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| 39 Health - Influenza Resources |
| A clamp for emerging flu viruses |
| When the human body becomes infected with new influenza viruses, the immune system rapidly activates an inborn protective mechanism to inhibit the intruding pathogen. A protein known as Mx plays an important role in this process, keeping the spread of viruses in check. Exactly how Mx accomplishes this task was previously unknown. |
| View Source | April 28, 2010 | Provides Information |
| Alnylam, Mount Sinai scientists discover svRNAs that play a critical role in influenza A virus replication |
| Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today the publication of new research findings in the journal Proceedings of the National Academy of Sciences (PNAS) by Alnylam scientists and collaborators from Mount Sinai School of Medicine. In the new study, Alnylam and Mount Sinai scientists discovered a novel class of virus-produced small non-coding RNAs, called small viral RNAs (svRNAs), which play a critical role in the replication of influenza A virus. Antagonism of these svRNAs resulted in decreased viral mRNA and blocked viral infectivity. These new findings provide further understanding of how influenza virus is able to infect cells, and identify new targets and strategies for anti-influenza virus-based therapies. |
| View Source | June 2, 2010 | Provides Information |
| Antibody may help treat and prevent influenza outbreaks |
| Researchers have discovered a monoclonal antibody that is effective against "Avian" H5N1, seasonal H1N1 and the 2009 "Swine" H1N1 influenza. Scientists at Sea Lane Biotechnologies, LLC, in collaboration with Mt. Sinai School of Medicine, St. Jude Research Hospital and the Scripps Research Institute, have shown that this antibody potently prevents and treats the Swine H1N1 influenza in mouse models of the disease. Results are published July 8 in the open-access journal PLoS Pathogens. |
| View Source | July 8, 2010 | Provides Information |
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| Back to the future for flu fighters |
| Australian National University researchers have breathed new life into an old protein drug target in a discovery that could open the door to a new range of drugs to combat influenza. |
| View Source | July 20, 2010 | Provides Information |
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| Canine influenza vaccine found effective against secondary infections |
| Recent research by Ron Schultz, professor and chair of the Department of Pathobiological Sciences at the University of Wisconsin-Madison School of Veterinary Medicine, has shown the newly approved Canine Influenza Virus (CIV) vaccine to be effective not only in reducing length, severity and spread of the virus, but also in protecting against secondary infections. |
| View Source | July 8, 2010 | Provides Information |
| Computer-Aided Influenza Virus Vaccine Method Could Lead To Effective And Safe Seasonal Vaccines |
| A team of molecular biologists and computer scientists at Stony Brook University have used a novel method to weaken (attenuate) influenza virus by way of designing hundreds of mutations to its genetic code to create an effective vaccine. |
| View Source | June 16, 2010 | Provides Information |
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| Diagnostic Hybrids receives Chinese SFDA approval for D3 Ultra DFA Respiratory Virus Screening and ID Kit |
| Diagnostic Hybrids, a Quidel Company, received approval from the People's Republic of China's State Food and Drug Administration (SFDA) for its D3 Ultra DFA Respiratory Virus Screening and ID Kit. |
| View Source | July 1, 2010 | Provides Information |
| Directing immune traffic -- signposts to the lung |
| Inducing cellular immunity as a means to protect against influenza virus is the focus of several laboratories at the Trudeau Institute. Researchers here have recently identified two important signaling components required by the immune system that might allow us to pre-position our own virus-fighting T cells to the lungs, the site of initial infection. |
| View Source | May 10, 2010 | Provides Information |
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| Findings could shield humans from influenza virus |
| A University of Alberta-led research team has discovered an influenza detector gene that could potentially prevent the transmission of the virus to humans. |
| View Source | March 30, 2010 | Provides Information |
| Flu Shot Tip Sheet |
| Flu season is here. Get the flu shot facts with this timely tipsheet. |
| View Source | | Provides Information |
| Flu vaccine to be available at local pharmacies, doctor's offices |
| Flu vaccine will soon be available at local pharmacies and doctor's offices, and government officials are urging everyone over 6 months of age to receive it. This year's vaccine protects against H1N1 and two other strains of seasonal flu. |
| View Source | August 23, 2010 | Provides Information |
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| Google Flu Trends estimates off |
| Google Flu Trends is not as accurate at estimating rates of laboratory-confirmed influenza as CDC national surveillance programs, according to a new study from the University of Washington. |
| View Source | May 17, 2010 | Provides Information |
| GSK anticipates to supply over 30 million doses of FLULAVAL, FLUARIX for 2010-2011 flu season |
| GlaxoSmithKline announced today that the U.S. Food and Drug Administration's Center for Biologics Evaluation and Research has released the first lots of FluLaval® allowing distribution in the U.S. to begin for the 2010-2011 flu season. |
| View Source | July 30, 2010 | Provides Information |
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| Health-Care Worker Vaccination Rates Remain Perilously Low |
| Healthcare personnel influenza immunization rates have remained low, despite recommendations from the Centers for Disease Control and Prevention (CDC) and other leading healthcare organizations that all healthcare personnel receive annual flu vaccines. Experts say these levels are perilous. Increasing vaccination rates substantially improves patient safety, lowering flu deaths by 40 percent. |
