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194 Health - Double Helix - DNA - Genes - Genetics - Genome Resources 3D Imaging of Bleomycin-DNA Binding Indiana University School of Medicine and the Purdue School of Science scientists have for the first time successfully imaged a chemotherapy agent, bleomycin, binding to DNA. Open Open Tab March 21, 2008 Provides Information 480 Genes That Control Human Cell Division Identified A team of U.S., Israeli and German scientists used computational biology techniques to discover 480 genes that play a role in human cell division and to identify more than 100 of those genes that have an abnormal pattern of activation in cancer cells. Open Open Tab January 8, 2008 Provides Information 1,000 Genomes: Most Detailed Map Of Human Genetic Variation To Support Disease Studies An international research consortium today announced the 1000 Genomes Project, an ambitious effort that will involve sequencing the genomes of at least a thousand people from around the world to create the most detailed and medically useful picture to date of human genetic variation. Open Open Tab January 23, 2008 Provides Information 6,000 genes help determine body weight Reporting in the online journal BMC Genetics, researchers from the Monell Center have for the first time attempted to count the number of genes that contribute to obesity and body weight. Open Open Tab January 15, 2008 Provides Information A A Gene Divided Reveals The Details Of Natural Selection In a molecular tour de force, researchers at the University of Wisconsin-Madison have provided an exquisitely detailed picture of natural selection as it occurs at the genetic level. Open Open Tab October 12, 2007 Provides Information A global DNA barcode database The idea of barcoding is familiar to many: in almost every supermarket the checkout operator shows the ticket labelled with a series of black bars to a laser scanner which responds with a beep; a computer analyses the code, identifies the product and the price is sent to the till. Open Open Tab June 30, 2008 Provides Information Abnormal 'Editing' Of Gene Messages May Be A Cause Of Lupus Researchers at Wake Forest University have uncovered evidence that the abnormal "editing" of gene messages in a type of white blood cell may be behind the development of lupus. Scientists hope the finding will lead to earlier diagnosis, a way to monitor patients' response to therapy and possibly a new way to treat the disease. Open Open Tab May 21, 2008 Provides Information Advanced Research Fellowship May Lead To DNA Being Used as a Building Block For Self Assembling Nanostructures Dr Glenn Burley, from the University of Leicester, has been awarded one of only 8 coveted Advanced Research Fellowships in Chemistry worth £922 K, given annually by the Engineering and Physical Sciences Research Council (EPSRC). Open Open Tab August 15, 2007 Provides Information All UK 'must be on DNA database' The whole population and every UK visitor should be added to the national DNA database, a senior judge has said. Open Open Tab September 5, 2007 Provides Information All-in DNA database plan hinges on human rights case ECHR could make DNA retention without. Open Open Tab September 10, 2007 Provides Information All-in-one gene detection on a chip Scientists in Singapore have invented a tiny machine that can rapidly prepare, purify and genetically analyse blood or other biological samples in less than 20 minutes. Open Open Tab May 9, 2008 Provides Information Ancient 'Out Of Africa' Migration Left Stamp On European Genetic Diversity Human migration from Africa to Europe more than 30,000 years ago appears to have left a mark on the genes of Europeans today. Open Open Tab February 22, 2008 Provides Information Antibody test faster, cheaper than DNA profiling Federal researchers say they have developed a human identification test that's faster and possibly cheaper than DNA testing. Open Open Tab April 29, 2008 Provides Information Asf1, the protein that oversees DNA replication and packaging in the cell At the Institut Curie, the CNRS team of Geneviève Almouzni(1) has just discovered how the protein Asf1 ensures the correct (re)organization of duplicated DNA. During DNA replication, all the information in the mother cell must be transmitted to the daughter cells. Open Open Tab January 11, 2008 Provides Information Automated microfluidic device reduces time to screen small organisms for genetic studies Genetic studies on small organisms such as worms and flies can now be done more quickly using a new microfluidic device developed by engineers at the Georgia Institute of Technology. Open Open Tab June 23, 2008 Provides Information B Bioethics group raises DNA database concerns There has to be a limit to police powers. Open Open Tab September 19, 2007 Provides Information BioNanomatrix and Complete Genomics form joint venture after NIST grant awarded BioNanomatrix, Inc. and Complete Genomics Inc. (CGI) have announced that they have formed a joint venture that has received an $8.8 million grant award from the U.S. National Institute of Standards and Technology Advanced Technology Program (NIST-ATP) to develop a system capable of sequencing the entire human genome in eight hours at a cost of less than $100. Open Open Tab September 30, 2007 Provides Information BioNanomatrix issued new nanofluidics patent BioNanomatrix has announced the issuance of a patent for a key element of the company's whole genome analyzer. Open Open Tab September 25, 2007 Provides Information Biotech That Mines Canadian Genomes Lands $31 Million This population has a historically low rate of intermarriage, which reduces the genetic noise surrounding important genes. Open Open Tab January 7, 2008 Provides Information BiPar Sciences presents data for novel DNA repair inhibitor BiPar Sciences, Inc. today announced the results of first-in-human clinical studies of its lead product, BSI-201, in patients with solid tumors. Open Open Tab June 2, 2008 Provides Information Bread Mold May Unlock Secret To Eliminating Disease-causing Genes When most people discover mold on their bread, they immediately throw it out. Others see a world of possibilities in the tiny fungus. A University of Missouri scientist, along with a collaborative research team, has examined a new mechanism in the reproductive cycle of a certain species of mold. This mechanism protects the organism from genetic abnormalities by "silencing" unmatched genes during meiosis (sexual reproduction). Open Open Tab May 11, 2008 Provides Information Boffins uncover ginger gene in neanderthal DNA The continuing analysis of samples of neanderthal DNA have revealed that some of them had ginger hair. Open Open Tab October 26, 2007 Provides Information Boy Living in Bubble Develops Leukemia From Experimental Therapy One of the first children in Britain to receive pioneering gene therapy for an immune system disorder has developed leukemia as a result of his treatment. Open Open Tab December 18, 2007 Provides Information Building A Better DNA Molecule Building faultless objects from faulty components may seem like alchemy. Yet scientists from the Weizmann Institute's Computer Science and Applied Mathematics, and Biological Chemistry Departments have achieved just that, using a mathematical concept called recursion. Open Open Tab May 27, 2008 Provides Information C Can We Stop Cancer