies, has created a way to isolate RNA from specific cells, opening a new window on how gene expression drives normal development and disease-causing breakdowns. Open Open Tab May 18, 2009 Provides Information Q Quadrupole DNA sequencing Research at Oak Ridge National Laboratory is exploring how a system of nanotubes, magnets and electrically charged particles could lead to a quicker, cheaper way to conduct DNA sequencing. Open Open Tab September 12, 2008 Provides Information Quantum dots light up individual DNA binding proteins Proteins that bind to specific sites of DNA are essential to all biological functions of DNA. These DNA-binding proteins include transcription factors which modulate the process of transcription, various polymerases, nucleases which cleave DNA molecules, and histones which are involved in chromosome packaging in the cell nucleus. Open Open Tab May 19, 2009 Provides Information R RainDance Technologies Introduces Sequence Enrichment Solution for the Human Genome RainDance Technologies, Inc., a provider of innovative microdroplet-based solutions for human health and disease research, today officially introduced its Sequence Enrichment Solution for targeted sequencing applications of the human genome. Open Open Tab November 12, 2008 Provides Information Raman reveals DNA in action Researchers at the University of Strathclyde, UK, have been able to use Raman spectroscopy to observe strands of DNA pairing up and falling apart by attaching them to silver nanoparticles ("Control of enhanced Raman scattering using a DNA-based assembly process of dye-coded nanoparticles"). Open Open Tab July 15, 2008 Provides Information Rare Genetic Disorder Gives Clues To Autism, Epilepsy, Mental Retardation A rare genetic disorder called tuberous sclerosis complex (TSC) is yielding insight into a possible cause of some neurodevelopmental disorders: structural abnormalities in neurons, or brain cells. Researchers in the F.M. Kirby Neurobiology Center at Children's Hospital Boston, led by Mustafa Sahin, MD, PhD, and Xi He, PhD, also found that normal neuronal structure can potentially be restored. Open Open Tab September 25, 2008 Provides Information READNA consortium to accelerate development of DNA/nucleic acid analysis technologies A new consortium was launched today to further the development of new technologies for the analysis of DNA and other nucleic acids. The REvolutionary Approaches and Devices for Nucleic Acid analysis (READNA) consortium includes projects to accelerate new breakthrough DNA sequencing technologies and methods to enhance existing analysis methods. Open Open Tab December 3, 2008 Provides Information Reduction in antibody gene rearrangement in B cells related to type 1 diabetes, lupus More drafts usually mean a better product and so it also seems to go with the human immune system. As B cells develop, genes rearrange to allow antibodies to recognize different foreign invaders or pathogens. Open Open Tab December 23, 2008 Provides Information Relaxation Response Can Influence Expression Of Stress-related genes How could a single, nonpharmacological intervention help patients deal with disorders ranging from high blood pressure, to pain syndromes, to infertility, to rheumatoid arthritis? Open Open Tab July 3, 2008 Provides Information Report Examines the Fundamentals of RNAi's Technologies, Markets and Companies Research and Markets has announced the addition of Jain PharmaBiotech's new report "RNAi - Technologies, Markets and Companies" to their offering. Open Open Tab February 10, 2009 Provides Information Report Suggest DNA Probes-Based Diagnostics Market to Reach $24.5 Billion by 2015 DNA probes-based diagnostics is an emerging application area in the in-vitro diagnostics industry. DNA probes, popular across the medical diagnostics industry, determine the presence of a suspected disease caused by an organism or pathogen. Open Open Tab October 30, 2008 Provides Information Research breakthrough targets genetic diseases A cure for debilitating genetic diseases such as Huntington’s disease, Friedreich’s ataxia and Fragile X syndrome is a step closer to reality, thanks to a recent scientific breakthrough. Open Open Tab January 20, 2009 Provides Information Research into RNA Could Lead to Remarkable Advances in Treatment of Diseases Research into RNA, a molecule found in every cell of our bodies, could lead to remarkable advances in the treatment of diseases such as cancer and diabetes, a meeting organised by the European Science Foundation was told. Open Open Tab March 4, 2009 Provides Information Research Sheds Light on Possible Functions of Abundant 'Non-Coding' RNA Molecules A very small fraction of our genetic material--about 2%-- performs the crucial task scientists once thought was the sole purpose of the genome: to serve as a blueprint for the production