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493 Health - Double Helix - DNA - Genes - Genetics - Genome Resources

Misc. - Numbers

3D imaging technique maps migration of DNA-carrying material at the center of cells
Scientists have mapped the reorganization of genetic material that takes place when a stem cell matures into a nerve cell. Detailed 3-D visualizations show an unexpected connectivity in the genetic material in a cell's nucleus, and provide a new understanding of a cell's evolving architecture.
November 22, 2016
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3D Printer Hacked to Perform Fast and Cheap DNA Sequencing
Scientists at AI Biosciences, a company out of College Station, Texas, modified a 3D printer to perform automated nucleic acid extraction and DNA amplification, the crucial steps for DNA sequencing. Typically, laboratory devices that perform extraction and amplification can cost tens of thousand of dollars. the hacked printer approach, on the other hand, costs in the hundreds of dollars.
August 19, 2016
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23andMe is finally allowed to tell you if you have the genes for Parkinson's
The Food and Drug Administration finally gave 23andMe a long sought-after green light today to sell to consumers genetic tests and their accompanying health risk reports for up to 10 diseases, including late-onset Alzheimer's and Parkinson's.
April 6, 2017
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23andMe President Andy Page is departing
He will remain on the board of the personal genomics company.
November 16, 2016
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23andMe reportedly no longer working on next-gen sequencing
23andMe won't continue with next-generation DNA sequencing and has reportedly laid off the lab working on the project.
October 26, 2016
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23andMe wants researchers to use its kits, in a bid to expand its collection of genetic data
'It brings new people into the 23andMe database.'
July 13, 2016
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23andMe wins FDA approval to give customers health risk info
The gene testing company can now tell US customers who use its home DNA kit whether they have a genetic risk for any of 10 diseases and conditions.
April 6, 2017
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23andMe: a Medgadget Review
In 2007, Anne Wojcicki's 23andMe transformed personalized health with the unveiling of a direct to consumer genetic testing service in which subscribers would receive information about their ancestry, physical traits, and disease carriers by simply providing a saliva sample via mail to the company's labs.
May 11, 2017
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23andMe's Anne Wojcicki has a plan to include better genetic data from people of color
One of the first consumer genetic testing companies, 23andMe says it aims to be at the forefront in gathering genetically diverse data throughout the world.
September 22, 2016
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Misc. - A

A big-picture look at the world's worst Ebola epidemic
International team of scientists show how real-time sequencing and data-sharing can help stop the next outbreak
April 12, 2017
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A chicken-egg question: Where do baby genes come from?
New genes are more likely to emerge full-fledged from a genome's 'junk' DNA, according to scientists
April 26, 2017
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A chip-sized ultra-resolution microscope
Creating a new type of chip-sized optical microscope with high resolution capabilities is the challenge of ChipScope, a European project led by the University of Barcelona which counts with the participation of SMEs, universities and research institutes from five European countries. the objective is to develop the necessary science and technology to see extremely small structures such as viruses, DNA molecules or the inside of cells, in real time and without the disadvantages of the current high resolution techniques.
April 6, 2017
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A fresh look inside the protein nanomachines
Proteins perform vital functions of life, they digest food and fight infections and cancer. They are in fact nano-machines, each one of them designed to perform a specific task. But how did they evolve to match those needs, how did the genes encode the structure and function of proteins?
May 24, 2017
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A gene's journey from covert to celebrated
Unmasking a previously misunderstood gene, scientists discover an unlikely potential drug target for gastrointestinal cancers.
January 23, 2017
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A milestone in small RNA biology
piRNA biogenesis from start to finish
November 16, 2016
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A new Flavor of CRISPR Could Tackle some of the Worst Genetic Diseases
Most of the time, when people talk about the cutting edge gene editing technology CRISPR, they are actually talking about CRISPR-Cas9. CRISPR, you see, is just one half of the genome editing tool, the programming that instructs where a DNA edit will actually be made. the other part consists of proteins that actually do the cutting. and one particular protein, called Cas9, has long been the snipping tool of choice. But now, there's a new protein on the block--and it may open the door to curing a devastating genetic disease.
April 12, 2017
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A new Lab-Built Fungus Eats Sugar and Burps Out Drugs
THERE MIGHT BE older fromances out there, but by most accounts the bond between humans and yeast has been the most prolific.
March 9, 2017
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A new tool for genetically engineering the oldest branch of life
CRISPR-Cas9 successfully used to modify an archaeal species for the first time
March 8, 2017
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A novel testing platform to assess, in real time, the efficacy of nanomaterials in regulating gene expression
Northwestern Medicine scientists have developed a novel testing platform to assess, in real time, the efficacy of nanomaterials in regulating gene expression. the findings, published in Proceedings of the National Academy of Sciences, could help to facilitate preclinical investigations and optimize nanotherapeutics for cancers before they reach clinical trials.
April 12, 2017
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A Personalized Nutrition Company will Use your DNA to Tell you what to Eat
Is a Diet Based on your Genome the Future of Nutrition?
October 25, 2016
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A three-dimensional map of the genome
Cells face a daunting task. they have to neatly pack a several meter-long thread of genetic material into a nucleus that measures only five micrometers across. this origami creates spatial interactions between genes and their switches, which can affect human health and disease. Now, an international team of scientists has devised a powerful new technique that 'maps' this three-dimensional geography of the entire genome.
March 10, 2017
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A three-dimensional map of the genome
Gene mapping technique promises to unlock the power of proximity to find genes implicated in diseases
March 8, 2017
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Aboriginal hair shows 50,000 year connection to Australia
DNA in hair samples collected from Aboriginal people across Australia in the early to mid-1900s has revealed that populations have been continuously present in the same regions for up to 50,000 years -- soon after the peopling of Australia.
March 8, 2017
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Adaptive PCR, a new Powerful Technique to Speed Up Genetic Analysis
Researchers at Vanderbilt University have developed a new way of performing PCR (polymerase chain reaction), or amplifying DNA so there's enough of it to perform genetic analysis. the technique is called adaptive PCR and it relies on using only left-handed DNA (L-DNA), which is the mirror of normal DNA, to help regulate and monitor PCR. PCR is currently a fragile process that can be impeded by inexact sample preparation and environmental conditions. Having a way of continuously monitoring and guiding the process can lead to faster and cheaper results from genetic analysis and reduce the size of the machines used.
January 17, 2017
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Advancing nanopore sensing towards lower cost and more accurate DNA sequencing
In a future of personalized medicine, doctors may quickly glean the changes in the DNA sequences of patients that predispose them to specific diseases or determine the most appropriate therapeutic approach simply by analyzing a saliva sample. at present, however, reading DNA sequences from genomes using current next generation sequencing methods is still a costly endeavor restricted to well-equipped laboratories.
October 10, 2016
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After the epigenome: the epitranscriptome
After genetics, and epigenetics, the epitranscriptome might offer new answers to some diseases
March 22, 2017
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Aging process increases DNA mutations in important type of stem cell
Researchers say results should be considered when designing iPSC therapies
December 12, 2016
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Algorithms offer insight into cellular development
Through RNA sequencing, researchers can measure which genes are expressed in each individual cell of a sample. a new statistical method allows researchers to infer different developmental processes from a cell mixture consisting of asynchronous stages.
August 31, 2016
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Algorithms offer insight into cellular development
Through RNA sequencing, researchers can measure which genes are expressed in each individual cell of a sample. a new statistical method allows researchers to infer different developmental processes from a cell mixture consisting of asynchronous stages.
August 31, 2016
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Allen Institute for Cell Science releases gene edited, fluorescently tagged human iPS cells
The Allen Institute for Cell Science has released the Allen Cell Collection: the first publicly available collection of gene edited, fluorescently tagged human induced pluripotent stem cells that target key cellular structures with unprecedented clarity.
November 30, 2016
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An 'ignition key' revs up DNA shuffling to make antibodies
Researchers studying mouse proteins uncover part of 'choreography of immunity'
February 9, 2017
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Analog DNA circuit does math in a test tube
DNA computers could one day be programmed to diagnose and treat disease
August 23, 2016
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Analysis of DNA from early settlers of the pacific overturns leading genetic model
A scientific team analyzed DNA from people who lived in Tonga and Vanuatu between 2,500 and 3,100 years ago, and were among the first people to live in these islands. the results overturn the leading genetic model for this last great movement of humans to unoccupied but habitable lands.
October 3, 2016
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Ancient DNA can both diminish and defend modern minds
A new study shows cognitive decline may be influenced by the interaction of genetics and ... worms?
December 30, 2016
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Ancient DNA evidence shows hunter-gatherers and farmers were intimately linked
In human history, the transition from hunting and gathering to farming is a significant one. As such, hunter-gatherers and farmers are usually thought about as two entirely different sets of people. But researchers reporting new ancient DNA evidence show that in the area we now recognize as Romania, at least, hunter-gatherers and farmers were living side by side, intermixing with each other, and having children.
May 25, 2017
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Ancient DNA reveals genetic 'continuity' between Stone Age, modern populations in East Asia
In contrast to Western Europeans, new research finds contemporary East Asians are genetically much closer to the ancient hunter-gatherers that lived in the same region eight thousand years previously.
February 1, 2017
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Ancient DNA showcases a war between our hominid ancestors and viruses
Viruses reproduce by infiltrating living cells and taking over the biological machinery inside. it's an insidious process that can leave the host with a life-threatening illness, a mild fever, or no ill effects at all. Recent advances in medical science have allowed humans to combat viruses like never before, but a new study from researchers at Rockefeller University shows how our primate ancestors may have waged war on a virus with only the weapon of evolution.
April 13, 2017
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Ancient hominid 'hanky panky' also influenced spread of STIs
With recent studies proving that almost everyone has a little bit of Neanderthal DNA in them ---- up to 5 percent of the human genome --- it's become clear our ancestors not only had some serious hominid 'hanky panky' going on, but with it, a potential downside: the spread of sexually transmitted infections, or STIs.
October 17, 2016
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AngioSculptX, a new Drug-Coated PTCA Catheter now Available in Europe
Spectranetics out of Colorado Springs, Colorado won the CE Mark in Europe to bring to market its AngioSculptX Drug-coated PTCA (percutaneous transluminal coronary angioplasty) Scoring Balloon Catheter. Originally developed by AngioScore, a company purchased by Spectranetics, the device is a drug coated version of the company's proven AngioSculpt PTCA scoring balloon catheter and is indicated for treatment of coronary artery stenosis, which includes in-stent restenosis.
August 12, 2016
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Anorexia nervosa has a genetic basis
Anorexia nervosa is associated with genetic anomalies on chromosome 12, a large-scale, international whole-genome analysis has now revealed for the first time. This finding might lead to new, interdisciplinary approaches to its treatment.
June 12, 2017
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Are you a 'night owl'? you may have this genetic mutation
Few of us enjoy waking up early in the morning, but some people struggle more than most. According to a new study, if you fall asleep late and are finding it extremely hard to wake up early in the morning, you may have a genetic mutation that alters your circadian rhythm.
April 6, 2017
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ARIES M1, a new Compact Clinical Real-Time PCR System
Luminex won clearance from the FDA and European CE-IVD mark of approval to introduce its ARIES M1 real-time PCR system. Designed for smaller clinical labs, the M1 is a lower throughput version of the company's ARIES system, offering essentially the same features in a smaller package.
July 11, 2016
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Artificial DNA Condensation Recreated on Biochip
Individual molecules of a genetic material naturally repel each other, but if space is limited, DNA molecules must be packed together more tightly.
August 10, 2016
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Astronauts sequence DNA in space for the first time
Microgravity does little to life's secret sauce, experiment confirms
August 31, 2016
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Australia was colonized by a single group 50,000 years ago
Finding could help explain aspects of Aboriginal communities' belief systems.
March 8, 2017
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Misc. - B

Barcodes show the blood family tree
By assigning a barcode to stem cells, researchers have made it possible to monitor large blood cell populations as well as individual blood cells, and study the changes over time. Among other things, they discovered that stem cells go through different stages where their ability to restore immune cells varies.
August 24, 2016
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Barley genome sequenced
Research could lead to better beer, single malt Scotch whiskey
April 26, 2017
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Best snacks for people with type 2 diabetes
Diabetes can lead to a wide range of symptoms including high blood pressure, circulation issues, kidney damage, blindness, and skin problems. But the right diet can help manage these symptoms.
April 24, 2017
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Beyond the DNA double helix: from twofold to fourfold DNA
Watson and Crick proposed the DNA double-helix structure over 60 years ago, but DNA is not always arranged in a double helix, also forming other structures. One such structure is fourfold DNA, which is found near DNA-encoded genes that are key in causing cancer. by the formation of such quadruplex DNA, the expression of cancer-related genes can be blocked.
November 7, 2016
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Binge-eating disorder may lead to other endocrine and circulatory systems-related illnesses
Binge-eating disorder was linked with a broad range of other illnesses in a recent study, with the strongest associations related to the endocrine and circulatory systems.
September 19, 2016
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Biocompatible nanomaterial that can be controlled with light finds a use in gene delivery
A tiny therapeutic delivery system that can control the body's ability to manufacture proteins has been developed by Saudi Arabia's King Abdullah University of Science and Technology researchers.
September 22, 2016
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Block copolymer micellization as a protection strategy for DNA origami
Scientists from the Center for Advancing Electronics Dresden (cfaed) / TU Dresden and the University of Tokyo led by Dr. Thorsten-Lars Schmidt developed a method to protect DNA origami structures from decomposition in biological media. this protection enables future applications in nanomedicine or cell biology.
March 16, 2017
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BNP Paribas sentenced in $8.9 billion U.S. sanctions accord
BNP Paribas SA was sentenced to five years probation by a U.S. judge on Friday in connection with a record $8.9 billion settlement resolving claims that it violated sanctions against Sudan, Cuba and Iran.
May 1, 2015
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Bone gene in mammals may take additional role to promote cognition in humans
A gene that regulates bone growth and muscle metabolism in mammals may take on an additional role as a promoter of brain maturation, cognition and learning in human and nonhuman prim ates, according to a new study led by neurobiologists at Harvard Medical School.
November 9, 2016
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Misc. - C