Cells From Reading Their Own DNA? A promising new line in anti-cancer therapy by blocking the molecular motors involved in copying genetic information during cell division is being pursued by young Dutch researcher Dr. Nynke Dekker in one of this year's EURYI award winning projects sponsored by the European Science Foundation and the European Heads of Research Councils. Open Open Tab August 14, 2007 Provides Information Capturing DNA molecules in a nanochannel An electric voltage can be used to propel DNA molecules through a channel a few nanometers deep, or to stop them in their tracks. In a strong electric field the molecules judder along the channel, while in weaker fields they move more smoothly. Open Open Tab June 24, 2008 Provides Information Capturing DNA Molecules In A Nanochannel An electric voltage can be used to propel DNA molecules through a channel a few nanometers deep, or to stop them in their tracks. In a strong electric field the molecules judder along the channel, while in weaker fields they move more smoothly. This enables DNA fragments to be ‘captured' on a chip and separated for analysis. Open Open Tab June 27, 2008 Provides Information Carbon Nanotubes May Damage DNA Researchers from the University of Dayton have completed the first study of its kind evaluating the potential toxicity of nanomaterials on the molecular level. Open Open Tab December 18, 2007 Provides Information Citizen's panels to put DNA database under microscope The government is bankrolling a massive "citizen's inquiry" that will see its DNA database policies scrutinised by panels of "ordinary" people, including criminals and youngsters, instead of scientists and legal professionals. Open Open Tab January 10, 2008 Provides Information Clockwork PCR including sample prep Analysis and diagnosis in a chip format are coming of age, but their practical application has been limited because until now, the sample usually had to be prepared separately and on a nonminiaturized scale. Open Open Tab May 6, 2008 Provides Information Concerns Over Potential Future Use Of DNA Of Innocents On National Database Professor Jeffreys -known as the father of DNA fingerprinting-spoke out over the 'significant ethical and social issues' as the government launched an inquiry into the way the national DNA database is used. The UK database, with the DNA of over 4 million people, was launched in 1995 and allows all DNA collected by forensics -- for whatever purposes -- to be stored indefinitely. Open Open Tab January 14, 2008 Provides Information Controlling Nanoparticle Self Assembly With DNA Learning how to control and tailor the assembly of nanoparticles, which have dimensions on the order of billionths of a meter, could potentially lead to applications ranging from more efficient energy generation and data storage to cell-targeted systems for drug delivery. Open Open Tab August 22, 2007 Provides Information Controversial DNA profiling technique approved An independent review of the science underpinning DNA forensics done on tiny samples has today declared the controversial technique sound for use in investigations. Open Open Tab April 11, 2008 Provides Information D Damaged DNA fixed in nuclear 'workshops' Researchers in the US are a step closer to understanding how the body deals with damaged DNA. The findings might pave the way for new cancer treatments, and could also be useful in predicting how likely cosmic rays are to trigger cancers in humans. Open Open Tab August 6, 2007 Provides Information Detecting Sequence-specific DNA Problems A group from Japan under Dr. Akimitsu Okamoto developed a molecular technique to sort through DNA molecules and look for methylated cytosine bases, reports Japan's RIKEN Research Institute. Open Open Tab December 21, 2007 Provides Information Detection of DNA Sequences Using an Alternating Electric Field in a Nanopore Capacitor Using computer simulations, researchers at the University of Illinois have demonstrated a strategy for sequencing DNA by driving the molecule back and forth through a nanopore capacitor in a semiconductor chip. Open Open Tab January 17, 2008 Provides Information Direct Multiplexed Measurement of Gene Expression with Color-Coded Probe Pairs The paper entitled Direct Multiplexed Measurement of Gene Expression with Color-Coded Probe Pairs describes the performance of the nCounter Analysis System, which captures and counts individual mRNA transcripts by a novel molecular bar-coding technology. Open Open Tab February 20, 2008 Provides Information Discovery Of New Family Of Genetic Mutations Involved In Inflammatory Intestinal Disease The discovery of new genetic mutations involved in inflammatory intestinal disorders could lead to a better understanding of these common conditions, two scientists told the annual conference of the European Society of Human Genetics June 2. Open Open Tab June 5, 2008 Provides Information Discovery of seven new genes that influence blood cholesterol levels An international study of 20,000 people found seven new genes that influence blood cholesterol levels, a major factor in heart disease, and confirmed 11 other genes previously thought to influence cholesterol. Open Open Tab January 15, 2008 Provides Information Discovery on human individuality and maternal and paternal DNA Have you ever wondered why you inherited your mother's smile but not your father's height? Open Open Tab October 19, 2007 Provides Information DNA Analysis Shows True Dispersal Of Protozoa A study in BMC Evolutionary Biology, shows that some protozoa are globally dispersed, while others are geographically restricted - by looking at a new fast-evolving DNA marker. The study also reveals that the biodiversity of protozoa may be much higher than previously realised. Open Open Tab September 19, 2007 Provides Information DNA Based Nano Sized Assembly The method, based on designed DNA shells that coat a particle’s surface, can be used to manipulate the structure – and therefore the properties and potential uses – of numerous materials that may be of interest to industry. Open Open Tab September 13, 2007 Provides Information DNA Knot Keeps Viral Genes Tightly Corked Inside Shell, Scientists Discover A novel twist of DNA may keep viral genes tightly wound within a capsule, waiting for ejection into a host, a high-resolution analysis of its structure has revealed. Open Open Tab June 23, 2008 Provides Information DNA Provides Clues To Outcome In Patients With Liver Cancer The main causes of liver cancer (also known as hepatocellular carcinoma [HCC]), which is the fifth most common cancer in the world, are well defined. However, the molecular pathways activated by the triggers of liver cancer are not well characterized. Open Open Tab August 27, 2007 Provides Information DNA Replication Behavior In Complex Organisms May Foreshadow Leaps In Genomic Discoveries For the first time, findings by scientists at the Genome Institute of Singapore (GIS) may be paving the way for more efficient analyses and tests related to the replication of cells, and ultimately, to the better understanding of human biology, such as in stem cell research. Open Open Tab August 17, 2007 Provides Information DNA sequencing for the masses New fathers always think their newborn baby daughters are beautiful, and Hugh Reinhoff was no exception. Sure, she had giant feet, a cleft uvula, and contractures in some of