Health — Alzheimers — April 12th, 2024

Brain Boosters: 12 Memory-Enhancing Foods for Your Cognitive Health
These foods will help you maintain a healthy brain and may even prevent conditions like dementia.
April 12th, 2024 — Source

Health — Alzheimers — April 10th, 2024

Young-onset Alzheimer's: When symptoms begin before age 65
When Alzheimer's begins in middle age, misdiagnosis may be more likely. This rare form of Alzheimer's affects work, finances and family.
April 10th, 2024 — Source

Health — Alzheimers — April 5th, 2024

Human neuron model paves the way for new Alzheimer's therapies
Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer's disease and frontotemporal dementia. This new model has led to the identification of novel therapeutic targets that could potentially block tau spread.
April 5th, 2024 — Source or Source

Health — Alzheimers — April 2nd, 2024

Hospice care for those with dementia falls far short of meeting people's needs at the end of life, says physician
Jimmy Carter, who chose to forgo aggressive medical care for complications of cancer and frailty in February 2023, recently reached his one-year anniversary since enrolling in hospice care. During this time, he celebrated his 99th birthday, received tributes far and wide and stood by the side of his beloved wife, Rosalynn, who died in November 2023.
April 2nd, 2024 — Source

Ultrasound alone improves cognitive function in neurodegenerative disorders, UQ study finds
University of Queensland researchers have found targeting amyloid plaque in the brain is not essential for ultrasound to deliver cognitive improvement in neurodegenerative disorders.
April 2nd, 2024 — Source or Source

Health — Alzheimers — March 29th, 2024

High-resolution images reveal similarities in protein structures between Alzheimer's disease and Down syndrome
More than 90% of people with Down syndrome, the most common chromosomal disorder in humans and the most frequent genetic cause of intellectual disability, are diagnosed with Alzheimer's disease by ages 55--60.
March 29th, 2024 — Source

Health — Alzheimers — March 28th, 2024

Familial Alzheimer's disease transferred via bone marrow transplant in mice
Familial Alzheimer's disease can be transferred via bone marrow transplant, researchers show in the journal Stem Cell Reports. When the team transplanted bone marrow stem cells from mice carrying a hereditary version of Alzheimer's disease into normal lab mice, the recipients developed Alzheimer's disease—and at an accelerated rate.
March 28th, 2024 — Source

Generation of tau dephosphorylation-targeting chimeras for the treatment of tauopathies
Accumulation of pathologic tau protein plays a pivotal role in the neurodegeneration of Alzheimer's disease (AD) and many other tauopathies. Thus, amelioration of pathological tau aggregates in the brain is an important direction for the development of drugs.
March 28th, 2024 — Source

Patients with delirium more likely to develop dementia, finds study
University of Queensland researchers have found older patients who experience delirium are three times more likely to develop dementia. Professor Ruth Hubbard from UQ's Center for Health Services Research (CHSR) said the study also found that every episode of delirium increased the chance of developing dementia by 20%.
March 28th, 2024 — Source

Research links age-related inflammation, microglia and Alzheimer's disease
Stanford researchers have uncovered a potential role for a protein called TREM1 in the development of age-related inflammation, cognitive decline, and Alzheimer's disease. This discovery could pave the way for new therapeutic strategies to combat these conditions.
March 28th, 2024 — Source

Unlocking how to use mRNA to target Alzheimer's disease
Scientists at The Florey have developed an mRNA technology approach to target the toxic protein tau, which builds up in patients with Alzheimer's disease and other dementias.
March 28th, 2024 — Source

Health — Alzheimers — March 27th, 2024

Evolving brain sizes from 1930 to 1970 could signal decreased dementia risk, researchers say NewsGuard 100/100 Score
The development and upkeep of the human brain are influenced by both genetic factors and environmental conditions, which may subsequently impact the risk of dementia later in life. Thus, a recent study published in JAMA Neurology assessed whether there were changes in skull and brain size, as well as the thickness of the cortex, across individuals born between the years 1930 and 1970.
March 27th, 2024 — Source

Sex-specific blood biomarkers linked to memory changes in middle-aged adults: The Framingham heart study
Dementia refers to a set of symptoms marked by a decline in cognitive abilities, including memory, language, reasoning and everyday tasks. It can result from various causes, such as Alzheimer's disease, vascular problems, traumatic brain injuries and other health issues.
March 27th, 2024 — Source

Xenotransplantation model used for studying microglial response to Alzheimer's disease
Microglia are specialized immune cells in the brain. While they normally protect our brains, they can also contribute to neurodegenerative diseases such as Alzheimer's. The exact mechanism behind this contribution is not yet fully understood due to the complexities involved in studying them in human brain samples.
March 27th, 2024 — Source

Health — Alzheimers — March 25th, 2024

Newly discovered beneficial mutation in mitochondrial DNA seems to help Alzheimer's gene carriers live longer
Researchers at the USC Leonard Davis School of Gerontology have discovered a genetic mutation in a small mitochondrial protein that may promote longevity, preserve cognitive function, and protect against Alzheimer's disease among carriers of APOE4, a gene associated with a dramatic increase in the risk of developing Alzheimer's disease.
March 25th, 2024 — Source

Study adds new evidence on the link between Type 2 diabetes and Alzheimer's disease
New research conducted in mice offers insights into what's going on at the molecular level that could cause people with diabetes to develop Alzheimer's disease.
March 25th, 2024 — Source

Health — Alzheimers — March 22nd, 2024

Researchers describe tools to better understand CaMKII, a protein involved in brain and heart disease
Review of drugs targeting CaMKII will help better investigate its function
March 22nd, 2024 — Source

Health — Alzheimers — March 20th, 2024

Investigating racial and ethnic differences in Medicare costs for older adults with dementia
In an analysis of information on Medicare beneficiaries with dementia, Medicare expenditures were higher for Black and Hispanic individuals compared with whites. The Journal of the American Geriatrics Society analysis also found that expenditures were highest for Black beneficiaries in every phase of care.
March 20th, 2024 — Source

Nutrition and Alzheimer's disease may be linked, study finds
Malnutrition may increase a person's chances of contracting Alzheimer's disease, which in turn exacerbates malnutrition. That's according to a March 2024 study out of China published in Frontiers in Nutrition.
March 20th, 2024 — Source

Rural and minority dementia patients face disparities in access to neurologists, study finds
Getting dementia diagnosed can be a long and difficult process for anyone, but some may face additional challenges based on race or ethnicity and where they live, according to a study led by Washington State University researchers.
March 20th, 2024 — Source

Study shows barriers to dementia diagnosis based on race, ethnicity, and location
Getting dementia diagnosed can be a long and difficult process for anyone, but some may face additional challenges based on race or ethnicity and where they live, according to a study led by Washington State University researchers.
March 20th, 2024 — Source

The middle-aged brain changes a lot—and it's key to understanding dementia
Our brains change more rapidly at various times of our lives, as though life's clock was ticking faster than usual. Childhood, adolescence and very old age are good examples of this. Yet for much of adulthood, the same clock seems to tick fairly regularly. One lap around the sun; one year older.
March 20th, 2024 — Source

X-Ray activated nanoparticles halt Alzheimer's in study
A novel approach in the field of Alzheimer's research is emerging that could potentially transform how we tackle this debilitating disease. Recent studies have revealed a paradigm shift in understanding Alzheimer's pathology, emphasizing the importance of targeting the early-stage aggregation of the pathogenic amyloid beta (A-beta) protein, specifically focusing on its soluble oligomeric form.
March 20th, 2024 — Source

Health — Alzheimers — March 18th, 2024

A new approach to treating amyotrophic lateral sclerosis and frontotemporal dementia
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that commonly occur in middle-aged people. FTD is second only to Alzheimer's disease in terms of dementia prevalence. Both ALS and FTD arise from neuronal degeneration through mechanisms that remain unclear.
March 18th, 2024 — Source

Class of Alzheimer's drug presents unique challenge for patients with cardiovascular disease
A new Viewpoint article published in the Journal of the American Medical Association (JAMA), titled " Use of Lecanemab for Patients with Cardiovascular Disease—The Challenge of Uncertainty," advocates for additional research to improve decision making prior to initiating lecanemab, commercially known as Leqembi, an FDA-approved Alzheimer's Disease drug.
March 18th, 2024 — Source

New fluid biomarker may one day detect ALS and FTD before symptoms appear
Two progressively degenerative diseases, amyotrophic lateral sclerosis (ALS, commonly known as Lou Gehrig's disease) and frontotemporal dementia (FTD, recently in the news with the diagnoses of actor Bruce Willis and talk show host Wendy Williams), are linked by more than the fact that they both damage nerve cells critical to normal functioning -; the former affecting nerves in the brain and spinal cord leading to loss of movement, the latter eroding the brain regions controlling personality, behavior and language.
March 18th, 2024 — Source

Health — Alzheimers — March 15th, 2024

Researchers identify mutation that alters Alzheimer's disease progression
The scientist of the Faculty of Medicine of the University of Malaga José Luis Royo has coordinated a study that summarizes eight years of research and brings together 100 multidisciplinary specialists, identifying a mutation that alters Alzheimer's disease progression.
March 14th, 2024 — Source

Zebrafish discovery could speed testing of motor neuron diseas
Tiny, transparent fish have made it possible for Macquarie University neuroscientists to observe damaging protein clusters forming in real time, opening the way for testing potential early interventions for motor neuron disease (MND) and dementia.
March 14th, 2024 — Source

Health — Alzheimers — March 14th, 2024

A healthier diet is linked with a slower pace of aging, reduced dementia risk, study shows
A healthier diet is associated with a reduced dementia risk and slower pace of aging, according to a new study. The findings show that a diet-dementia association was at least partially facilitated by multi-system processes of aging. Until now, the biological
March 14th, 2024 — Source

Alzheimer's drug fermented with help from AI and bacteria moves closer to reality
Galantamine is a common medication used by people with Alzheimer's disease and other forms of dementia around the world to treat their symptoms. Unfortunately, synthesizing the active compounds in a lab at the scale needed isn't commercially viable. The active ingredient is extracted from daffodils through a time-consuming process, and unpredictable factors, such as weather and crop yields, can affect supply and price of the drug.
March 14th, 2024 — Source or Source

Concussion from explosive blasts may induce Alzheimer's biomarkers in middle-aged veterans
Middle-age veterans who experienced concussions due to blasts from explosive devices may have biomarkers in their spinal fluid similar to people who develop Alzheimer's disease, according to a new study published in the March 13, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology.
March 14th, 2024 — Source

One step back: Why the new Alzheimer's plaque-attack drugs don't work
On Jan. 31, aducanumab, a pricey drug approved for treatment of early-stage Alzheimer's disease, was withdrawn from the market. And in early March, the Food and Drug Administration delayed its decision regarding whether to approve a separate, closely similar drug. A prescient commentary by Stanford Medicine neurologist Mike Greicius, MD, in the Journal of Alzheimer's Disease goes a long way toward explaining why.
March 14th, 2024 — Source

Poor neighborhoods linked to elevated dementia risk and faster brain aging
Living in a poorer neighborhood is linked to accelerated brain aging and increased dementia risk early in life, regardless of income level or education, a Duke University-led study finds.
March 14th, 2024 — Source

Study highlights potential of p-tau217 assays in Alzheimer's clinical trials and diagnosis
In a recent study published in eBioMedicine, researchers compared the performance of two commercial phospho-tau217 (p-tau217) assays.
March 14th, 2024 — Source

Study shows a healthy diet is linked with a slower pace of aging, reduced dementia risk
A healthier diet is associated with a reduced dementia risk and a slower pace of aging, according to a new study at Columbia University Mailman School of Public Health and The Robert Butler Columbia Aging Center. The findings show that multi-system processes of aging at least partially facilitated a diet-dementia association.
March 14th, 2024 — Source

Health — Alzheimers — March 11th, 2024

Wrist device that monitors activity could help provide early warning of Alzheimer's
Monitoring daily activity patterns using a wrist-worn device may detect early warning signs of Alzheimer's disease, according to a recent study led by researchers at the Johns Hopkins Bloomberg School of Public Health.
March 11th, 2024 — Source

Wristwatch-like devices detect early signs of Alzheimer's
Monitoring daily activity patterns using a wrist-worn device may detect early warning signs of Alzheimer's disease, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health.
March 11th, 2024 — Source

Health — Alzheimers — March 8th, 2024

FDA delays decision on new Alzheimer's drug
Instead of approving the new Alzheimer's drug donanemab this month, as was expected, the U.S. Food and Drug Administration will now require the experimental medication be scrutinized more closely by an expert panel, the drug's maker said Friday.
March 8th, 2024 — Source

Highly awaited Alzheimer's drug hit by delays
Eli Lilly's highly anticipated Alzheimer's drug has been held back for further review by regulators, the US pharmaceutical giant said Friday, in a blow for patients with the devastating brain disorder.
March 8th, 2024 — Source

Health — Alzheimers — March 6th, 2024

People with essential tremor may have increased risk of dementia
Dementia may be three times more common among people with essential tremor, a movement disorder that causes involuntary shaking, than the general population, according to research released today, March 6, 2024.
March 6th, 2024 — Source

Social determinants of health increase Alzheimer's risk
Social determinants of health are increasing the risk of Alzheimer's disease and related dementia, finds a recent study from the Brown School and the School of Medicine at Washington University in St. Louis.
March 6th, 2024 — Source

Study could lead to new way to detect brain changes associated with Alzheimer's risk
New research suggests there is a link between abnormal blood levels of amyloid—a protein associated with Alzheimer's disease—and subtle changes in brain microstructures on a type of MRI, findings that could lead to a new way to detect Alzheimer's earlier in people with no clinical signs.
March 6th, 2024 — Source

Health — Alzheimers — March 1st, 2024

Better sleep is a protective factor against dementia
Dementia is a progressive loss of cognitive abilities, such as memory, that is significant enough to have an impact on a person's daily activities.
March 1st, 2024 — Source

Is posttraumatic epilepsy associated with long-term dementia risk?
Long-term dementia risk is associated with both head injury and epilepsy. However, research has thus far documented the links between post-traumatic epilepsy (PTE) and short-term cognitive outcomes.
March 1st, 2024 — Source

Study finds daily fiber supplement improves older adults' brain function in just 12 weeks
A daily fiber supplement improved brain function in people over 60 in just 12 weeks. The study, published recently in Nature Communications by researchers from the School of Life Course & Population Sciences showed that this simple and cheap addition to diet can improve performance in memory tests associated with early signs of Alzheimer's disease.
March 1st, 2024 — Source

Tiny magnetic particles in air pollution linked to development of Alzheimer's
Magnetite, a tiny particle found in air pollution, can induce signs and symptoms of Alzheimer's disease, new research suggests.
March 1st, 2024 — Source

Health — Alzheimers — February 28th, 2024

AI finds key signs that predict patient survival across dementia types
Researchers at the Icahn School of Medicine at Mount Sinai and others have harnessed the power of machine learning to identify key predictors of mortality in dementia patients.
February 28th, 2024 — Source

ChatGPT aids in discovering potential Alzheimer's treatments through drug repurposing
In a recent proof-of-concept study published in the journal npj Digital Medicine, researchers from the United States of America used generative artificial intelligence (GAI) in the form of ChatGPT-4 (short for Chat generative pre-trained transformer 4) to identify drug repurposing candidates against Alzheimer's disease (AD).
February 28th, 2024 — Source

How 40Hz sensory gamma rhythm stimulation clears amyloid in Alzheimer's mice
Studies at MIT and elsewhere are producing mounting evidence that light flickering and sound clicking at the gamma brain rhythm frequency of 40 Hz can reduce Alzheimer's disease (AD) progression and treat symptoms in human volunteers as well as lab mice.
February 28th, 2024 — Source

Promising pathways to simplified Alzheimer's diagnosis unveiled in new study
The Global Alzheimer's Platform Foundation (GAP) is releasing the first results from the Bio-Hermes-001 Study. This study of more than 1,000 community-based participants from throughout the U.S. compared the results of blood and digital biomarkers with brain amyloid PET scans or cerebrospinal fluid assays.
February 28th, 2024 — Source

Using machine learning to identify key predictors of mortality in dementia patients
Researchers at the Icahn School of Medicine at Mount Sinai and others have harnessed the power of machine learning to identify key predictors of mortality in dementia patients.
February 28th, 2024 — Source