| View Source | March 22, 2010 | Provides Information |
| Hutterite Study: Vaccinating Children for Flu May Help Prevent Transmission, Protect Those Who Are Not Vaccinated |
| Immunizing children and adolescents with inactivated influenza vaccine resulted in reduced rates of influenza in their community compared to a similar community in which children did not receive the vaccine, suggesting that vaccinating children may help prevent transmission of the virus and offer protection for unimmunized community residents, according to a study in the March 10 issue of JAMA. |
| View Source | March 15, 2010 | Provides Information |
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| IDRI signs Research Collaboration Agreement with PATH |
| Two global health non-profit organizations headquartered in Seattle, Washington, the Infectious Disease Research Institute (IDRI) and PATH, have entered into a Research Collaboration Agreement to evaluate novel adjuvants for their ability to enhance the immune response of pandemic influenza vaccines in development. The collaboration supports the goal of PATH's influenza vaccine project to advance the development of promising new influenza vaccines focusing on novel technologies that can be accessible, affordable, and available to people in low-resource countries in a global outbreak. IDRI, a non-profit biotechnology organization, has developed numerous emulsion adjuvants for use with various antigens for the production of vaccines. |
| View Source | June 25, 2010 | Provides Information |
| Immunizing children against seasonal influenza can protect unvaccinated community against influenza |
| Trial results in rural Canadians show effect of herd immunity |
| View Source | March 15, 2010 | Provides Information |
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| Microneedle skin patches as effective as hypodermic needles for flu vaccination |
| Flu vaccine delivered through skin patches containing microneedles has proven at least as effective at preventing influenza in mice as intramuscular, hypodermic flu immunization. A team of researchers at Georgia Institute of Technology and Emory University believes the new microneedle skin patch method of delivering flu vaccine could improve overall seasonal and pandemic vaccination coverage in people because of stronger immune responses, decreased pain, increased convenience, lower cost, and simpler logistics over conventional hypodermic immunization. |
| View Source | June 16, 2010 | Provides Information |
| Mild-mannered metabolic helper rushes to fight invading viruses, researchers report |
| Within cells, an ancient antiviral duo can deliver a one-two knockout to thwart invading viruses, report researchers who have just unmasked the cellular sidekick that throws the first punch. The findings mean scientists must rethink the design of antiviral immunity and how the body fends off viruses of all types, including influenza and HIV. |
| View Source | May 7, 2010 | Provides Information |
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| NIH Scientists Advance Universal Flu Vaccine |
| A universal influenza vaccine — so-called because it could potentially provide protection from all flu strains for decades — may become a reality because of research led by scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. |
| View Source | July 15, 2010 | Provides Information |
| Novavax reports positive results from Phase II study of trivalent VLP influenza vaccine in older adults |
| Novavax, Inc. reported today that its trivalent seasonal influenza virus-like-particle (VLP)-based vaccine candidate was safe and immunogenic against the 2009-2010 seasonal influenza virus strains in older adults 60 years or higher in age. |
| View Source | April 30, 2010 | Provides Information |
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| Obesity limits body's ability to fight infections |
| Obesity may limit the body's ability to develop immunity to influenza viruses, particularly secondary infections, by inhibiting the immune system's ability to "remember" how it fought off previous similar bouts of illness, according to new research from the University of North Carolina at Chapel Hill. |
| View Source | March 16, 2010 | Provides Information |
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| Pandemic Flu, Like Seasonal H1N1, Shows Signs of Resisting Tamiflu |
| If the behavior of the seasonal form of the H1N1 influenza virus is any indication, scientists say that chances are good that most strains of the pandemic H1N1 flu virus will become resistant to Tamiflu, the main drug stockpiled for use against it. |
| View Source | March 1, 2010 | Provides Information |
| Putting a Light on Influenza |
| For his graduating thesis at the Department of Industrial Design at University of Technology Eindhoven, Jan van der Asdonk dreamed up a novel idea for a product to visualize a flu for people with an ongoing disease. Inside a special capsule would be bioluminescent bacteria that would light up inside a transparent chamber when exposed to influenza virions. It's always proper to get a good eye on your enemy. |
| View Source | June 24, 2010 | Provides Information |
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| Researchers approaching universal treatment for all strains of influenza |
| Researchers at Mount Sinai School of Medicine have discovered a novel component of the influenza virus that may be the key to disabling the virus's ability to replicate itself and to developing a universal anti-viral treatment. The findings were published June 1 online in Proceedings of the National Academy of Sciences. |
| View Source | June 3, 2010 | Provides Information |
| Researchers move closer to a universal influenza vaccine |
| Researchers at Mount Sinai School of Medicine have developed a new influenza vaccine that brings science one step closer to a universal influenza vaccine that would eliminate the need for seasonal flu shots. The new findings can be found in the inaugural issue of mBio, the first online, open-access journal published by the American Society for Microbiology. |