her fingers. Open Open Tab March 7, 2008 Provides Information DNA Sequencing Through Imaging of Base Pairs MIT Technology Review has brought to our attention ZS Genetics, a North Reading, MA company that is developing a surprisingly new method of sequencing DNA. Instead of using common bio-chemical methods like PCR, the company is using electron microscopy to effectively image the sequence of DNA molecule's base pairs. Open Open Tab May 19, 2008 Provides Information DNA sewing machine Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The work published in the Royal Society of Chemistry journal Lab on a Chip demonstrates a unique way to manipulate delicate DNA chains without breaking them. Open Open Tab July 10, 2008 Provides Information DNA Technique Used to Engineer 3D Structures for Catalytic, Magnetic and Optical Nanomaterials In an achievement some see as the "holy grail" of nanoscience, researchers at the U.S. Department of Energy's Brookhaven National Laboratory have for the first time used DNA to guide the creation of three-dimensional, ordered, crystalline structures of nanoparticles (particles with dimensions measured in billionths of a meter). Open Open Tab January 31, 2008 Provides Information DNA test hope over damages claims Scientists say a new DNA test may help prove if people have had their health damaged by exposure to chemicals. Open Open Tab September 17, 2007 Provides Information DNA Testing Company Stops Direct-to-Consumer Sales in California A genetic testing company has stopped direct-to-consumer sales in California as a result of receiving a cease-and-desist letter from the state's health department. Open Open Tab June 23, 2008 Provides Information DNA to track UK-Russia migration A DNA survey has been launched to trace the descendants of Britons who settled in Russia hundreds of years ago. Open Open Tab September 11, 2007 Provides Information DNA Vaccine Against Multiple Sclerosis Appears Safe, Potentially Beneficial A newly developed DNA vaccine appears safe and may produce beneficial changes in the brains and immune systems of individuals with multiple sclerosis, according to an article posted online today that will appear in the October 2007 print issue of Archives of Neurology. Open Open Tab August 13, 2007 Provides Information E Electronic Structure Of DNA Revealed For First Time Utilizing a technique that combines low temperature measurements and theoretical calculations, Hebrew University of Jerusalem scientists and others have revealed for the first time the electronic structure of single DNA molecules. Open Open Tab March 10, 2008 Provides Information Enzyme Helps Males Make Up For Their X Chromosome Shortage A chromatin modifying enzyme helps compensate for the fact that males have only one copy of the sex chromosome X, while females have two. The enzyme distinguishes between male and female sex chromosomes in fruit flies and binds to different locations on the male and female X chromosome, the scientists have recently reported in the journal Cell. The evolutionarily conserved enzyme is also found in humans. Open Open Tab June 1, 2008 Provides Information Enzyme Key To 'Sister Act' That Maintains Genome Stability Keeping the genome stable is a "sister act" of matched chromatids -- the pairs of the double helix DNA molecule that exist during the chromosome duplication in the S phase of the cell cycle. Open Open Tab July 14, 2008 Provides Information Experts call for DNA restrictions A group of eminent lawyers and scientists is calling for anyone not convicted of a crime to have their details wiped from the DNA database. Open Open Tab September 18, 2007 Provides Information F Firm offers online DNA analysis A company has launched an online service that will enable people to receive a profile of their own genome. Open Open Tab November 16, 2007 Provides Information First DNA molecule made almost entirely of artificial parts Chemists in Japan report development of the world's first DNA molecule made almost entirely of artificial parts. The finding could lead to improvements in gene therapy, futuristic nano-sized computers, and other high-tech advances, they say. Open Open Tab July 2, 2008 Provides Information First DNA Molecule Made Almost Entirely Of Artificial Parts Chemists in Japan report development of the world's first DNA molecule made almost entirely of artificial parts. The finding could lead to improvements in gene therapy, futuristic nano-sized computers, and other high-tech advances. Open Open Tab July 7, 2008 Provides Information Flaw Found In Model Describing DNA Elasticity DNA, the biomolecule that provides the blueprint for life, has a lesser-known identity as a stretchy polymer. Open Open Tab September 18, 2007 Provides Information G Gene Defect Causes Immune Deficiency And Balance Disorder he study, published online Feb. 21 in the Journal of Clinical Investigation, examined a specialized strain of Jackson Laboratory mice with a mutation that eliminates the production a protein called p22phox. Disruption of this protein causes a form of chronic granulomatous disease (CGD) -- a severe immune deficiency -- in humans. Open Open Tab February 25, 2008 Provides Information Gene Detection Platform Made From Self Assembled DNA Nanostructures Scientists at Arizona State University's Biodesign Institute have developed the world's first gene detection platform made up entirely from self-assembled DNA nanostructures. The results, appearing in the January 11 issue of the journal Science, could have broad implications for gene chip technology and may also revolutionize the way in which gene expression is analyzed in a single cell. Open Open Tab January 11, 2008 Provides Information Gene network disrupted by obesity According to new research an entire network of genes in the body is disrupted by overeating and this not only causes obesity, but also diabetes and heart disease. Open Open Tab March 17, 2008 Provides Information Gene silencer and quantum dots reduce protein production to a whisper More than 15 years ago scientists discovered a way to stop a particular gene in its tracks. The Nobel Prize-winning finding holds tantalizing promise for medical science, but so far it has been difficult to apply the technique, known as RNA interference, in living cells. Open Open Tab June 23, 2008 Provides Information Gene silencer and quantum dots reduce protein production to a whisper More than 15 years ago, scientists discovered a way to stop a particular gene in its tracks. The Nobel Prize-winning finding holds tantalizing promise for medical science, but so far it has been difficult to apply the technique, known as RNA interference, in living cells. Open Open Tab July 9, 2008 Provides Information Gene That Can Block The Spread Of HIV Discovered A team of researchers at the University of Alberta has discovered a gene that is able to block HIV, and in turn prevent the onset of AIDS. Open Open Tab February 29, 2008 Provides Information Gene Therapy Can Cause Leukemia In Large Animals Individuals with a number of life-threatening genetic diseases of the immune system have been successfully treated by gene therapy -- that is, they were infused with early precursors of immune cells that had the correct form of the defective gene delivered into them by agents known as retroviral vectors. Open Open Tab March 23, 2008 Provides Information Gene Therapy Clinical Trial