of proteins, the molecules that make cells work and sustain life. This 2% of human DNA is converted into intermediary molecules called RNAs, which in turn carry instructions within cells for protein manufacture. Open Open Tab November 27, 2008 Provides Information Researchers Compile 'Molecular Manual' For Hundreds Of Inherited Diseases An international research team has compiled the first catalogue of tissue-specific pathologies underlying hundreds of inherited diseases. These results provide information that may help treat conditions such as breast cancer, Parkinson's disease, heart disease and autism. The report from scientists at the Technical University of Denmark and Massachusetts General Hospital (MGH) will appear in the Proceedings of the National Academy of Sciences and has been published online. Open Open Tab December 21, 2008 Provides Information Researchers control the assembly of nanobristles into helical clusters From the structure of DNA to nautical rope to distant spiral galaxies, helical forms are as useful as they are abundant in nature and manufacturing alike. Researchers at Harvard’s School of Engineering and Applied Sciences (SEAS), the Wyss Institute for Biologically Inspired Engineering, and the Radcliffe Institute for Advanced Study have discovered a way to synthesize and control the formation of nanobristles, akin to tiny hairs, into helical clusters and have further demonstrated the fabrication of such highly ordered clusters, built from similar coiled building blocks, over multiple scales and areas. Open Open Tab January 8, 2009 Provides Information Researchers Create Nanoscale Trap that can Stop Free Floating DNA Molecules and Nanoparticles Using a beam of light shunted through a tiny silicon channel, researchers have created a nanoscale trap that can stop free floating DNA molecules and nanoparticles in their tracks. By holding the nanoscale material steady while the fluid around it flows freely, the trap may allow researchers to boost the accuracy of biological sensors and create a range of new 'lab on a chip' diagnostic tools. Open Open Tab January 3, 2009 Provides Information Researchers Developed Novel Nanotechnology Test for Chemical DNA Modifications Researchers at The Johns Hopkins University School of Medicine in Baltimore have developed a novel test to screen for chemical modifications to DNA known as methylation. The technology potentially could be used both for early cancer diagnoses and for assessing patients' response to cancer therapies. Open Open Tab September 24, 2008 Provides Information Researchers Discover the Atomic Structure of a Powerful Molecular Motor Researchers have discovered the atomic structure of a powerful "molecular motor" that packages DNA into the head segment of some viruses during their assembly, an essential step in their ability to multiply and infect new host organisms. Open Open Tab December 30, 2008 Provides Information Researchers Discover Way to Synthesize and Control Formation of Nanobristles Researchers at the Harvard School of Engineering and Applied Sciences (SEAS) have discovered a way to synthesize and control the formation of nanobristles, akin to tiny hairs, into helical clusters and have further demonstrated the fabrication of such highly ordered clusters, built from similar coiled building blocks, over multiple scales and areas. Open Open Tab January 9, 2009 Provides Information Researchers identify biochemical switch required for nerve cells to respond to DNA damage Most children with the inherited disease ataxia telangiectasia are wheelchair-bound by age 10 because of neurological problems. Patients also have weakened immune systems and more frequent leukemias, and are more sensitive to radiation. Open Open Tab January 20, 2009 Provides Information Researchers illuminate mechanisms that regulate DNA damage control and replication Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating replication following DNA repair. Open Open Tab January 5, 2009 Provides Information Researchers solve structure of enzyme vital for DNA repair When dividing cells copy their DNA, mistakes can - and do - occur. To compensate, cells have a built-in system to correct these errors. That correction process isn't thoroughly understood, but researchers are piecing it together bit by bit. Open Open Tab August 11, 2008 Provides Information Researchers Solve Structure Of An Enzyme Vital For DNA Repair When dividing cells copy their DNA, mistakes can — and do — occur. To compensate, cells have a built-in system to correct these errors. That correction process isn't thoroughly understood, but researchers are piecing it together bit by bit. Open Open Tab August 14, 2008 Provides Information Researchers Unveil Near-complete Protein Catalog For Mitochondria Imagine trying to figure out how your car's power train works from just a few