Health — Alzheimers — February 27th, 2024

Abdominal fat depots can impact brain health and cognition in individuals at high risk for Alzheimer's disease
The impact of abdominal fat on brain health and cognition is generally more pronounced in middle-aged men at high risk of Alzheimer's disease than in women, according to researchers at Rutgers Health.
February 27th, 2024 — Source or Source

How frontotemporal dementia changes the brain: Research is untangling its genetic causes
About 55 million people worldwide suffer from dementia such as Alzheimer's disease. On Feb. 22, 2024, it was revealed that former talk show host Wendy Williams had been diagnosed with frontotemporal dementia, or FTD, a rare type of dementia that typically affects people ages 45 to 64.
February 27th, 2024 — Source

Health — Alzheimers — February 26th, 2024

A clearer image of glaucoma: The relationship between unfolding and aggregation for glaucoma-associated myocilin
From Parkinson's and Alzheimer's to cardiac arrhythmia, amyloids are linked to a number of diseases. These aggregates of proteins form in the body when a protein loses its normal structure and misfolds or mutates. And since many of these proteins are large and complicated, just how some of these mutations occur and aggregate remains a mystery—as does the creation of effective treatments.
February 26th, 2024 — Source

May I have a quick word? Study shows talking faster is linked to better brain health as we age
As we get older, we may start to notice it takes us longer to find the right words. This can lead to concerns about cognitive decline and dementia.
February 26th, 2024 — Source

Unlocking Alzheimer's secrets by studying neuropsychiatric symptoms
As the years add up, it's common to notice slight changes in our ability to remember and think. Older people who have more marked changes than their peers can be diagnosed with mild cognitive impairment (MCI). Currently, we can't easily predict which of these patients will develop Alzheimer's disease and which will not.
February 26th, 2024 — Source

What is frontotemporal dementia?
Frontotemporal dementia (FTD) is a group of neurologic disorders associated with changes in personality, behavior, language or movement. Some FTD forms are inherited, and some are not. Typically, people develop FTD symptoms before age 60.
February 26th, 2024 — Source

Yoga provides unique cognitive benefits to older women at risk of Alzheimer's disease, study finds
A new UCLA Health study found Kundalini yoga provided several benefits to cognition and memory for older women at risk of developing Alzheimer's disease, including restoring neural pathways, preventing brain matter decline, and reversing aging and inflammation-associated biomarkers—improvements not seen in a group who received standard memory training exercises.
February 26th, 2024 — Source

Health — Alzheimers — February 23rd, 2024

Cell engineering team links cancer drug to potential therapy for Alzheimer's disease
In experiments with lab-grown brain cells and mouse models, scientists at Johns Hopkins Medicine say they have discovered that a cell surface protein called Lag3 is not only a biological target for FDA-approved drugs that stimulate the immune system to attack cancer, but also may be a target for a drug designed to clean up "misfolded" Tau proteins linked to Alzheimer's disease.
February 23rd, 2024 — Source

Mouse study shows long COVID-19 infection linked with tangled protein that causes Alzheimer's disease
With a newly developed mouse model that more accurately represents human infection with COVID-19, Johns Hopkins scientists say they have found long-term infection with SARS-CoV-2 results in brain deposits of clumped and tangled Tau proteins commonly found in people with Alzheimer's disease.
February 23rd, 2024 — Source

Health — Alzheimers — February 21st, 2024

Alzheimer's disease: Viagra is seen as a potential treatment, but the research shows contradictory findings
A recent study reported that sildenafil, sold under the brand name Viagra, and other medicines from the same group called phosphodiesterase type-5 inhibitors may reduce the risk of Alzheimer's disease. But other research has found no effect.
February 21st, 2024 — Source

Heavy alcohol, drug use linked to increased risk of falls among people with HIV
The consequences of a fall can be devastating, particularly among people who are at higher risk of a fracture such as people with HIV. Alcohol consumption and drug use are important risk factors for falls or fractures, but there are no standard medical guidelines on the level of consumption or type of alcohol or other drug use (AOD) that increases one's risk for falls and fall-related injuries, particularly among populations with conditions that already affect balance.
February 21st, 2024 — Source

How AI can help spot early risk factors for Alzheimer's disease
UC San Francisco scientists have found a way to predict Alzheimer's disease up to seven years before symptoms appear by analyzing patient records with machine learning.
February 21st, 2024 — Source

Researchers design novel drug delivery system that could reverse Alzheimer's disease impact
University of North Carolina at Chapel Hill researchers have developed a new drug delivery platform that harnesses helical amyloid fibers designed to untwist and release drugs in response to body temperatures.
February 21st, 2024 — Source

Researchers develop molecules for a new class of antibiotics that can overcome drug resistant bacteria
About a decade ago, researchers in UC Santa Barbara chemistry professor Guillermo Bazan's lab began to observe a recurring challenge in their research: Some of the compounds they were developing to harness energy from bacteria were instead killing the microbes. Not good if the objective of the project was to harness the metabolism of living bacteria to produce electricity.
February 21st, 2024 — Source

Health — Alzheimers — February 19th, 2024

Drug repairs systems that remove Alzheimer's-causing waste from the brain, study shows
A team of Rutgers undergraduates has shown that an experimental drug known as Yoda1 may help drain cranial waste plus neurotoxins that cause Alzheimer's disease and other forms of dementia.
February 19th, 2024 — Source

Inside the plan to diagnose Alzheimer's in people with no memory problems and who stands to benefit
In a darkened Amsterdam conference hall this summer, a panel of industry and academic scientists took the stage to announce a plan to radically expand the definition of Alzheimer's disease to include millions of people with no memory complaints.
February 19th, 2024 — Source

Team develops highly accurate universal diagnostic blood test for Alzheimer's disease and mild cognitive impairment
An HKUST-led international research collaboration has achieved a significant milestone in Alzheimer's disease (AD) diagnosis and management. The team has developed a cutting-edge blood test for the early detection of AD and mild cognitive impairment (MCI), surpassing remarkable accuracy rates of over 96% and 87% respectively.
February 19th, 2024 — Source

Health — Bacteria & Viruses — February 16th, 2024

Bacteria in the Arctic seabed are active all year round, researchers find
Despite the pronounced seasonality in their habitat, the bacterial community in Arctic sediments is taxonomically and functionally very stable.
February 16th, 2024 — Source

Brazil's health agents scour junkyards and roofs for mosquitos to fight dengue epidemic
The small team of state public health workers slalomed between auto parts strewn across a Rio de Janeiro junkyard, looking for standing water where mosquitoes might have laid their eggs.
February 16th, 2024 — Source

High vaccination coverage key against expected increase of measles cases in the EU/EEA
Measles cases are expected to continue increasing in the European Union and European Economic Area (EU/EEA) in the coming months due to sub-optimal vaccination coverage for measles-containing vaccines (MCV) in a number of EU/EEA countries, the high probability of importation from areas experiencing high circulation and the fact that the coming months represent the seasonal peak of the virus.
February 16th, 2024 — Source

Newly discovered bacterial defense system functions as self-destruct button
Wageningen researchers have discovered a molecular self-destruct mechanism in a bacterium living on seaweed. With this mechanism the bacteria sacrifice themselves when they are infected, thus protecting their brothers and sisters from infections. By reprogramming this mechanism, researchers aim to utilize it in diagnostic (self-)tests. The study is published in Science.
February 16th, 2024 — Source

Q&A: Pork, pathogens and progress—a close look at PRRSV research
The pork industry provides people across different cultures a considerable source of protein, essential nutrients and a versatile ingredient for diverse culinary traditions. So, when the problem of porcine reproductive and respiratory syndrome virus (PRRSV) infection in the pork industry results in an economic loss of $650 million annually in the United States, finding a solution is of critical significance.
February 16th, 2024 — Source

Researchers investigate how the mpox virus infiltrates brain cells
A multidisciplinary team at the University of Alberta is seeking to understand how monkeypox (mpox) virus may be causing neurological symptoms in people affected by the global outbreak of mpox disease, declared by the World Health Organization in 2022.
February 16th, 2024 — Source

Review shares 'state-of-the-art' knowledge about fungal disease
A review paper, published in the New England Journal of Medicine, focuses on how fungal diseases present in people with healthy immune systems and examines current diagnostics and treatments.
February 16th, 2024 — Source

The hepatitis E virus: New insights into targeted treatment and diagnosis
Common symptoms of liver inflammation caused by hepatitis E viruses (HEV) include fever, abdominal pain, pale stools, nausea, and jaundice. Individuals at risk for this infection include persons with weakened immune systems (immunocompromised) as well as pregnant women. Immunocompromised patients often suffer from chronic infections, which is a larger problem for the Global North.
February 16th, 2024 — Source

Health — Alzheimers — February 16th, 2024

Exploring the potential of a novel PET-tracer in spotting early signs of Alzheimer's disease
Researchers at Karolinska Institutet have made exciting discoveries about Alzheimer's disease, a common form of dementia affecting millions of people around the world. In a study published in Alzheimer's & Dementia, they have explored the potential of novel synaptic PET-tracer UCB-J as an important early diagnostic biomarker/tool for Alzheimer's disease.
February 16th, 2024 — Source

New genetic therapy shows promise for motor neuron disease and frontotemporal dementia
Macquarie University neuroscientists have developed a single-dose genetic medicine that has been proven to halt the progression of both motor neuron disease (MND) and frontotemporal dementia (FTD) in mice—and may even offer the potential to reverse some of the effects of the fatal diseases.
February 16th, 2024 — Source

Health — Alzheimers — February 14th, 2024

New study confirms double the risk of dementia after mouth herpes simplex virus
People who have had the herpes virus at some point in their lives are twice as likely to develop dementia compared to those who have never been infected. A new study from Uppsala University confirms previous research on whether herpes can be a possible risk factor for dementia.
February 14th, 2024 — Source

Health — Alzheimers — February 12th, 2024

Protein biomarkers predict dementia 15 years before diagnosis, according to new study
In the largest study of its kind, scientists have shown how protein "biomarkers" predict dementia 15 years before diagnosis.
February 12th, 2024 — Source

Protein modifications found to be key influencers in neurodegenerative diseases
Neurodegenerative diseases, such as Alzheimer's and Parkinson's, present a significant health challenge, affecting over 50 million people globally. One common feature of these diseases is the accumulation of misfolded protein aggregates in the brain, known as amyloid fibrils, which disrupt normal cell function and eventually lead to cell death.
February 12th, 2024 — Source

Health — Alzheimers — February 9th, 2024

Dementia care costs can quickly burn through people's savings: Study
Dementia care can eat through the savings of cash-strapped seniors, a new study warns.
February 9th, 2024 — Source

Language barriers could contribute to higher aggression in people with dementia
Researchers from ECU's Center for Research in Aged Care and HammondCare's The Dementia Center noted that behaviors and psychological symptoms of dementia (BPSD), such as agitation and aggression, are common; however, its presentation may be influenced by the cultural background of the person.
February 9th, 2024 — Source

Men using erectile dysfunction drugs less likely to develop Alzheimer's disease
Drugs commonly used to treat erectile dysfunction may reduce the risk of Alzheimer's disease, finds a new study led by UCL researchers.
February 9th, 2024 — Source

Protein accumulation on fat droplets implicated in late-onset Alzheimer's disease
UNC School of Medicine researcher Sarah Cohen, Ph.D., and Ian Windham, a former Ph.D. student from the Cohen lab, have made a new discovery about apolipoprotein E (APOE)—the biggest genetic risk factor for late-onset Alzheimer's disease.
February 9th, 2024 — Source

Health — Alzheimers — February 7th, 2024

Do lifestyle factors affect late-life cognition and dementia pathology impact?
In a recent study published in the journal JAMA Neurology, scientists from the Rush University Medical Center in Chicago, United States, investigated whether brain pathology related to dementia, such as cerebrovascular pathology, phosphorylated tau fibril tangles, and &beta-amyloid accumulation, modify the association between healthy lifestyle choices and cognition during the later years in life.
February 7th, 2024 — Source

Erectile dysfunction drugs may be linked to reduced risk of Alzheimer's disease
The drugs used to treat erectile dysfunction may also be associated with a reduced risk of Alzheimer's disease, according to a study published in Neurology. The study does not prove that erectile dysfunction drugs reduce the risk of Alzheimer's disease. It only shows an association.
February 7th, 2024 — Source

Health — Alzheimers — February 5th, 2024

Hearing impairment may lead to depression, isolation, dementia
If you've ever found yourself repeating parts of a conversation for an older person or walking into a room where they've turned the TV up full blast, you might have discovered more than just a typical byproduct of aging.
February 5th, 2024 — Source

Health — Alzheimers — February 2nd, 2024

How a natural protein can help fight Alzheimer's disease
A new study published in Nature Communications gives insights into the underlying mechanisms of the formation of protein clumps in Alzheimer's disease. The study, led by researchers from Karolinska Institutet, could pave the way for new treatments for this devastating neurodegenerative disorder.
February 2nd, 2024 — Source

What are the early signs of dementia, and how does it differ from normal aging?
Forgetting names and misplacing items happen to us all, more so as we age.
February 2nd, 2024 — Source

Health — Alzheimers — February 1st, 2024

Dementia risk can be the highest in the first year after stroke
Having a stroke may significantly increase the risk of developing dementia. The risk of dementia was the highest in the first year after a stroke and remained elevated over a period of twenty years, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2024.
February 1st, 2024 — Source

Research finds risk of dementia nearly three times higher the first year after a stroke
Having a stroke may significantly increase the risk of developing dementia.
February 1st, 2024 — Source

Scientists discover a potential way to repair synapses damaged in Alzheimer's disease
While newly approved drugs for Alzheimer's show some promise for slowing the memory-robbing disease, the current treatments fall far short of being effective at regaining memory. What is needed are more treatment options targeted to restore memory, said Buck Institute for Research on Aging Assistant Professor Tara Tracy, Ph.D., the senior author of a study that proposes an alternate strategy for reversing the memory problems that accompany Alzheimer's disease and related dementias.
February 1st, 2024 — Source

Health — Alzheimers — January 31st, 2024

Abnormal proteins found in the spinal fluid of people with ALS and frontotemporal dementia
Proteins could serve as biomarkers that improve diagnosis and guide the development of novel therapies.
January 31, 2024 — Source

Biogen pulls controversial Alzheimer's drug Aduhelm
A controversial Alzheimer's drug that was trumpeted as the first to ever treat the cognitive decline associated with the devastating brain disorder has been pulled from the market, its maker Biogen announced Wednesday.
January 31, 2024 — Source

Computer-designed proteins allow for tunable hydrogels that can form both inside and outside of cells
When researchers want to study how COVID makes us sick, or what diseases such as Alzheimer's do to the body, one approach is to look at what's happening inside individual cells. Researchers sometimes grow the cells in a 3D scaffold called a "hydrogel." This network of proteins or molecules mimics the environment the cells would live in inside the body.
January 31, 2024 — Source

Meat-based and processed foods foods linked to Alzheimer's
A study has found a strong link between Alzheimer's disease and the daily consumption of meat-based and processed foods. Researchers at Bond University came to the conclusion after examining the diets of 438 Australians—108 with Alzheimer's and 330 in a healthy control group.
January 31, 2024 — Source

New initiative aims to transform how Alzheimer's disease is diagnosed, treated across healthcare settings
The AD-RIDDLE programme will offer healthcare professionals a suite of validated solutions for timely detection and diagnosis of Alzheimer's disease and dementias, to match individuals with the right interventions at the right time, enabling people to better understand what they can do to reduce risk and prevent cognitive decline.
January 31, 2024 — Source

Researchers hack neurons' internal clocks to accelerate the study of neurological diseases
The neurons that make up our brains and nervous systems mature slowly over many months. And while this may be beneficial from an evolutionary standpoint, the slow pace makes growing cells to study neurodegenerative and neurodevelopmental diseases—like Parkinson's disease, Alzheimer's disease, and autism—in the laboratory quite challenging.
January 31, 2024 — Source

Study finds 1 in 10 veterans diagnosed with dementia may instead have cognitive decline from cirrhosis
As many as 10% of older U.S. veterans diagnosed with dementia may suffer instead from reversible cognitive decline caused by advanced liver disease, according to an analysis from the Virginia Commonwealth University's School of Medicine and the Richmond VA Medical Center.
January 31, 2024 — Source

Health — Alzheimers — January 29th, 2024

Alzheimer's disease acquired from historic medical treatments
Five cases of Alzheimer's disease are believed to have arisen as a result of medical treatments decades earlier, reports a team researchers.
January 29, 2024 — Source