Yields Promising Results For Batten Disease Promising results from a team of NewYork-Presbyterian Hospital/Weill Cornell Medical Center physician-scientists show that gene therapy is both safe and effective at slowing the progression of Batten disease, or Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL), a rare, genetic, degenerative neurological disorder that usually becomes fatal in children by the age of 8 to 12. Open Open Tab May 14, 2008 Provides Information Genetic Breakthrough Supercharges Immunity To Flu And Other Viruses Researchers at McGill University have discovered a way to boost an organism's natural anti-virus defences, effectively making its cells immune to influenza and other viruses. Open Open Tab February 14, 2008 Provides Information Genetic Counselors Turn To Unconventional Counseling To Meet Demand For Genetic Testing Imagine receiving genetic test results for a disease you could develop later in life without having anyone with whom to discuss your options for managing the risk. Open Open Tab March 31, 2008 Provides Information Genetic Diversity Of European Americans And Disease Gene Mapping Labels such as "European American", "white", or "Caucasian" are often viewed as representing a homogeneous category in gene mapping studies and census reports, but each of these labels actually groups together multiple populations, which have diverse origins due to the complex history of European immigration to the United States. Open Open Tab January 19, 2008 Provides Information Genetic researchers fill 1TB a week Fresh from its recent sinister triumph, the Wellcome Trust says that its research into genetic diseases is generating such huge data volumes that it has had to buy an extra 42TB of SATA disk arrays, 30TB of which are already full. Open Open Tab August 3, 2007 Provides Information Genetic switches could lower cost of producing drugs, proteins Bacteria have evolved complex mechanisms called quorum sensing systems that provide for cell-to-cell communication, an adaptation that allows them to wait until their population grows large enough before mounting an attack on a host or competing for nutrients. Open Open Tab January 23, 2008 Provides Information Genetic Variation To Predict Initial Response To Warfarin Identified Scientists have identified which variations of a specific gene determine a patient's initial response to treatment with the blood-thinning (anticoagulant) drug warfarin. Researchers with the National Institutes of Health (NIH) Pharmacogenetics Research Network found that the gene VKORC1 plays a major role in determining a patient's initial sensitivity to warfarin treatment -- when dosage amounts are most critical to prevent clotting problems in patients. Open Open Tab March 8, 2008 Provides Information Genome Communication: Alleles Of Homologous Genes Can Silence One Another In the late 19th century Gregor Mendel used peas to show that one copy of a gene (allele) is inherited from the mother and one from the father. In the progeny, the inherited genes are expressed at the right time and in the right place, but until recently, it was thought that although gene products could be modified during the life of the organism, the genes themselves were unchanged, except for random mutation. Open Open Tab June 29, 2008 Provides Information Genome-wide Study Shed Lights On Factors That Contribute To DNA Mutations A team of Penn State University researchers is the first to conduct a genome-wide study to compare the relative importance of factors that contribute to DNA mutations, which are implicated in cancer and over 40 neurological disorders. Open Open Tab January 29, 2008 Provides Information Good News In Our DNA: Defects You Can Fix With Vitamins And Minerals As the cost of sequencing a single human genome drops rapidly, with one company predicting a price of $100 per person in five years, soon the only reason not to look at your "personal genome" will be fear of what bad news lies in your genes. Open Open Tab June 3, 2008 Provides Information H Handheld DNA Detector A researcher at the National University at San Diego has taken a mathematical approach to a biological problem - how to design a portable DNA detector. Writing in the International Journal of Nanotechnology, he describes a mathematical simulation to show how a new type of nanoscale transistor might be coupled to a DNA sensor system to produce a characteristic signal for specific DNA fragments in a sample. Open Open Tab March 13, 2008 Provides Information Home Office minister invites DNA database debate As records hit four million. Open Open Tab October 18, 2007 Provides Information Hotspots Found For Chromosome Gene Swapping Crossovers and double-strand DNA breaks do not occur randomly on yeast chromosomes during meiosis, but are greatly influenced by the proximity of the chromosome's telomere, according to research in the laboratory of Whitehead Fellow Andreas Hochwagen. Open Open Tab December 4, 2007 Provides Information How DNA Barcoding Can Help Science About 350 DNA barcoding experts from 46 nations will converge in Taipei amid spiralling interest from health officials, government agencies and others beginning to realize potential applications in a range of areas -- from consumer protection and food safety to disease prevention and better environmental monitoring. Open Open Tab September 17, 2007 Provides Information How mutant gene causes fragile X A mutant gene can trigger learning difficulties by preventing brain cells communicating with each other effectively, research shows. Open Open Tab September 18, 2007 Provides Information How to delete your DNA profile It's a little known fact that it's possible to have your DNA profile removed from the National DNA Database (NDNAD). While the Police have processes to gather and retain DNA samples - they don't yet have a procedure to delete the DNA of innocent members of the public. Open Open Tab January 7, 2008 Provides Information Human Aging Gene Found In Flies Scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) have found a fast and effective way to investigate important aspects of human aging. Open Open Tab May 12, 2008 Provides Information Human evolution in genetic fast lane Countering a common theory that human evolution has slowed to a crawl or even stopped in modern humans, a new study examining data from an international genomics project describes the past 40,000 years as a time of supercharged evolutionary change, driven by exponential population growth and cultural shifts. Open Open Tab December 11, 2007 Provides Information Human Genetic Variation Named as Science "Breakthrough of the Year" In 2007, researchers were dazzled by the degree to which genomes differ from one human to another and began to understand the role of these variations in disease and personal traits. Science and its publisher, AAAS, the nonprofit science society, recognize “Human Genetic Variation” as the Breakthrough of the Year, and identify nine other of the year’s most significant scientific accomplishments in the 21 December issue. Open Open Tab December 21, 2007 Provides Information Human Genome Has Four Times More Imprinted Genes Than Previously Identified Scientists at Duke University have created the first map of imprinted genes throughout the human genome, and they say a modern-day Rosetta stone -- a form of artificial intelligence called machine