Caltech scientists develop simple way to visualize gene expression with MRI
Genes tell cells what to do -- for example, when to repair DNA mistakes or when to die--and can be turned on or off like a light switch. Knowing which genes are switched on, or expressed, is important for the treatment and monitoring of disease. Now, for the first time, Caltech scientists have developed a simple way to visualize gene expression in cells deep inside the body using a common imaging technology.
December 23, 2016
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Cambridge Consultants creates new Evonetix spin-out to focus on accurate DNA synthesis
A breakthrough in DNA synthesis has led to the creation of a new spin-out company from the stable of product design and development firm Cambridge Consultants. the joint venture, supported by technology entrepreneur and venture capitalist Hermann Hauser, heralds a new era. It opens the door to the kind of rapid drug discovery that is crucial for truly personalised 'precision' medicine or the race against time to find the next generation of antibiotics.
July 19, 2016
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Can Childhood Traumas Make you Old Before your Time?
Study suggests link between family stress and potential damage to DNA
October 3, 2016
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Captured on video: DNA nanotubes build a bridge between 2 molecular posts
In a microscopic feat that resembled a high-wire circus act, Johns Hopkins researchers have coaxed DNA nanotubes to assemble themselves into bridge-like structures arched between two molecular landmarks on the surface of a lab dish.
January 5, 2017
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CAR T cells more powerful when built with CRISPR, researchers find
Researchers have harnessed the power of CRISPR/Cas9 to create more-potent chimeric antigen receptor (CAR) T cells that enhance tumor rejection in mice.
February 22, 2017
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Catching CRISPR in action
One of the most talked about biological breakthroughs in the past decade was the discovery of the genome editing tool CRISPR/Cas9, which can alter DNA and potentially remove the root causes of many hereditary diseases.
January 11, 2017
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Catching CRISPR in action: First all-atom simulation of genome editing in action
Scientists have performed the first all-atom molecular dynamics simulations of Cas9-catalyzed DNA cleavage in action. the simulations shed light on the process of Cas9 genome editing and helped resolve controversies about specific aspects of the cutting.
January 11, 2017
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Cell biology: Take the mRNA train
Messenger RNAs bearing the genetic information for the synthesis of proteins are delivered to defined sites in the cell cytoplasm by molecular motors. Researchers have elucidated how the motors recognize their mRNA freight.
January 17, 2017
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Chemists color world of 3-D crystals with advances in self-assembly
A team of New York University chemists has created self-assembled, three-dimensional DNA crystals that can bind a separate, dye-bearing strand--a breakthrough that enhances the functionality of these tiny building blocks. the advance, reported in the journal Nature Chemistry ("Self-assembled 3D DNA crystal device "), offers promise for the creation of enhanced synthetic chemistry.
March 13, 2017
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Chemists create clusters of organelles by mimicking nature
Scientists from the University of Basel have succeeded in organizing spherical compartments into clusters mimicking the way natural organelles would create complex structures. they managed to connect the synthetic compartments by creating bridges made of DNA between them.
November 2, 2016
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Chinese patient is first to be treated with CRISPR-edited cells
Chinese scientists have injected a person with CRISPR/Cas9-edited cells, marking the first time cells altered with the technique have been used in humans. Researchers used the powerful gene editor to alter immune cells to fight lung cancer, Nature reports November 15.
November 16, 2016
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Chromatrap® kit shown to excel in DNA purification
Chromatrap® reports on the excellent results achieved by customers using their 96 well high throughput plates for ultra-pure DNA purification.
January 26, 2017
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CNIO researchers find panoramic view of proteins that intervene in a cellular process
Three years ago, the research team directed by Óscar Fernández-Capetillo, head of the Genomic Instability Group at the Spanish National Cancer Research Centre (CNIO), obtained, for the first time, a panoramic view of the proteins that intervene in one of the most important and delicate cellular processes: the copying of genetic material during cellular division. they observed that the parts of the genome where the DNA was copied were also very rich in the modification by some very particular proteins, SUMOylations, and poor in others, ubiquitinations, but they were unable to understand why.
March 8, 2016
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Coffee Cravings May Spring from your DNA
Genes appear to influence how much caffeine you need, researchers find
August 25, 2016
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Coffee drinking habits can be written in our DNA, study finds
Researchers have identified a gene that appears to curb coffee consumption. People with a DNA variation in a gene called PDSS2 tend to drink fewer cups of coffee, the study found.
August 25, 2016
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Computational modeling of genome mapping in nanochannels helps untangle the physics of DNA knots
While DNA sequencing provides precise, nucleotide-by-nucleotide genomic information, genome mapping provides a bigger-picture perspective of sequenced DNA that can provide valuable structural information. Like mapping roads to depict a city's structural information without needing to detail each home or business, genome mapping can be a powerful tool for understanding variations of large pieces of rearranged or altered DNA.
April 12, 2017
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Cortisol excess hits natural DNA process and mental health hard
High concentrations of the stress hormone cortisol in the body affect important DNA processes and increase the risk of long-term psychological consequences. These relationships are evident in a study on patients with Cushing's Syndrome, but the findings also open the door for new treatment strategies for other stress-related conditions such as anxiety, depression and post-traumatic stress.
March 28, 2017
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CRISPR-Cas9 breaks genes better if you disrupt DNA repair
In competition between cutting and repair, adding pieces of DNA boosts cutting efficiency
August 17, 2016
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Crispr creator Jennifer Doudna On the promises--and pitfalls--of easy genetic modification
For $150, you can buy a Crispr kit online and use it to engineer heartier gut bacteria in your kitchen. That's thrilling, but the technology is giving Jennifer Doudna, an inventor of the gene-­editing method, nightmares.
May 18, 2017
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CRISPR gene editing can cause hundreds of unintended mutations
As CRISPR-Cas9 starts to move into clinical trials, a new study published in Nature Methods ("Unexpected mutations after CRISPR-Cas9 editing in vivo") has found that the gene-editing technology can introduce hundreds of unintended mutations into the genome.
May 29, 2017
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CRISPR: is It Possible to Remove Disease from DNA?
Can you roll your tongue? Do you have a widow's peak? Does peppermint make you sneeze? the answers are written in your DNA, along with a host of other assembly instructions that gave you certain traits, skills, and susceptibilities. your DNA also contains information about your health -- both your current status and your chances of developing certain diseases.
April 10, 2017
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Critical step in DNA repair, cellular aging pinpointed
The body's ability to repair DNA damage declines with age, which causes gradual cell demise, overall bodily degeneration and greater susceptibility to cancer. Now, research reveals a critical step in a molecular chain of events that allows cells to mend their broken DNA.
March 23, 2017
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Cultural differences may leave their mark on DNA
Signatures of ethnicity in the genome appear to reflect an ethnic group's shared culture and environment, rather than their common genetic ancestry, report scientists. Epigenetic signatures distinguishing Mexican and Puerto Rican children in this study cannot be explained by genetic ancestry alone, the researchers say.
January 10, 2017
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Cut the long story short, and stitch it back together
A species of unicellular ciliate has found a special trick to make use of the cellular machinery in seemingly impossible ways. Researchers have for the first time described a mechanism in detail how so called "junk"-DNA is transcribed before being degraded -- and this mechanism is remarkably clever.
March 19, 2017
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Misc. - D

De-bookmarking could be key to better reprogramming of fibroblasts into iPS cells
In reading, a bookmark tells where you stopped. Cells use bookmarks too, specific proteins that help the cell remember what collection of genes needs to be turned on again after the brief halt of gene expression during cell division. University of Alabama at Birmingham researchers are exploring the implications removing those bookmarks has on the promise of stem cells.
September 20, 2016
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Defect in non-coding DNA could give rise to language impairments in children
The human genome is made up of ~3 billion letters of DNA and at each position it is possible to have different letters, called variants. some variants are harmless but others can be detrimental, making it a mammoth task to find out which variants cause a disorder. Researchers often choose to search only the 1-2% of the genome that carries the information to make proteins.
March 14, 2017
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Defect in non-coding DNA might trigger brain disorders such as severe language impairment
Genetic variation in the non-coding DNA could give rise to language impairments in children and other neurodevelopmental disorders including schizophrenia, autism, and bipolar disorder, scientists have found.
March 14, 2017
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Dental plaque DNA shows Neanderthals used 'aspirin'
Ancient DNA found in the dental plaque of Neandertals -- our nearest extinct relative -- has provided remarkable new insights into their behavior, diet and evolutionary history, including their use of plant-based medicine to treat pain and illness.
March 8, 2017
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Dentistry: new biotechnology to inhibit microRNA activity and novel applications
New biotechnology to inhibit microRNA activity and novel applications for craniofacial and dental research
March 18, 2016
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Desert elephants pass on knowledge -- not mutations -- to survive
Despite reported differences in appearance and behavior, DNA evidence finds that Namibian desert elephants share the same DNA as African savanna elephants. However, Namibian desert-dwelling elephants should be protected so they can continue to pass on their unique knowledge and survival skills to future generations.
August 03, 2016
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Designer proteins fold DNA: Biophysicists construct complex hybrid structures using DNA and proteins
Scientists have developed a new method that can be used to construct custom hybrid structures using DNA and proteins. the method opens new opportunities for fundamental research in cell biology and for applications in biotechnology and medicine.
March 23, 2017
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Detailed new genome for maize shows the plant has deep resources for continued adaptation
Maize's gene-regulatory flexibility bodes well for expanding the staple's growing range as the planet warms
June 12, 2017
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Diamond publishes milestone paper that reveals discovery of genetic triggers behind birth defects
Researchers at the UK's national synchrotron facility, Diamond Light Source, have just published the 5000th scientific paper using data from the facility. this milestone marks a significant step for the synchrotron that is used by over 8,000 scientists each year.
October 7, 2016
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Diet or Exercise: best for Middle-Aged Heart?
Study finds each effective, as long as healthy weight loss is the result
September 15, 2016
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Dietary and exercise interventions can enhance physical function in elders with obesity
A recent review and analysis of published studies since 2005 found low-to-moderate evidence that dietary and exercise interventions can improve physical function and quality of life in older adults with obesity.
September 19, 2016
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Discounts Spur More People to Eat Fruit, Veggies
Study of financial incentives for healthful eating also banned payments for sugary foods, sodas
September 19, 2016
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Discovery of link between RNA quality control and longevity may shed light on mechanisms behind aging
The vigors of youth and the greener pastures of yesteryears. some might refer to these and other similar cliches as nothing more than rose-tinted literations of the past; a cognitive side effect of life. Romanticizing collective memories aside, however, it would be a challenge to find anyone who could argue against the physical degradations that accompany aging. One needs only to search for 'photos of aging' to realize that such yearnings are perhaps nothing more than ourselves giving form to the personal struggle with the byproducts of life.
March 10, 2017
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Discovery of male-harming DNA mutation reinforces 'mother's curse' hypothesis
A male-harming DNA mutation has been discovered in Drosophila that demonstrates that the 'mother's curse' -- the possibility that moms may transmit genes to their children that harm their sons but not their daughters - holds true in animals.
August 02, 2016
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Discovery of new genes linked to Erdheim-Chester disease provides hope for improving diagnoses
National Human Genome Research Institute (NHGRI) researchers have identified new genes associated with the Erdheim-Chester disease (ECD) and some possible new therapies. Findings on this ultra-rare disease, found in approximately 600 people in the world, were published in Blood Advances.
March 31, 2017
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Discrete Molecular Imaging Technology Distinguishes Individual Molecular Features
Proteins do not work individually but rather form larger complexes similar to the molecular machines that facilitate cell communication, transport cargo in their interiors or replicate their own DNA. Examining and tracking every individual protein inside these machines is critical to the eventually understanding these processes. Nevertheless, super-resolution microscopy that has permitted scientists to visualize closely positioned molecules or molecular complexes with 10-20 nm resolution is not powerful to differentiate individual molecular characteristics inside densely packed complexes.
July 6, 2016
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Disease-associated genes routinely missed in some genetic studies
New research reveals two new ways to identify genes that routinely are missed in studies using a common gene-sequencing method. Many of these missed genes are associated with leukemia, psoriasis, heart failure, and other diseases. as part of their new research, the team of scientists have packaged their new methods into open-source software for other researchers to use.
April 24, 2017
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Diseases that run in families not all down to genes, study shows
Family history of disease may be as much the result of shared lifestyle and surroundings as inherited genes, research has shown. Factors that are common to the family environment -- such as shared living space and common eating habits -- can make a major contribution to a person's risk of disease, the study found.
July 20, 2016
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Disentangling chloroplast genetics
Scientists isolate a critical gene for plant health
May 11, 2017
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DNA + nanoparticles = self-assembled 'diamond'
The remarkable properties that diamonds possess result from their crystalline structure; similar structures in which nanoparticles substitute for carbon atoms could lead to materials with new and undiscovered properties.
December 5, 2016
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DNA analyses reveal genetic identities of world's first farmers
Research reshapes understanding of genetic heritage of modern West Eurasians
July 25, 2016
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DNA 'barcoding' allows rapid testing of nanoparticles for therapeutic delivery
Using tiny snippets of DNA as 'barcodes,' researchers have developed a new technique for rapidly screening the ability of nanoparticles to selectively deliver therapeutic genes to specific organs of the body. the technique could accelerate the development and use of gene therapies for such killers as heart disease, cancer and Parkinson's disease.
February 7, 2017
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DNA computer brings 'intelligent drugs' a step closer
Researchers present a new method that should enable controlled drug delivery into the bloodstream using DNA computers. the team developed the first DNA computer capable of detecting several antibodies in the blood and performing subsequent calculations based on this input. this is an important step towards the development of smart, 'intelligent' drugs that may allow better control of medication with fewer side-effects and at lower cost.
February 17, 2017
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DNA computer brings 'intelligent drugs' a step closer
Researchers at Eindhoven University of Technology (TU/e) present a new method that should enable controlled drug delivery into the bloodstream using DNA computers.
February 17, 2017
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DNA Computer can Sense Multiple Antibody Inputs, with Potential for Smart Drug Delivery
Researchers at the University of Eindhoven in the Netherlands have developed a DNA computer that can respond to the presence of specific antibodies and make calculations, with the potential for intelligent drug delivery in the future. DNA computing involves using DNA molecules and other molecular biological components as molecular circuitry, instead of traditional silicon-based circuitry in computer devices. the DNA sequence dictates which other DNA molecules a DNA strand can interact with, allowing researchers to program DNA circuitry.
February 21, 2017
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DNA dominos on a chip
Normally, individual molecules of genetic material repel each other. However, when space is limited DNA molecules must be packed together more tightly.
August 09, 2016
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DNA double helix structures crystals
Method developed for DNA programmed material synthesis
April 4, 2017
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DNA duplicator small enough to hold in your hand
Engineers have developed a new method for duplicating DNA that makes devices small enough to hold in your hand that are capable of identifying infectious agents before symptoms appear.
January 11, 2017
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DNA evidence shows the Soviets covered up an anthrax accident that killed dozens
The US intelligence community had long suspected the Soviet scientists were working on anthrax as a biological weapon, so the news of an outbreak of the disease in April of 1979 certainly looked like an accidental weapon release. a total of 66 people died in the city of Sverdlovsk (now renamed Yekaterinburg) and many more fell ill.
November 28, 2016
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DNA fingerprinting reveals how malaria hides from our immune system
DNA fingerprinting has revealed how the malaria parasite shuffles genes to create different strains and hide from our immune system. this trick allows the parasite to remain undetected and re-infect the same people, much like the flu.
May 2, 2017
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DNA from extinct humans discovered in cave sediments
Researchers have developed a new method to retrieve hominin DNA from cave sediments -- even in the absence of skeletal remains
April 27, 2017
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DNA influences selection of partners for educational achievement
People with genes for high educational achievement tend to marry, and have children with, people with similar DNA, new research shows.
November 23, 2016
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DNA is Being Collected to Protect Sex Workers, But It Could Also be Used Against Them
Nearly a decade ago, Dallas police proposed a new program designed to get sex workers off the streets. Rather than just send them to jail, police would set up shop at truck stops, accompanied by counselors, social workers and nurses, and give the sex workers a choice of either prison or talking to a counselor. But the program also had a grimmer, more ethically fraught component--collecting sex workers' DNA in hopes of identifying their bodies should they wind up dead.
March 28, 2017
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DNA labels predict mortality
Methyl labels in the DNA regulate the activity of our genes and, thus, have a great influence on health and disease. Scientists have now revealed that an altered methylation status at only 10 specific sites in the genome can indicate that mortality is increased by up to seven times. Smoking has a particularly unfavorable impact on the methylation status.
March 19, 2017
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DNA ladders: Inexpensive molecular rulers for DNA research
New license-free tools will allow researchers to estimate the size of DNA fragments for a fraction of the cost of currently available methods. The tools, called a DNA ladders, can gauge DNA fragments ranging from about 50 to 5,000 base pairs in length.
May 26, 2017
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DNA ladders: Inexpensive molecular rulers for DNA research
New, license-free DNA ladders will allow researchers to estimate the size of fragments of DNA for a fraction of the cost of currently available methods. A research team of undergraduate students led by Penn State Professor of Biochemistry and Molecular Biology Song Tan and former undergraduate student Ryan C. Henrici developed two plasmids -- a circular form of DNA -- that can be cut by DNA scissors known as restriction enzymes to create the DNA ladders. T
May 26, 2017
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DNA markers distinguish between harmless, deadly bacteria
Large genome study IDs potential virulence factors to discriminate new species
December 19, 2016
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DNA methods can help identify microbial hot spots in buildings
Genetic investigations are the latest tool for busting unsafe microorganisms and improving air quality in buildings
April 13, 2017
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DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases
Diseases such as epilepsy, neuropathic pain, anxiety, depression, drug addiction and Alzheimer's are all associated with changes in the excitability of brain neurons. University of Alabama at Birmingham researchers show, for the first time, that the well-known mechanism of gene expression control -- dynamic changes in DNA methylation -- is also involved in changes to the excitability of neural cells.
August 24, 2016
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DNA origami lights up a microscopic glowing Van Gogh
Using folded DNA to precisely place glowing molecules within microscopic light resonators, researchers at Caltech have created one of the world's smallest reproductions of Vincent van Gogh's the Starry Night. the reproduction and the technique used to create it are described in a paper published in the advance online edition of the journal Nature on July 11.
July 12, 2016
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DNA origami lights up a microscopic glowing Van Gogh
A technique that allows humanmade DNA shapes to be placed wherever desired -- to within a margin of error of just 20 nanometers -- now removes a major hurdle for the large-scale integration of molecular devices on chips.
July 12, 2016
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DNA patterns can unlock how glucose metabolism drives cancer, study finds
Less aggressive cancers are known to have an intact genome--the complete set of genes in a cell--while the genome of more aggressive cancers tends to have a great deal of abnormalities. Now, a new multi-year study of DNA patterns in tumor cells suggests that these aberrant genetic signatures are not random but reflect selective forces in tumor evolution.
February 15, 2017
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DNA points to millennia of stability in East Asian hunter-fisher population
7,700-year-old remains show lack of influx from other groups
February 3, 2017
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DNA Self-Assembly Allows Control of the Optical Properties of Plasmonic Metamolecules
Plasmonic nanoparticles reveal properties based on their geometries and relative positions. Now, researchers have developed a simple way to control the optical properties of plasmonic nanostructures that strongly rely on their spatial arrangement.
April 25, 2017
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DNA sent on sequential, and consequential, building mission
A team of scientists has developed a method to create structures whose building blocks are a millionth of a meter in size by encoding DNA with assembly instructions.
June 16, 2017
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DNA sequencing uncovers latent risk for developing cystic fibrosis
All babies with a known mutation for cystic fibrosis (CF) and second mutation called the 5T allele should receive additional screening in order to better predict the risk of developing CF later in life, new research shows.
July 25, 2016
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DNA testing for jobs may be on its way, warns Gartner
There may be a future where genetics informs hiring and promotions
October 18, 2016
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DNA vaccine protects against toxic proteins linked to Alzheimer's
A new DNA vaccine, when delivered to the skin, prompts an immune response that produces antibodies to protect against toxic proteins associated with Alzheimer's disease -- without triggering severe brain swelling that earlier antibody treatments caused in some patients.
May 23, 2017
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DNA's dynamic nature makes it well-suited to serve as the blueprint of life
A new study could explain why DNA and not RNA, its older chemical cousin, is the repository of genetic information. the DNA double helix is a more forgiving molecule that can contort itself into different shapes to absorb chemical damage to the basic building blocks -- A, G, C and T -- of genetic code. In contrast, when RNA is in the form of a double helix, it is so rigid that rather than accommodating damaged bases, it falls apart.
August 1, 2016
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DNA-altering technology developed to tackle diseases
The ability to alter DNA accurately will open more doors in the development of personalized medicine that could help to tackle human diseases that currently have few treatment options. Examples of diseases that have unmet therapeutic needs include neurodegenerative diseases like Huntington's disease, muscular dystrophies, and blood disorders like sickle cell anemia.
September 13, 2016
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DNA-based nano-tweezers measure the forces between nucleosomes
Every human cell contains some two meters of deoxyribonucleic acid (DNA), which encodes the genetic information that specifies the cellular structures and functions.
February 27, 2017
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DNA-based nanocontainers for drug delivery
Scientists from the London Centre for Nanotechnology have engineered a novel nanoscale drug delivery vehicle which can be tuned to release a range of cargos.
August 30, 2016
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DNA-Based Nanomachine Could Help Detect Traces of Substances
Scientists from McMaster University have established a new method to use DNA as the engine of a nano-machine for detection of substances ranging from bacteria and viruses to metals and cocaine.
July 7, 2016
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DNAe's article on semiconductor DNA analysis technology placed in Scientific Reports' top 100 read list for 2016
DNA Electronics ('DNAe'), the inventor of semiconductor DNA sequencing technology and developer of a new, revolutionary blood-to-result test for bloodstream infections, announces that an article on research utilizing the Company's patented semiconductor DNA analysis technology has achieved recognition as one of the top 100 read articles for 2016 in Scientific Reports, a peer reviewed journal from the publishers of Nature.
May 19, 2017
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Drinking tea may alter women's gene expression
It seems that we can't get enough of tea; statistics show that almost 80 percent of households in the United States drink it. But do you know what this popular beverage does once it passes our lips? New research sheds some light on how tea affects gene expression.
June 1, 2017
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Misc. - E