| View Source | May 25, 2010 | Provides Information |
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| Scientists use computer algorithms to develop seasonal flu vaccines |
| Defeating the flu is challenging because the virus responsible for the disease undergoes frequent changes of its genetic code, making it difficult for scientists to manufacture effective vaccines for the seasonal flu in a timely manner. Now, a University of Miami (UM) computer scientist, Dimitris Papamichail, and a team of researchers from Stony Brook University have developed a rapid and effective approach to produce vaccines for new strains of influenza viruses. The researchers hope to develop the new technology and provide an efficient method to confront the threat of seasonal epidemics. |
| View Source | July 9, 2010 | Provides Information |
| Seasonal flu vaccinations reach record high |
| H1N1 fears spurred 40 percent of Americans to get regular flu shots in 2009 |
| View Source | April 29, 2010 | Provides Information |
| Seasonal influenza immunization rates among health-care workers |
| Campaigns to increase seasonal influenza vaccination rates amongst health care workers in Canada that include a combination of interventions had the greatest effect on increasing vaccine coverage, according to a study published in CMAJ (Canadian Medical Association Journal). |
| View Source | July 19, 2010 | Provides Information |
| Something in the air kills flu virus |
| A British company continues to offer a portable decontamination device that should come as breath of fresh air to a flue-weary public. |
| View Source | May 13, 2009 | Provides Information |
| Stony Brook team creates live attenuated influenza virus vaccine by computer-aided rational design |
| A team of molecular biologists and computer scientists at Stony Brook University have used a novel method to weaken (attenuate) influenza virus by way of designing hundreds of mutations to its genetic code to create an effective vaccine. Reported online and in the July issue of Nature Biotechnology, the method may be a major step in developing more effective and safe vaccines against influenza, which claims 250,000 to 500,000 lives annually worldwide, partly because existing vaccines are not fully effective. |
| View Source | June 17, 2010 | Provides Information |
| Strategies increase health-care worker vaccination rates -- protecting patients |
| Healthcare personnel influenza immunization rates have remained low, despite recommendations from the Centers for Disease Control and Prevention (CDC) and other leading healthcare organizations that all healthcare personnel receive annual flu vaccines. Experts say these levels are perilous. Increasing vaccination rates substantially improves patient safety, lowering flu deaths by 40 percent. |
| View Source | March 17, 2010 | Provides Information |
| Study finds that drugs used for treatment of influenza in pregnancy appear to be safe |
| Tamiflu and two other drugs used to treat influenza appear safe for pregnant women and their babies, researchers at UT Southwestern Medical Center have found in a retrospective study of 239 cases of women who received the medications during pregnancy. |
| View Source | April 27, 2010 | Provides Information |
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| Targeting Blood Vessels, Immune System May Offer Way to Stop Infection-Caused Inflammation |
| Treating virulent influenza, sepsis, and other potentially deadly infections long has focused on looking for ways to kill viruses and bacteria. But new research from the University of Utah and Utah State University shows that modulating the body's own overeager inflammatory response to infection may help save more lives. |
| View Source | March 17, 2010 | Provides Information |
| TCAD therapy superior to double combinations and monotherapy against influenza viruses |
| Adamas Pharmaceuticals, Inc., a privately held company, announced today results from in vivo animal studies and in vitro tests demonstrating that its triple combination antiviral drug (TCAD) therapy is superior relative to double combinations and monotherapy against multiple strains of pandemic and avian influenza viruses. Results of these studies were presented Sunday evening in an oral session at the XII International Symposium on Respiratory Viral Infections being held in Taipei. |
| View Source | March 15, 2010 | Provides Information |
| The Maximization of Vaccinations |
| How does vaccinating pregnant women against influenza affect their babies' health? That's what researcher Saad Omer wants to know. |
| View Source | April 30, 2010 | Provides Information |
| Time to get your flu shot, but just one this year |
| Health experts now urge vaccination for all, but will people heed advice? |
| View Source | August 30, 2010 | Provides Information |
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| Universal Treatment for All Strains of Influenza Within Sight |
| Researchers at Mount Sinai School of Medicine have discovered a novel component of the influenza virus that may be the key to disabling the virus's ability to replicate itself and to developing a universal anti-viral treatment. The findings were published June 1 online in Proceedings of the National Academy of Sciences. |
| View Source | June 4, 2010 | Provides Information |
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| Vaccinating children against flu helps protect wider community: study |
| Results of a clinical trial conducted in a largely self-contained religious community during the 2008-09 influenza season show that immunizing children against seasonal influenza can significantly protect unvaccinated community members against influenza as well. The study was conducted to determine if immunized children could act as a barrier to limit the spread of influenza to the wider, unvaccinated community, a concept known as herd immunity. |
| View Source | March 9, 2010 | Provides Information |