learning -- was the key to their success. Open Open Tab November 30, 2007 Provides Information I Identical twins are not genetically identical Contrary to our previous beliefs, identical twins are not genetically identical. Open Open Tab February 18, 2008 Provides Information Immune Cells Kill Foes By Disrupting Mitochondria Two Ways When killer T cells of the immune system encounter virus-infected or cancer cells, they unload a lethal mix of toxic proteins that trigger the target cells to self-destruct. Open Open Tab May 17, 2008 Provides Information Individual Differences Caused By Shuffled Chunks Of DNA In The Human Genome A study by Yale researchers offers a new view of what causes the greatest genetic variability among individuals -- suggesting that it is due less to single point mutations than to the presence of structural changes that cause extended segments of the human genome to be missing, rearranged, or present in extra copies. Open Open Tab October 3, 2007 Provides Information Innocent 'terror techie' purges DNA records More than two years after his arrest and subsequent release, techie and some-time Reg contributor David Mery has succeeded in purging the police databases of his fingerprints and DNA. Open Open Tab September 17, 2007 Provides Information Intel bets millions on speedy DNA sequencing chips Intel is among several investors pumping $100m into a biotech start-up that wants to make mapping an individual's genome as routine as taking an X-ray. Open Open Tab July 15, 2008 Provides Information Invention Gives Improved Gene Technology Analysis A newly patented invention from Norwegian researchers gives more reliable results in gene technology-based diagnostic tests. Previously, the state of the art was to use an unprotected internal control reagent to verify the validity of results. The problem was that it could only be added late in the analysis. The use of tailored coating of the internal control opens for, and enables presence of the control throughout the whole analytical process -- giving improved quality assurance. Open Open Tab April 27, 2008 Provides Information Is DNA Repair A Substitute For Sex? Birds and bees may do it, but the microscopic animals called bdelloid rotifers seem to get along just fine without sex, thank you. What's more, they have done so over millions of years of evolution, resulting in at least 370 species. Open Open Tab April 4, 2008 Provides Information K Key gene work scoops Nobel Prize Two US scientists and their UK collaborator have been awarded the Nobel Prize for medicine for their groundbreaking work in gene technology. Open Open Tab October 8, 2007 Provides Information L Link between DNA palindromes and disease discovered In the past 10 years, researchers in genome stability have observed that many kinds of cancers are associated with areas where human chromosomes break. More recently, scientists have discovered that slow or altered replication causes chromosomal breaking. But why does DNA replication stall? Open Open Tab July 14, 2008 Provides Information M Mapping own DNA changes scientist's life Biologist-entrepreneur J. Craig Venter is part of a new kind of scientific explorer whose uncharted territory was his own genes. Open Open Tab September 4, 2007 Provides Information Massive MicroRNA Scan Uncovers Leads To Treating Muscle Degeneration Researchers have discovered the first microRNAs -- tiny bits of code that regulate gene activity -- linked to each of 10 major degenerative muscular disorders, opening doors to new treatments and a better biological understanding of these debilitating, poorly understood, often untreatable diseases. Open Open Tab October 22, 2007 Provides Information Massive MicroRNA Scan Uncovers Leads To Treating Muscle Degeneration Researchers have discovered the first microRNAs -- tiny bits of code that regulate gene activity -- linked to each of 10 major degenerative muscular disorders, opening doors to new treatments and a better biological understanding of these debilitating, poorly understood, often untreatable diseases. Open Open Tab October 19, 2007 Provides Information Mechanistic model of DNA repair Ionizing radiation, toxic chemicals, and other agents continually damage the body's DNA, threatening life and health: unrepaired DNA can lead to mutations, which in turn can lead to diseases like cancer. Open Open Tab August 6, 2007 Provides Information Medical Geneticists Cautions Against Rushing Into Genetic Testing Just because scientific advances now allow individuals to learn their genetic make-up doesn't mean they should rush into genetic testing in hopes of making revolutionary improvements to their health, cautions a geneticist and practicing physician at the University of North Carolina at Chapel Hill. Open Open Tab June 3, 2008 Provides Information Micro-Sized Sewing Machine to Sew Long Threads of DNA into Shape Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The work published in the Royal Society of Chemistry journal Lab on a Chip demonstrates a unique way to manipulate delicate DNA chains without breaking them. Open Open Tab July 11, 2008 Provides Information Microarray-based genomic selection accelerates discovery of subtle DNA variations A new technology developed by scientists at Emory University will allow researchers to more easily discover subtle and overlooked genetic variations that may have serious consequences for health and disease. Open Open Tab October 15, 2007 Provides Information Miniaturized DNA sewing machines They've designed these laser-directed microdevices to pick up and manipulate individual molecules of DNA. The scientists have used optical tweezers to catch and move these microdevices, which could be used in the future to detect genetic disorders such as Down's syndrome. Open Open Tab July 13, 2008 Provides Information Missing DNA fails to kill mice DNA sequences we share with mice might not be as important as researchers previously thought. Open Open Tab September 7, 2007 Provides Information Mitochondrial DNA Mutations Can Cause Degenerative Heart And Muscle Disease A single change in the DNA of mitochondria -- the cellular power plants that generate energy in all human cells -- has been found to cause degenerative heart and muscle disease, according to University of California, Irvine researchers. Open Open Tab February 18, 2008 Provides Information Mitochondrial Eve Research: Humanity Was Genetically Divided For 100,000 Years The human race was divided into two separate groups within Africa for as much as half of its existence, says a Tel Aviv University mathematician. Climate change, reduction in populations and harsh conditions may have caused and maintained the separation. Open Open Tab May 16, 2008 Provides Information Molecular Glue Cohesin Acts As Regulator Of Gene Expression Ten years ago, researchers at the IMP - a basic research institute in Vienna - discovered a fundamental and amazingly plausible mechanism of cell division. They identified a protein complex, which, as a ring-shaped molecule, slides over the doubled chromosomes and holds precisely these together until the time they again separate. Open Open Tab February 13, 2008 Provides Information Molecular delivery system could lead to blood tests using a cell phone This kind of nanoscale biological motor is able to load/unload particular types of cargo without external stimuli, and transport them