Earn Free Hearthstone Packs and Hero When you Recruit Friends
Blizzard has added a new Recruit-a-Friend feature, which can earn you some free stuff if they end up playing the game.
July 12, 2016
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Efficacy of innovative gene therapy can be tested quickly and cost-effectively using new cellular model
Using a new cellular model, innovative gene therapy approaches for the hereditary immunodeficiency Chronic Granulomatous Disease can be tested faster and cost-effectively in the lab for their efficacy. a team of researchers from the University of Zurich and the Children's Hospital Zurich successfully achieved this using the 'gene-scissor' CRISPR/Cas9 technology. the aim is to treat severely affected patients in the near future using novel approaches.
March 21, 2017
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Engineers make nanoscale 'muscles' powered by DNA
The base pairs found in DNA are key to its ability to store protein-coding information, but they also give the molecule useful structural properties. Getting two complementary strands of DNA to zip up into a double helix can serve as the basis of intricate physical mechanisms that can push and pull molecular-scale devices.
November 18, 2016
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Enhancers can boost frequency of transcriptional bursting, study shows
A new study by researchers at Princeton University suggests that sporadic bursts of gene activity may be important features of genetic regulation rather than just occasional mishaps. the researchers found that snippets of DNA called enhancers can boost the frequency of bursts, suggesting that these bursts play a role in gene control.
July 20, 2016
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Enigmatic molecules maintain equilibrium between fighting infection, inflammatory havoc
Study identifies new drug target for inflammatory disorders
August 24, 2016
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Entire operating system written into DNA at 215 Pbytes/gram
High data density thanks to techniques developed for error-prone communication.
March 3, 2017
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Environmental DNA effectively monitors aquatic species populations
Environmental DNA (eDNA), the nuclear or mitochondrial DNA shed from an organism into its environment, is a rapidly evolving tool for monitoring the distribution of aquatic species. a new study discusses the ability of eDNA to accurately predict the presence, relative abundance, and biomass of wild Brook Trout (Salvelinus fontinalis) populations.
December 9, 2016
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Environmental DNA helps protect great crested newts
Research has revealed how tiny amounts of DNA (eDNA) released into water by great crested newts can be used to monitor the species. this can bring benefits for its conservation, and help protect great crested newts from major construction projects. It has also revealed, for the first time, how great crested newt eDNA varies throughout the year in relation to population size and environmental factors.
April 11, 2017
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Environmental 'memories' passed on for 14 generations
The impact of environmental change can be passed on in the genes of tiny nematode worms for at least 14 generations -- the most that has ever been seen in animals -- scientists have discovered.
April 20, 2017
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Epigenetic changes promote development of fatty liver in mouse and human
Mice with a strong tendency to obesity already exhibit epigenetic changes at six weeks of age, inducing the liver to amplify its production of the enzyme DPP4 and release it into the circulation. Over the long term, this favors the development of a fatty liver. Such changes in DNA methylation are also detectable in humans with fatty liver and suggest a similar causal chain.
January 9, 2017
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Epigenetic marks may help assess toxic exposure risk – someday
More work needed to understand what chemical tags on DNA, proteins mean
December 9, 2016
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Erasing unpleasant memories with a genetic switch
Dementia, accidents, or traumatic events can make us lose the memories formed before the injury or the onset of the disease. Researchers have now shown that some memories can also be erased when one particular gene is switched off.
June 30, 2016
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Exercise can Overcome the 'Obesity Gene'
Physical activity appears to lower effects of key DNA linked to weight gain, study finds
April 27, 2017
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Experts discuss potential of DNA origami
Ten years after its introduction, DNA origami, a fast and simple way to assemble DNA into potentially useful structures, is finally coming into its own.
July 7, 2016
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Extra-coding RNAs regulate DNA methylation in the adult brain
The ecRNAs appear to act in memory formation, and may offer a new therapeutic approach to neuropsychiatric diseases.
July 7, 2016
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Evolution may have moved at a furious pace on a much warmer earth
The rate of a certain chemical change in DNA -- a key driver of spontaneous mutation and thus of evolution's pace -- increases rapidly with temperature, researchers have discovered. the scientists concluded that the rate of spontaneous mutation was at least 4,000 times higher than it is today.
July 6, 2016
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Misc. - F

Fat stem cells can lower risk of Diabetes in healthy obese individuals
Obesity is responsible for the deaths of over three million people a year worldwide due to its associated diseases such as diabetes, cancer and cardiovascular disease.
September 16, 2016
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First human clinical trial for nicotinamide riboside
Vitamin safely boosts levels of important cell metabolite linked to multiple health benefits
October 10, 2016
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First steps in human DNA replication dance captured at atomic resolution
It's a good thing we don't have to think about putting all the necessary pieces in place when one of our trillions of cells needs to duplicate its DNA and then divide to produce identical daughter cells.
March 17, 2017
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First steps in human DNA replication dance captured at atomic resolution
Human ORC complex captured in action in x-ray crystallography and cryo-EM
March 17, 2017
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First Use of Gene Editing Technique in Humans
The first use of a new gene-editing technique in humans has been reported by Chinese scientists.
November 16, 2016
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Fly study shows RNA pathway plays major role in normal health and longevity
Humans and other animals carry rogue sequences of DNA in their genomes called transposable elements (TEs). to prevent passing TEs to their offspring, they employ the piRNA pathway in their reproductive organs to block the elements from being active in their sperm and eggs. with a new study in flies, Brown University biologists are the first to show that the anti-TE activity of the piRNA pathway also operates in a normal non-reproductive body tissue, the fly fat body, and that it helps to sustain the life of the animal.
December 21, 2016
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Food intolerance testing: an interview with Dr Gill Hart
What are food intolerances and how many people are thought to be affected by them?
September 15, 2016
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Food or fraud?
A smart universal tool based on a simplified DNA barcoding technique combined with nanotechnology enables food authentication with the naked eye
June 14, 2017
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For keeping X chromosomes active, chromosome 19 marks the spot
After nearly 40 years of searching, researchers report they have identified a part of the human genome that appears to block an RNA responsible for keeping only a single X chromosome active when new female embryos are formed, effectively allowing for the generally lethal activation of more than one X chromosome during development.
April 17, 2017
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Force employees to take DNA tests for bosses? We've got a new law to make that happen, beam House Republicans
Give us your genes or pay 50% more for company healthcare
March 10, 2017
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Former SpaceX engineers launch Synthego, CRISPRevolution to accelerate genome engineering research
Former SpaceX engineers release CRISPRevolution to accelerate low cost biological research with rapid, high quality genome editing
August 12, 2016
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Forming a second line of plant defense: Capturing disease-resistant DNA
Scientists have developed a new improved method for capturing longer DNA fragments, doubling the size up to 7,000 DNA bases that can be analyzed for novel genes which provide plants with immunity to disease.
December 13, 2016
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From cancer to crop genomics -- using Research as a Service at the intersection of computers and biology
Ever since Nicola Bonzanni was a little boy playing in the tiny Italian village of Bonatte Sotto, just north of Milan, he was fascinated by nature and by building things. as he grew up, he wondered how computing and nature might be intertwined. "While I was studying computer science I was inspired by nature in building new algorithms. But then I thought perhaps you could do it the other way around, basically taking things that are being developed in computer science and apply them to biological problems.'
March 28, 2017
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From gene sequencing to genome mapping with nanopores and nanochannels
One reason why people are so excited about nanopore DNA sequencing is that the technology could possibly be used to create 'tricorder'-like devices for detecting pathogens or diagnosing genetic disorders rapidly and on-the-spot.
November 21, 2016
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Fruit flies can be powerful model for unraveling cellular, molecular bases of damaging cold perception
The tiny fruit fly can help humans investigate the genetic and neural bases of detecting painful or harmful cold stimuli and offer intriguing, potential implications for human health, according to a new study.
November 10, 2016
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Misc. - G