of its myriad components: It would be nearly impossible. Scientists have long faced a similar challenge in understanding cells' tiny powerhouses -- called "mitochondria" -- from scant knowledge of their molecular parts. Open Open Tab July 14, 2008 Provides Information Researchers Unzip Molecules To Measure Interactions Keeping DNA Packed In Cells Anyone who has ever battled a stuck zipper knows it's a good idea to see what's stuck, where and how badly -- and then to pull hard. Open Open Tab February 2, 2009 Provides Information Restoring Function Of A Mutant Gene Without Altering DNA Might Be Possible Researchers at Fox Chase Cancer Center have demonstrated that it might be possible to treat genetic diseases, including some forms of cancer, by "rescuing" the misshapen, useless proteins produced by some mutant genes. Open Open Tab February 12, 2009 Provides Information RNA Emerges From DNA's Shadow RNA, the transporter of genetic information within the cell, has emerged from the shadow of DNA to become one of the hottest research areas of molecular biology, with implications for many diseases as well as understanding of evolution. Open Open Tab July 13, 2008 Provides Information RNA Interference Company to Present at Discovery on Target Conference Dicerna Pharmaceuticals, Inc., an RNA interference company developing novel therapeutics in multiple disease areas, today announced that Bob D. Brown, Ph.D., senior vice president of research, Dicerna, and Dicerna co-founder and Scientific Advisory Board member Mark Behlke, M.D., Ph.D., vice president of molecular genetics and biophysics and chief scientific officer at Integrated DNA Technologies (IDT), will present at the Discovery on Target Conference at the World Trade Center in Boston, Mass. Open Open Tab October 22, 2008 Provides Information RNA Interference Plays Bigger Role Than Previously Thought In a paper published online in the journal Nature, IBM and the Genome Institute of Singapore reported findings from a joint research study that provides new information on how stem cell differentiation is controlled by microRNAs. Open Open Tab September 18, 2008 Provides Information RNA molecules boost vaccine effectiveness A novel delivery system that could lead to more efficient and more disease-specific vaccines against infectious diseases has been developed by biomedical engineers at The University of Texas at Austin. Open Open Tab October 8, 2008 Provides Information RNA Molecules Significantly Bolster Vaccine's Effectiveness A novel delivery system that could lead to more efficient and more disease-specific vaccines against infectious diseases has been developed by biomedical engineers at The University of Texas at Austin. Open Open Tab October 8, 2008 Provides Information RNAi-Based Compounds from MDRNA Demonstrates High Potency Against Multiple Targets in Preclinical Studies MDRNA, Inc., a biotechnology company focused on the development and commercialization of therapeutic products based on RNA interference (RNAi), announced today positive in vivo efficacy data showing that its proprietary UsiRNA constructs are highly potent and highly specific against ApoB and Factor VII message Open Open Tab May 19, 2009 Provides Information RNAI Partnership Program Members Gain Access to Sigma-Aldrich's shRNA Libraries Sigma-Aldrich, a leading life science company and member of The RNAi Consortium (TRC), proudly welcomes the Memorial Sloan-Kettering Cancer Center to the RNAi Partnership Program (http://sigma-aldrich.com/rpp). The RNAi Partnership Program provides new members with access to cutting-edge products in Sigma-Aldrich's functional genomics portfolio, including shRNA libraries developed by TRC targeting more than 15,000 human genes and 15,000 mouse genes. Open Open Tab October 15, 2008 Provides Information Rosetta Genomics Launches MicroRNA-Based Plant Biotechnology Project Rosetta Genomics Ltd, a leading developer of microRNA-based diagnostics and therapeutics, announced today it has launched Rosetta Green, a microRNA-based plant biotechnology project. Rosetta Green will leverage the extensive knowledge gained at Rosetta Genomics in microRNAs, as well as its proprietary technologies and strong IP position, to develop a wide range of plant-based applications. The company has recently completed a financing round from private investors exclusively for this project. Open Open Tab October 28, 2008 Provides Information S Scientists control complex nucleation processes using DNA origami seeds The construction of complex man-made objects--a car, for example, or even a pizza--almost invariably entails what are known as "top-down" processes, in which the structure and order of the thing being built is imposed from the outside (say, by an automobile assembly line, or the hands of the pizza maker). Open Open Tab April 8, 2009 Provides Information