along cytoskeletal filaments by using the energy of adenosine triphosphate (ATP) hydrolysis within cells. Open Open Tab April 28, 2008 Provides Information Molecular Level Nanoelectronics a Step Closer to Reality With DNA Nanowire Research Biological and physical studies on DNA structure have revealed considerable interest into the electronic properties of DNA. Open Open Tab November 7, 2007 Provides Information Molecular Sized Machines Might Get Around Using Two Legged DNA Walker Legs Researchers at the California Institute of Technology report they are able to program the pathways by which DNA molecules self-assemble, and hence to engineer diverse dynamic functions at the molecular level. Open Open Tab January 29, 2008 Provides Information More Functional DNA In Genome Than Previously Thought Surrounding the small islands of genes within the human genome is a vast sea of mysterious DNA. While most of this non-coding DNA is junk, some of it is used to help genes turn on and off. Open Open Tab December 13, 2007 Provides Information More regulatory DNA than previously thought Surrounding the small islands of genes within the human genome is a vast sea of mysterious DNA. While most of this non-coding DNA is junk, some of it is used to help genes turn on and off. Open Open Tab December 13, 2007 Provides Information N N-TER Nanoparticle siRNA Transfection System Delivers siRNA into Difficult-to-Transfect Cell Types Sigma-Aldrich announced today the global release of the N-TER Nanoparticle siRNA Transfection System. N-TER allows researchers to reproducibly interrogate gene function, via siRNA transfection, in model cell types that have previously not been considered amenable to conventional lipid-based siRNA delivery reagents. Open Open Tab October 19, 2007 Provides Information Nano Sized Valves Bring Control to the Transport of Drugs and Nanoparticles in the World of Nanotechnology We encounter valves every day, whether in the water faucet, the carburetor in our car, or our bicycle tire tube. Valves are also present in the world of nanotechnology. A team of researchers headed by J. Fraser Stoddart and Jeffrey I. Zink at the University of California, Los Angeles, has now developed a new nanovalve. Open Open Tab March 10, 2008 Provides Information Nano-rings Made of Double-Stranded DNA, With Little Gaps For New Molecules What appear under an atomic force microscope to be tiny rings with little bits missing are actually nanoscopic rings made of double-stranded DNA with a little gap in the form of a short single-stranded fragment. Open Open Tab March 8, 2008 Provides Information Nano-softball Made Of DNA For quite some time, DNA, the stuff our genes are made of, has also been considered the building material of choice for nanoscale objects. A team led by Günter von Kiedrowski at the Ruhr University in Bochum has now made a dodecahedron (a geometric shape with twelve surfaces) from DNA building blocks. Open Open Tab April 3, 2008 Provides Information Nanorings Made from Double-Stranded DNA What appear under an atomic force microscope to be tiny rings with little bits missing are actually nanoscopic rings made of double-stranded DNA with a little gap in the form of a short single-stranded fragment. Open Open Tab December 6, 2007 Provides Information Nanorings Made From Rigid DNA Rings May be Used as Variable Nanocomposites What appear under an atomic force microscope to be tiny rings with little bits missing are actually nanoscopic rings made of double-stranded DNA with a little gap in the form of a short single-stranded fragment. Open Open Tab December 7, 2007 Provides Information Nanoscale Whole Genome Imaging Technology to be used in Genetic Analysis System Using Agilent Technologies Inc. and BioNanomatrix Inc. announced that they have entered into a collaboration to develop a new genetic analysis system combining the two companies' technologies. Open Open Tab November 6, 2007 Provides Information Nanoscopic Rings Have the Potential to Form into Nanocomposite Materials What appear under an atomic force microscope to be tiny rings with little bits missing are actually nanoscopic rings made of double-stranded DNA with a little gap in the form of a short single-stranded fragment. As Michael Famulok and his team from the University of Bonn, Germany, explain in the journal Angewandte Chemie , this gap is a place to attach other molecules that have the potential to transform the rings into versatile nanocomposites for various applications. Open Open Tab March 7, 2008 Provides Information NCI scientists visualize gene regulation in living cells A research team led by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has applied advanced imaging methods and computer simulations to be able to glance at the regulation of a cancer-related gene in a living cell. Open Open Tab May 22, 2008 Provides Information New Carcinogenic Role of microRNAs Discovered Though microRNA's have been known of playing a role in cancer development for some time, an MIT postdoc demonstrated that they play a significant role in the metastatic process of cancer cells. Open Open Tab September 28, 2007 Provides Information New Cataract Gene Discovered The international team of researchers was able to identify the location and defect in the coding region of the gene through analysis of genetic material (DNA) from members of a large Swiss family, the majority of whom suffered from autosomal dominant juvenile cataract. The corresponding protein belongs to a family of monocarboxylate transporters which move small molecules across cell mem-branes. Open Open Tab February 18, 2008 Provides Information New Discovery Illuminates How Cells Repair Damaged DNA When the genetic material inside a cell's nucleus starts to fall apart, a protein called ATM takes charge and orchestrates the rescue mission. Open Open Tab November 2, 2007 Provides Information New DNA technique will speed up chemical compensation claims A new DNA technique developed by scientists in the U.S. may help prove if people have had their health damaged by exposure to chemicals. Open Open Tab September 18, 2007 Provides Information New Gene Prediction Method Capitalizes On Multiple Genomes Researchers at Stanford University report in the online open access journal, Genome Biology, a new approach to computationally predicting the locations and structures of protein-coding genes in a genome. Gene finding remains an important problem in biology as scientists are still far from fully mapping the set of human genes. Open Open Tab December 20, 2007 Provides Information New Insights Into The Evolution Of The Human Genome Which came first, the chicken genome or the egg genome? Open Open Tab October 9, 2007 Provides Information New insight on jumping genes Keck Graduate Institute (KGI) announced that Dr. Animesh Ray, KGI professor and director of KGI's PhD program, has published a paper in the international online journal PLoS ONE that sheds new light on the evolution of moveable genetic elements, or "jumping genes." Open Open Tab October 9, 2007 Provides Information New Light Shed On The Mechanics Of Gene Transcription The molecular machinery behind gene transcription -- the intricate transfer of information from a segment of DNA to a corresponding strand of messenger RNA -- isn't stationed in special "transcription factories" within a cell nucleus, according to Cornell researchers. Instead, the