Gene mutation appears to increase risk of Parkinson's disease in Caucasians
A defect in a gene that produces dopamine in the brain appears to accelerate the onset of Parkinson's disease, according to new research from Iowa State University. the effect is particularly dramatic for people under age 50.
November 28, 2016
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Gene mutation linked to early onset of Parkinson's disease in caucasians
A defect in a gene that produces dopamine in the brain appears to accelerate the onset of Parkinson's disease, according to new research. the effect is particularly dramatic for young-to-middle-age adults.
November 28, 2016
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Gene silencing shows promise for treating two fatal neurological disorders
NIH-funded preclinical studies suggest designer drug may treat ALS and spinocerebellar ataxia 2.
April 12, 2017
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Gene that helps form trauma-related memories can be manipulated to prevent PTSD, study finds
A specific gene that helps form memories from traumatic events can be manipulated -- and in doing so may actually help prevent post-traumatic stress disorder (PTSD), according to a new study led NYU Langone Medical Center that recently published in Neuropharmacology.
February 13, 2017
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Gene therapy for LPLD patients linked to lower frequency and severity of pancreatitis
Up to 6 years after receiving a single treatment with the gene therapy product lipoprotein lipase (LPL), patients with the debilitating genetic disease LPL deficiency (LPLD) had about 50% fewer episodes of pancreatitis than before receiving the treatment.
September 28, 2016
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Gene therapy shows promise for treating Niemann-Pick disease type C1
NIH mouse study could lead to human clinical trials.
October 26, 2016
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'Gene therapy in a box' effective
A table-top device that enables medical staff to genetically manipulate a patient's blood to deliver potential new therapies for cancer, HIV and other diseases would eliminate the need for multi-million-dollar "clean rooms," making gene therapy more possible for even the poorest of countries.
October 20, 2016
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Gene therapy: what personalized medicine means for you
From CNET Magazine: what if the next pill you took were tailored to your genetic makeup? that day is almost here.
March 22, 2017
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'Gene-silencing' technique is a game-changer for crop protection
Ground-breaking research based on nanotechnology promises to help conquer the greatest threat to global food crops -- pests and diseases in plants, report scientists who have developed a non-toxic, degradable spray which is capable of disabling specific genes in plant. 'BioClay' spray protects plants from disease-causing pathogens without altering their DNA, they report.
January 11, 2017
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Genes find their partners without matchmakers
A new study provides more evidence that identical sections of DNA can match up with each other without the help of other molecules.
July 22, 2016
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Genes influence ability to read a person's mind from their eyes
Our DNA influences our ability to read a person's thoughts and emotions from looking at their eyes, suggests a new study.
June 7, 2017
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Genes May Govern your Risk for PTSD
Link with the psychiatric disorder is more apparent for women, study contends
April 26, 2017
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Genes, early environment sculpt the gut microbiome
Environment and genetics determine relative abundance of specific microbes in the gut, new research shows. the findings represent an attempt to untangle the forces that shape the gut microbiome, which plays an important role in keeping us healthy.
November 28, 2016
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Genetic defects in tooth enamel conducive to development of cavities
Bacteria are not the sole cause of cavities; tooth resistance also plays an instrumental role. Researchers demonstrate that mutated genes lead to defects in the tooth enamel and can therefore encourage the development of cavities.
February 7, 2017
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Genetic discovery provides new insight into cognitive disorders
Findings could ultimately lead to new treatments for disorders such as schizophrenia, ADHD
January 17, 2017
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Genetic diversity data offers medical benefits
Study finds human DNA can vary in more than 7 million spots
August 17, 2016
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Genetic proneness to illnesses may contribute to self-reported tiredness and low energy
Already feeling drained so early in the year? Genes might contribute in a small but significant way to whether people report being tired and low in energy. this is according to UK researchers led by Vincent Deary of Northumbria University, Newcastle, and Saskia Hagenaars of the University of Edinburgh, in a paper in Springer Nature's journal Molecular Psychiatry.
February 14, 2017
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Genetic study uncovers potential new treatments for inflammatory diseases
Researchers have studied over ten million DNA variations and found new links between the human genome and inflammation tracers. the study uncovered new possibilities for treatment of diseases such as multiple sclerosis, Crohn's disease and celiac disease.
February 1, 2017
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Genetic Sudoku is here, and it vastly speeds genomic analysis
Right now, the problems with DNA have nothing to do with DNA. the molecule itself, deoxyribonucleic acid, is extremely well characterized at this point. we can read it, write it, and manipulate it. we can edit it in living cells, and create alternate versions of it with special properties we need. we can use it to do computing or even fold it up to make simple little robots.
November 15, 2016
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Genetic testing startup Color Genomics is switching CEOs
CEO Elad Gil is becoming the chairman and co-founder Othman Laraki is now CEO.
December 22, 2016
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Genetic variants linked to higher BMI may be protective against Parkinson disease
Genetic variants linked to higher body mass index (BMI) are associated with lower risk of Parkinson disease, according to a new study.
June 13, 2017
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Geneticists Get to the Roots of Hair Loss in Men
Researchers spot close to 300 genetic regions linked to baldness, which could provide targets for treatment
February 14, 2017
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Genetics reveal mysteries of hard-to-treat bacterial infection in cystic fibrosis
New research on bacteria that cause major problems for those with cystic fibrosis reveals clues as to how it proliferates for so long in the lungs and offers new ideas for treatments to explore.
March 27, 2017
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Genetics startup Genos wants to pay you for your DNA data
The first whole human genome sequencing cost a whopping $2.7 billion. that didn't bode well for making any breakthroughs on genetic disorders. Luckily, the cost has dropped dramatically since then, leading to a new breed of consumer genetics startups taking a deeper dive into all the double helix's that make up you.
November 1, 2016
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Genomic analysis technologies: past, present and future
Can you please give a brief history of Illumina?
April 10, 2017
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Genomic sequencing illuminates recent Shigella outbreaks in California
Researchers identify genes associated with toxin production and antibiotic resistance
December 23, 2016
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Genomic sequencing reveals new insights into major shigellosis outbreaks in California
In a study that could have significant impact on how disease outbreaks are managed, researchers at UC Davis and the California Department of Public Health (CDPH) have sequenced and analyzed genomes from Shigella sonnei (S. sonnei) bacteria associated with major shigellosis outbreaks in California in 2014 and 2015.
December 23, 2016
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GIANT study finds rare, but influential, genetic changes related to height
International study of more than 750,000 people probes deeper into height than ever before
February 1, 2017
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Glowing mice could mark major step forward for new gene therapy
Timothy Blake, a postdoctoral fellow in the Waymouth lab, was hard at work on a fantastical interdisciplinary experiment. He and his fellow researchers were refining compounds that would carry instructions for assembling the protein that makes fireflies light up and deliver them into the cells of an anesthetized mouse. If their technique worked, the mouse would glow in the dark.
February 16, 2017
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Graphene Nanoribbons in Solutions Possess Properties for Use with Biological Systems
According to researchers at Rice University, graphene nanoribbons (GNRs) can be adapted for biological applications, such as drug delivery, DNA analysis, and biomimetic applications, as they bend and twist easily in solution.
August 16, 2016
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Gunk from Neanderthals' teeth tells us they used medicine
And what they ate and what their mouth bacteria were like
March 8, 2017
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Gut's microbial community shown to influence host gene expression
New research is helping to tease out the mechanics of how the gut microbiome communicates with the cells of its host to switch genes on and off.
November 23, 2016
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GWAS identifies genomic locations linked to personality traits and psychiatric disorders
A meta-analysis of genome-wide association studies (GWAS) has identified six loci or regions of the human genome that are significantly linked to personality traits, report researchers at University of California San Diego School of Medicine in this week's advance online publication of Nature Genetics. the findings also show correlations with psychiatric disorders.
December 9, 2016
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Misc. - H

Have we Entered the Era of the $100 Genome?
At a San Francisco biotech conference on Monday, DNA sequencing giant Illumina announced the launch of a new DNA sequencer that could push the cost of decrypting the human genome from $1,000 to just $100.
January 9, 2017
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Healthy fat stem cells can protect against obesity-associated type 2 diabetes
Obesity is responsible for the deaths of over three million people a year worldwide due to its associated diseases such as diabetes, cancer and cardiovascular disease. However, a subset of obese individuals seems to be protected from such diseases.
September 16, 2016
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Here's the first 3D glimpse of how DNA is packaged up in a single cell
The balled structure reveals organization, which is critical for gene activity.
March 13, 2017
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HIV breakthrough: Scientists remove virus in animals using gene editing
Worldwide, tens of millions of people are living with HIV. While scientists and medical professionals do not yet have a permanent cure for the virus, researchers have just made a breakthrough: they managed to eliminate the HIV-1 infection in mice.
May 4, 2017
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How breaks in DNA are repaired
The results are significant for gene therapy procedures and for our understanding of cell transformation. a team of researchers has discovered that the processes for repairing DNA damage are far more complex than previously assumed.
February 2, 2017
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How DNA data storage works
DNA data storage is a big deal. Partly, it's because we're based on DNA, and any research into manipulation of that molecule will pay dividends for medicine and biology in general – but in part, it's also because the world's most wealthy and powerful corporations are getting discouraged at cost estimates for data storage in the future.
July 8, 2016
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How do metals interact with DNA?
Since a couple of decades, metal-containing drugs have been successfully used to fight against certain types of cancer. the lack of knowledge about the underlying molecular mechanisms slows down the search for new and more efficient chemotherapeutic agents. Scientists have now developed a protocol that is able to detect how metal-based drugs interact with DNA.
March 22, 2017
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How ionizing radiation damages DNA and causes cancer
Two characteristic patterns of DNA damage found
September 12, 2016
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How photosynthetic cells deal with a lack of iron
Researchers discovered a small RNA molecule in cyanobacteria that affects metabolic acclimation.
May 5, 2017
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How proteins control gene expression by binding both DNA and RNA
Proteins that bind DNA or RNA are usually put in different categories, but researchers recently showed how the p53 protein has the capacity to bind both and how this controls gene expression on the levels of both transcription (RNA synthesis) and mRNA translation (protein synthesis).
August 04, 2016
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How RNA formed at the origins of life
A single process for how a group of molecules called nucleotides were made on the early Earth, before life began, has been suggested by a team of researchers.
May 19, 2017
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How to see living machines
It sounds like something out of the Borg in Star Trek. Nano-sized robots self-assemble to form biological machines that do the work that keeps one alive. and yet something like this really does go on.
November 23, 2016
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How will genomics enter day-to-day medicine?
Recommendations for clinicians, lab workers, researchers and families
June 30, 2016
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Misc. - I

Identifying species from a single caviar egg
A new tool enables identification of high-end caviar from Beluga sturgeons by analyzing DNA from a single caviar, a development that helps ensure the fair international trade of caviar and contributes to conservation of the species in the wild.
May 30, 2017
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Illumina introduces fast, highly accurate Veriseq NIPT Solution in the European Union
Illumina, Inc. today announced the launch of the VeriSeq™ NIPT Solution, a CE-IVD marked next-generation sequencing (NGS)-based approach to noninvasive prenatal testing (NIPT), including CE-IVD marked library prep and analysis software, which enables laboratories in the European Union to bring efficient, highly accurate NIPT in-house. the automated comprehensive solution allows laboratories to screen for certain fetal chromosomal abnormalities in approximately one day.
April 10, 2017
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Illumina wants to sequence your whole genome for $100
The first sequencing of the whole human genome in 2003 cost roughly $2.7 billion, but DNA sequencing giant Illumina has now unveiled a new machine that the company says is "expected one day" to order up your whole genome for less than $100.
January 10, 2017
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Imaging mRNA right where it is made - at the site of translation
Think of life as a house: if DNA molecules are blueprints, then messenger RNAs (mRNAs) are orders, describing the required parts (proteins) and when they should arrive. But putting in many orders doesn't always mean you'll get all of the parts on time -- maybe there's a delay with your vendor or delivery service. Similarly, mRNA levels alone do not dictate protein levels.
May 3, 2017
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Imaging mRNA right where it is made: at the site of translation
Think of life as a house: if DNA molecules are blueprints, then messenger RNAs (mRNAs) are orders, describing the required parts (proteins) and when they should arrive. But putting in many orders doesn't always mean you'll get all of the parts on time -- maybe there's a delay with your vendor or delivery service. Similarly, mRNA levels alone do not dictate protein levels. In a new article, researchers report a method to address that issue.
May 3, 2017
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Impact of genetics on human height is not increasing
The relative impact of genetics on height does not increase with improvements to the standard of living. These are the findings of an international research group that analyzed the impact of genetic and environmental factors on adult height over a span of more than a century. the research material comprised 40 twin cohorts, including more than 143,000 twin pairs from 20 countries.
January 27, 2017
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Improving DNA-detecting transistors with graphene
Researchers in India and Japan have developed an improved method for using graphene-based transistors to detect disease-causing genes.
February 24, 2017
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In a possible step forward for gene therapy, researchers made mice glow like fireflies
Timothy Blake, a postdoctoral fellow in the Waymouth lab, was hard at work on a fantastical interdisciplinary experiment. He and his fellow researchers were refining compounds that would carry instructions for assembling the protein that makes fireflies light up and deliver them into the cells of an anesthetized mouse. If their technique worked, the mouse would glow in the dark.
February 21, 2017
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In fruit fly and human genetics, timing is everything
Scientists show how DNA is accessed and used during the journey to maturation in fruit flies, and what this might mean to our understanding of how cancers arise
May 25, 2017
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InClosure VCD Large Bore Vascular Closure Device for Transcatheter Procedures Cleared in Europe
InSeal Medical (Caesarea, Israel) landed the CE Mark of approval in Europe for its InClosure VCD large bore vascular closure device. Procedures such as transcatheter aortic valve replacements that require fairly large devices to be introduced through the vasculature produce substantial access holes that can be difficult to close securely. the InClosure VCD is intended to effectively automate the process and lead to consistent hemostasis.
August 12, 2016
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Inflammation awakens sleepers
Gene transfer
March 29, 2017
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Innovative self-testing service for vital signs launched in Norfolk
The Norfolk Community Health and Care Trust has launched an innovative new self-testing service to help monitor patients with heart failure and lung disease.
August 12, 2016
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Inorganic double helix
It is the double helix, with its stable and flexible structure of genetic information, that made life on Earth possible in the first place. now a team from the Technical University of Munich (TUM) has discovered a double helix structure in an inorganic material (Advanced Materials, "Inorganic Double Helices in Semiconducting SnIP"). the material comprising tin, iodine and phosphorus is a semiconductor with extraordinary optical and electronic properties, as well as extreme mechanical flexibility.
September 12, 2016
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Interaction between our two genomes, nuclear and mitochondrial, is the key to healthy aging
Non-pathogenic mitochondrial DNA variants impact metabolism and the way that individuals age, new research shows. the study provides information with important implications for mitochondrial donation therapies, which produce children with three genetic parents.
July 6, 2016
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Interactions between rare and common genetic variants may contribute to craniosynostosis
During the first year of life, the human brain doubles in size, and continues growing through adolescence. But sometimes, the loosely connected plates of a baby's skull fuse too early, a disorder known as craniosynostosis. Variants of this disorder can produce facial and skull deformities, and put potentially damaging constraints on a young brain.
September 12, 2016
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Introducing metallic ions within a DNA molecule will have many uses in bio- and nanotechnology
Researchers from the University of Granada have proven, for the first time, that introducing slight chemical modifications in DNA molecules may allow to introduce metallic ions in it, keeping its double-stranded structure and molecular recognition properties (for other DNA molecules, enzymes, proteins, etc.).
October 27, 2016
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It is easier for a DNA knot...
In an article published in PNAS, a research team from SISSA studied the passage of knotted DNA through nanopores, shedding light on an intriguing and underexplored phenomenon.
March 28, 2017
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Misc. - J

'Junk RNA' molecule found to play key role in cellular response to stress
A new study has found a surprising role for what had been considered a nonfunctional 'junk' RNA molecule: controlling the cellular response to stress.
December 14, 2016
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Misc. - K