Overcoming the stigma: Study recommends steps to move past barriers of brain health conversation
Approximately four of five primary care clinicians consider themselves on the front lines of brain health. In the U.S., clinicians are the first point of contact for patients worried about memory loss and are most likely the first to detect and evaluate patients experiencing mild cognitive impairment, Alzheimer's disease or related dementias.
January 29, 2024 — Source

Re-energizing mitochondria to treat Alzheimer's disease
Nerve cells in the brain demand an enormous amount of energy to survive and maintain their connections for communicating with other nerve cells. In Alzheimer's disease, the ability to make energy is compromised, and the connections between nerve cells (called synapses) eventually come apart and wither, causing new memories to fade and fail.
January 29, 2024 — Source

Researchers discover Alzheimer's disease cases acquired from past medical treatments
Five cases of Alzheimer's disease are believed to have arisen as a result of medical treatments decades earlier, reports a team of UCL and UCLH researchers.
January 29, 2024 — Source

Health — Alzheimers — January 26th, 2024

Nasopharyngeal lymphatics found to be crucial for draining cerebrospinal fluid from the brain
In a study published in Nature, South Korean researchers led by Director Koh Gou Young of the Center for Vascular Research within the Institute for Basic Science (IBS) have uncovered a distinctive network of lymphatic vessels at the back of the nose that plays a critical role in draining cerebrospinal fluid (CSF) from the brain.
January 26, 2024 — Source

New tool helps predict progression of Alzheimer's
About 55 million people worldwide are living with dementia, according to the World Health Organization. The most common form is Alzheimer's disease, an incurable condition that causes brain function to deteriorate.
January 26, 2024 — Source

Health — Alzheimers — January 24th, 2024

Protein TDP-43 keeps genetic zombies at bay: New insights into neurodegenerative disease mechanisms
A new Cell Reports paper from Bing Yao's lab in Emory's Department of Human Genetics provides insights into mechanisms underlying several neurodegenerative diseases, such as ALS (amyotrophic lateral sclerosis) and Alzheimer's.
January 24, 2024 — Source

Health — Alzheimers — January 22nd, 2024

A newly characterized form of tau may be involved in initiating Alzheimer's disease
The tau protein accumulates in abnormal shapes in the brains of individuals with Alzheimer's disease (AD), but the early steps of tau misfolding and aggregation are unknown.
January 22, 2024 — Source

Discovery of toxic and protective short RNAs associated with Alzheimer's disease and superior memory capacity
In a recent study published in Nature Communications, a group of researchers explored how Death Induced by Survival gene Elimination (DISE) through the analysis of ribonucleic acid (RNA)-induced silencing complex (RISC)-bound short RNAs (R-sRNAs) in Alzheimer's disease (AD) models, influences neuronal survival and correlates with neurotoxicity in AD.
January 22, 2024 — Source

How To Restore Your Facebook Account If You Can't Get Into Your Old Email Address
Most of us have had our Facebook accounts for so long that we may not even know what email address we used to sign up, or if we do know the address, we may no longer have access to it. For example, if you opened your account with a work or college issued email address, you may have lost access to the one associated with your Facebook account post-graduation or after changing jobs
January 22, 2024 — Source

Neuroticism Isn't Funny and May Impact Your Health
In the 1979 comedy Manhattan, Mary (played by Diane Keaton) tells Isaac (Woody Allen) to vent his frustrations so they can finally get their feelings out in the open. “I don't get angry,” Isaac replies. “I grow a tumor instead.”
January 22, 2024 — Source

Thinning brain tissue predicts dementia up to a decade before symptoms
A ribbon of brain tissue called cortical gray matter grows thinner in people who go on to develop dementia, and this appears to be an accurate biomarker of the disease five to 10 years before symptoms appear, researchers from The University of Texas Health Science Center at San Antonio (also called UT Health San Antonio) reported.
January 22, 2024 — Source

Thinning of brain region may signal dementia risk 5–10 years before symptoms
A ribbon of brain tissue called cortical gray matter grows thinner in people who go on to develop dementia, and this appears to be an accurate biomarker of the disease five to 10 years before symptoms appear, researchers from The University of Texas Health Science Center at San Antonio (also called UT Health San Antonio) report.
January 22, 2024 — Source

Health — Alzheimers — January 19th, 2024

Don't look back: The aftermath of a distressing event is more memorable than the lead-up
The moments that follow a distressing episode are more memorable than the moments leading up to it
January 19, 2024 — Source

New links revealed between late-onset Alzheimer's disease and the immune system
Researchers have revealed new links between Alzheimer's disease and the blood-brain barrier, finding connections between variants of a gene called EphA1 and the disease.
January 19, 2024 — Source

Treating Alzheimer's, Parkinson's, type 2 diabetes by eliminating protein aggregation in brain, pancreas
Purdue University researchers have taken the first steps to treat Alzheimer's disease, Parkinson's disease and Type 2 diabetes by creating multiple patent-pending compounds shown to inhibit protein aggregation associated with those diseases.
January 19, 2024 — Source

Understanding the impact of a dementia board game
Specialist dementia researchers from the University of Liverpool have seen positive initial findings when analyzing the outcomes of a board game that shines a light on dementia inequalities. Their paper, "Co-producing a boardgame to learn and engage about dementia inequalities: First impacts on knowledge in the general population," was published in Health Expectations.
January 19, 2024 — Source

Health — Alzheimers — January 12th, 2024

Study reveals function of little-understood synapse in the brain
New research from Oregon Health & Science University for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications for conditions ranging from multiple sclerosis to Alzheimer's disease, to a type of brain cancer known as glioma.
January 12, 2024 — Source

The FDA has reportedly approved an AI product that predicts cognitive decline
BrainSee assigns a score forecasting the advancement of memory loss within five years.
January 12, 2024 — Source

Health — Alzheimers — January 13th, 2024

Differences in cerebrospinal fluid of Alzheimer's patients suggests possibility of variants
A large team of neuroscientists and neurodegenerative disease specialists affiliated with multiple entities across the Netherlands, working with colleagues from the U.S., Belgium, the U.K. and Sweden, has found five categories of fluid surrounding the brain in Alzheimer's patients.
January 13, 2024 — Source

Health — Alzheimers — January 11th, 2024

Flagging dementia patients for better hospital care
Cedars-Sinai investigators are using electronic health records to identify hospitalized patients likely to have dementia. The method they developed, detailed in a study published in the Journal of the American Geriatrics Society, is designed to help medical staff tailor care to best serve these patients.
January 11, 2024 — Source

Health — Alzheimers — January 10th, 2024

Ancient DNA reveals reason for high multiple sclerosis and Alzheimer's rates in Europe
Researchers have created the world's largest ancient human gene bank by analyzing the bones and teeth of almost 5,000 humans who lived across western Europe and Asia up to 34,000 years ago.
January 10, 2024 — Source

'Exhausted' immune cells may drive Alzheimer's
Mice reach the twilight of their lives at around age two, the rough equivalent of 80 in human years. And when researchers introduce specific mutations into mice and then age them up, the mice can grow forgetful and irritable—eventually exhibiting signs of Alzheimer's disease not unlike that of many elderly humans.
January 10, 2024 — Source

Study: Amyloid-&beta protein affects cognitive decline after small-sized cerebral infarction
A research team has confirmed that brain amyloid-&beta (A&beta) deposition, a biomarker for Alzheimer's disease, is an essential predictor for post-stroke cognitive impairment (PSCI) development and cognitive decline after small-sized cerebral infarction.
January 10, 2024 — Source

Health — Alzheimers — January 9th, 2024

Different biological variants discovered in Alzheimer's disease
Dutch scientists have discovered five biological variants of Alzheimer's disease, which may require different treatments. As a result, previously tested drugs may incorrectly appear to be ineffective or only minimally effective. This is the conclusion of researcher Betty Tijms and colleagues from Alzheimer Center Amsterdam, Amsterdam UMC and Maastricht University.
January 9, 2024 — Source

Examining molecular biomarkers to diagnose vascular cognitive impairment and dementia
A recent study from UNSW Sydney's Center for Healthy Brain Aging (CHeBA) suggests that the research pace into understanding biomarkers for the diagnosis of vascular cognitive impairment and dementia needs to be accelerated.
January 9, 2024 — Source

Photostimulation of lymphatic clearance of &beta-amyloid: A new strategy for Alzheimer's disease therapy
Alzheimer's disease (AD) is an age-related neurodegenerative disorder. &beta-amyloid (A&beta) deposition in the brain is a crucial contributor to the pathogenesis of AD, mitigating excessive cerebral A&beta burden has been considered as a possible therapeutic strategy for AD.
January 9, 2024 — Source

Health — Alzheimers — January 8th, 2024

A new platform to fast-track lifesaving brain research
An international team led by Australian researchers has developed a platform that could transform neuroimaging data analysis worldwide. The Neurodesk platform will enable scientists to accelerate research on conditions such as epilepsy, dementia, schizophrenia and traumatic brain injury by enabling faster processing and analysis of neuroimaging data.
January 8, 2024 — Source

Bariatric surgery may mitigate the natural history of cognitive decline in people with obesity
Within the next 10 years, it's projected that up to 50% of United States adults will be affected by obesity, which is associated with cognitive impairment and dementia.
January 8, 2024 — Source or Source

'Disease in a dish' model sheds light on the triggers for some forms of dementia
New understanding of a gene that is linked to some forms of dementia and other age-related diseases gives scientists fresh hope that action can be taken against these diseases long before the onset of symptoms.
January 8, 2024 — Source

High-quality nursing home dementia care is not only a matter of adding staff, says study
Additional staffing alone will not be sufficient to bridge the quality-of-care and health outcome disparities among nursing home facilities with varying percentages of residents with dementia, according to a first-of-its-kind study led by the University of California, Irvine. Specialized training, an easy-to-navigate environment and staff stability are also critical to meeting the unique challenges presented by this population.
January 8, 2024 — Source

Health — Alzheimers — January 8th, 2024

Gut microbiota: the new frontier in Alzheimer's disease research and therapy
In a review published in the Experimental & Molecular Medicine journal, researchers discussed the current evidence of the role of gut microbiota in Alzheimer's disease (AD) pathogenesis.
January 8, 2024 — Source

Health — Alzheimers — January 5th, 2024

Hearing loss increases the risk of dementia
In a new study featuring data from 573,088 people, researchers have found a link between hearing loss and the development of dementia. The study is the largest of its kind to date.
January 5, 2024 — Source

Health — Alzheimers — December 29th, 2023

Alzheimer's discovery reveals dire effect of toxic tau protein on brain cells
Researchers have discovered how harmful tau proteins damage the essential operating instructions for our brain cells, a finding which could lead to new treatments.
December 29, 2023 — Source

Brain lesions in former football players linked to vascular, brain changes
Signs of injury to the brain's white matter called white matter hyperintensities, as seen on brain scans, may be tied more strongly to vascular risk factors, brain shrinkage, and other markers of dementia in former tackle football players than in those who did not play football.
December 29, 2023 — Source

Experimental therapy eases Alzheimer's signs, symptoms in mice
A new cellular therapy improved learning and memory in mice with Alzheimer's disease, researchers report.
December 29, 2023 — Source

Health — Alzheimers — December 27th, 2023

Artificial intelligence lowers the barrier to ultrasound brain disease treatment
Focused ultrasound technology is a non-invasive treatment method that focuses ultrasound energy on a few millimeters of the brain, including deep regions, to treat neurological disorders without opening the skull. It has been applied to the treatment of various intractable brain diseases such as depression and Alzheimer's disease because it minimizes the impact on the surrounding healthy tissue and reduces side effects such as complications and infections.
December 27, 2023 — Source

Daily learning test can detect Alzheimer's disease-related changes in memory among cognitively normal older adults
Detecting cognitive changes associated with Alzheimer's disease in older adults can be difficult in early stages of disease, but daily testing on smartphones may provide a less time-consuming and less labor-intensive way to reveal amyloid-related changes in memory.
December 27, 2023 — Source

Negative wealth shock linked to accelerated cognitive decline
For older adults, negative wealth shock is associated with accelerated cognitive decline and increased risks for dementia, according to a study published online Dec. 26 in JAMA Network Open.
December 27, 2023 — Source

Health — Alzheimers — December 26th, 2023, 2023

Increased &beta-amyloid accumulation may be linked to Alzheimer's dementia risk in oldest of the old
A new study indicates that severity of amyloid deposition in the brain -; not just age -; may be key to determining who will benefit from new anti-amyloid therapies to delay the progression of Alzheimer's disease.
December 26, 2023 — Source

Risk of young-onset dementia could be reduced through targeting health and lifestyle factors, finds study
Researchers have identified a wide range of risk factors for young-onset dementia. The findings challenge the notion that genetics are the sole cause of the condition, laying the groundwork for new prevention strategies.
December 26, 2023 — Source

Health — Alzheimers — December 22nd, 2023

Predicting Alzheimer's dementia in oldest of the old
A new study indicates that severity of amyloid deposition in the brain—not just age—may be key to determining who will benefit from new anti-amyloid therapies to delay the progression of Alzheimer's disease.
December 22, 2023 — Source

Health — Alzheimers — December 21st, 2023

Midlife blood test may predict cognitive decline, Alzheimer's in later life
Researchers from the University of Michigan have connected two blood biomarkers to changes in cognitive function in women in midlife, opening a potentially powerful path to noninvasive, earlier detection and interventions for Alzheimer's disease and other dementias.
December 21, 2023 — Source

Health — Alzheimers — December 19th, 2023

Alzheimer's discovery reveals dire effect of toxic tau protein
Alzheimer's disease researchers at the University of Virginia have discovered how harmful tau proteins damage the essential operating instructions for our brain cells, a finding that could lead to new treatments.
December 19, 2023 — Source

Health — Alzheimers — December 15th, 2023

'Financial Ruin Is Baked Into the System': Readers on the Costs of Long-Term Care
Thousands of readers reacted to the articles in the "Dying Broke" series about the financial burden of long-term care in the United States. They offered their assessments for the government and market failures that have drained the lifetime savings of so many American families. And some offered possible solutions.
December 15, 2023 — Source

Study shows COVID-19 infection alters gene transcription of olfactory mucosal cells in Alzheimer's disease
A new study identifies alterations in the transcriptomic signatures in human olfactory mucosal cells of individuals with Alzheimer's disease following SARS-CoV-2 infection, potentially contributing to exacerbated COVID-19 outcomes. The study was conducted at the University of Eastern Finland in collaboration with the University of Helsinki and published in Journal of Neuroinflammation.
December 15, 2023 — Source

Health — Alzheimers — December 12th, 2023

Two biomarkers in saliva could provide a means to detect pain in people with dementia
A team from the UCO's Nursing Department has determined the presence of two pain biomarkers and their levels in saliva as a tool to diagnose pain, effectively and non-invasively, in people with dementia and communication problems
December 12, 2023 — Source

Health — Alzheimers — December 11th, 2023

Alzheimer's in one sibling raises risk of shortened lifespan in others
An Alzheimer's diagnosis in a sibling raises the risk of a shortened lifespan in other family members—even those without dementia, according to new USC research based on data from the Swedish Twin Registry.
December 11, 2023 — Source

Clues to preventing Alzheimer's come from patient who evaded disease, despite genetics
Alzheimer's disease has plagued one large Colombian family for generations, striking down half of its members in the prime of life. But one member of that family evaded what had seemed would be fate: Despite inheriting the genetic defect that caused her relatives to develop dementia in their 40s, she stayed cognitively healthy into her 70s.
December 11, 2023 — Source

Nanoparticle-delivered RNA reduces neuroinflammation in lab tests
In mice and human cell cultures, researchers showed that novel nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer's disease.
December 11, 2023 — Source

Health — Alzheimers — December 8th, 2023

CRISPR-based gene editing therapy approved by the FDA for the first time
Authorities have greenlit two new drugs that treat sickle cell disease.
December 8, 2023 — Source

Health — Alzheimers — December 6th, 2023

Light therapy may improve symptoms of Alzheimer's disease
Light therapy leads to significant improvements in sleep and psycho-behavioral symptoms for patients with Alzheimer's disease, according to a new study published in PLOS ONE by Qinghui Meng of Weifang Medical University, China, and colleagues.
December 6, 2023 — Source

New protein linked to early-onset dementia identified
Scientists have identified abnormal aggregates of a protein called TAF15 in the brains of individuals with early-onset dementia, known as frontotemporal dementia, where the cause was not previously known.
December 6, 2023 — Source