enzyme RNA polymerase II (Pol II) and other key molecules can assemble at the site of an activated gene, regardless of the gene's position. Open Open Tab January 9, 2008 Provides Information New Method To Identify Mutated Genes In Human Diseases Identification of mutated genes is a crucial first step towards understanding the molecular mechanisms at the origin of diseases and devising a treatment. In many cases, we do not know the identity of the affected gene, only a chromosomal region in which the mutation is located. Open Open Tab March 30, 2008 Provides Information New Software Aids Researchers Analyzing Millions Of DNA Sequences It took a global corps of scientists approximately $500 million and 13 years to identify the more than 35,000 genes of the human genome. Five years later, Boston College Biologist Gabor Marth and his research team have developed software that can analyze half a million DNA sequences in 10 minutes. Open Open Tab March 31, 2008 Provides Information New technique could dramatically lower costs of DNA sequencing Using computer simulations, researchers at the University of Illinois have demonstrated a strategy for sequencing DNA by driving the molecule back and forth through a nanopore capacitor in a semiconductor chip. Open Open Tab January 16, 2008 Provides Information New Technique for Assessing Radiation Damage to DNA A new technique for assessing the damage radiation causes to DNA indicates that the spatial arrangement of damaged sites, or lesions, is more important than the number of lesions in determining the severity of the damage. Open Open Tab March 25, 2008 Provides Information New Tool To Understand Evolution Of Multi-domain Genes Developed Carnegie Mellon scientists have discovered critical flaws in the standard method used to analyze gene evolution. Standard methods fail when applied to genes that encode multi-domain proteins, an important class of proteins crucial to human health. Open Open Tab May 18, 2008 Provides Information O On Telepathy of DNA Molecules Researchers at Imperial College London and the National Institute of Health in the US have discovered something amazing: the ability of similar DNA segments to recognize each other. Open Open Tab January 28, 2008 Provides Information P Personalized medicine will alter treatment of genetic disorders One of the nation's pre-eminent genetic researchers, Eric Hoffman, PhD, of Children's Research Institute at Children's National Medical Center, predicts that in relatively short order, medicine's next innovation--individualized molecular therapies--will have the unprecedented ability to treat muscular dystrophies, and other disorders. Open Open Tab December 31, 2007 Provides Information Plastic packages of enzymes upgrade human cells in lab Swiss researchers have found that the insertion of tiny plastic packages of enzymes in human cells may help upgrade their metabolisms, without having to alter their genes. Open Open Tab May 26, 2008 Provides Information Police want DNA collection superpowers All your genes are belong to us, sonny Jim. Open Open Tab August 2, 2007 Provides Information Political Participation Is Partially Rooted In Genetic Inheritance The research, by James H. Fowler and Christopher T. Dawes, of the University of California, San Diego and Laura A. Baker, of the University of Southern California, is the first to show that genes influence participation in elections and in a wide range of political activities. Open Open Tab July 3, 2008 Provides Information Possible Key To Autoimmune Disease A human peptide that acts as a natural antibiotic against invading microbes can also bind to the body's own DNA and trigger an immune response in the absence of an infection. Open Open Tab September 21, 2007 Provides Information Potential Treatments From Cryptic Genes Big pharma gave up on soil bacteria as a source of antibiotics too soon, according to research published in the June issue of Microbiology. Scientists have been mining microbial genomes for new natural products that may have applications in the treatment of MRSA and cancer and have made some exciting discoveries. Open Open Tab June 4, 2008 Provides Information R Race row DNA scientist quits lab A Nobel laureate who claimed Africans were less clever than Europeans has retired from his post at an American research institution. Open Open Tab October 25, 2007 Provides Information Raman reveals DNA in action Researchers at the University of Strathclyde, UK, have been able to use Raman spectroscopy to observe strands of DNA pairing up and falling apart by attaching them to silver nanoparticles ("Control of enhanced Raman scattering using a DNA-based assembly process of dye-coded nanoparticles"). Open Open Tab July 15, 2008 Provides Information Real Time Repair of DNA Observed For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time. They observed this at the level of a single DNA molecule. Open Open Tab May 23, 2008 Provides Information Real-time Observation Of DNA-repair Mechanism For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time. Open Open Tab May 25, 2008 Provides Information Real Time Footage of the Nanoscale Interaction of an Enzyme, a DNA Strand and an Attacking Virus Researchers from the University of Cambridge have used a revolutionary Scanning Atomic Force Microscope in Japan to produce amazing footage of a protective enzyme unravelling the DNA of a virus trying to infect a bacterial host. Open Open Tab September 18, 2007 Provides Information Real-time observation of the DNA-repair mechanism For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time. They observed this at the level of a single DNA molecule. Insight into this type of repair mechanism is essential as errors in this process can lead to the development of cancerous cells. Open Open Tab May 22, 2008 Provides Information Researchers Unveil Near-complete Protein Catalog For Mitochondria Imagine trying to figure out how your car's power train works from just a few of its myriad components: It would be nearly impossible. Scientists have long faced a similar challenge in understanding cells' tiny powerhouses -- called "mitochondria" -- from scant knowledge of their molecular parts. Open Open Tab July 14, 2008 Provides Information Reconstructing Jumping Gene: New Tool For Elucidating The Function Of Genes hey can be found in plants, animals and even in humans -- inactive remains of jumping genes, transposons. Researchers are striving to develop active transposons from these remains, using them as tools to decode gene function. At the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, researchers have now succeeded in reconstructing the first active transposon of the Harbinger transposon superfamily. Open Open Tab March 19, 2008 Provides Information Relaxation Response Can Influence Expression Of Stress-related genes How could a single, nonpharmacological intervention help patients deal with disorders ranging from high blood pressure, to pain syndromes, to infertility, to rheumatoid arthritis? Open Open Tab July 3, 2008 Provides Information Researchers Make Nanosized, Softball Shaped Dodecahedron From DNA For quite some time, DNA, the stuff our genes are made of, has also been considered the building material of choice for nanoscale objects. A team led by Günter von Kiedrowski at the Ruhr University in Bochum has now made a dodecahedron (a geometric