Scientists Create Artifical Tissue Consisting of Robust Network of DNA Strands and Carbon Nanotubes For modern implants and the growth of artificial tissue and organs, it is important to generate materials with characteristics that closely emulate nature. Open Open Tab May 15, 2009 Provides Information Scientists demonstrate modulation of gene expression by protein coding regions A research team at the Stowers Institute has discovered how the expression of one of the Hox master control genes is regulated in a specific segment of the developing brain. The findings provide important insight into how and where the brain develops some of its unique and important structures. Open Open Tab December 23, 2008 Provides Information Scientists develop new, more sensitive nanotechnology test for chemical DNA modifications Researchers at The Johns Hopkins University School of Medicine in Baltimore have developed a novel test to screen for chemical modifications to DNA known as methylation. The technology potentially could be used both for early cancer diagnoses and for assessing patients' response to cancer therapies. Open Open Tab September 23, 2008 Provides Information Scientists Discover New Class of Small RNAs Researchers at Cold Spring Harbor Laboratory (CSHL) announced today the discovery of a new class of small RNAs. At the same time, they reported that their discovery suggests the presence of a strikingly novel biochemical pathway for RNA processing in which these and possibly other small RNAs are produced. The research, which is part of a multinational project called ENCODE, also provided information concerning the biological function of the new short RNA class. Open Open Tab January 26, 2009 Provides Information Scientists discover reservoir of mitochondrial DNA mutations present in the general population Clinical analysis of blood samples from almost 3,000 infants born in north Cumbria, England, showed that at least 1 in 200 individuals in the general public harbor mitochondrial DNA mutations that may lead to disease. Open Open Tab August 11, 2008 Provides Information Scientists Examine in Detail Processes that Help to Ensure Stability of DNA When Exposed to UV Light Complex computer simulations have, for the first time, allowed scientists to examine in detail the processes that help to ensure the stability of DNA when exposed to UV light. The findings, achieved primarily in relation to DNA component 9H-adenine, have been published in the Journal of the American Chemical Society (JACS). Open Open Tab February 23, 2009 Provides Information Scientists Found Way to Uncover Critical Genes Responsible for Disease Development Scientists believe that complex diseases such as schizophrenia, major depression and cancer are not caused by one, but a multitude of dysfunctional genes. A novel computational biology method developed by a research team led by Ali Abdi, PhD, associate professor in NJIT's department of electrical and computer engineering, has found a way to uncover the critical genes responsible for disease development. Open Open Tab October 29, 2008 Provides Information Scientists identify key decision-point at which cells with broken DNA repair themselves or die When cells undergo potentially catastrophic damage, for example as a result of exposure to ionizing radiation, they must make a decision: either to fix the damage or program themselves for death, a process called apoptosis. Open Open Tab April 10, 2009 Provides Information Scientists map genomes of malaria parasites Discovery will help in creating new treatments, vaccines, researchers say.     October 8, 2008 Provides Information Scientists Shed Light On Evolution Of Gene Regulation Scientists at Penn State have shed light on some of the processes that regulate genes -- such as the processes that ensure that proteins are produced at the correct time, place, and amount in an organism -- and they also have shed light on the evolution of the DNA regions that regulate genes. Open Open Tab November 26, 2008 Provides Information Scientists shed light on how DNA is unwound so that its code can be read Researchers at The Scripps Research Institute have figured out how a macromolecular machine is able to unwind the long and twisted tangles of DNA within a cell's nucleus so that genetic information can be "read" and used to direct the synthesis of proteins, which have many specific functions in the body. Open Open Tab November 24, 2008 Provides Information Sequencing Thousand And One Genomes Researchers report the simultaneous completion of the first genomes of wild Arabidopsis thaliana strains as part of the 1001 Genomes Project. Open Open Tab October 7, 2008 Provides Information Shortened DATE Gene Region Linked To Breast Cancer Reza Zarnegar and colleagues, at the University of Pittsburgh, Pittsburgh, have determined that genetic