Study finds cilostazol is well tolerated but doesn't prevent cognitive decline
A recent study demonstrated the safety of cilostazol in patients with mild cognitive impairment, but did not demonstrate any efficacy in preventing disease progression. However, after administration of cilostazol, the blood concentrations of the albumin and &beta-amyloid complex increased in the treated patients compared with those receiving placebo.
December 6, 2023 — Source

Twice daily electrical stimulation boosts brain plasticity and improves memory in Alzheimer's patients
Twice daily non-invasive electrical stimulation of the brain may boost mental processes (cognitive function) in people with Alzheimer's disease, suggest the results of a small clinical trial published online in the open access journal General Psychiatry.
December 6, 2023 — Source

Health — Alzheimers — December 5th, 2023

Cell-type-specific genetic risk contributes to distinct stages of Alzheimer's disease progression, finds study
Developing treatments for Alzheimer's disease (AD) is difficult because complex underlying mechanisms drive different types of cells that may contribute to the disorder. Microglia and astrocytes, resident immune and support cells in the central nervous system, are known to exclusively express several genes linked to the risk of AD—particularly AD dementia.
December 5, 2023 — Source

Health — Alzheimers — December 4th, 2023

Four tips to help your loved one with dementia enjoy the festive season
The festive season is fast approaching, and if you're organizing celebrations with family or friends, you might be grappling with a seemingly endless to-do list. But as you make these plans, it's important to consider how you can best include any friends or loved ones living with dementia.
December 4, 2023 — Source

Neuroimaging and network modeling tools shed light on Alzheimer's disease in animal models
Indiana University researchers are collaborating on a novel approach to use neuroimaging and network modeling tools-;previously developed to analyze brains of patients in the clinic-;to investigate Alzheimer's disease progression in preclinical animal models.
December 4, 2023 — Source

'Salty' immune cells surrounding the brain linked to hypertension-induced dementia
A study suggests that the response of immune system cells inside the protective covering surrounding the brain may contribute to the cognitive decline that can occur in a person with chronic high blood pressure. This finding, published in Nature Neuroscience, may shed light on new ways to counteract the effects of high blood pressure on cognition.
December 4, 2023 — Source

Salty immune cells surrounding the brain linked to hypertension-induced dementia
Possible new target for high blood pressure treatments
December 4, 2023 — Source

Study finds visions of nonphysical world are common among cognitively healthy Ojibwe individuals
Visual hallucinations are common among people with Lewy body dementia and other types of dementia. Identifying visual hallucinations is an important component of a wide variety of medical and psychiatric diagnoses and treatments, but without cultural context, some patients' symptoms can be misinterpreted or misdiagnosed.
December 4, 2023 — Source

Understanding diet's role in modifying risk of Alzheimer's disease
In a detailed study, "Diet's Role in Modifying Risk of Alzheimers Disease: History and Present Understanding

" published in the Journal of Alzheimer's Disease, we can finally see which diets are helpful in reducing the risk of developing Alzheimer's disease. The role of diet in modifying the risk of Alzheimer's disease is discussed in detail.
December 4, 2023 — Source

What is the difference between Alzheimer's and dementia?
Alzheimer's and related forms of dementia are commonplace with the Centers for Disease Control and Prevention reporting that 5.8 million people in the United States live with these diseases. This number is expected to rise to 14 million by 2060.
December 4, 2023 — Source

Health — Alzheimers — December 1st, 2023

Coverage of Bruce Willis' frontotemporal degeneration shows media misconstrues the disease
A new paper in Innovation in Aging shows that a great deal of media coverage of the actor Bruce Willis' condition, frontotemporal degeneration, was inaccurate, revealing the public's limited knowledge of the disease.
December 1, 2023 — Source

Study evaluates personality predictors of dementia diagnosis and neuropathology
In a recent study published in Alzheimer's & Dementia, researchers analyzed individual-level data from multiple studies to develop Bayesian models to test whether the Big Five personality traits and subjective well-being (SWB) differentially predict dementia diagnoses and neuropathology at autopsy.
December 1, 2023 — Source

Health — Alzheimers — November 30th, 2023

Here are 10 early-career scientists you should know about in 2023
This year's SN 10: Scientists to Watch are shaping our future and our understanding of ourselves
November 30, 2023 — Source

Individuals with high Alzheimer's risk may use attention to process, rather than suppress, distracting stimuli
Alzheimer's disease is a neurodegenerative condition that damages a person's ability to think, remember, and perform basic functions. According to the National Institutes of Health, Alzheimer's affects more than 6 million Americans, mostly ages 65 and older. Though the neurological damage from the disease is irreversible, its progression can be slowed by early interventions such as exercise and nutrition regimens. Thus, an early screening for Alzheimer's risk can be vital in helping people manage and plan for their symptoms.
November 30, 2023 — Source

Nanoplastics linked to Parkinson's and some types of dementia--new study
Since it was first produced at the start of the 20th century, synthetic plastic--and especially plastic packaging--has been an ever-present fixture in everyday life. Yet all the convenience plastic has given us comes at a price.
November 30, 2023 — Source

Researchers develop new brain network modeling tools to advance Alzheimer's disease research
Indiana University researchers are collaborating on a novel approach to use neuroimaging and network modeling tools--previously developed to analyze the brains of patients in the clinic--to investigate Alzheimer's disease progression in preclinical animal models.
November 30, 2023 — Source

Health — Alzheimers — November 29th, 2023

Conscientious personalities less at risk of dementia diagnosis
People with personality traits such as conscientiousness, extraversion and positive affect are less likely to be diagnosed with dementia than those with neuroticism and negative affect, according to a new analysis. The difference was not linked to physical damage to brain tissue found in dementia patients, but more likely to how certain personality traits help people navigate dementia-related impairments.
November 29, 2023 — Source

Embedding fibers to undo the tapestry of memory loss in Alzheimer's disease
Every 65 seconds, someone in the United States develops Alzheimer's disease, a devastating form of dementia that affects 6.2 million Americans.
November 29, 2023 — Source

Study finds link between early coronary heart disease and dementia
Adults diagnosed with coronary heart disease, especially before the age of 45, may be at increased risk of developing dementia, Alzheimer's disease and vascular dementia later in life, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.
November 29, 2023 — Source

Targeting personality traits could be a way to reduce dementia risk
People with personality traits such as conscientiousness, extraversion and positive affect are less likely to be diagnosed with dementia than those with neuroticism and negative affect, according to a new analysis by researchers at the University of California, Davis and Northwestern University. The difference was not linked to physical damage to brain tissue found in dementia patients, but more likely to how certain personality traits help people navigate dementia-related impairments.
November 29, 2023 — Source

Health — Alzheimers — November 28th, 2023

Personal wealth associated with health care costs in people with Alzheimer's disease
Finland has a strong public health care system; nevertheless, personal wealth is associated with the costs of hospital care and medication in people with Alzheimer's disease. Higher levels of wealth were associated with greater costs of hospital care before diagnosis, a new study from the University of Eastern Finland shows.
November 28, 2023 — Source

Understanding the impact of transferring patients with dementia between hospitals
It is common for individuals seeking medical care for symptoms of concern to go to the nearest hospital. Physicians there may determine the facility cannot provide the care they believe the patient needs and recommend transfer to another hospital offering a higher level of care or specialized services.
November 28, 2023 — Source

Health — Alzheimers — November 22nd, 2023

Is food insecurity among older adults associated with higher subsequent dementia risk and memory decline?
There are approximately 6 million Americans aged 65 years or over who have Alzheimer's disease and Alzheimer's disease--related dementias (AD/ADRD); this number is expected to shoot up to 14 million, more than double the current total by 2060.
November 22, 2023 — Source

Health — Alzheimers — November 21st, 2023

Food insecurity in seniors linked to increased risk for dementia
For older adults, food insecurity is associated with an increased risk for dementia with poorer memory function and faster memory decline, according to a study published online Nov. 21 in JAMA Network Open.
November 21, 2023 — Source

Hearing loss is associated with subtle changes in the brain
Hearing loss affects more than 60 percent of adults aged 70 and older in the United States and is known to be related to an increased risk of dementia. The reason for this association is not fully understood.
November 21, 2023 — Source

Nanoscale Gates Unveil Secrets of Disease-Causing Protein Clumps
Proteins that aggregate into clumps are common culprits in challenging-to-treat conditions like ALS, Alzheimer's, and Parkinson's. Investigating how these proteins interact has historically been a complex task.
November 21, 2023 — Source

Research finds sex differences in immune response and metabolism drive Alzheimer's disease
Cleveland Clinic researchers analyzed genes and brain tissue of patients with Alzheimer's and found that differences in brain immunometabolism--the interactions between the immune system and the ways cells create energy--may contribute to women's increased risk for the disease and its severity.
November 21, 2023 — Source

Health — Alzheimers — November 20th, 2023

New Alzheimer's drug shines light on need for assessments to head off 'a tsunami of cognitive afflictions'
Two stories dominated Alzheimer's news this year: The FDA's approval of Leqembi, the first drug to slow progression of the disease, and a surprising study showing that mild cognitive impairment is wildly underdiagnosed.
November 20, 2023 — Source

New blood tests for dementia announced, but what can they tell us and who will benefit?
A five-year, £5 million initiative has just been launched to investigate the feasibility of using new blood tests in the diagnosis of Alzheimer's disease. Alzheimer's Research UK and the Alzheimer's Society are working with the National Institute for Health and Care Research to use these blood tests in the NHS.
November 20, 2023 — Source

Tiny traps can provide new knowledge about difficult-to-treat diseases
Proteins that form clumps occur in many difficult-to-treat diseases, such as ALS, Alzheimer's, and Parkinson's. The mechanisms behind how the proteins interact with each other are difficult to study, but now researchers at Chalmers University of Technology, Sweden, have discovered a new method for capturing many proteins in nano-sized traps.
November 20, 2023 — Source

Using tiny traps to study protein interactions can provide new knowledge about difficult-to-treat diseases
Proteins that form clumps occur in many difficult-to-treat diseases, such as ALS, Alzheimer's, and Parkinson's. The mechanisms behind how the proteins interact with each other are difficult to study, but now researchers at Chalmers University of Technology, Sweden, have discovered a new method for capturing many proteins in nano-sized traps.
November 20, 2023 — Source

Health — Alzheimers — November 17th, 2023

Scientists produce human norepinephrine neurons from stem cells
Researchers at the University of Wisconsin--Madison have identified a protein key to the development of a type of brain cell believed to play a role in disorders like Alzheimer's and Parkinson's diseases and used the discovery to grow the neurons from stem cells for the first time.
November 17, 2023 — Source

Study sheds light on sporadic early-onset Alzheimer's disease, potential target for novel treatment
Alzheimer's disease (AD), the most prevalent neurodegenerative disease globally, poses a significant threat to human health. Most AD patients are diagnosed after the age of 65, categorized as late-onset AD (LOAD). However, about 5%--10% of AD patients show symptoms before the age of 65, exhibiting the same pathological characteristics as AD, classified as early-onset AD (EOAD).
November 17, 2023 — Source

Health — Alzheimers — November 16th, 2023

Gantenerumab does not slow clinical decline in early Alzheimer disease, research finds
Randall J. Bateman, M.D., from the Washington University School of Medicine in St. Louis, and colleagues conducted two phase 3 trials involving participants aged 50 to 90 years with mild cognitive impairment or mild dementia due to Alzheimer disease and evidence of amyloid plaques. Overall, 985 and 980 participants in the GRADUATE I and GRADUATE II trials, respectively, were randomly assigned to receive gantenerumab or placebo every two weeks.
November 16, 2023 — Source

How a mutation in microglia elevates Alzheimer's risk
A rare but potent genetic mutation that alters a protein in the brain's immune cells, known as microglia, can give people as much as a three-fold greater risk of developing Alzheimer's disease. A new study by researchers in The Picower Institute for Learning and Memory at MIT details how the mutation undermines microglia function, explaining how it seems to generate that higher risk.
November 16, 2023 — Source

Q&A: Alzheimer's disease basics and what you can do to prevent it
Alzheimer's disease is feared by many―and for good reason. The brain disorder slowly destroys memory along with a person's ability to reason, speak, carry out daily tasks and recognize loved ones. To date, there's no cure. The good news, however, is that there are steps you can take to lessen your chances of developing Alzheimer's disease, and promising possibilities for treating it, experts say.
November 16, 2023 — Source

Rare APOE3-R136S mutation offers protection against Alzheimer's disease pathologies in new study
In a recent study in Nature Neuroscience, researchers investigated whether the R136S genetic mutation protected against apolipoprotein E4 (APOE4)-induced late-onset Alzheimer's disease (LOAD).
November 16, 2023 — Source

Smaller hippocampus linked to cognitive decline
Association found even in people without Alzheimer's disease
November 16, 2023 — Source

Study reveals broader impact of Alzheimer's on brain function
Scientists at The University of Texas at Dallas Center for Vital Longevity (CVL) have published new evidence that shows changes in brain network patterns that occur in early-stage Alzheimer's disease differ from those associated with normal aging.
November 16, 2023 — Source

Health — Alzheimers — November 15th, 2023

Investigating the link between gut inflammation, aging, and Alzheimer's disease
Aging is often accompanied by and contributed to by chronic inflammation, thus giving rise to the term "inflammaging." A recent study in Scientific Reports discusses how gut inflammation is associated with age and Alzheimer's disease (AD).
November 15, 2023 — Source

Health — Alzheimers — November 13th, 2023

Intensive blood pressure control reduces dementia risk in adults with hypertension
An intensive, four-year blood-pressure intervention significantly reduced the risk of developing dementia among adults with high blood pressure compared to people who received usual care, in a study reported as late-breaking science today at the American Heart Association's Scientific Sessions 2023.
November 13, 2023 — Source or Source

Wireless, handheld, non-invasive device detects Alzheimer's and Parkinson's biomarkers
An international team of researchers has developed a handheld, non-invasive device that can detect biomarkers for Alzheimer's and Parkinson's Diseases. The biosensor can also transmit the results wirelessly to a laptop or smartphone.
November 13, 2023 — Source

Health — Alzheimers — November 6th, 2023

High biological age linked to increased risk of stroke and dementia
The study, which was led by Sara Hägg, associate professor, and Jonathan Mak, doctoral student at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, shows that the increased risk persists even if other risk factors such as genetics, lifestyle and socioeconomics are taken into account.
November 6, 2023 — Source

Reducing poverty may reduce risk of developing dementia
Could reducing poverty go hand-in-hand with reducing the risk of developing dementia, the kind in which an elderly person shows signs of Alzheimer's disease but is cognitively healthy and autonomous?
November 6, 2023 — Source

Research team discovers new role of cerebellum in coordinating the brain network essential for social recognition memory
As millions of Americans struggle with memory loss and dementia brought on by increasingly common neurodegenerative disorders, like Alzheimer's disease and Parkinson's disease, greater understanding of how the brain works and is affected in those suffering from memory loss will be key to advancing more effective and targeted treatments.
November 6, 2023 — Source

Health — Alzheimers — November 3rd, 2023

Analysis of dementia incidence trends for England and Wales for 2002-2019
In a recent article published in The Lancet Public Health, researchers analyzed the temporal trend in dementia incidence in England and Wales from 2002 to 2019.
November 3, 2023 — Source

Researchers discover new molecular drug targets for progressive neurological disorder
There is no cure for progressive supranuclear palsy (PSP), a brain disorder marked by walking and balance difficulties. Its symptoms also mimic Parkinson's disease and dementia. The condition leads to rapid, progressive decline and death.
November 3, 2023 — Source

Health — Alzheimers — November 2nd, 2023

Being bilingual slows brain aging and can prevent Alzheimer's, researcher says
Humans are organized into around 200 nations, yet there are roughly 6,000 languages in existence. It therefore seems obvious that bilingualism is much more common than many of us might assume. This is an increasingly visible fact that appears to undermine the predominant model of "one state, one language," a consequence of unifying previously distinct regions and cultures into larger nations.
November 2, 2023 — Source

Researchers reveal mechanisms of alarmin release at an early stage of immune reaction
Many common diseases such as arteriosclerosis and diabetes or neurodegenerative diseases such as Alzheimer's are associated with inflammatory processes. A better understanding of these processes is therefore an important building block for the development of new therapeutic options.
November 2, 2023 — Source