Key insight about mitochondrial replacement therapy
Mitochondrial donors should be carefully selected to avoid transmission of harmful mutations, outlines a new report. Mitochondrial replacement therapy offers hope for women genetically predisposed to pass on mutant mitochondria, the tiny powerhouses inside nearly every cell of the body. Mitochondrial DNA is passed only from mothers to their children. Mutations can cause a range of potentially fatal disorders affecting organs with high-energy demands such as the heart, muscle and brain.
November 30, 2016
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Key to regulating cell's powerhouse discovered
Fundamental discovery has implications for health and disease
July 15, 2016
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Misc. - L

Laboratory-on-a-chip technique simplifies detection of cancer DNA biomarkers
Cancer is the second leading cause of death in the U.S., making early, reliable diagnosis and treatment a priority. Miniaturized lab-on-chip approaches are prime candidates for developing viable diagnostic tests and instruments because they are small, need only limited test volumes, and can be cost-effective. Researchers have developed just such an approach capable of processing biomolecular samples from blood.
December 13, 2016
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Laboratory-on-a-chip technique simplifies detection of cancer DNA biomarkers
Cancer is the second leading cause of death in the U.S., making early, reliable diagnosis and treatment a priority for researchers. Genomic biomarkers offer great potential for diagnostics and new forms of treatment, such as immunotherapy. Miniaturized lab-on-chip approaches are prime candidates for developing viable diagnostic tests and instruments because they are small, need only limited test volumes, and can be cost-effective.
December 13, 2016
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Leaked Documents Reveal the NSA Spying on Scientists to Find 'Nefarious' Genetic Research
A new document made public this week via Edward Snowden's leak of NSA documents reveals a fascinating aim of signals intelligence program: the agency, it turns out, monitored international scientific developments in hopes of detecting "nefarious' genetic engineering projects more than a decade ago.
April 25, 2017
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Length of telomeres may reveal if vitamin D and omega-3 supplements improve heart health, longevity
The length of your telomeres appears to be a window into your heart health and longevity, and scientists are measuring them to see if vitamin D and omega-3 supplements really improve both.
November 14, 2016
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Long noncoding RNA found to quell inflammation
Researchers implicate lincRNA in immune system
July 14, 2016
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Low levels of simple chemical associated with aging, DNA damage
Treatment with a simple chemical restores DNA repair to aging mice.
March 24, 2017
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Misc. - M

Major family of gene-regulating proteins has drug-sized pocket
An entire class of proteins called transcription factors has largely been ignored by the pharmaceutical industry because it's difficult to design and screen drugs against them. But a new study suggests that a key group of transcription factors are in fact 'druggable,' including several that could be targeted to treat cancer, metabolic disease, or autoimmune conditions.
November 3, 2016
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Make It Better with Basil
If the herb garden held a popularity contest, basil would likely win first place. this aromatic herb is a late-summer favorite, especially when paired with ripe tomatoes or blended into pesto. These lovely leaves are surprisingly wholesome too.
September 15, 2016
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Mapping pluripotency differences between mice, monkeys, and humans
New research shows that certain primate stem cells have pluripotency superior to some types derived from mice. the study maps how pluripotency differs among mice, monkeys, and humans, and illustrates for the first time the characteristics unique to primate stem cells.
August 25, 2016
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Marriage May Help Diabetics Keep Weight Off
Study also found it lowered chances of risk factors for heart disease among men, but not women
September 16, 2016
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Massive genome analysis suggests life first thrived in hot springs
The first cells may have been anaerobic, heat tolerant, and hydrogen-fed.
July 27, 2016
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Measuring forces in the DNA molecule
DNA, our genetic material, normally has the structure of a twisted rope ladder. Experts call this structure a double helix. Among other things, it is stabilized by stacking forces between base pairs. Scientists at the Technical University of Munich (TUM) have succeeded at measuring these forces for the very first time on the level of single base pairs.
September 12, 2016
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Measuring the forces of biology
Biology, at the nitty-gritty level of motor proteins, DNA, and microtubules, takes its cue from physics. Consider, for example, the mitosis stage of cell division: two identical sets of DNA from the parent cell must be perfectly divided and separated into two new daughter cells. it's a physical act, and the cellular structure that does it, the mitotic spindle, is a machine that uses mechanical forces -- push, pull, and resistance -- to complete the task.
October 22, 2016
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Mechanical force triggers gene expression by stretching chromatin
How genes in our DNA are expressed into traits within a cell is a complicated mystery with many players, the main suspects being chemical. However, a new study has demonstrated that external mechanical force can directly regulate gene expression. the study also identified the pathway that conveys the force from the outside of the cell into the nucleus.
August 26, 2016
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MedCision announce participation at upcoming conference on cell and gene therapy
MedCision, a leader in the automation of pre-clinical and clinical processes, today announced the company's participation in Phacilitate Cell and Gene Therapy 2017, a conference with the most comprehensive cell and gene therapy agenda in the industry.
January 13, 2017
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Memory of a heart attack is stored in our genes
Both heredity and environmental factors influence our risk of cardiovascular disease. a new study shows now that the memory of a heart attack can be stored in our genes through epigenetic changes.
September 16, 2016
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Methylation status of ten positions in genome correlates with all-cause mortality
Various chemical modifications in the genome determine whether genes are read or deactivated. Methyl labels in the DNA play a key role in this "epigenetic" regulation of gene activity. Life style and environmental factors influence the methylation in the genome. Scientists have already well documented links between the methylation status of specific positions in the genome and cancer as well as other diseases.
March 19, 2017
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Microbe, virus co-evolution: Model of CRISPR, phage co-evolution explains confusing experimental results
A new study suggests that researchers planning to use the CRISPR genome-editing system to produce designer gut bacteria may need to account for the dynamic evolution of the microbial immune system.
February 21, 2017
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Microbiology: Many forks make light work
New insights into the control of DNA replication and cell division in Corynebacterium glutamicum, a biotechnologically important microorganism, could help to optimize the industrial production of amino acids.
June 7, 2017
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Microchip Sorts DNA Fragments by Size in Minutes
At the University of Twente in The Netherlands, scientists have come up with a rapid and inexpensive way of separating out DNA fragments from a sample. The technology will help speed up DNA sequencing, which normally relies on using computers to virtually combine millions of DNA fragments into a single string.
June 1, 2017
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Micronic Univo Screw Cap Recapper could effectively seal valuable DNA samples
RadboudUMC, one of the largest and leading Academic Medical Centers in the Netherlands, has reported on its effective use of the Micronic Univo Screw Cap Recapper SR096 to securely seal its valuable DNA samples.
December 14, 2016
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Microparticles show potential to deliver DNA-based vaccines and gene therapies in pill form
A microscopic corn-and-shrimp cocktail could eventually make DNA-based vaccinations and cancer-treating gene therapies an easier pill to swallow, according to new research from the University of Nebraska-Lincoln.
April 12, 2017
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Microplate specifically for seed genomics designed by Porvair Sciences
Porvair Sciences launched their new Seed Genomics microplate at the recent Plant & Animal Genomics 2017 conference in San Diego (USA) and received an enthusiastic response from the assembled scientists.
February 27, 2017
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Microsoft has found a way to store 200MB of data in synthetic DNA
Microsoft and the University of Washington have created synthetic DNA that is able to store 200MB of data. the DNA could hold, among other things, an HD version of a music video from OK Go!
July 7, 2016
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Microsoft stored an OK Go music video in strings of DNA
A University of Washington partnership produced the largest DNA data trove to date
July 7, 2016
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Mimicking an impact on Earth's early atmosphere yields all 4 RNA bases
A big rock hitting the right atmosphere could make RNA building blocks.
April 12, 2017
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MIT Research Team Develops Innovative DNA Origami
The founding mission of MIT may seem like an unusual meal-time story for a child. But, when Mark Bathe was growing up, it was a regular topic of conversation around the dinner table.
June 5, 2017
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MIT's Microscopy Method Paves Way for Scientists to Locate RNA Molecules in Brain
Several thousand messenger RNA molecules can be found in cells. These molecules carry copies of DNA's genetic instructions to the other areas of the cell.
July 5, 2016
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Molecular selfie reveals how a chemical bond breaks: Proton is seen escaping the molecule
Imagine what it would be like to watch how the individual atoms of molecules rearrange during a chemical reaction to form a new substance, or to see the compounds of DNA move, rearrange and replicate. Such capability would give unprecedented insight to understand and potentially control the processes.
December 14, 2016
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Monoclonal antibody cures Marburg infection in monkeys
NIH-funded groups preparing for next filovirus outbreak.
April 5, 2017
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Move over Cas9, CRISPR-Cas3 might hold the key to solving the antibiotics crisis
Researchers at North Carolina-based Locus Biosciences think they have a potential cure for antibiotic resistance using CRISPR's lesser-known Cas3 enzyme.
December 21, 2016
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mRNA selective drug release from nanoparticles
Scientists from the University of Southampton designed an advanced type of nanoparticle, which is able to carry drugs directly into cells and release them only in the presence of an appropriate mRNA signature; in other words, the nanoparticle carriers release their payload only in specific -- metastatic cancer -- cells and remain inactive in healthy cells.
October 30, 2016
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MSK researchers publish new review that focuses on genome-driven oncology
Researchers from Memorial Sloan Kettering Cancer Center (MSK) today published a seminal review of the rapidly evolving field of precision oncology, which allows doctors to recommend therapies based on a genetic understanding of a person's cancer. Appearing in the special cancer-focused February 9 issue of Cell, the article " "Implementing Genome-Driven Oncology" " presents a critically self-reflective but solutions-focused perspective on this approach to cancer treatment.
February 9, 2017
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Multi-institutional collaboration uncovers how molecular machines assemble
Ribosomes -- macromolecular machines consisting of RNA and proteins that twist, fold and turn -- are responsible for making all of the protein within a cell and could hold the key to deciphering a range of diseases. Despite the intricacies of ribosomes, cells are able to churn out 100,000 of them every hour. But because they assemble so speedily, researchers haven't been able to figure out how they come together.
December 1, 2016
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Mummy DNA shows that the ancients don't have much in common with modern Egyptians
This will pave the way for more genetics studies
May 30, 2017
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Mummy DNA unveils the history of ancient Egyptian hookups
Egyptian mummies are back in style at the summer box office -- and in genetics labs. A study of genetic blueprints from 90 mummies repairs the frayed reputation of sarcophagus occupants as sources of ancient DNA. And it reveals evidence of a hookup history with foreigners from the east.
May 31, 2017
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Mutant enzyme study aids in understanding of sirtuin's functions
The enzyme sirtuin 6, or SIRT6, serves many key biological functions in regulating genome stability, DNA repair, metabolism and longevity, but how its multiple enzyme activities relate to its various functions is poorly understood. a team of researchers has devised a method for isolating one specific enzyme activity to determine its contribution and lead to better overall understanding of SIRT6.
June 28, 2016
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Mutated genes lead to tooth enamel defects that increase risk of caries
Bacteria are not the sole cause of caries; tooth resistance also plays an instrumental role. Researchers from the University of Zurich demonstrate that mutated genes lead to defects in the tooth enamel and can therefore encourage the development of caries.
February 7, 2017
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Misc. - N