variation in a piece of DNA that regulates activity of the HGF gene might be a useful marker to identify individuals with an increased risk of developing breast cancer. Open Open Tab February 3, 2009 Provides Information Single MicroRNA That Controls Blood Vessel Development Identified Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs. Open Open Tab August 13, 2008 Provides Information Small RNAs yield great amounts of data from ocean microbe samples An ingenious new method of obtaining marine microbe samples while preserving the microbes' natural gene expression has yielded an unexpected boon: the presence of many varieties of small RNAs -- snippets of RNA that act as switches to regulate gene expression in these single-celled creatures. Open Open Tab May 14, 2009 Provides Information Snippet Of RNA Helps Make Individuals Remarkably Alike "No two people are alike." Yet when we consider the thousands of genes with frequent differences in genetic composition among different people, it is remarkable how much alike we are. Open Open Tab May 6, 2009 Provides Information Specific DNA variations of the serotonin transporter gene can influence drinking intensity The brain's serotonergic system plays an important role in alcohol preference and consumption. The serotonin transporter gene (SLC6A4), in particular, may regulate a person's propensity for severe drinking. A study of six different single nucleotide polymorphisms – DNA sequence variations – of SLC6A4 has found that they influence drinking intensity among alcohol-dependent (AD) individuals in treatment. Open Open Tab November 20, 2008 Provides Information Stopgap DNA Repair Needs A Second Step One can have a dream, two can make that dream so real, goes a popular song. Now a Weizmann Institute study has revealed that it takes two to perform an essential form of DNA repair. Open Open Tab May 4, 2009 Provides Information Storm-petrel DNA Gives Clues to Cellular Aging At Bucknell University Mark Haussmann has been studying the DNA of storm-petrels, seabirds that have unusually long lives. Open Open Tab October 10, 2008 Provides Information Strong Immune Response To New SiRNA Drugs In Development May Cause Toxic Side Effects Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong immune response, causing toxic side effects. Open Open Tab May 25, 2009 Provides Information Study Describes Simultaneous Profiling of 450 Human MicroRNAs From Samples as Small as a Single Cell Researchers from the Ghent University Hospital in Belgium and Applied Biosystems Inc. have published a study demonstrating the effectiveness of a new method for profiling microRNAs in small samples. The study, entitled "High-throughput stem-loop RT-PCR miRNA expression profiling using minute amounts of input RNA," describes the simultaneous profiling of 450 human microRNAs from samples as small as a single cell. Open Open Tab October 29, 2008 Provides Information Study Questions Reliability of Some Results DNA barcoding is a movement to catalog all life on earth by a simple standardized genetic tag, similar to stores labeling products with unique barcodes. The effort promises foolproof food inspection, improved border security and better defenses against disease-causing insects, among many other applications. Open Open Tab August 26, 2008 Provides Information Study reveals intermediary steps of genetic encoding for the first time In a new study this week in Nature, researchers at Brandeis University and the MRC Laboratory of Molecular Biology (Cambridge, U.K.) for the first time shed light on a crucial step in the complex process by which human genetic information is transmitted to action in the human cell and frequently at which point genetic disease develops in humans. Open Open Tab March 27, 2009 Provides Information Study shows how defective DNA repair triggers 2 neurological diseases Scientists at St. Jude Children's Research Hospital have teased apart the biological details distinguishing two related neurological diseases—ataxia telangiectasia-like disease (ATLD) and Nijmegen breakage syndrome (NBS). Open Open Tab January 15, 2009 Provides Information Symposium on RNAi in Human Therapy The EU-funded research project RIGHT ('RNA interference technology as human therapeutic tool') and the European Science Foundation (ESF) will hold a symposium on ribonucleic acid interference (RNAi) in human therapy on 9 November in Lisbon, Portugal. Open Open Tab September 25, 2008 Provides Information Synthetic DNA nanomachines go to work inside living cells DNA nanotechnology has gained lots of attention recently, and sensationally titled articles like "Nanotechnology may have found its Henry Ford – tiny DNA robots could be the future of assembly lines" are certainly pushing the topic into the public awareness. Open Open Tab April 9, 2009 Provides Information T Team led by Scripps