Health — Alzheimers — October 31st, 2023

Pilot Awards for Global Brain Health Leaders awarded to encourage innovative dementia research
Today, the Alzheimer's Association, Global Brain Health Institute (GBHI), and the UK-based Alzheimer's Society announced the most recent awardees of the Pilot Awards for Global Brain Health Leaders, a competitive funding initiative dedicated to nurturing efforts and improving outcomes in the fields of brain health and dementia.
October 31, 2023 — Source

Health — Alzheimers — October 30th, 2023

Enhancing deep sleep in older years could stave off dementia
As little as 1 per cent reduction in deep sleep per year for people over 60 years of age translates into a 27 per cent increased risk of dementia, according to a study which suggests that enhancing or maintaining deep sleep, also known as slow wave sleep, in older years could stave off dementia.
October 30, 2023 — Source

Hearing aid advice from an audiologist
Hearing loss is one of the most common chronic conditions as we age and is linked with increased risk for dementia and depression. Despite that, only one-fifth of adults with hearing loss actually seek intervention.
October 30, 2023 — Source or Watch Video

Improving deep sleep may prevent dementia, study finds
As little as 1% reduction in deep sleep per year for people over 60 years of age translates into a 27% increased risk of dementia, according to a study which suggests that enhancing or maintaining deep sleep, also known as slow wave sleep, in older years could stave off dementia.
October 30, 2023 — Source

Health — Alzheimers — October 27th, 2023

Reducing air pollution associated with lower risk of all-cause dementia and Alzheimer's disease
Previous reports have linked long-term air pollution exposure with accumulation of Alzheimer's disease-related brain plaques, but this is the first accumulated evidence that reducing pollution, especially fine particulates in the air and pollutants from the burning of fuel, is associated with lower risk of all-cause dementia and Alzheimer's disease.
October 27, 2023 — Source

Health — Alzheimers — October 26th, 2023

A century of research shows eating these compounds can help protect against heart disease and Alzheimer's
Perhaps the word "polyphenol" means little to you, but they certainly mean a lot to your health. Polyphenols are a family of chemical compounds present in foods of vegetable origin and seaweed that have been studied over the last century for their health effects.
October 26, 2023 — Source

Dementia is not just about memory loss: Study highlights importance of assessing standard emotional responses
We focus too much on memory loss in relation to dementia and not enough on difficulties with identifying emotions in social situations, according to researchers from UNSW Sydney's Center for Healthy Brain Aging (CHeBA) and the MARCS Institute for Brain, Behavior and Development at Western Sydney University.
October 26, 2023 — Source

Doubts Abound About a New Alzheimer's Blood Test
For the first time, people worried about their risk of Alzheimer's disease can go online, order a blood test, and receive results in the privacy of their homes.
October 26, 2023 — Source

Health — Alzheimers — October 24th, 2023

Proximity to traffic linked to increased dementia risk and brain structural changes
Living near major roadways correlates with a higher incidence of dementia and alterations in brain structure, largely due to traffic-related air pollution, according to a study conducted in China and the UK. The research, recently published in Health Data Science, sheds new light on the public health implications of traffic-related pollution and dementia, a growing concern worldwide.
October 24, 2023 — Source

Health — Alzheimers — October 23rd, 2023

Can strawberries mitigate Alzheimer's risk? Recent study suggests a possibility
In a recent study published in the Nutrients Journal, researchers investigated whether strawberry supplementation mitigates the risk for late-life dementia in middle-aged people.
October 23, 2023 — Source

Health — Alzheimers — October 20th, 2023

High risk for psychiatric disorders seen before dementia diagnosis
Minjia Mo, Ph.D., from the Karolinska Institutet in Stockholm, and colleagues examined temporal risk patterns of psychiatric disorders among patients with dementia before, at the time of, and after diagnosis. The analysis included 796,505 individuals, including 209,245 with dementia (2000 to 2017).
October 20, 2023 — Source

Study on largest genetic risk factor for Alzheimer's points toward new drug target
If you're one of the nearly 25 percent of people with the gene variant known as APOE4, you have a higher-than-average chance of developing Alzheimer's disease. But while scientists have long known that APOE4 leads to changes in the brain that can contribute to dementia, the exact mechanism of that effect has been unclear.
October 20, 2023 — Source

Health — Alzheimers — October 19th, 2023

Identifying a signature biomarker for early-onset Alzheimer's disease
Sporadic early-onset Alzheimer's disease (EOAD) is rare and understudied. However, it is known to be a devastating form of Alzheimer's disease (AD) affecting patients often in their 40s and 50s at the peak of their productive life, when they may be balancing careers, family responsibilities and community roles.
October 19, 2023 — Source

Health — Alzheimers — October 18th, 2023

Aged care could be beneficial for people with dementia: Australian report
Australians living with dementia who move into residential aged care after a hospital stay are less likely to be readmitted to hospital within one year than those who return to living in the community, according to a new report from the Australian Institute of Health and Welfare (AIHW)
October 18, 2023 — Source

New model leverages stem cells to provide window into Alzheimer's disease development
A new model developed by Van Andel Institute, Lund University and University of Florence scientists will enable researchers to better understand how Alzheimer's disease progresses in the brain.
October 18, 2023 — Source

Health — Alzheimers — October 17th, 2023

Female sex hormones play significant role in Alzheimer's disease
Alzheimer's disease disproportionately affects women, who represent about two-thirds of those diagnosed with the late-onset type of the disease.
October 17, 2023 — Source

Health — Alzheimers — October 16th, 2023

Brain fungal infection produces Alzheimer's disease-like changes, says new study
Previous research has implicated fungi in chronic neurodegenerative conditions such as Alzheimer's disease, but there is limited understanding of how these common microbes could be involved in the development of these conditions.
October 16, 2023 — Source

Personalized coaching decreases cognitive decline in early-stage Alzheimer's disease patients, study shows
Supplementing the standard of treatment for early-stage Alzheimer's disease patients with personalized lifestyle coaching leads to less cognitive decline compared to standard of care alone, an ISB-led study shows. An early online version of this paper detailing the findings has been published, and it is scheduled for publication in the November issue of Journal of Alzheimer's Disease.
October 16, 2023 — Source

Health — Alzheimers — October 12th, 2023

New Alzheimer's study to combine drugs targeting amyloid and tau proteins
A new study will combine an Alzheimer's medication that slows disease progression in some patients with two other drugs to see if their effects can be amplified. The trial will be the first to test drugs acting on two disease-driving proteins, amyloid and tau, for patients with late-onset Alzheimer's, the most common type of dementia.
October 12, 2023 — Source

Health — Alzheimers — October 11th, 2023

Clinical trial finds herbal medicine Sailuotong effective for brain health in older people
Western Sydney University's NICM Health Research Institute has led a world-first clinical trial in Australia that offers new hope in the treatment of mild cognitive impairment (MCI) among older people. The trial's results, published in the journal Alzheimer's and Dementia, signal the efficacy and safety of Sailuotong (SLT), a novel herbal extract, as a potential treatment for MCI.
October 11, 2023 — Source

New AI model can identify neuroanatomical regions vulnerable to age-related changes
Bottom line: The aging brain undergoes structural and cellular changes that can impact function and increase susceptibility to neurodegenerative disorders like Alzheimer's disease. Age acceleration-;or the differences between biological and chronological age-;in the brain can reveal insights about mechanisms and normal functions of one of the body's most important organs. It can also explain age-related changes and functional decline, as well as identify early changes related to diseases, indicating the onset of a brain disorder.
October 11, 2023 — Source

New methodology to study the intricacies of amyloid plaques in Alzheimer's disease
Researchers have now combined STED microscopy, a technology that allows superresolution visualization, and a recently created new antibody to observe the amyloidogenic aggregates characteristic of Alzheimer's disease. The work, led by scientists from the Universitat Autònoma de Barcelona (UAB), the Karolinska Institute (KI), and the biotechnology company BioArctic, both in Sweden, has surpassed the capabilities of conventional confocal microscopy, and will allow further study of the structure and morphology of amyloid deposits and the mechanisms involved in their formation.
October 11, 2023 — Source

New study finds link between subjective and objective memory decline
Among people who report memory and thinking problems, some show no signs of a problem on standard tests, while others have subtle declines on their tests. A new study shows that people who have subtle problems with these tests may have an increased risk of developing mild cognitive impairment, which can be a precursor to dementia.
October 11, 2023 — Source

Risk factors for dementia vary by ethnicity, study finds
The number of people with dementia is on the rise around the world. There has been increasing interest in potentially modifiable risk factors, as eliminating these could theoretically prevent around 40% of dementia cases. However, most risk factor studies have been conducted only in people of European descent.
October 11, 2023 — Source

Specific navigational errors may indicate early signs of Alzheimer's disease
People with early Alzheimer's disease have difficulty turning when walking, according to a new study using virtual reality led by UCL researchers.
October 11, 2023 — Source

Health — Alzheimers — October 10th, 2023

$4.39 million NIH grant awarded to study the link between atrial myopathy and dementia
Lin Yee Chen, MD, MS, a professor at the University of Minnesota Medical School and director of the Lillehei Heart Institute, has been awarded a $4.39 million grant from the National Institutes of Health to study atrial myopathy-;a heart condition associated with a higher risk of dementia and vascular brain injury.
October 10, 2023 — Source

Alzheimer's researchers use physics techniques to investigate iron storage in the brain
Exactly how Alzheimer's disease develops is not well understood, but an imbalance of iron in the brain might just play a role. Martina Huber of the Leiden Institute of Physics studied iron storage in the brain and managed to combine two techniques to gain more insight. "To achieve this, we had to bring together expertise from different fields and I am proud that we succeeded," Huber says.
October 10, 2023 — Source

Researchers develop age prediction model for human brain tissue using artificial intelligence
The aging brain undergoes structural and cellular changes that can impact function and increase susceptibility to neurodegenerative disorders like Alzheimer's disease. Age acceleration--or the differences between biological and chronological age--in the brain can reveal insights about mechanisms and normal functions of one of the body's most important organs.
October 10, 2023 — Source

The biggest financial, legal and functional challenges of caregivers of persons living with dementia
About 6.5 million Americans age 65 and older live with Alzheimer's disease and Alzheimer's-related dementias, and this number is expected to grow to 13.8 million by 2060. These diseases lead to the loss of memory, motor function and other debilitating conditions. The causes of dementia remain unknown, and there is no cure.
October 10, 2023 — Source

Health — Alzheimers — October 9th, 2023

McLean Hospital partners with Rippl Care to address mental health needs of seniors with dementia
Rippl provides specialty dementia care and is pioneering a new care model in an effort to expand access to high quality, wraparound behavioral healthcare for seniors, their families and caregivers. Under McLean's agreement with Rippl Care, leaders in the Division of Geriatric Psychiatry will provide advisory and consultative services to Rippl teams and plan to co-develop a professional educational and training program, the Rippl Academy. Mass General Brigham Ventures is a founding investor in Rippl Care.
October 9, 2023 — Source

Physicians debate best screening tools and practices for patients with potential dementia and cognitive impairment
In a new Annals 'Beyond the Guideline's feature, two experts review the available evidence about cognitive impairment to determine effective screening tools, interventions to improve patient outcomes, and the circumstances under which they would recommend screening for cognitive impairment (CI).
October 9, 2023 — Source

Health — Alzheimers — October 6th, 2023

Breakthrough antibody therapy targets Alzheimer's risk gene, offers hope for effective treatment
This platform aims to inform future treatment approaches for Alzheimer's disease (AD) and consists of apolipoprotein E (ApoE)-Christchurch (Ch)-inspired mAbs, anti-ApoE-heparan sulfate proteoglycans (HSPG), and anti-ApoE-group-specific antigens (GAGs). These components target the ApoE gene, a robust genetic risk factor for sporadic AD.
October 6, 2023 — Source

New Alzheimer's disease pathways identified
Dementia, which includes Alzheimer's disease, currently affects around 1.8 million people in Germany. The exact cause has not yet been clarified, but genetic factors play a significant role in the development of the disease. Most previous analyses aimed at the identification of novel Alzheimer's genes used, a "case-control design."
October 6, 2023 — Source

Study discovers possible tool to diagnose common contributor to vascular dementia
A research team led by the Keck School of Medicine of USC has discovered that a non-invasive eye exam may be a possible tool for screening Black Americans and other people from underdiagnosed and high-risk populations for cerebral small vessel disease, a major contributor to cognitive impairment and dementia.
October 6, 2023 — Source

Health — Alzheimers — October 5th, 2023

New antibody shows promise in reducing tau proteins associated with Alzheimer's disease
A team led by researchers from Mass General Brigham reports promising results for a monoclonal antibody that takes aim at a new target for Alzheimer's disease. Inspired by their previous identification of a genetic variant in the APOE gene that provides extreme resistance against Alzheimer's disease, the team, which includes investigators from Mass Eye and Ear and Massachusetts General Hospital, developed a therapy that mimics the behavior of this genetic variant in a preclinical model, reducing abnormal tau proteins associated with Alzheimer's disease and offering a path to treatment that does not target amyloid beta plaque buildups.
October 5, 2023 — Source

Study maps brain wave disruptions affecting memory recall
The brain circuitry that is disrupted in Alzheimer's disease appears to influence memory through a type of brain wave known as theta oscillation, a team led by UT Southwestern Medical Center researchers report. The findings, published in Nature Communications, could help researchers design and evaluate new treatments for Alzheimer's, a condition that affects millions of people around the globe and has no cure.
October 5, 2023 — Source

Health — Alzheimers — October 3rd, 2023

Protein experts show altered ubiquitin signaling induces hallmarks of sporadic Alzheimer's disease
New discoveries in the development of Alzheimer's disease in a study led by Professor Michael Glickman and Dr. Inbal Maniv from the Faculty of Biology at the Technion were published in Nature Communications.
October 3, 2023 — Source

Study addresses possible associations between chronic stress, mild cognitive impairment and Alzheimer's
Researchers from Karolinska Institutet have published a study in Alzheimer's Research & Therapy that addresses possible associations between chronic stress, mild cognitive impairment and Alzheimer's disease. The study shows how people aged between 18 and 65 with a previous diagnosis of chronic stress and depression were more likely than other people to be diagnosed with mild cognitive impairment or Alzheimer's disease.
October 3, 2023 — Source

Health — Alzheimers — October 2nd, 2023

Early indicators of dementia: Five behavior changes to look for after age 50
Dementia is often thought of as a memory problem, like when an elderly person asks the same questions or misplaces things. In reality, individuals with dementia will not only experience issues in other areas of cognition like learning, thinking, comprehension and judgment, but they may also experience changes in behavior.
October 2, 2023 — Source

In forming long-term memories, vascular cells are crucial
A new study reveals the crucial role of vascular system cells — known as pericytes — in the formation of long-term memories of life events — memories that are lost in diseases such as Alzheimer's disease.
October 2, 2023 — Source

Study indicates possible link between chronic stress and Alzheimer's disease
Researchers from Karolinska Institutet have published a study in Alzheimer's Research & Therapy that addresses possible associations between chronic stress, mild cognitive impairment and Alzheimer's disease. The study shows how people aged between 18 and 65 with a previous diagnosis of chronic stress and depression were more likely than other people to be diagnosed with mild cognitive impairment or Alzheimer's disease.
October 2, 2023 — Source

Tips to protect long-term brain health
There is a growing understanding of the role lifestyle choices play in preventing and slowing the progression of cognitive decline. While we await new treatments for Alzheimer's disease and other age-related dementias, emerging research can offer some advice for keeping our brains healthy and sharp.
October 2, 2023 — Source

Health — Alzheimers — September 28th, 2023

Experts present pioneering vision on reducing brain disorders by 2050
A special supplement to the Journal of Alzheimer's Disease presents insights and new directions in both basic and clinical research into neurodegenerative diseases. Because by 2050, the number of people suffering from brain disorders is estimated to reach 155 million, now is the time to think innovatively to discover new pathways for future brain studies.
September 28, 2023 — Source

In-depth review reveals dietary lipid intervention as potential strategy to prevent brain aging
A new review published in the journal Engineering by Fazheng Ren's research team at China Agricultural University highlights the significant role of dietary lipids in preventing brain aging and cognitive decline. As the global burden of aging-related brain diseases, particularly dementia, continues to rise, this research offers promising insights into potential nutritional interventions that could improve brain function during aging.
September 28, 2023 — Source