Nanoparticle-based method shows promise in DNA vaccine delivery
Researchers have developed a novel method for delivering therapeutic molecules into cells. the method harnesses gold nanoparticles that are electrically activated, causing them to oscillate and bore holes in cells' outer membranes and allowing key molecules -- such as DNA, RNA, and proteins -- to gain entry.
December 19, 2016
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Nanoparticle-based method shows promise in DNA vaccine delivery
Scientists at Brigham and Women's Hospital have developed a novel method for delivering therapeutic molecules into cells. the method harnesses gold nanoparticles that are electrically activated, causing them to oscillate and bore holes in cells' outer membranes and allowing key molecules -- such as DNA, RNA, and proteins -- to gain entry.
December 19, 2016
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Nanopore technology makes leap from DNA sequencing to identifying proteins
In PLOS Computational Biology ("Single-molecule protein identification by sub-nanopore sensors"), scientists from UC San Diego and the University of Notre Dame report on a study that could open up the field for nanopore-based protein identification -- and eventually proteomic profiling of large numbers of proteins in complex mixtures of different types of molecules.
May 26, 2017
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Nanopores could map small changes in DNA that signal big shifts in cancer
Detecting cancer early, just as changes are beginning in DNA, could enhance diagnosis and treatment as well as further our understanding of the disease. a new study by University of Illinois researchers describes a method to detect, count and map tiny additions to DNA called methylations, which can be a warning sign of cancer, with unprecedented resolution.
April 13, 2017
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Nanopores could map small changes in DNA that signal big shifts in cancer
Detecting cancer early, just as changes are beginning in DNA, could enhance diagnosis and treatment as well as further our understanding of the disease. a new study describes a method to detect, count and map tiny additions to DNA called methylations, which can be a warning sign of cancer, with unprecedented resolution.
April 13, 2017
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Nanoscale electronic motion sensor could be used as a DNA sequencer
Researchers have proposed a design for the first DNA sequencer based on an electronic nanosensor that can detect tiny motions as small as a single atom.
October 3, 2016
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Nanotechnology-based delivery system may help treat rare genetic disorder
Researchers at Oregon State University and other institutions have discovered a type of drug delivery system that may offer new hope for patients with a rare, ultimately fatal genetic disorder - and make what might become a terrible choice a little easier.
August 30, 2016
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Nature can beat back scientific tinkering with genes of entire species
Scientists have revealed daunting challenges to changing the DNA of entire populations of species via the most promising techniques available today to produce 'gene drive.'
March 1, 2017
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Nanovaccine could enhance cancer immunotherapy, reduce side effects
National Institute of Biomedical Imaging and Bioengineering researchers have created a nanovaccine that could make a current approach to cancer immunotherapy more effective while also reducing side effects. the nanovaccine helps to efficiently deliver a unique DNA sequence to immune cells -- a sequence derived from bacterial DNA and used to trigger an immune reaction. the nanovaccine also protects the DNA from being destroyed inside the body, where DNA-cutting enzymes are pervasive, as well as outside of the body when exposed to warm temperatures while being stored or transported.
August 24, 2016
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Nanovesicles with DNA Nanopores for Selective release of Therapeutic Compounds
At the London Centre for Nanotechnology, a project organized by University College London and Imperial College London, researchers developed novel nanoscale drug delivery vesicles that can be designed to selectively release only certain cargo.
August 30, 2016
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'Neighbor maps' reveal the genome's 3-D shape
Genome sequencing is a milestone in modern biology as it allows access to the entire "list of instructions" (the chemical sequence of genetic makeup) for the development and function of organisms. Sequencing the genome is a bit like writing down the exact order of the colour of beads in a necklace: knowing how they are arranged along the thread gives us no indication as to the shape of the necklace.
October 27, 2016
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'Neighbour maps' reveal the genome's 3D shape
A three-dimensional computer model of the human genome has been created by researchers. the shape of DNA (as well as its sequence) significantly affects biological processes and is therefore crucial for understanding its function. this new study has provided a first three-dimensional, approximate but realistic, identikit of the human genome.
October 27, 2016
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Neanderthal teeth tell tales of diet and medicine
But interpreting rudimentary DNA evidence requires some leaps.
March 8, 2017
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New crispr-based diagnostic platform unveiled
New system adapts tool known for gene editing for rapid, inexpensive disease diagnosis
April 13, 2017
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New DNA 'hard drive' could keep files intact for millions of years
Microsoft and genetics boffins predict genetics in the datacenter
July 7, 2016
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New drug treatment could reduce body weight in obese patients with rare genetic disorder
As part of a phase II study at Charite - Universitatsmedizin Berlin and the Berlin Institute of Health, two obese patients with a rare genetic disorder were given a drug treatment to stimulate the satiety center in the brain. After only a few weeks, both patients, which were severely hyperphagic before the study start, showed a normalization of their hunger feeling as well as a significant reduction of body weight.
August 03, 2016
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New explanation offered for symptoms of fragile X syndrome
Until recently, scientists thought they understood one of the underlying causes of fragile X syndrome, the most common inherited cause of intellectual disability in the United States. the syndrome, which is associated with autism, was believed to be linked primarily to overactivity in a molecular pathway in the brain.
September 21, 2016
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New gene therapy shows promising results for treating neurodegenerative disorders
A new gene therapy approach designed to replace the enzyme that is deficient in patients with the inherited neurodegenerative disorders Tay-Sachs and Sandhoff diseases successfully delivered the therapeutic gene to the brains of treated mice, restored enzyme function, and extended survival by about 2.5-fold.
July 28, 2016
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New gene-editing technology partially restores vision in blind animals
Researchers have discovered a holy grail of gene editing -- the ability to, for the first time, insert DNA at a target location into the non-dividing cells that make up the majority of adult organs and tissues.
November 16, 2016
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New genetic roots for intelligence discovered
Scientists have made a major advance in understanding the genetic underpinnings of intelligence. Using a large dataset of more than 78,000 individuals with information on DNA genotypes and intelligence scores, the team discovered novel genes and biological routes for intelligence.
May 23, 2017
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New giant viruses suggest their genomes expanded like an accordion
More giant virus genomes suggest their DNA is mostly random scraps.
April 7, 2017
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New global map shines light on genetic roots of diseases
A global genetic interaction map is revolutionizing how genes are being studied. a new study, involving University of Minnesota researchers, is no longer looking at genes as loners, but instead as a social network of the body, interacting in groups. the new approach may ultimately change our understanding of the genetic roots of diseases.
September 23, 2016
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New heart disease risk genes point to flaws in blood vessel walls
Study aims to identify targets for cardiovascular treatments
May 23, 2017
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New IDT webinar to highlight benefits of using RNP complexes for efficient genome modifications
IDT demonstrates how ribonucleoprotein delivery overcomes challenges in CRISPR-mediated genome editing
December 9, 2016
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New imaging technology catches DNA naturally fluorescing
Many of the secrets of cancer and other diseases lie in the cell's nucleus. But getting way down to that level -- to see and investigate the important genetic material housed there -- requires creative thinking and extremely powerful imaging techniques.
February 17, 2017
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New insights into 'plant memories'
A special stretch of ribonucleic acid (RNA) called COOLAIR is revealing its inner structure and function to scientists, displaying a striking resemblance to an RNA molecular machine, territory previously understood to be limited to the cells' protein factory (the 'ribosome') and not a skill set given to mere strings of RNA.
September 21, 2016
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New major gene expression regulator in fungi
Researchers report prevalent DNA base modification in the earliest fungal lineages
May 8, 2017
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New microchip speeds up DNA separation from hours to minutes
Researchers of the University of Twente developed a glass microchip for ultrafast separation and purification of DNA fragments. The chip, moreover, is easy to produce and cheap.
May 29, 2017
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New NuGenius gel imaging system powered by Raspberry Pi computer offers accurate method to detect disease causing genes
Syngene, a world-leading manufacturer of image analysis solutions, is pleased to introduce its powerful, NuGenius gel imaging system, the first in the world to be run by a Raspberry Pi computer. this easy-to-use system quickly generates high quality images of DNA gels and is a sensitive, affordable routine imager for applications such as detecting disease causing genes.
March 17, 2017
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New protein regulated by cellular starvation
An unexpected role for a protein has been found, involved in the DNA repair mechanism. the protein SHPRH not only helps to fix mistakes generated during DNA replication, but also contributes to the generation of new ribosomes, the cell's "protein factories.' the newly discovered task depends on the nutritional state of the cell and might be associated with aging and anemia.
April 11, 2017
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New software tool enables quick, easy deletion of DNA in living cells
Until recently, genomics was a "read-only" science, but scientists have developed a tool for quick and easy deletion of DNA in living cells. this software, published in PLOS Computational Biology, will boost efforts to understand the vast regions of non-coding DNA, or "Dark Matter", in our DNA and may lead to discovery of new disease-causing genes and potential new drugs.
March 3, 2017
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New study helps solve a great mystery in the organization of our DNA
After decades of research aiming to understand how DNA is organized in human cells, scientists at the Gladstone Institutes have shed new light on this mysterious field by discovering how a key protein helps control gene organization.
May 18, 2017
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New study may shed light on diseases associated with mutations in aminoacyl tRNA synthetases
New research led by scientists at the Scripps Research Institute (TSRI) reveals that a human enzyme has changed little from its days as a bacterial enzyme. In fact, the enzyme appears to be unique in its ability to change its shape–and its job in cells–without overhauling its basic architecture.
December 14, 2016
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New study shows variation in junk DNA can affect health
All humans are 99.9 percent identical, genetically speaking. But that tiny 0.1 percent variation has big consequences, influencing the color of your eyes, the span of your hips, your risk of getting sick and in some ways even your earning potential.
August 30, 2016
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New type of nanosensor detects DNA building blocks
Researchers at Uppsala University and in Brazil have developed a new type of nanosensor that can detect single molecules. the nanosensor, comprising a combination of two different materials, has been used to identify the different building blocks in DNA.
February 15, 2017
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New 'value harnessing' approach could help reduce unhealthy eating habits among adolescents
It's no secret that the adolescent years can be challenging: young teens have a heightened sensitivity to perceived injustice and react against authority. and their newfound social conscience and desire for autonomy can motivate many of their decisions - even food choices.
September 13, 2016
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New Zealand wren DNA analysis reshapes geological theory
A DNA analysis of living and extinct species of mysterious new Zealand wrens may change theories around the country's geological and evolutionary past.
July 27, 2016
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Newly discovered DNA sequences can protect chromosomes in rotifers
Findings may have implications for aging research
June 5, 2017
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Next-generation sequencing to evaluate cell-free DNA yields more accurate results in diagnosis of MDS
Using next-generation sequencing (NGS) methods to analyze cell-free DNA in the blood of patients with myelodysplastic syndrome (MDS) yields more accurate results than the current standard approach of Sanger sequencing. this finding, and the greater likelihood of detecting the genetic abnormality responsible for the disorder by analyzing cell-free DNA versus DNA extracted from a patient's blood cells, is reported in a new study published in Genetic Testing and Molecular Biomarkers, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
August 02, 2016
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NIH researchers design new set of assays for initial screening of patients with Fragile X syndrome
Fragile X syndrome, the most common heritable cause of intellectual disability and a frequent cause of autism, is characterized by abnormalities of the FMR1 gene that are difficult to analyze. Preclinical studies of Fragile X and the Fragile X-related disorders are hampered by the lack of low-cost and sensitive yet simple methods.
August 12, 2016
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NIH researchers find potential genetic cause of Cushing syndrome
Finding may lead to therapies that prevent pituitary tumor recurrence.
June 1, 2017
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NIH scientists uncover genetic explanation for frustrating syndrome
Previously unexplained symptoms found associated with multiple copies of a single gene.
October 17, 2016
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NIH to expand critical catalog for genomics research
The National Institutes of Health plans to expand its Encyclopedia of DNA Elements (ENCODE) Project, a genomics resource used by many scientists to study human health and disease. Funded by the National Human Genome Research Institute (NHGRI), part of NIH, the ENCODE Project is generating a catalog of all the genes and regulatory elements – the parts of the genome that control whether genes are active or not – in humans and select model organisms.
February 2, 2017
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NIH-funded scientists deploy CRISPR to preserve photoreceptors in mice
Silencing a gene called Nrl in mice prevents the loss of cells from degenerative diseases of the retina, according to a new study. the findings could lead to novel therapies for preventing vision loss from human diseases such as retinitis pigmentosa. the study was conducted by researchers at the National Eye Institute (NEI), part of the National Institutes of Health, and was published online today in Nature Communications.
March 14, 2017
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NIST releases new 'family' of standardized genomes
Scientists Expand set of Tools for Accurate DNA Sequencing
September 16, 2016
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Nobel laureate-led study uses new technology to watch interaction between telomerase and telomeres
As the rope of a chromosomes replicates, it frays at the ends. No problem: a chromosome's ends have extra twine so that fraying doesn't reach into the body of the rope where the important information resides. this extra twine is called a "telomere". Over time and across replications, this telomere twine breaks down until the chromosome loses its protective ends and this "fraying" reaches into the rope, wrecking the chromosome and resulting in the death of the cell.
August 19, 2016
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Nokia Lumia 1020 used as microscope in low-cost DNA sequencer
The Nokia Lumia 1020 was launched back in 2013, but with its large 41MP sensor and innovative down-scaling algorithms is by many still regarded as one of the best smartphone cameras today.
January 19, 2017
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Novel application of CRISPR/Cas9 in plants - Visualizing DNA in living cells
A research team around Andreas Houben from the Leibniz Institute of Plant Genetics and Crop Plant Research in Gatersleben and Holger Puchta from the Botanical Institute of the Karlsruhe Institute of Technology developed a method to visualize defined genomic sequences in living plant cells and demonstrated its ability to reveal dynamic movements of chromosome ends.
June 15, 2017
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Novel innovation could help scientists study new treatments for mitochondrial diseases
A new study published in the Proceedings of the National Academy of Sciences (PNAS) from the University of Missouri has succeeded in creating embryos with "heteroplasmy," or the presence of both maternal and paternal mitochondrial DNA. this new innovation will allow scientists to study treatments for mitochondrial diseases in humans as well as the significance of mitochondrial inheritance for livestock.
August 23, 2016
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Novel mechanism that detains mobile genes in plant genome
A team researchers has discovered a hitherto-unknown mechanism that detains transposable elements or "mobile genes" - which can move and insert into new positions in plant genomes.
March 10, 2017
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Novel nanoscale detection of real-time DNA amplification holds promise for diagnostics
Polymerase chain reaction (PCR) is a simple and ubiquitous method in molecular biology for amplifying DNA segments into millions of copies. this is important not only for basic research, but also in diagnostics, forensics, and medical applications. Quantitative real-time PCR is a modified version that incorporates fluorescence labeling to cumulatively measure DNA amplification, rather than monitoring it at the end of the process, as in conventional PCR
September 7, 2016
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Novel technique to 'taste' DNA
Scientists have demonstrated for the first time that it is possible to selectively sequence fragments of DNA in real time, greatly reducing the time needed to analyze biological samples.
July 25, 2016
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Nuclease-resistant hybrid nanoflowers
An eco-friendly method to synthesize DNA-copper nanoflowers with high load efficiencies, low cytotoxicity, and strong resistance against nucleases has been developed by Professor Hyun Gyu Park in the Department of Chemical and Biomolecular Engineering and his collaborators.
April 17, 2017
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Misc. - O

Obesity-linked genetic variant changes brain's response to food cues
Genetic predisposition to obesity causes changes even in normal-weight children.
December 29, 2016
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Of mice and migrations: how a rodent's DNA maps to architectural complexity
Don't cloudify your IT infrastructure lightly
May 8, 2017
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OIST scientists use zebrafish model to unravel causes behind human LCA
Newborns babies can be at risk of congenital blindness, presenting sight defects due to lesions or to genetic mutations in their genome. Among the latter, Leber Congenital Amaurosis -- or LCA -- is one of the most widespread causes of child blindness and accounts for nearly 5% of vision impairments overall.
April 5, 2017
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Oligochitosans can Improve Gene Therapy
Scientists from UPV/EHU-University of the Basque Country's have proven that the oligochitosan polymer has the potential to directly supply DNA to tumor cells to act on them.
July 18, 2016
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Online self-management program benefits parents with bipolar disorder
That is the finding of researchers from the Spectrum Centre for Mental Health Research at Lancaster University, who recruited 97 parents with Bipolar Disorder who have children aged between 3 and ten years old.
May 17, 2017
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Only half of a chromosome is DNA, 3-D imaging study shows
DNA makes up only half of the material inside chromosomes -- far less than was previously thought -- a study has revealed.
November 21, 2016
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ORC as loader of the rings: Study details ringed structure of ORC in DNA replication
An international collaboration of life scientists has described in exquisite detail the critical first steps of DNA replication, which allows cells to divide and most advanced life, including human, to propagate.
February 21, 2017
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Misc. - P

People could be genetically predisposed to social media use
Social media use attributable to genetic traits
May 2, 2017
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Potential phage therapy virus massively alters RNA metabolism during infection
Next-Generation approaches detail bacteriophage life cycle as it replicates inside P. aeruginosa
July 5, 2016
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Porvair Sciences extends range of high performance PCR plates
Porvair Sciences range of high performance PCR plates are made from polypropylene for extra rigidity. These plates are compatible with the majority of 96- and 384-well block PCR and sequencing instruments, including fast sequencers and the Roche Light Cycler (TM) RT-PCR machine.
July 8, 2016
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Precision NanoSystems launches NanoAssemblr Scale-Up system to support production of novel medicines
Precision NanoSystems has launched the NanoAssemblr™ Scale-Up system to support the clinical development of nanomedicines. this latest addition to the NanoAssemblr range is designed for the manufacture of clinical trial material in GMP environments, and will support the production of novel medicines, including siRNA, mRNA and CRISPR/Cas9 therapeutics.
March 9, 2017
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Preimplantation genetic screening using next generation sequencing: an interview with Dr Luis Alcaraz
Can you please give a brief introduction to preimplantation genetic screening (PGS)? When and why is it used?
August 24, 2016
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Problems with nuclear membrane play role in leukemia, heart disease and aging disorders
We put things into a container to keep them organized and safe. In cells, the nucleus has a similar role: keeping DNA protected and intact within an enveloping membrane. But a new study by Salk Institute scientists, detailed in the November 2 issue of Genes & Development, reveals that this cellular container acts on its contents to influence gene expression.
November 2, 2016
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Professor Illana Gozes from Tel Aviv University receives 2016 RARE Champion of Hope award
Tel Aviv University's Prof. Illana Gozes was awarded the 2016 RARE Champion of Hope -- Science International Prize by Global Genes, a leading global advocacy non-profit organization for patients and families fighting rare and genetic diseases.
October 5, 2016
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'Protective' DNA strands are shorter in adults who had more infections as infants
People who had more infections as babies harbor a key marker of cellular aging as young adults: the protective stretches of DNA which "cap" the ends of their chromosomes are shorter than in adults who were healthier as infants, report researchers.
January 25, 2017
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Protein complex prevents genome instability
Structural and organizational roles for key protein complex in yeast model of DNA repair
January 19, 2017
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Protein synthesis: Ribosome recycling as a drug target
Researchers have elucidated a mechanism that recycles bacterial ribosomes stalled on messenger RNAs that lack termination codons. the protein involved provides a potential target for future antibiotics.
December 5, 2016
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Protein that kick-starts gene expression in developing embryos.
The formation of a human embryo starts with the fertilization of the oocyte by the sperm cell. this yields the zygote, the primordial cell that carries one copy each of the maternal and paternal genomes. However, this genetic information starts being expressed only after the zygote divides a couple of times. But what triggers this process, called "zygotic genome activation," was unknown until now. Scientists have just found that members of the DUX family of proteins are responsible for igniting the gene expression program of the nascent embryo.
May 1, 2017
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Misc. - Q