research scientists finds new way that cells fix damage to DNA A team of researchers at The Scripps Research Institute and other institutions has discovered a new way by which DNA repairs itself, a process that is critical to the protection of the genome, and integral to prevention of cancer development. Open Open Tab June 10, 2009 Provides Information Tekmira Pharmaceuticals to Present Data Using SNALP RNAi Delivery Technology Tekmira Pharmaceuticals Corporation announced today that studies conducted by Tekmira and Johnson + Johnson Pharmaceutical Research + Development, Division of Janssen Pharmaceutica, N.V., have shown that novel small interfering RNA (siRNA) molecules enabled by Tekmira's proprietary SNALP technology significantly reduce fat storage in the liver. Open Open Tab October 23, 2008 Provides Information The gripping potential of DNA nanotechnology DNA, the fundamental building block of our genetic makeup, has become an intense nanotechnology research field. DNA molecules can serve as precisely controllable and programmable scaffolds for organizing functional nanomaterials in the design, fabrication, and characterization of nanometer scale electronic devices and sensors. Open Open Tab November 5, 2008 Provides Information The Human Genome: Yours for $48,000 A new sequencing service aims to take whole-genome sequencing mainstream. Open Open Tab June 11, 2009 Provides Information Thermo Fisher Scientific Launches New NanoDrop 2000 Series Spectrophotometers Thermo Fisher Scientific today announced the launch of the Thermo Scientific NanoDrop 2000 and 2000c Spectrophotometers. Open Open Tab March 3, 2009 Provides Information Thermo Fisher Scientific Welcomes Two New Members to RNAi Global Initiative Thermo Fisher Scientific Inc., the world leader in serving science, announced today that two new members have joined the RNAi Global initiative - an alliance of the Thermo Scientific Dharmacon Products team and leading international research centers. Open Open Tab February 28, 2009 Provides Information Third-Generation Human Genome Sequencing Company Launched Complete Genomics, Inc., a third-generation human genome sequencing company, today announced its formal launch as the world's first provider of large-scale human genome sequencing services. Open Open Tab October 6, 2008 Provides Information Tiny Differences In Our Genes Help Shed Light On The Big Picture Of Human History By examining very small differences in people's genes, scientists from Cornell University have developed a new tool for identifying big events in human history and pinpointing the origins of specific gene mutations. Open Open Tab April 30, 2009 Provides Information Together Rx Access™ is a free savings program that helps eligible participants save approximately 25%-40% and sometimes more* on over 275 brand-name prescription drugs and other prescription products, as well as savings on a wide range of generic drugs. Open Open Tab   Provides a Service Too much of a good thing: Excessive DNA repair can lead to retinal degeneration A naturally occurring DNA repair system that normally protects cells from damage can cause retinal degeneration and blindness when overstimulated, according to a new study by MIT researchers. Open Open Tab January 9, 2009 Provides Information Transfer RNA Challenges Long-Held Ideas about Evolutionary History of Protein Synthesis A new study of transfer RNA, a molecule that delivers amino acids to the protein-building machinery of the cell, challenges long-held ideas about the evolutionary history of protein synthesis. Open Open Tab August 18, 2008 Provides Information Trius Therapeutics awarded $28 million to develop novel drugs targeting bacterial DNA Gyrase and Topoisomerase IV Trius Therapeutics, Inc., today announced the award of a $28 million contract from the National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health, for the development of novel antibiotics directed against multiple Gram-negative bacterial pathogens. Open Open Tab October 22, 2008 Provides Information Turning Down Gene Expression Promotes Nerve Cell Maintenance Anyone with a sweet tooth knows that too much of a good thing can lead to negative consequences. The same can be said about the signals that help maintain nerve cells, as demonstrated in a new study of myelin, a protein key to efficient neuronal transmission. Open Open Tab February 2, 2009 Provides Information Two-Armed Nanorobotic Device that can Manipulate Molecules within Device Built from DNA Chemists at New York University and China's Nanjing University have developed a two-armed nanorobotic device that can manipulate molecules within a device built from DNA. The device is described in the latest issue of the journal Nature Nanotechnology. Open Open Tab February 15, 2009 Provides Information Types Of Genes Necessary For Brain Development