shape with twelve surfaces) from DNA building blocks. Open Open Tab April 2, 2008 Provides Information Researchers question genetic screening programs The researchers say telling couples their fetuses have a treatable genetic disorder leads many of them to terminate the pregnancy. Open Open Tab September 20, 2007 Provides Information Researchers Reveal Electronics Structure of DNA Utilizing a technique that combines low temperature measurements and theoretical calculations, Hebrew University of Jerusalem scientists and others have revealed for the first time the electronic structure of single DNA molecules. Open Open Tab February 29, 2008 Provides Information Researchers Use DNA as the Tools and Equipment to build a 3D Structure from Pure Gold DNA is the blueprint of all life, giving instruction and function to organisms ranging from simple one-celled bacteria to complex human beings. Now Northwestern University researchers report they have used DNA as the blueprint, contractor and construction worker to build a three-dimensional structure out of gold, a lifeless material. Open Open Tab January 31, 2008 Provides Information Researchers use DNA to drive the assembly of 3D gold structures DNA is the blueprint of all life, giving instruction and function to organisms ranging from simple one-celled bacteria to complex human beings. Open Open Tab February 4, 2008 Provides Information RNA Emerges From DNA's Shadow RNA, the transporter of genetic information within the cell, has emerged from the shadow of DNA to become one of the hottest research areas of molecular biology, with implications for many diseases as well as understanding of evolution. Open Open Tab July 13, 2008 Provides Information RNA Shown To Silence Cancer Suppressor Gene One way cancer arises is when tumor suppressor genes that normally keep cell growth in check are mysteriously turned off. Now, researchers at Johns Hopkins have discovered that at least one tumor suppressor gene is in fact turned off by a “noncoding” single stranded RNA nucleic acid similar to its double-stranded DNA cousin. Open Open Tab January 15, 2008 Provides Information RNA toxicity contributes to neurodegenerative disease Expanding on prior research performed at the University of Pennsylvania, Penn biologists have determined that faulty RNA, the blueprint that creates mutated, toxic proteins, contributes to a family of neurodegenerative disorders in humans. Open Open Tab May 21, 2008 Provides Information S Scientists Achieve Direct Electrical Measurements on Single-Molecule DNA Nanowerk's Michael Berger is reporting about the efforts by a group of scientists under Dr. Wonbong Choi at Nanomaterials & Device Laboratory in the Department of Mechanical and Materials Engineering at Florida International University (FIU) in Miami to study the electrical properties of a DNA molecule, as a potential electrode for nano-based electronics. Open Open Tab January 4, 2008 Provides Information Scientists characterizes novel regulator of chromosome function Acetyltransferases are enzymes that introduce a new acetyl functional group into histone proteins, a process by which all chromosome functions are controlled. Open Open Tab March 11, 2008 Provides Information Scientists create new nanotechnology building blocks In the fast-growing world of nanotechnology, researchers are constantly on the lookout for new building blocks to push innovation and discovery to scales much smaller than the tiniest speck of dust. Open Open Tab June 3, 2008 Provides Information Scientists Discover Small RNAs That Regulate Gene Expression And Protect The Genome RNA is best known as a working copy of the DNA sequence of genes. In this role, it's a carrier of the genes' instructions to the cell, which manufactures proteins according to information in the RNA molecule. Open Open Tab May 15, 2008 Provides Information Scientists hail DNA repair study Research into how the human body repairs damaged DNA has been described as a "major breakthrough". Open Open Tab October 17, 2007 Provides Information Scientists Make Chemical Cousin Of DNA For Use As New Nanotechnology Building Block In the rapid and fast-growing world of nanotechnology, researchers are continually on the lookout for new building blocks to push innovation and discovery to scales much smaller than the tiniest speck of dust. Open Open Tab April 30, 2008 Provides Information Scientists sequence first female DNA Geneticists of Leiden University Medical Centre (LUMC) are the first to determine the DNA sequence of a woman. She is also the first European whose DNA sequence has been determined. This has been announced by the researchers this morning, during a special press conference at 'Bessensap', a yearly meeting of scientists and the press in the Netherlands. Open Open Tab May 27, 2008 Provides Information Short RNA Strand Helps Exposed Skin Cells Protect Body From Bacteria, Dehydration And Even Cancer Exposed skin cells weather conditions harsh enough to mutate DNA. To keep these mutations from spreading, evolution has found a way to keep these cells from proliferating. Rockefeller University and HHMI researchers have now discovered evolution's solution: a tiny strand of RNA. But the research's implications go deeper, and may also suggest how healthy cells elsewhere in the body can turn cancerous. Open Open Tab March 5, 2008 Provides Information Specific Genetic Mutations May Contribute To Preterm Birth Risk Genetic mutations in the enzyme methylenetetrahydrofoloate reductase (MTHFR) and coagulation protein Factor V appear to have significant association with blood clots and tissue injury to the placenta and developing baby, researchers from the University of Pittsburgh's department of obstetrics, gynecology and reproductive sciences report at the 28th annual meeting of the Society for Maternal-Fetal Medicine. Open Open Tab February 1, 2008 Provides Information Structure Of Protein That Mutates DNA Of The AIDS Virus HIV-1 Determined Understanding the structure of proteins involved in inhibiting HIV-1 infection could help in the battle against AIDS, and University of Minnesota researchers have taken a crucial step in that direction. Open Open Tab February 21, 2008 Provides Information Synthetic Chromosome First Step Towards Creating Artificial Life The Guardian in the UK is reporting that Craig Venter, the controversial DNA researcher involved in the race to decipher the human genetic code, has built a synthetic chromosome out of laboratory chemicals and is poised to announce the creation of the first new artificial life form on Earth. Open Open Tab October 8, 2007 Provides Information Synthetic DNA in The Lab At the J. Craig Venter Institute, scientists reproduced artificially the DNA of bacterium Mycoplasma genitalium JCVI-1.0, its genome consisting of 582,970 base pairs. This is the first time that a full sequence for life has come out of a lab. Well, surely only God knows what this technology could lead to. Open Open Tab January 24, 2008 Provides Information T Take One: Scientists Capture DNA-Enzyme Interaction Movie Researchers from the University of Cambridge claim they created the first ever real time footage of DNA-protein interaction. Open Open Tab September 18, 2007 Provides Information Targeted quantum dot conjugates for siRNA delivery Take a quantum dot, add a coating of poly(ethylene glycol) (PEG), and attach a homing pept