Quadruple helix form of DNA may aid in the development of targeted cancer therapies
Scientists have identified where a four-stranded version of DNA exists within the genome of human cells, and suggest that it may hold a key to developing new, targeted therapies for cancer.
September 12, 2016
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Misc. - R

Radiocarbon dating and DNA show ancient Puebloan leadership in the maternal line
Discovering who was a leader, or even if leaders existed, from the ruins of archaeological sites is difficult, but now a team of archaeologists and biological anthropologists, using a powerful combination of radiocarbon dating and ancient DNA, have shown that a matrilineal dynasty likely ruled Pueblo Bonito in new Mexico for more than 300 years.
February 21, 2017
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Rare genetic disorders: New approach uses RNA in search for genetic triggers
In about half of all patients with rare hereditary disorders, it is still unclear what position of the genome is responsible for their condition. One reason for this is the quantity of information encoded in human genes. A team of researchers has developed a method that significantly increases the chances of a successful search. The new approach looks not only at DNA, but also at RNA.
June 13, 2017
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Readers ponder the randomness of DNA errors
John Day wondered if replication errors are truly random, not just unpredictable. And he questioned whether all cancers not known to be caused by inherited genes or the environment must be caused by replication errors. "Isn't it plausible that many or most of the cancers attributed to replication errors in this study involve genetic or environmental factors that are too ubiquitous to be identified as such?' Day asked.
May 17, 2017
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Repurposing the ribosome for synthetic biology
Over the past several years, Northwestern Engineering's Michael Jewett did the seemingly impossible. He overcame the critical barrier to making mutant ribosomes, the core catalyst in cells that are responsible for life.
July 12, 2016
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Research on DNA Nanotubes Leads to new Means for Direct Communication with Cells
A remarkable microscopic feat resembling a high-wire circus act was achieved by Johns Hopkins researchers when they successfully managed to coax DNA nanotubes to arrange themselves into bridge-like structures arched between two molecular landmarks on the surface of a lab dish. Examples of this unusual nanoscale feat were captured on video.
January 6, 2017
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Research reveals role of Rrm3 protein in repair of breaks that occur during DNA replication
Findings like this, which allow the physiological mechanisms that prevent genetic instability to be understood, have vital importance in the research against cancer
June 8, 2017
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Research supports expanded use of cell free DNA prenatal testing
Non-invasive cell free DNA prenatal testing can be effectively and appropriately offered to all pregnant women, regardless of maternal age or risk factors, through primary obstetrical care providers, researchers have demonstrated.
February 3, 2017
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Research tracks interplay of genes and environment on physical, educational outcomes
Over the course of the 20th century, genes began to play a greater role in the height and body mass index (BMI) of Americans, while their significance decreased in educational outcomes and occurrence of heart disease.
July 26, 2016
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Researchers are first to see DNA 'blink'
Many of the secrets of cancer and other diseases lie in the cell's nucleus. But getting way down to that level -- to see and investigate the important genetic material housed there -- requires creative thinking and extremely powerful imaging techniques.
February 17, 2017
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Researchers complete design phase for fully synthetic yeast genome
Working as part of an international research consortium, a multidisciplinary team at the Johns Hopkins University has completed the design phase for a fully synthetic yeast genome.
March 10, 2017
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Researchers create synthetic cells to isolate genetic circuits
Synthetic biology allows scientists to design genetic circuits that can be placed in cells, giving them new functions such as producing drugs or other useful molecules. However, as these circuits become more complex, the genetic components can interfere with each other, making it difficult to achieve more complicated functions.
November 14, 2016
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Researchers design DNA-based circuit that does math in a test tube
Often described as the blueprint of life, DNA contains the instructions for making every living thing from a human to a house fly.
August 24, 2016
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Researchers determine how Ki-67 protein disperses chromosomes in dividing cells
Billions of your cells divide every day. Cell division fuels growth and also replaces short-lived cells in some organs, like your skin, blood, and gut.
June 30, 2016
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Researchers develop DNA-based single-electron electronic devices
Nature has inspired generations of people, offering a plethora of different materials for innovations. One such material is the molecule of the heritage, or DNA, thanks to its unique self-assembling properties.
October 13, 2016
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Researchers develop new software tool to provide fast, accurate quantification of gene expression
A group of computational biological researchers, led by Stony Brook University's Rob Patro, an Assistant Professor in the Department of Computer Science in the College of Engineering and Applied Sciences, has developed a new software tool, Salmon -- a lightweight method to provide fast and bias-aware quantification from RNA-sequencing reads.
March 22, 2017
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Researchers develop new way to assemble genome of an organism from scratch
A team spanning Baylor College of Medicine, Rice University, Texas Children's Hospital and the Broad Institute of MIT and Harvard has developed a new way to sequence genomes, which can assemble the genome of an organism, entirely from scratch, dramatically cheaper and faster. While there is much excitement about the so-called "$1000 genome" in medicine, when a doctor orders the DNA sequence of a patient, the test merely compares fragments of DNA from the patient to a reference genome.
March 24, 2017
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Researchers develop novel label-free method for detecting real-time DNA amplification
Research team led by Nagoya University develop a label-free method for detecting DNA amplification in real time based on refractive index changes in diffracted light.
September 7, 2016
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Researchers develop protocol to analyze many cells at once
The new FISH-Flow protocol could lead to faster, more accurate diagnoses
May 19, 2017
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Researchers discover genetic bases of Opitz C syndrome
Opitz C syndrome is a genetic disease that causes severe disabilities in patients and has been diagnosed in three people in the Iberian Peninsula, and sixty people in the world. a team led by the professors Daniel Grinberg and Susana Balcells, from the Group on Human Molecular Genetics of the University of Barcelona and the Biomedical Research Networking Center of Rare Diseases (CIBERER) has now identified a gene that causes the Opitz C syndrome in the only patient in Catalonia diagnosed with this severe congenital disease.
March 10, 2017
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Researchers discover new class of compounds that inhibit bacterial DNA gyrase
An international team of scientists have discovered a new class of compounds that inhibit bacterial DNA gyrase.
June 1, 2017
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Researchers discover new genes that help prevent prostate and other cancers
New genes which help prevent prostate, skin and breast cancer development in mice have been discovered by researchers at the Wellcome Trust Sanger Institute and their collaborators. the study identified genes that cooperate with the well-known tumour suppressor gene PTEN, and showed their relevance in human prostate tumours.
March 19, 2017
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Researchers discover that DNA naturally fluoresces
A Northwestern University team recently caught DNA doing something that has never been seen before: it blinked.
August 16, 2016
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Researchers find dozens of genes associated with measures of intelligence
Lots of genes, but a cumulatively small impact.
May 23, 2017
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Researchers harness DNA as the engine of super-efficient nanomachine
New platform detects traces of everything from bacteria to viruses, cocaine and metals
July 7, 2016
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Researchers identify 26 novel genes linked to intellectual disability
Researchers at the Centre for Addiction and Mental Health (CAMH) and Queen's University have identified 26 new genes linked to intellectual disability. Currently most patients with intellectual disability receive no molecular diagnosis, which significantly affects their health and shortens their lifespan.
April 11, 2017
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Researchers identify genes that regulate cellular senescence
A research group including Professor KAMADA Shinji, Research Fellow NAGANO Taiki, and Unit Chief ENARI Masato has succeeded in identifying genes that control cellular senescence - permanently arrested cell growth.
September 13, 2016
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Researchers identify genetic cause of rare neurological movement disorder
Researchers at the University of Liverpool have identified the basis for how a single gene mutation can cause a rare neurological movement disorder known as dystonia.
April 10, 2017
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Researchers identify microRNA biomarker linked to incidence of atrial fibrillation
Researchers have identified a microRNA biomarker that demonstrates a strong association with the incidence of atrial fibrillation, the most common abnormal heart rhythm that affects more than 2.7 million Americans.
May 11, 2017
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Researchers investigate why N14Y, N14K mutations have distinct effects in KID syndrome patients
A team of new York-based researchers has compared the effects of two disease-causing mutations, potentially explaining why patients with the rare genetic disorder keratitis-ichthyosis-deafness (KID) syndrome can experience different sets of symptoms.
June 28, 2016
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Researchers propose new explanation for symptoms of fragile X syndrome
Until recently, scientists thought they understood one of the underlying causes of fragile X syndrome, the most common inherited cause of intellectual disability in the United States. the syndrome, which is associated with autism, was believed to be linked primarily to overactivity in a molecular pathway in the brain.
September 20, 2016
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Researchers send DNA on sequential, and consequential, building mission
A team of scientists has developed a method to create structures whose building blocks are a millionth of a meter in size by encoding DNA with assembly instructions.
June 16, 2017
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Researchers show novel technique that can 'taste' DNA
Scientists at the University of Nottingham have demonstrated for the first time that it is possible to selectively sequence fragments of DNA in real time, greatly reducing the time needed to analyse biological samples.
July 25, 2016
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Researchers solve medical mystery through genetics
Researchers have identified the genetic mutation responsible for one patient's serious health problems, finally solving a medical mystery that has endured for over 30 years. Thanks to this discovery, the researcher developed a therapy that could also help a lot of people who have problems related to the immune system, whether they are genetic or due to a transplant or an illness.
April 6, 2017
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Researchers take significant step forward in genetic sex reprogramming research
An international team of researchers, led by the University of Granada (UGR), has taken a significant step forward on the research on 'genetic sex reprogramming', which is closer now, although it's still an utopia.
October 26, 2016
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Researchers uncover first 'off-switches' for better control of CRISPR/Cas9 gene editing
CRISPR/Cas9 genome editing is quickly revolutionizing biomedical research, but the new technology is not yet exact. the technique can inadvertently make excessive or unwanted changes in the genome and create off-target mutations, limiting safety and efficacy in therapeutic applications.
December 9, 2016
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Researchers uncover global regulator that 'switches on' silent biosynthetic gene clusters
Bacteria have supplied some of today's most indispensable anti-cancer and anti-bacterial drugs. Yet these compounds comprise only a fraction of their possible offerings. Now, researchers have found a way to unleash their full potential as natural product dispensers.
April 13, 2017
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Researchers use novel technique to unravel key mystery of earliest stage of development
A Ludwig Cancer Research study published online September 14th in Nature reports a novel technique to map specific chemical (or "epigenetic") modifications made to the protein packaging of DNA using a small population of cells. Such epigenetic marks play a central role in the regulation of the genome's expression.
September 20, 2016
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Revolutionary method to map brains at single-neuron resolution successfully demonstrated
MAPseq uses RNA sequencing to rapidly and inexpensively find the diverse destinations of thousands of neurons in a single experiment in a single animal
August 19, 2016
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Rice scientists unveil behavior of graphene nanoribbons in solutions
Graphene nanoribbons bend and twist easily in solution, making them adaptable for biological uses like DNA analysis, drug delivery and biomimetic applications, according to scientists at Rice University.
August 17, 2016
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Rising temperatures could accelerate radiation induced DNA effects in marine mussels
Increased sea temperatures could have a dramatic effect on radiation-induced damage in marine invertebrates, a new study suggests.
August 23, 2016
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RNA pathway plays key role in health, lifespan, fly study shows
The piRNA pathway was thought to be most active in the reproductive organs of animals, but researchers have discovered in the common fruit fly that the pathway also operates in a non-reproductive body tissue, playing a vital role in maintaining health and lifespan.
December 21, 2016
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Role for enhancers in bursts of gene activity
A new study suggests that sporadic bursts of gene activity may be important features of genetic regulation rather than just occasional mishaps. the researchers found that snippets of DNA called enhancers can boost the frequency of bursts, suggesting that these bursts play a role in gene control.
July 19, 2016
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Misc. - S