Scientists create virtual marmite for World Marmite Day, with potential for Alzheimer's diagnosis
Scientists at the University of Warwick have produced virtual flavors of marmite and vegemite from scratch, using technology that can replicate the flavor of almost any food or drink and is being used in a new taste test to help with early Alzheimer's diagnosis.
September 28, 2023 — Source

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer's disease progression
Alzheimer's disease affects more than 6 million people in the United States, and there are very few FDA-approved treatments that can slow the progression of the disease.
September 28, 2023 — Source

Health — Alzheimers — September 26th, 2023

Traumatic life events may directly increase your risk for dementia
Studies included in the review encompassed outcomes of 276,570 participants with median age ranging from 50.3 to 77 years and a follow-up time ranging between two to 37 years (average = 9.5 years).
September 26, 2023 — Source

Health — Alzheimers — September 25th, 2023

Examining dementia risk in adults with intellectual disability
Both genetic and acquired factors contribute to the onset of intellectual disability (ID), and people with ID are presumed to be at a higher risk of developing dementia. It is also understood that a lower cognitive reserve--thinking ability gained via learning and conscious mental activity--increases the risk of dementia in the general population.
September 25, 2023 — Source

Finnish study finds revised dementia guidelines did not reduce psychotropic use
A recent register-based study examined the impact of Finland's revised clinical guidelines for the treatment of dementia, published in 2017, on the trend of users of psychotropics in older people with dementia in 2009-2020.
September 25, 2023 — Source

Team presents new approach to discover targets for Alzheimer's, other diseases with protein phase separation
Recent research demonstrates that protein phase separation (PPS) is widely present in cells and drives a variety of important biological functions. Protein phase separation at the wrong place or time could create clogs or aggregates of molecules linked to neurodegenerative diseases like Alzheimer's and Parkinson's, and poorly formed cellular condensates could contribute to cancers and might help explain the aging process.
September 25, 2023 — Source

Health — Alzheimers — September 22nd, 2023

Mechanisms of phototherapy of Alzheimer's disease during sleep and wakefulness
Photobiomodulation during sleep turns the brain into a washing machine, helping to cleanse its tissues of toxic beta-amyloid and increase resistance to the progression of Alzheimer's disease.
September 22, 2023 — Source

Midlife insomnia may increase risk for later dementia
Xiao Tan, from the Zhejiang University School of Public Health in Hangzhou, China, and colleagues used data from 22,078 participants in the Swedish National March Cohort, who were free from dementia and stroke at baseline. Dementia incidence during a median 19.2 years of follow-up was determined through national registries.
September 22, 2023 — Source

Health — Alzheimers — September 21st, 2023

Researchers discover possible new cause for Alzheimer's disease
Scientists at Oregon Health and Science University have made a development that could lead to a greater understanding of Alzheimer's disease and vascular dementia: a new cause for the diseases that impact cognitive functioning.
September 21, 2023 — Source

Health — Alzheimers — September 20th, 2023

FAU awarded $1.3 million grant to improve quality of life for individuals with dementia and their families
Florida Atlantic University's María de los Ángeles Ortega, DNP, APRN, in the Christine E. Lynn College of Nursing, has been awarded a three-year, $1.3 million grant from the Administration for Community Living's (ACL) Alzheimer's Disease Program Initiative for a groundbreaking project designed to advance health equity and improve quality of life for individuals living with or at high risk for Alzheimer's disease and related dementias (ADRD) and their family caregivers.
September 20, 2023 — Source

New research reveals link between finger tapping and Alzheimer's
Suddenly getting lost, failing to recognize family members, or forgetting words and names are well-known symptoms of Alzheimer's disease. Psychologists have now discovered that the disease also manifests in more subtle ways: through the rhythm of finger tapping.
September 20, 2023 — Source

Health — Alzheimers — September 19th, 2023

EEG Headset Could Spot Early Alzheimer's Disease
Researchers at the University of Colorado Anschutz Medical Campus have developed a technique that may spot the very early signs of Alzheimer's disease, years before symptoms arise. The method may alert patients and clinicians to an increased risk of the disease, potentially allowing them to take steps to slow the disease progression.
September 19, 2023 — Source

Health — Alzheimers — September 18th, 2023

'Circular logic' of RNAs in Parkinson's disease
Researchers are gaining new insights into neurological diseases by studying circular RNAs (circRNAs) in brain cells. A new study has identified over 11,000 distinct RNA circles that characterized brain cells implicated in Parkinson's disease and Alzheimer's disease.
September 18, 2023 — Source

Do cyanobacteria make the neurotoxin β-N-methylamino-L-alanine?
&beta-N-methylamino-L-alanine (BMAA), a non-protein amino acid initially discovered in Cycas in 1967, has gained attention for its potential association with neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinson's and Alzheimer's.
September 18, 2023 — Source

New study challenges classic tenet of memory research
Connections among one set of activated neurons in rat brains grew stronger while memories were being formed, but those in another weakened, UT Southwestern Medical Center researchers have discovered.
September 18, 2023 — Source

Telecare cuts costs, boosts quality of life for dementia patients
A telecare program that improves outcomes for patients with dementia and lightens the load for unpaid caregivers also has the surprising bonus of cutting Medicare costs, according to new research.
September 18, 2023 — Source

Health — Alzheimers — September 14th, 2023

Researchers find preclinical evidence that a nasal immunotherapy may help treat Alzheimer's disease
Alzheimer's is a debilitating neurodegenerative and neuroinflammatory disease that is difficult to treat. Most existing therapies target the buildup of amyloid beta (Aβ) plaques in the brain, which requires early intervention and intravenous therapy.
September 14, 2023 — Source

Researchers show how repeated traumatic brain injury contributes to Alzheimer's disease
The causes of Alzheimer's disease (AD) are unclear, and the interventions for AD are very limited. However, researchers led by Prof. He Zhuohao from the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences, in collaboration with researchers worldwide, have recently proposed a new strategy for the intervention in certain neurodegenerative diseases, including AD, based on a better understanding of disease mechanisms. T
September 14, 2023 — Source

Health — Alzheimers — September 13th, 2023

Could a breakdown in the brain's networks allow infections to contribute to Alzheimer's disease?
New data gives more evidence to the possibility that developing a pathobiome in the brain could cause some forms of Alzheimer's and related dementias.
September 13, 2023 — Source or Source

Could your daily routine lead to dementia? New research points to sedentary lifestyle as potential risk factor
The global population is engaging in more sedentary-type activities such as sitting while using the computer, watching television, and driving. Studies have reported associations between sedentary behavior and cardiometabolic diseases and related mortality; however, its relationship with new-onset dementia is not clear.
September 13, 2023 — Source

Is there anything Ozempic can't do?
Semaglutide, the main ingredient in Ozempic and Wegovy, could soon be used for a lot more than weight loss.
September 13, 2023 — Source

Risk for dementia reduced in association with antihypertensive use
Matthew J. Lennon, M.D., from the University of New South Wales in Sydney, and colleagues examined the associations of hypertension history, antihypertension use, and baseline-measured blood pressure (BP) in late life with dementia in longitudinal, population-based studies of aging adults participating in the Cohort Studies of Memory in an International Consortium group.
September 13, 2023 — Source

Using focused ultrasound to treat Alzheimer's and Parkinson's
The Ultrasound and Elasticity Imaging Laboratory, led by Elisa Konofagou, Robert and Margaret Hariri Professor of Biomedical Engineering, develops novel, ultrasound-based techniques for both imaging and therapeutic applications.
September 13, 2023 — Source

Health — Alzheimers — September 12th, 2023

Care home study highlights poor care for dementia residents with hearing problems
Hard of hearing people with dementia are not receiving the care they desperately need, according to a new study by University of Manchester researchers.
September 12, 2023 — Source

Is exposure to infections or autoimmune diseases associated with dementia incidence?
Infections have been considered as potential causes of dementia, especially Alzheimer's disease (AD). While some studies target specific infections or pathogens, it is uncertain whether specific agents are the cause or if infection-induced inflammation is the risk factor.
September 12, 2023 — Source

Large amounts of sedentary time linked with higher risk of dementia in older adults, study shows
Adults aged 60 and older who spend more time engaging in sedentary behaviors like sitting while watching TV or driving may be at increased risk of developing dementia, according to a new study by USC and University of Arizona researchers.
September 12, 2023 — Source or Source

New link between increased astrocytes in the brain and blood in early Alzheimer's disease
A new study shows that the activation of the brain's immune defense cells—astrocytes—in the early stages of Alzheimer's disease could be tracked early with a brain PET scanner and is linked to changes that can be detected in the blood later in the course of the disease.
September 12, 2023 — Source

Shorter white blood cell telomeres linked to higher dementia risk
They are associated with smaller total and white matter brain volume, which helps the body process information, and may be a predictor of future brain health, say the researchers.
September 12, 2023 — Source

Study reports on contributions to white matter injury in Alzheimer's disease
In their new editorial, researchers Zsolt Bagi, Larry S. Sherman and Stephen A. Back from Augusta University discuss mechanisms of cognitive impairment and dementia. Impairments in cognitive and executive function of presumed cerebral microvascular origin are important and recently recognized neuropathological manifestations of vascular contributions to cognitive impairment and dementia (VCID).
September 12, 2023 — Source

Health — Alzheimers — September 8th, 2023

Breakthrough genome-wide study uncovers new loci impacting apolipoprotein E levels and Alzheimer's risk
In a recent study published in the Molecular Psychiatry Journal, a team of researchers from the United States conducted a large-scale genome-wide association study to identify new genetic factors that affect the plasma apolipoprotein E levels and to test the association between baseline plasma levels of apolipoprotein E and incident dementia and cognitive function.
September 8, 2023 — Source

Eye-tracking technology can help improve quality of life assessment for older people with dementia
More than 50% of Australians living in residential aged care facilities have a dementia diagnosis, with aged care services around the world preparing for the number of older people aged 65 years and above to double in the next 30 years.
September 8, 2023 — Source

Panel of 48 CSF proteins complements existing Alzheimer biomarkers
A panel of 48 proteins in the cerebrospinal fluid (CSF 48 panel) complements existing CSF biomarkers for Alzheimer disease (AD), according to a study published in the Sept. 6 issue of Science Translational Medicine.
September 8, 2023 — Source

Senolytic therapy in mild Alzheimer's disease shows safety in phase I trial
Cellular senescence, a hallmark of aging, contributes to AD pathogenesis through stress responses like mitochondrial dysfunction, deoxyribonucleic acid (DNA) damage, and proteotoxic stress. Despite the development of disease-modifying agents, these therapies have limited clinical results, highlighting the need for new drug targets.
September 8, 2023 — Source

Health — Alzheimers — September 7th, 2023

Antipsychotics are likely overprescribed among homebound patients with dementia, study shows
New research published in the Journal of the American Geriatrics Society indicates that antipsychotics are likely overprescribed and used inappropriately among patients with Alzheimer's disease and related dementias (ADRD) receiving home health care, and such use is linked to worse patient outcomes.
September 7, 2023 — Source

Eye-tracking technology helps give a voice to older people living with dementia
More than 50% of Australians living in residential aged care facilities have a dementia diagnosis, with aged care services around the world preparing for the number of older people aged 65 years and above to double in the next 30 years.
September 7, 2023 — Source

Poor metabolic health could increase risk of developing dementia later in life
Poor metabolic health was defined as having three or more of the following conditions: high waist circumference, high triglycerides, high blood pressure, high blood glucose, and low high-density lipoprotein (HDL) cholesterol, sometimes known as "good" cholesterol.
September 7, 2023 — Source

Health — Alzheimers — September 6th, 2023

Antipsychotic drugs likely overprescribed to homebound patients with dementia, study finds
New research published in the Journal of the American Geriatrics Society indicates that antipsychotics are likely overprescribed and used inappropriately among patients with Alzheimer's disease and related dementias (ADRD) receiving home health care, and such use is linked to worse patient outcomes.
September 6, 2023 — Source

How sleep deprivation can harm the brain
Not only does a lack of sleep make you feel awful, research has shown it impairs the brain. What's more, sleep loss over long periods can even increase risk for Alzheimer's and other neurological diseases. Researchers want to understand how sleep deprivation causes this harm. In a new study, a team working with mice has identified a protective protein whose level declines with sleep deprivation, leading to neuronal death.
September 6, 2023 — Source

Researchers identify new gene mutation that alters Alzheimer's disease risk
A groundbreaking study has shed new light on the genetic underpinnings of Alzheimer's disease.
September 6, 2023 — Source

Researchers to study Alzheimer's disease in marmosets
Neuroscientists created the first non-human primate model of hereditary Alzheimer's in marmosets to accelerate the pace of drug discovery and rebuild the foundation for future translational studies.
September 6, 2023 — Source

Health — Alzheimers — September 5th, 2023

Direct oral anticoagulants reduce dementia risk in Asian AFib patients compared to traditional blood thinners: Study
The use of direct oral anticoagulants (DOACs) was associated with a reduction in dementia risk compared to traditional blood thinners--like warfarin--in atrial fibrillation patients, particularly in Asian patients. According to a study published in JACC: Asia, this benefit may reverse with increased age and necessitates further follow-up study.
September 5, 2023 — Source

Scientists discover new cause of Alzheimer's, vascular dementia
Researchers have discovered a new avenue of cell death in Alzheimer's disease and vascular dementia.
September 5, 2023 — Source

Health — Alzheimers — September 4th, 2023

New perspectives on understanding, preventing and treating vascular dementia
Dementia is a group of brain diseases that share similar symptoms, such as memory, language, orientation, and behavioral issues. Vascular dementia generally develops in the elderly, affecting between 1% and 4% of people over the age of 65, according to Alzheimer's Switzerland. It is caused by vascular lesions that disrupt the blood supply to the brain, leading to the death of neurons.
September 4, 2023 — Source

Health — Alzheimers — August 31st, 2023

'Fitness Tracker' for Your Brain Could Detect Alzheimer's Early
The headband uses EEG to look for brain waves that could indicate amyloid and tau buildup.
August 31, 2023 — Source

Is There a Link Between Dementia and Vision Problems? Yes and No
Both occur more commonly in older adults and impact the way we connect with the world, but drawing a straight line from one to the other is tricky.
August 31, 2023 — Source

New blood test gives very high accuracy to screen for Alzheimer's disease
A new blood test called p-tau217 shows promise as an Alzheimer's disease biomarker, and when used in a two-step workflow very high accuracy to either identify or exclude brain amyloidosis, the most important and earliest pathology.
August 31, 2023 — Source

Radiologists must monitor novel Alzheimer's treatment side effect, says study
A new article published in RadioGraphics examines the use of monoclonal antibody therapies for treating Alzheimer's disease and alerts physicians to be on the lookout for a potential side effect: amyloid-related imaging abnormalities (ARIA).
August 31, 2023 — Source

Health — Alzheimers — August 30th, 2023

Alzheimer's treatments: What's on the horizon?
Despite many promising leads, new treatments for Alzheimer's are slow to emerge.
August 30, 2023 — Source

Alzheimer's: Drugs help manage symptoms
Alzheimer's still has no cure, but two types of drugs can help manage symptoms of the disease.
August 30, 2023 — Source

Educational attainment found to protect against a genetic risk factor for Alzheimer's disease
A new study by researchers from Mass General Brigham further illustrates that when it comes to risk of Alzheimer's disease, even genetically determined forms of the disease, genetics is only one piece of the puzzle.
August 30, 2023 — Source

Gene variant protects against Alzheimer's and Parkinson's diseases
About one in every five people carries a version of a gene that, although largely unsung, appears to confer protection against both Alzheimer's disease and Parkinson's disease, Stanford Medicine investigators and their colleagues have learned. These lucky people may someday benefit all the more from a vaccine that could slow or stall the progression of these two most common neurodegenerative conditions.
August 30, 2023 — Source

Lecanemab for Alzheimer's disease: An option for you?
The drug lecanemab appears to slow mental decline in people with early Alzheimer's disease. Learn whether it might be right for you.
August 30, 2023 — Source

Three ways of rejuvenating aging brains may work via the same protein
The molecule may be a promising therapy but exactly how it works is unclear
August 30, 2023 — Source

Health — Alzheimers — August 29th, 2023

A 'mini-brain' traces the link between concussion and Alzheimer's disease
How much time elapses between a blow to the head and the start of damage associated with Alzheimer's disease?
August 29, 2023 — Source

Molecule reduces inflammation in Alzheimer's models
A potential new Alzheimer's drug represses the harmful inflammatory response of the brain's immune cells, reducing disease pathology, preserving neurons and improving cognition in preclinical tests.
August 29, 2023 — Source