Discovered Researchers from Harvard Medical School and Brandeis University have successfully completed a full-genome RNAi screen in neurons, showing what types of genes are necessary for brain development. Open Open Tab July 9, 2008 Provides Information U Unique Fingerprint of Individual can be Built Up by Using Common Spectroscopy Technique to Identify Molecules Involved Recent advances in DNA sequencing have made it relatively easy to acquire the full genotype of an individual, but it is equally important to match those genes to their functions. One useful step is to build up a 'metabolic phenotype' outlining all the processes operating to sustain the individual's life. Open Open Tab April 17, 2009 Provides Information Unique Platform Greatly Streamlines DNA-Sequencing Research Agilent Technologies, Inc. chose the Advances in Genome Biology and Technology (AGBT) meeting to introduce the Agilent SureSelect Target Enrichment System, a unique tool for greatly streamlining DNA-sequencing research by enabling scientists to sequence only genomic areas of interest with next-generation sequencing instrumentation. Open Open Tab February 8, 2009 Provides Information Untangling DNA Regulation: Biologists Theorize Role For DNA Packaging In Stem Cell Development MIT biologists have discovered that the organization of DNA's packing material plays a critical role in directing stem cells to become different types of adult cells. Open Open Tab November 10, 2008 Provides Information Use of DNA Security Technology for Laminated Documents Validated Applied DNA Sciences, Inc., a provider of DNA-based security solutions, announced today that in collaboration with a world leader in security laminated materials, it has validated its proprietary SigNature® DNA into laminates typically used in travel documents, credit cards, drivers licenses and other government issued identification cards. Open Open Tab June 9, 2009 Provides Information Using light to move and trap DNA molecules A major goal of nanotechnology research is to create a "lab on a chip," in which a tiny biological sample would be carried through microscopic channels for processing. This could make possible portable, fast-acting detectors for disease organisms or food-borne pathogens, rapid DNA sequencing and other tests that now take hours or days. Open Open Tab January 2, 2009 Provides Information V Validated Solution Features NuGEN Ovation and Hamilton MICROLAB STARlet NuGEN Technologies, Inc., a privately held company that develops and commercializes nucleic acid amplification and sample preparation systems, and the Hamilton Company, a world leader in precision liquid handling announced today the two companies have assembled an automated, total target preparation solution to address the high-throughput challenges required in processing large sets of clinical samples for global gene expression analysis. Open Open Tab September 17, 2008 Provides Information Vile Gossip: Power Packed Test Fleet It has been a heavy week, one that will stand out for the sheer amount of power packed into our test fleet. You can't imagine how perilous it can be, driving all that heavy metal in greenest Ann Arbor, home of dreadlocked grandmas who picket the Federal Building across the street and of lovely young ladies who spit on passing Hummers. Open Open Tab September 4, 2008 Provides Information Virus Weaves Itself Into The DNA Transferred From Parents To Babies Parents expect to pass on their eye or hair color, their knobby knees or their big feet to their children through their genes. But they don't expect to pass on viruses through those same genes. Open Open Tab September 3, 2008 Provides Information W Work with fungus uncovering keys to DNA methylation Researchers in a University of Oregon lab have shed more light on the mechanism that regulates DNA methylation, a fundamental biological process in which a methyl group is attached to DNA, the genetic material in cells of living organisms. Open Open Tab December 15, 2008 Provides Information Y You Can Be Replaced: Immune Cells Compensate For Defective DNA Repair Factor A new mouse model has provided some surprising insight into XLF, a molecule that helps to repair lethal DNA damage. Open Open Tab September 8, 2008 Provides Information Z ZyGEM to Produce Innovative DNA Extraction Products Under Agreement ZyGEM Corp. Ltd. today announced that it has entered into an agreement with the Advalytix product team of Olympus Life Science Research Europa GmbH to produce a private-label line of DNA extraction products. The collaboration will combine ZyGEM's advanced enzymatic nucleic acid extraction technology and Advalytix's expertise in single-cell molecular tests for life science research and diagnostic applications. Open Open Tab October 16, 2008 Provides Information
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