Q&A: The signs of dementia and what can be done to stave it off
The number one risk factor for Alzheimer's disease is age, far more than genetics. Because of the aging of the U.S. population, there are currently 6.7 million Americans with dementia, including Alzheimer's.
August 29, 2023 — Source

Study: How cardio fitness and rigorous exercise counteract cognitive decline
New research from The University of Texas at Dallas' Center for Vital Longevity (CVL) supports the idea that the brains of older adults who maintain physical fitness by engaging in regular strenuous exercise more closely resemble those of younger adults.
August 29, 2023 — Source

Health — Alzheimers — August 25th, 2023

LGBTQ+ caregivers of people with dementia face unique stresses that lead to poorer physical and mental health
Caring for someone living with dementia can be a stressful experience that harms the physical and mental health of caregivers. Many caregivers experience depression and lower quality of life. LGBTQ+ caregivers face unique challenges that can magnify these strains.
August 25, 2023 — Source

New 3D model mimics brain cell and immune cell interactions in Alzheimer's disease
Cognitive decline associated with Alzheimer's disease (AD) develops when neurons begin to die, which can be caused by inappropriate immune responses and excessive inflammation in the brain triggered by amyloid beta deposits and tau tangles, two hallmarks of the disease.
August 25, 2023 — Source

New risk score strongly predicts dementia chances within 14 years
A new dementia risk score, which draws on 11 mostly modifiable risk factors, identifies people at risk--from midlife onward--of developing the disease within the next 14 years, suggests a large long term study published in the open access journal BMJ Mental Health.
August 25, 2023 — Source or Source

Health — Alzheimers — August 24th, 2023

The most recent neuroimaging procedures and machine learning approaches for the prediction of Alzheimer's progression
In a recent systematic review published in BMC Neurology, researchers examined recent studies exploring neuroimaging modalities aided by advanced machine learning (ML) algorithms that predicted Alzheimer's disease (AD) progression from mild cognitive impairment (MCI) to AD dementia.
August 24, 2023 — Source

Health — Alzheimers — August 23rd, 2023

Catheter ablation linked to lower risk of dementia in all patients with atrial fibrillation
Previous studies have shown a link between catheter ablation and a lower risk of dementia and premature death for patients with atrial fibrillation. This procedure involves a flexible wire that is inserted into a blood vessel in the groin and guided to the heart where it destroys tissue that is causing rapid and irregular heartbeats. It's unclear if the associations between catheter ablation and lower dementia and mortality risks hold among different subgroups of patients stratified by age, sex, co-morbidities, and medication use.
August 23, 2023 — Source

New study to investigate link between agricultural fire smoke and dementia risk
Worldwide, the practice of preparing agricultural fields by burning crop residue contributes large quantities of gaseous pollutants and aerosol particles to the atmosphere and is a known cardiorespiratory health hazard. It has been shown that combustion byproducts in smoke cross the blood-brain barrier causing brain inflammation, and repeated inhalation of smoke can contribute to cognitive decline and dementia among older adults.
August 23, 2023 — Source

Taking adult education classes may help prevent dementia
How can we best keep our brain fit as we grow older? It's well known that regular cognitive activity, for example brainteasers, sudokus, or certain video games in middle and old age tends to protect against cognitive decline and dementias like Alzheimer's. But many of us regularly engage in adult education classes, for example learning a language or a new skill. I
August 23, 2023 — Source

Health — Alzheimers — August 14th, 2023

Brains with Alzheimer's disease have subnormal levels of important dietary antioxidants
Alzheimer's disease is a progressive neurodegenerative disease estimated to affect 6 million Americans and 33 million people worldwide. Large numbers of those affected have not yet been diagnosed.
August 14, 2023 — Source

The real costs of the new Alzheimer's drug, most of which will fall to taxpayers
The first drug purporting to slow the advance of Alzheimer's disease is likely to cost the U.S. health care system billions annually even as it remains out of reach for many of the lower-income seniors most likely to suffer from dementia.
August 14, 2023 — Source

The role of self-extracellular nucleic acids in neuroinflammation
Neuroinflammation contributes to neurological diseases like stroke, infections, traumatic brain injury, AD, PD, and MS. This inflammation is driven by the immune system's response to both danger-associated molecular patterns (DAMPs) and microbial pathogen-associated molecular patterns (PAMPs).
August 14, 2023 — Source

Wildfires and farming activities may be top sources of air pollution linked to increased risk, cases of dementia
Wildfires and farming may pose threats to cognitive health, according to new research from the University of Michigan.
August 14, 2023 — Source

Health — Alzheimers — August 11th, 2023

New Alzheimer's drug raises hopes — along with questions
The FDA has approved Leqembi, the first disease-modifying treatment for early-stage Alzheimer's and a precursor condition, mild cognitive impairment. Medicare has said it will pay for the therapy. Medical centers across the country are scrambling to finalize policies and procedures for providing the medication to patients, possibly by summer's end or early autumn.
August 11, 2023 — Source or Source

Health — Alzheimers — August 9th, 2023

Are mushrooms an effective early dietary intervention for Alzheimer's Disease?
Their review highlights how bioactive compounds in mushrooms, especially neuroprotective small molecules, might help delay the onset and progression of the condition and present mushrooms as a functional food and early dietary intervention for individuals living with the disease.
August 9, 2023 — Source

Genetic marker that often points to heart disease and Alzheimer's may have fertility benefit
Previous research has revealed that the Apolipoprotein-e4 allele increases the risk for a variety of diseases in aging populations, specifically Alzheimer's and cardiovascular disease.
August 9, 2023 — Source

Long-term use of certain acid reflux drugs linked to higher risk of dementia
People who take acid reflux medications called proton pump inhibitors for four-and-a-half years or more may have a higher risk of dementia compared to people who do not take these medications, according to new research published in Neurology. This study does not prove that acid reflux drugs cause dementia; it only shows an association.
August 9, 2023 — Source

Stem cell therapy rescues symptoms of Alzheimer's disease
In the ongoing search for a cure for Alzheimer's disease, a burgeoning branch of medicine is bringing new hope. Stem cell therapies are already being used to treat various cancers and disorders of the blood and immune system. In a new proof-of-concept study, scientists at University of California San Diego show stem cell transplants may also be a promising therapeutic against Alzheimer's.
August 9, 2023 — Source

Health — Alzheimers — August 7th, 2023

Increased risk of dementia diagnosis, benzodiazepine exposure in seniors with anxiety
Research from Saint Louis University School of Medicine finds that among patients 65 and older, a diagnosis of anxiety was significantly associated with an increased risk of dementia diagnosis, and benzodiazepine exposure was associated with a 28% increased risk of dementia.
August 7, 2023 — Source

Research discovers key cause of restricted blood flow to the brain in vascular dementia
High blood pressure is a main cause of vascular dementia, a condition characterized by poor blood flow to the brain. The reduced blood supply starves brain cells of nutrients and over time they become damaged and die. Symptoms of vascular dementia include loss of energy, lack of concentration and poor memory.
August 7, 2023 — Source

Unraveling Alzheimer's catalysts as weavers of amyloid β fibrils
Researchers from the National Institutes of Natural Sciences and Nagoya City University have achieved a significant breakthrough by elucidating the structure of amyloid β bound to glycolipids on the surface of nerve cells. This finding shed light on the critical role of abnormal Aβ fibril formation, a major contributor to Alzheimer's disease, and holds promise for innovative advancements in medicine and pharmacy.
August 7, 2023 — Source

Health — Alzheimers — August 4th, 2023

Researchers propose a strategy to stratify risk of progression from mild cognitive impairment to Alzheimer's
The projected cost of caring for millions of individuals who have Alzheimer's disease (AD) worldwide will exceed a $1 trillion in a few years. In addition to the enormous health burden, patients and their caregivers experience financial, physical and psychological strain.
August 4, 2023 — Source

Health — Alzheimers — August 3rd, 2023

Researchers find potential new tool for early identification of dementia risk
Research at the Florida State University College of Medicine has identified a potential low-cost method for predicting if a person is at risk of developing dementia.
August 3, 2023 — Source

Health — Alzheimers — August 1st, 2023

New £3 million research unit seeks to tackle dementia
Funded by a £3 million grant from The National Institute for Health and Care Research (NIHR), the DeNPRU will produce research on prevention, diagnosis and treatment, care service, and workforce needs.
August 1, 2023 — Source

Sweet smell of success: Simple fragrance method produces major memory boost
When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed. Participants in this study by University of California, Irvine neuroscientists reaped a 226% increase in cognitive capacity compared to the control group.
August 1, 2023 — Source

Health — Alzheimers — July 28th, 2023

Australians living longer, but dementia and Alzheimer's are a greater risk: Study
A new analysis of Australia's disease burden reveals Australians are living six years longer than they were 30 years ago, but more people are being diagnosed with Alzheimer's disease and dementia.
July 28, 2023 — Source

Health — Alzheimers — July 27th, 2023

Biological clock disruptions sound Alzheimer's alarm
New Alzheimer's research from UVA Health suggests that enhanced light sensitivity may contribute to "sundowning"--the worsening of the disease's symptoms late in the day--and spur sleep disruptions thought to contribute to the disease's progression.
July 27, 2023 — Source

Blood-based biomarkers for Alzheimer's disease: Study in China
Discrepancies in diagnostic biomarkers for Alzheimer's Disease (AD) may arise from racial disparities, risk factors, or lifestyle differences. Moreover, there has been a lack of systematic and multicenter studies to evaluate baselines of the AD biomarkers in Chinese populations.
July 27, 2023 — Source

Guidance on new treatments for early Alzheimer's disease issued
New therapies for early Alzheimer's disease, monoclonal antibodies that remove amyloid-β plaques in the brain, are bringing hope to people whose lives have been affected by the disease.
July 27, 2023 — Source

Phyllodulcin could be a potential candidate for treating Alzheimer's disease
Alzheimer's disease is the most common neurodegenerative disorder in the world, associated with symptoms like memory loss and cognitive impairment. Brain lesions caused by the aggregation of amyloid β (Aβ) and neurofibrillary tangles are believed to be the main cause of AD.
July 27, 2023 — Source

Researching twins to better understand memory decline
As people age, they often worry about declining memory and other cognitive abilities. Many of them will see a doctor, who may do some tests to find out that they are functioning normally. This is generally referred to as subjective cognitive complaints (SCC). Previous research has shown that some of these individuals indeed progress to mild cognitive impairment and dementia when followed up over several years; however, the majority do not.
July 27, 2023 — Source

Tau-regulating protein identified as a promising target for developing Alzheimer's disease treatment
A gene encoding a protein linked to tau production--tripartite motif protein 11 (TRIM11)--was found to suppress deterioration in small animal models of neurodegenerative diseases similar to Alzheimer's disease (AD), while improving cognitive and motor abilities, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
July 27, 2023 — Source

Health — Alzheimers — July 25th, 2023

AI study uncovers olive oil's potential in combating Alzheimer's disease
A recent study has used artificial intelligence (AI) to reveal the remarkable potential of extra virgin olive oil (EVOO) in the fight against Alzheimer's disease (AD). Researchers combined AI technology, chemistry, and omics research to identify specific bioactive compounds in EVOO that show promising effects in treating and preventing AD.
July 25, 2023 — Source

Study finds people with dementia and caregivers face stigma, barriers to care
A study led by King's College London has found that people with dementia and their caregivers are frequently met with misunderstanding and social stigma by local community health care services, which is creating a barrier for timely and adequate access to the support they need.
July 25, 2023 — Source

Taking the First Step Towards 6G Standardization: Meet the Researchers Behind the Development of the Draft 6G Framework Recommendation
When we travel abroad, we can freely use our smartphones in different countries and regions through connected roaming services. This is because most countries follow the same standards — an agreed-upon promise — for communication technologies. If these telecommunications standards were any different, we wouldn't be able to use our smartphones as easily and conveniently in different countries as we are able to today.
July 25, 2023 — Source

Health — Alzheimers — July 21st, 2023

Alzheimer's genetic risk tracked across sex, race
A new study of genetic risks for cognitive impairment later in life uses data from 32,426 research participants aged 60 and older to elaborate risk across sex and across the intersection of sex and race.
July 21, 2023 — Source

Scientists spot 32 proteins that hint at Alzheimer's risk
It's difficult to fully predict who will develop Alzheimer's disease in advance. Now, a new study suggests that certain markers in the blood may occur 10 to 20 years before the start of symptoms and could help doctors determine who is at high risk for dementia.
July 21, 2023 — Source

Health — Alzheimers — July 20th, 2023

Bodybuilding supplement may help stave off progression of Alzheimer's
RUSH researchers recently discovered that a muscle-building supplement called beta-hydroxy beta-methylbutyrate, also called HMB, may help protect memory, reduce plaques and ultimately help prevent the progression of Alzheimer's disease.
July 20, 2023 — Source

Donanemab: A trailblazer for Alzheimer's disease treatment?
Early-stage AD involves the buildup of beta-amyloid, which results in neurofibrillary tangles made of tau protein and other distinctive brain alterations collectively known as the amyloid cascade.
July 20, 2023 — Source

Finger prick, venous blood can ID key Alzheimer disease biomarkers
Finger prick or venous blood collection can identify key Alzheimer disease-related biomarkers, according to a study presented at the annual Alzheimer's Association International Conference, held from July 16 to 20 in Amsterdam.
July 20, 2023 — Source or Source

MIND diet trial finds no significant cognitive improvements or changes in brain morphology
Research into the effects of the MIND diet led by the Rush Alzheimer's Disease Center, Chicago, has found no significant improvement after three years compared to a control diet group with mild caloric restriction.
July 20, 2023 — Source

Researchers develop algorithm to help predict Alzheimer's risk in various ethnic populations
Using data from diverse populations around the world, researchers from Children's Hospital of Philadelphia have developed an algorithm to help predict the risk of developing Alzheimer's disease based on genetic information in patients with a wide variety of ethnic backgrounds.
July 20, 2023 — Source

Residence in disadvantaged neighborhoods increases dementia risk
Christina S. Dintica, Ph.D., from the University of California in San Francisco, and colleagues examined the association between the Areas Deprivation Index and dementia in a retrospective cohort study involving a national cohort of older veterans. The final analytic sample included 1,637,484 participants with at least one follow-up visit.
July 20, 2023 — Source

Volunteering in late life may protect the brain against cognitive decline and dementia
Volunteering in late life is associated with better cognitive function--specifically, better executive function and episodic memory. Those are the findings of a new study from UC Davis Health presented today (July 20) at the Alzheimer's Association International Conference 2023 in Amsterdam.
July 20, 2023 — Source or Watch Video

Which aspects of sleep architecture and respiratory-related sleep disturbances are associated with cognitive function in middle-aged to older adults?
There is an overall shortage of data on associations between poor sleep and dementia. The Lancet Commission on Dementia Prevention did not include poor sleep in 12 modifiable risk factors for dementia.
July 20, 2023 — Source

Health — Alzheimers — July 19th, 2023

Blood clots
Blood clots are gel-like clumps of blood. When they form in response to a cut or other injury, they stop the bleeding by plugging the injured blood vessel. These blood clots help the body heal.
July 19, 2023 — Source

Constipation may be a marker for dementia risk
Chronic constipation may not only be an indicator of gut health, but a potential warning sign of thinking declines, a preliminary study suggests.
July 19, 2023 — Source

Do certain amino acids modify the risk of dementia linked to air pollution?
Higher levels of vitamin B-related amino acids may be linked to the risk of dementia associated with a certain type of air pollutants called particulate matter, according to a study published in Neurology. The study does not prove that pollution or amino acids cause dementia, but it suggests a possible link among them.
July 19, 2023 — Source

Espresso coffee prevents Alzheimer's tau protein clumping in lab tests
Whether enjoyed on its own or mixed into a latte, Americano or even a martini, espresso provides an ultra-concentrated jolt of caffeine to coffee lovers. But it might do more than just wake you up. Research now published in the Journal of Agricultural and Food Chemistry shows that, in preliminary in vitro laboratory tests, espresso compounds can inhibit tau protein aggregation--a process that is believed to be involved in the onset of Alzheimer's disease.
July 19, 2023 — Source

New Alzheimer's Drug Dramatically Slows Disease Progression
A donanemab treatment by Eli Lilly could help delay the onset of severe Alzheimer's symptoms.
July 19, 2023 — Source

New Alzheimer's drug is first to show it slows disease. But It's facing a rocky rollout
Eisai Co.'s breakthrough Alzheimer's drug--the first to show it slows the brain-destroying disease--is facing a rocky rollout as doctors grapple with logistical issues, insurance uncertainties and complicated safety testing requirements.
July 19, 2023 — Source

Solanezumab does not slow cognitive decline in preclinical Alzheimer disease
Reisa A. Sperling, M.D., from Massachusetts General Hospital in Boston, and colleagues tested solanezumab, which targets monomeric amyloid, in a phase 3 trial involving persons aged 65 to 85 years with preclinical Alzheimer disease and elevated brain amyloid levels. Participants were randomly assigned to receive solanezumab or placebo (578 and 591, respectively).
July 19, 2023 — Source

Ulcerative colitis flare-ups: 5 tips to manage them
Diet and lifestyle changes may help control ulcerative colitis symptoms and lengthen the time between flare-ups.
July 19, 2023 — Source

Health — Alzheimers — July 14th, 2023

New evidence links sight loss to dementia
A new study suggests that sight loss in people over 71 years old may be linked to dementia.
July 14, 2023 — Source

Health — Alzheimers — July 7th, 2023

Patient portal use explored for older adults with dementia diagnosis
Older adults with dementia diagnosis are as likely to be registered for a patient portal as those without dementia, and they have a lower portal activity metric, according to a research letter published online June 26 in JAMA Internal Medicine.
July 7, 2023 — Source

The first drug that slows Alzheimer's has finally received FDA approval
Leqembi will cost a user around $26,500-per-year.
July 7, 2023 — Source

The Risks and Benefits of Leqembi, the Newest Alzheimer's Drug, Explained
The FDA granted Leqembi full approval on July 6. Here's what to know about who it is for and how much it may help.
July 7, 2023 — Source

What is 'sundowning' and why does it happen to many people with dementia?
The term "sundowning" is sometimes used to describe a tendency for people living with dementia to become more confused in the late afternoon and into the night.
July 7, 2023 — Source

Alzheimer — Resources — A

A little-understood sleep disorder affects millions and has clear links to dementia--4 questions answered
A little-known and poorly understood sleep disorder that occurs during the rapid eye movement, or REM, stage of sleep has been garnering attention for its role in foreshadowing neurodegenerative brain diseases such as Parkinson's disease and dementia with Lewy bodies.
May 26, 2023 — Source

A self-administered mobile app to detect Alzheimer's disease using speech data
Alzheimer's disease is the most common form of dementia. It is important to start intervention from an early stage, e.g., the mild cognitive impairment stage, to prevent or delay the progression of AD. For the early detection of AD and MCI, there is a growing need to develop user-friendly, self-administered screening tools for use in everyday life.
May 11, 2023 — Source

Air pollution may increase risk of dementia, complicated by genetics
Three years ago, an international study commissioned by the journal Lancet listed 12 modifiable factors that increased the risk of dementia, including three new ones: excessive alcohol, head injury and air pollution.
May 2, 2023 — Source or Source

Alzheimer — Resources — C

Cutting-Edge Nasal Tech Could Usher in a New Era of Medicine
Noses are like caverns — twisting, turning, no two exactly the same. But if you nose past anyone's nostrils, you'll discover a surprisingly sprawling space.
June 20, 2023 — Source

Alzheimer — Resources — D

Dementia and self-harm: Why it's crucial to support patients in first year after diagnosis
People diagnosed with dementia are more likely to self-harm within the first six to 12 months after initial diagnosis, highlighting the need for health services to offer more follow-up support in this crucial period.
May 2, 2023 — Source

Dementia can take a toll on financial health, as some families learn the hard way
Angela Reynolds knew her mother's memory was slipping, but she didn't realize how bad things had gotten until she started to untangle her mom's finances: unpaid bills, unusual cash withdrawals, and the discovery that, oddly, the mortgage on the family home had been refinanced at a higher interest rate.
June 20, 2023 — Source or Source

Dementia is not the end of learning, finds researcher
People with dementia still have the ability to learn new things despite their illness. This is the conclusion of a doctoral thesis recently presented at Linköping University, Sweden. Its findings debunk the general belief that people with dementia are empty shells, according to Elias Ingebrand, who conducted the study.
July 3, 2023 — Source

Alzheimer — Resources — E

Early data suggest the Bacillus Calmette-Guerin vaccine could have a protective effect against Alzheimer's
The Bacillus Calmette-Guerin (BCG) vaccine--which prevents tuberculosis--offers multiple beneficial effects, and it's currently a recommended therapy for non--muscle-invasive bladder cancer. In a new study led by investigators at Massachusetts General Hospital (MGH) and Brigham and Women's Hospital (BWH), treatment with the BCG vaccine was associated with a reduced risk of Alzheimer's disease and related dementias.
May 19, 2023 — Source

Early diagnosis of Alzheimer's: Ultra-long protein fibrils give clues on dementia risk
The early detection and treatment of dementia such as Alzheimer's is still one of the great challenges of modern medicine. It is already known that certain proteins in the cerebrospinal fluid can be used to diagnose Alzheimer's disease.
May 9, 2023 — Source

Alzheimer — Resources — F

FDA approves first drug meant to ease Alzheimer's-linked agitation
The FDA gave supplemental approval to Otsuka Pharmaceutical Company Ltd., and Lundbeck Inc. for Rexulti (brexpiprazole) oral tablets on Thursday. Rexulti is the first FDA-approved treatment for these symptoms.
May 12, 2023 — Source

Former football player's cognitive symptoms improve after case study reveals alternative diagnosis and treatment
Football players who have had repetitive head trauma and concussion are at heightened risk for chronic traumatic encephalopathy (CTE), an irreversible condition that leads to dementia.
May 5, 2023 — Source

Alzheimer — Resources — G

Genomics- and image-guided subtyping refines characterization of Alzheimer's disease
A new computational technique that combines genomic and tau PET imaging data promises a more personalized approach for subtyping Alzheimer's disease. Based on a novel clustering framework using sparse canonical correlation analysis (SCCA), the integrated approach was successful in identifying four subtypes of Alzheimer's disease and the top genes associated with each.
June 27, 2023 — Source

Alzheimer — Resources — H

Having dementia and reduction in social participation are associated with increased depression and anxiety
An increased risk of depression and anxiety among US older adults with dementia and poor activity participation has been demonstrated through an analysis of data from the National Health and Aging Trends Study (NHATS), a nationally representative population-based study.
May 11, 2023 — Source

Heat waves are a hazard for people with dementia: How to keep them safe
Heat waves that hit the triple digits, like the ones now gripping many parts of the United States this week, can create dangerous conditions for folks who are vulnerable.
July 3, 2023 — Source

How 'extracellular chaperones' help remove abnormal proteins
Proteins tend to fold wrongly and become defective when exposed to stressors such as heat, oxidation, and pH changes. Accumulation of abnormal proteins contributes to neurodegenerative diseases like Alzheimer's.
May 11, 2023 — Source

Alzheimer — Resources — I

Insights into the direction and extent of gut microbiome dysbiosis in Alzheimer's disease and mild cognitive impairment
Researchers performed a meta-analysis to determine the association between intestinal microbiota and Alzheimer's disease (AD).
May 26, 2023 — Source

Intermittent fasting could help protect the brain from age-related diseases like Alzheimer's
As the world population has grown older, Alzheimer's disease has become increasingly common. Alzheimer's disease is the most prevalent form of dementia. Dementia is a term used to describe a range of symptoms linked to the decline in brain function with age.
June 30, 2023 — Source

Alzheimer — Resources — M

Menopausal hormone therapy associated with increased rate of dementia and Alzheimer's disease
An increase was seen in long-term users of menopausal hormone therapy, but also in short-term users around the age of menopause (55 years or younger) as is currently recommended.
July 3, 2023 — Source

Multi-disciplinary program shows promise for treating ADHD, post-concussion syndrome, and memory loss
The Journal of Alzheimer's Disease Reports published a paper today by nationally-recognized neurologist Dr. Majid Fotuhi, MD, PhD that details a multi-disciplinary program for patients with Attention Deficit Hyperactive Disorder (ADHD), post-concussion syndrome (PCS), or memory loss.
June 30, 2023 — Source

Multiple co-occurring sensory impairments may increase the risk of dementia
Emerging science shows that sensory dysfunction can increase the risk of dementia, and the new research presented at AAIC 2019 further demonstrates the impact of multiple co-occurring sensory impairments.
May 2, 2023 — Source

Alzheimer — Resources — N

Need for formal bereavement support in dementia care is largely underestimated
The need for grief counseling in dementia care may be substantially underestimated, according to new research led by a UCL academic.
June 9, 2023 — Source

New study reveals how blood triggers brain disease
In patients with neurological diseases like Alzheimer's disease and multiple sclerosis, immune cells in the brain known as microglia that normally fulfill beneficial functions become harmful to neurons, leading to cognitive dysfunction and motor impairment. These harmful immune cells may also contribute to age-related cognitive decline in people without dementia.
June 8, 2023 — Source

Noninvasive modulation of brain hemodynamic and metabolic states by near-infrared light
The human brain is a dominant site for energy metabolism in the body. The intrinsic contraction and relaxation of the vascular walls, also known as "vasomotion," is responsible for metabolic and hemodynamic activity in the human brain. Disturbances in vasomotion are associated with neurological conditions, such as atherosclerosis, Alzheimer's disease, Parkinson's disease, and stroke.
June 6, 2023 — Source

Novel engineered approach makes protein aggregates amenable to spatial manipulations in cells
Protein aggregates accumulate during aging and are linked to neurodegenerative diseases like Alzheimer's, Parkinson's or Huntington's disease.
June 30, 2023 — Source

Nursing home dementia residents' care linked to majority presence, new study finds
The quality of care for nursing home residents with Alzheimer's disease and related dementias is best when they are in the majority, but most facilities also accommodate a heterogeneous population, where specialized staff training is limited, according to a study led by the University of California, Irvine.
June 6, 2023 — Source

Alzheimer — Resources — P

Passing the sniff test: Can we train our brain to boost smell and memory?
A new study is investigating whether learning to remember smells can boost memory more broadly and reduce the risk of dementia.
May 2, 2023 — Source

Patients with Alzheimer's disease, dementia face twice the risk of dying after ICU discharge
Older patients with Alzheimer's disease and related dementia (ADRD) have almost twice the risk of dying soon after they are discharged from an intensive care unit (ICU) and within the 12 months afterward, according to research published in the American Journal of Critical Care.
July 3, 2023 — Source

Poorly insulated nerve cells shown to promote Alzheimer's disease in old age
Alzheimer's disease, an irreversible form of dementia, is considered the world's most common neurodegenerative disease. The prime risk factor for Alzheimer's is age, although it remains unclear why.
June 2, 2023 — Source

Alzheimer — Resources — R

Reducing dementia risks
Former first lady Rosalynn Carter has been diagnosed with dementia. A family statement, posted on The Carter Center website, says that she continues to live happily at home with her husband, enjoying spring in Plains, Georgia, and visits with loved ones.
June 6, 2023 — Source

Regular napping linked to larger brain volume
Daytime napping may help to preserve brain health by slowing the rate at which our brains shrink as we age
June 20, 2023 — Source

Research reveals clues to why immune cells seem to cause brain damage
In the human central nervous system, there are tiny cells that--for most people, most of the time--provide important immune protection to the brain and spinal cord. Occasionally these microglia cells run terribly awry, leading to neurodegenerative diseases like multiple sclerosis and Alzheimer's disease.
May 30, 2023 — Source

Researchers discover novel 'Shanghai APP' mutation in late-onset Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting tens of millions of people worldwide, and it is the most common cause of dementia. Early-onset AD is typically associated with mutations in the genes APP, PSEN1, and PSEN2, leading to a more aggressive form of the disease with atypical symptoms.
May 12, 2023 — Source

Alzheimer — Resources — S

Single-cell dissection of Alzheimer's vascular changes across six brain regions
Your brain is powered by 400 miles of blood vessels that provide nutrients, clear out waste products, and form a tight protective barrier--the blood brain barrier--that controls which molecules can enter or exit.
June 2, 2023 — Source

Slow walking could be sign of dementia in older dogs
Dogs who slow down physically also slow down mentally, according to a new study from North Carolina State University. Measuring gait speed in senior dogs could be a simple way to monitor their health and to document decline in their neurological function as they age.
June 27, 2023 — Source

Stress increases Alzheimer's risk in female mice but not males
Alzheimer's proteins rise sharply in response to stress in female mice
May 2, 2023 — Source or Source

Study: Blood vessel damage could be an Alzheimer's driver
Blood vessel abnormalities in the eye are a major factor in the progression of Alzheimer's disease, according to research from Cedars-Sinai investigators published in the journal Alzheimer's & Dementia. These changes correspond to changes in the brain, offering a new possibility for early diagnosis.
May 19, 2023 — Source

Study finds some motor neuron disease and dementia patients share genetic defects
New research has discovered that some patients with motor neuron disease (MND) and frontotemporal dementia (FTD) carry the same rare genetic defects that cause other neurodegenerative diseases.
May 9, 2023 — Source

Study shows traffic-related air pollution in Irvine weakens brain function
Researchers from the University of California, Irvine have found that exposure to traffic-related air pollution in Irvine led to memory loss and cognitive decline and triggered neurological pathways associated with the onset of Alzheimer's disease.
May 11, 2023 — Source

Study suggests resistance training can prevent or delay Alzheimer's disease
Regular physical exercise, such as resistance training, can prevent Alzheimer's disease, or at least delay the appearance of symptoms, and serves as a simple and affordable therapy for Alzheimer's patients
July 3, 2023 — Source

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Tallulah Willis Opens Up About Dad's Dementia Battle In Emotional Essay
Tallulah Willis' recent emotional essay left many in tears as it featured some heartbreaking revelations. The actress opened up about her father Bruce Willis' dementia battle.
June 2, 2023 — Source

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Ultra-long protein fibrils are a signature of severe Alzheimer's disease, study shows
During the course of Alzheimer's disease, protein fibrils appear in the spinal fluid of affected individuals. Empa researchers, together with the Department of Neurology at the Cantonal Hospital in St. Gallen, have now visualized the wide spectrum of protein aggregates from oligomers, protofibrils to fibrils in the spinal fluid.
May 9, 2023 — Source

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Wegovy and Ozempic: Could the new weight-loss drug also treat dementia?
Over 55 million people worldwide have dementia. This mind-robbing condition has a huge impact on society and the economy, so scientists are working hard to find ways to treat or prevent it. One of the avenues being explored is the new weight-loss jab, Wegovy.
May 19, 2023 — Source

What causes Alzheimer's? Genes, environment and lifestyle play roles
To help you better understand the condition and what you can do to manage it, experts detail what causes Alzheimer's disease. In this guide, you'll learn about the genetic, environmental and lifestyle factors that scientists think may interact to contribute to the development of this memory-robbing disease.
June 20, 2023 — Source

When someone living with dementia is distressed or violent, 'de-escalation' is vital
Today's reporting about the alleged tasering of a 95-year-old woman living at the Yallambee Lodge aged care home in New South Wales has brought the issue of behaviors and psychological symptoms of dementia into sharp focus.
May 19, 2023 — Source

Why subjective cognitive decline is a growing health issue among women
Have you thought about your memory lately? According to the CDC, 11% of people over age 45 have Subjective Cognitive Decline, a form of cognitive impairment that can be one of the earliest noticeable symptoms of Alzheimer's disease and related dementias. That's 1 in 9.
May 23, 2023 — Source

Women with common heart rhythm disorder found to have faster cognitive decline than men
Women with atrial fibrillation progress more rapidly to cognitive impairment and dementia than men with the heart rhythm condition, according to research presented today at ACNAP 2023, a scientific congress of the European Society of Cardiology (ESC) and published in the journal Alzheimer's & Dementia.
June 23, 2023 — Source

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You may soon be able to get a blood test for Alzheimer's, but will you want one?
When Daniel Gibbs, M.D., enrolled in an Alzheimer's study at UC San Francisco almost a decade ago, researchers needed access to a secure government facility just to confirm that he had the disease. They summoned Gibbs to the Lawrence Berkeley National Laboratory, hooked him up to an IV, and wheeled him into a donut-shaped machine called a PET (positron emission tomography) scanner.
June 30, 2023 — Source

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Alzheimer's Association
Our vision is a world without Alzheimer's disease
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