Safe Delivery of Therapeutic Genes by DNA Barcoding
Researchers used small snippets of DNA as barcodes to develop a new technique for rapidly screening the capability of nanoparticles to selectively deliver therapeutic genes to particular organs of the body. this new technique succeeded in accelerating the development and use of gene therapies for Parkinson™ disease, cancer and heart disease.
February 8, 2017
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Safety in darkness: Team lays bare melanin's DNA guarding mechanism
With a little help from chickens and video cameras, scientists have captured live the moment when skin gets darker. In a new study, a team has filmed and demystified the process by which melanin -- molecules that give skin its color -- are carried to the epidermis.
December 6, 2016
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Same genes could make us prone to both happiness and depression
Psychology researchers say studies in cognitive bias and genetics must be brought together to better understand how best to tackle mental ill health
July 19, 2016
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Same genes, same environment, different personality: Is individuality unavoidable?
Genetically identical Amazon mollies raised individually and under identical environmental conditions, nevertheless develop different personality types. Additionally, increasing the opportunity for social interactions early in life appears to have no influence of the magnitude of personality variation. These results of a recent study shed a new light on the question of which factors are responsible for the individuality of vertebrate animals.
May 17, 2017
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Sat nav for bread wheat uncovers hidden genes
Most comprehensive analysis yet will enhance food security
April 18, 2017
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Scientists can now Sequence DNA with a Smartphone
It was not so long ago that sequencing even tiny snippets of DNA was a costly, cumbersome process that required access to a state-the-art lab. Today, we are inching close to putting a DNA sequencer in every pocket.
January 17, 2017
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Scientists create first stable semisynthetic organism
Life's genetic code has only ever contained four natural bases. These bases pair up to form two "base pairs"--the rungs of the DNA ladder--and they have simply been rearranged to create bacteria and butterflies, penguins and people. Four bases make up all life as we know it.
January 23, 2017
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Scientists develop DNA-altering technology to tackle diseases
Researchers in Singapore have developed a new protein that can alter DNA in living cells with much higher precision than current methods.
September 13, 2016
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Scientists devise new approaches to personalized medicines
Scientists on the Florida campus of the Scripps Research Institute (TSRI) have developed broad methods to design precision medicines against currently incurable diseases caused by RNA.
December 12, 2016
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Scientists discover a way to sequence DNA of rare animals
Rare and extinct animals are preserved in jars of alcohol in natural history museum collections around the world, which provide a wealth of information on the changing biodiversity of the planet. But, scientists have not been able to effectively sequence DNA from these specimens until now.
January 25, 2017
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Scientists discover new switch that coordinates DNA repair and cell death
The genetic information of every cell is encoded in the sequence of the DNA double helix. Double strand breaks in the DNA, which can be induced by radiation, are a dangerous threat to the cells, and if not properly repaired can lead to cancer. Damaged cells need to decide whether the breaks can be fixed or whether they should be removed by a cellular suicide program called "apoptosis" before initiating cancer.
September 28, 2016
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Scientists explore black box of genome biology
Scientists at Florida State University, Baylor College of Medicine and the Broad Institute of Harvard and MIT have broken ground in a little-understood area of human genetics.
July 19, 2016
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Scientists find evidence for gene to be linked to social phobia
People with social anxiety avoid situations in which they are exposed to judgment by others. Those affected also lead a withdrawn life and maintain contact above all on the Internet. Around one in ten people is affected by this anxiety disorder over the course of their life.
March 9, 2017
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Scientists find new genetic locations for type 2 diabetes
Scientists from University College London and Imperial College London in the United Kingdom have identified new genetic locations that might make some people more prone to developing type 2 diabetes.
May 4, 2017
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Scientists Hack a Human Cell and Reprogram It Like a Computer
CELLS ARE BASICALLY tiny computers: they send and receive inputs and output accordingly. If you chug a Frappuccino, your blood sugar spikes, and your pancreatic cells get the message. Output: more insulin.
March 27, 2017
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Scientists identify commonly affected genes sets among people with three mental disorders
Studying brain tissue from deceased donors, Johns Hopkins scientists have found common groups of genes disrupted among people with schizophrenia, bipolar disorder and major depression. the commonly affected genes sets, identified with RNA sequencing methods, engage in making proteins, controlling brain cell communications and mounting an immune system response, the researchers say.
October 26, 2016
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Scientists identify essential enzymes for efficient and precise repair of damaged DNA
Scientists at the Australian National University (ANU) and Heidelberg University in Germany have found an essential component in the DNA repair process which could open the door to the development of new cancer drugs.
October 30, 2016
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Scientists identify genetic cause and biological mechanisms linked to new human immunodeficiency
A multi-institutional, international team of scientists has discovered the genetic cause and biological mechanisms linked to a new human immunodeficiency.
October 22, 2016
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Scientists identify key gene in 22q11.2 that contributes to genitourinary birth defects
The 22q11.2 region of human chromosome 22 is a hotspot for a variety of birth defects. Scientists learned about this region because it is deleted in about 1 in 4,000 births, causing the loss or duplication of up to 40 genes. This chromosome microdeletion or microduplication can result in a number of developmental abnormalities that vary greatly in severity among affected individuals.
May 25, 2017
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Scientists identify mutation responsible for new, rare genetic disorder
An international team of researchers has discovered the mutation responsible for a rare, newly identified genetic disorder that causes craniofacial abnormalities and developmental delays. the mutation disrupts normal protein transport within cells, shedding light on a fundamental process in cell biology and early human development.
July 28, 2016
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Scientists Just Took a Major Step Toward the First Complex Artificial Life
In 2008, researchers built the first artificial genome, a wonder of synthetic biology in which scientists generated all 582,970 base pairs of the bacterium Mycoplasma genitalium's genome entirely from scratch. It was an unparalleled scientific achievement, requiring scientists to carefully design 101 unique DNA fragments so that their codes would overlap and stick together, then bind those fragments piece by piece.
March 9, 2017
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Scientists overcome inaccessibility of caves through molecular genetic approach
An international group of scientists has used a novel highly sensitive method for detection of environmental DNA in groundwater to extend the poorly known range of the rare subterranean amphibian from the Dinaric Karst. with this highly sensitive non-invasive method they discovered 12 new localities of the olm (Proteus anguinus).
March 27, 2017
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Scientists predict academic achievement from DNA alone
Scientists have used a new genetic scoring technique to predict academic achievement from DNA alone. this is the strongest prediction from DNA of a behavioral measure to date.
July 19, 2016
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Scientists predict reading ability from DNA analysis alone
Researchers have used a genetic scoring technique to predict reading performance throughout school years from DNA alone.
March 29, 2017
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Scientists prove they can store 215 petabytes in a single gram of DNA, retrieve it error free
Researchers at Columbia University have managed to push forward the limits of data storage on DNA, and bring the exciting bio-technology closer to being a reality. by utilizing new techniques, they were able to store a movie, an operating system, and other data in DNA strands and retrieve them error-free.
March 3, 2017
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Scientists reveal new mRNA method to deliver safe, cost-effective therapeutic antibodies
Using antibodies to treat disease has been one of the great success stories of early 21st-century medicine. Already five of the ten top-selling pharmaceuticals in the United States are antibody products.
March 2, 2017
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Scientists try to unwrap the secrets of Egyptian mummy DNA
They might not have much in common with modern Egyptians.
May 31, 2017
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Scientists uncover genetic evidence that 'we are what we eat'
Researchers have demonstrated that the diets of organisms can affect the DNA sequences of their genes.
November 15, 2016
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Scientists uncover thousands of human genes that are expressed differently in the two sexes
Men and women differ in obvious and less obvious ways -- for example, in the prevalence of certain diseases or reactions to drugs. how are these connected to one's sex? Weizmann Institute of Science researchers recently uncovered thousands of human genes that are expressed -- copied out to make proteins -- differently in the two sexes. Their findings showed that harmful mutations in these particular genes tend to accumulate in the population in relatively high frequencies, and the study explains why. the detailed map of these genes, reported in BMC Biology, provides evidence that males and females undergo a sort of separate, but interconnected evolution.
May 4, 2017
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Scientists use machine learning to interpret mosquito genome
Scientists are using machine learning to identify important sequences of DNA within the mosquito genome that regulate how the insect's cells develop and behave.
July 12, 2016
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Screening the dark genome for disease
Researchers have developed a method to swiftly screen the non-coding DNA of the human genome for links to diseases that are driven by changes in gene regulation. the technique could revolutionize modern medicine's understanding of the genetically inherited risks of developing heart disease, diabetes, cancer, neurological disorders and others, and lead to new treatments.
April 3, 2017
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SETD8 enzyme protects against cellular senescence, research reveals
An enzyme that blocks cellular senescence and its mechanisms has been discovered by a research team from Kumamoto University, Japan. they found that a reduction of the enzyme SETD8, which regulates cell proliferation and gene function, results in the promotion of cell aging features.
March 8, 2017
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Self-assembled nanostructures can be selectively controlled
DNA self-assembly allows the unprecedented control of the optical properties of plasmonic metamolecules.
April 24, 2017
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Self-assembled nanostructures can be selectively controlled
DNA self-assembly allows the unprecedented control of the optical properties of plasmonic metamolecules, report scientists.
April 24, 2017
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Selfish mitochondria implicated in a variety of diseases
A research team has identified some of the methods that allow mutant mitochondrial DNA to act selfishly by circumventing the molecular mechanisms that cells use to regulate mitochondrial activity.
July 12, 2016
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Selfish mutant mtDNA exploits cellular defenses to cause many diseases
Mitochondrial disorders are a chameleon-like set of diseases that take many different forms and vary widely from individual to individual.
July 12, 2016
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Serum microRNAs could serve as promising biomarkers for monitoring progression of MS
MicroRNAs are small RNA molecules that influence basic cellular processes and have been proposed as biomarkers for the diagnosis, progression and treatment of multiple sclerosis. In a new study conducted at the Ann Romney Center of Neurologic Diseases at Brigham and Women's Hospital, researchers have found that serum microRNAs are linked to MRI findings in the brain and spinal cord in patients with MS.
January 23, 2017
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Separating DNA: From hours to minutes
Researchers have developed a glass microchip for ultrafast separation and purification of DNA fragments. The chip, moreover, is easy to produce and cheap.
May 29, 2017
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Shape-shifting molecular robots respond to DNA signals
A molecular robot consisting of biomolecules, such as DNA and protein, has now been developed by a team of scientists.
March 2, 2017
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"Sixth sense" may be more than just a feeling
NIH study of rare genetic disorder reveals importance of touch and body awareness.
September 22, 2016
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Skin disease caused by sperm cell transmission of keratin mutation
Nagoya University research identified a patient with the whole-body skin disease epidermolytic ichthyosis that had been inherited as a germline mutation from her father with the milder epidermolytic nevus. Analysis of genomic DNA from the patient revealed a mutation in the keratin 10 gene, which was identical to that observed in cells taken from patches of thickened skin on the father's body. Assessing transmission risk of such diseases allows affected couples to receive genetic counseling.
June 16, 2017
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Smallest-reported artificial virus could help advance gene therapy
Gene therapy is a kind of experimental treatment that is designed to fix faulty genetic material and help a patient fight off or recover from a disease. now scientists have engineered the smallest-reported virus-like shell that can self-assemble. It could someday carry potentially therapeutic DNA or RNA and transfer it to human cells.
September 21, 2016
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SMiLE-seq: a new technique speeds up genetics
Scientists at Ecole Polytechnique Federale de Lausanne (EPFL) have developed a technique that can be a game-changer for genetics by making the characterization of DNA-binding proteins much faster, more accurate, and efficient.
January 16, 2017
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Smoking Leaves Lasting Marks on DNA: Study
Changes related to disease found in more than 7,000 genes, though many 'recover' five years after quitting
September 20, 2016
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Social networking for the proteome, upgraded
New study maps protein interactions for a quarter of the human genome
May 17, 2017
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Some genetic disorders may be caused by defects we couldn't detect
Chromosome rearrangements may be behind more human disorders than we thought.
November 17, 2016
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Sonoporation: a new Way of Punching Holes in Cells to Deliver Gene Therapy
At University of Pittsburgh and University of Pittsburgh Medical Center researchers have devised a radically new way of opening carefully targeted living cells to allow various medications to enter. Reported on in the latest issue of Proceedings of the National Academy of Sciences, the scientists describe how microbubbles filled with genes can be excited with ultrasound to shove themselves into the interior of cells. Such microbubbles have been developed already, but while they're immeasurably safer than viruses they've had a problem of penetrating cells.
August 29, 2016
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Spatial reasoning is only partly explained by general intelligence
Genetics seems to play a role.
February 24, 2017
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Spelling mutations and evolutionary advantages
DNA codes carrying instructions for creating a protein can sometimes be 'spelt' differently, although they specify the exact same sequence information to create that protein. Scientists have now shown that such mutations, called 'synonymous' mutations can have large effects on the evolution of organisms.
March 18, 2016
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Spiky nanostructures capture life's fine details
Optical microscopes that use lenses to bounce photons off objects have trouble distinguishing nanometer-scale objects smaller than the imaging beam's wavelength, such as proteins and DNA.
February 22, 2017
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Squeezing life from DNA's double helix
Recipe for replication: Two DNA strands, one ring of proteins. Melt.
December 13, 2016
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Stem cells feel the force
Scientists have gained new insights into how stem cells feel and respond to external mechanical forces by changing the way DNA is organized in the nucleus, and thereby the expression of genes that are required for stem cell differentiation.
July 12, 2016
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Store and supply: how the brain saves time
Neurons in the brain store RNA molecules -- DNA gene copies -- in order to rapidly react to stimuli. this storage dramatically accelerates the production of proteins. this is one of the reasons why neurons in the brain can adapt quickly during learning processes.
December 21, 2016
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Structure of key DNA replication protein solved
A research team has solved the three-dimensional structure of a key protein that helps damaged cellular DNA repair itself. Investigators say that knowing the chemical structure of the protein will likely help drug designers build novel anti-cancer agents.
October 25, 2016
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Studies reveal link between rotator cuff disease and genetics
Rotator cuff disease is a common disorder that affects 30 to 50 percent of people over the age of 50. the disease often leads to shoulder pain and loss of function. While many think of this as a 'tear' due to an injury or sustained over/misuse, some studies suggest genetics might play a role.
February 6, 2017
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Study characterizes key molecular tool in DNA repair enzymes
Oxidative damage to a cell's DNA is constant and destructive and a complex suite of enzymes have evolved to repair and maintain it. In an important new step in teasing out these complex processes, an enzyme component known as Zf-GRF, which is highly conserved in several enzymes and across species, has been shown to be a key molecular tools that binds and orients repair enzymes to DNA.
January 6, 2017
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Study identifies African-specific genomic variant associated with obesity
Findings highlight the importance of genomic studies in diverse populations.
March 13, 2017
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Study provides insights into how species adapt to changing environments over many generations
A rapid, versatile mechanism that modifies proteins is revealed to be crucial for the evolutionary process.
October 14, 2016
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Study reveals how pluripotency differs among mice, monkeys, and humans
Not too shabby, humans. new research shows that certain primate stem cells have pluripotency superior to some types derived from mice. the study, published in Nature, maps how pluripotency differs among mice, monkeys, and humans, and illustrates for the first time a developmental counterpart of primate stem cells.
August 26, 2016
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Study reveals key role of mRNA's 'fifth nucleotide' in determining sex in fruit flies
A team of scientists has shown how a common mRNA modification, N6-methyladenosine (m6A), regulates gene expression to determine the sex of fruit flies. the function of m6A, an mRNA modification known as the 'fifth nucleotide', has long been a mystery. But a new study has revealed that m6A plays a key role in the regulation of the Sex-lethal (Sxl) gene, which controls sex determination of the fruit fly Drosophila.
November 30, 2016
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Study reveals vital new details about inner workings of CRISPR-Cas9 machinery in live cells
A study in the Journal of Cell Biology by scientists at the University of Massachusetts Medical School reveals important new details about the inner workings of the CRISPR-Cas9 machinery in live cells that may have implications for the development of therapeutics that use the powerful gene editing tool.
August 30, 2016
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Study shines new light on genetic makeup of river blindness parasite
The parasite that causes river blindness infects about 37 million people in parts of Africa and Latin America, causing blindness and other major eye and skin diseases in about 5 million of them. a study from Washington University School of Medicine in St. Louis sheds light on the genetic makeup of the parasite, a step toward the goal of eradication.
November 22, 2016
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Study shows how errors in specific gene can cause growth defects linked to dwarfism
A new study shows how errors in a specific gene can cause growth defects associated with a rare type of dwarfism.
February 13, 2017
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Study suggests microRNAs may connect inflammation with heart disease risk in obese people
Inflammation likely plays a role in the increased risk of heart disease that comes with obesity, but scientists don't fully understand how obesity leads to heart disease. Results from a new study suggest that small molecules known as microRNAs may be part of the pathway connecting inflammation with increased heart disease risk in obese people.
August 26, 2016
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Successful use of DNA as a computer in artificial cells
A group of Associate Professor Ryuji Kawano of Tokyo University of Agriculture and Technology, Division of Biotechnology and Life Science, Institute of Engineering, and Associate Professor Masahiro Takinoue of Tokyo Institute of Technology, School of Computing succeeded in detecting output molecules that are the calculation results of DNA computing using DNA molecules as electric information through a nanopore1 membrane protein (ACS Synthetic Biology, "Nanopore Logic Operation with DNA to RNA Transcription in a Droplet System").
May 25, 2017
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Sugar Companies Shifted Focus to Fat as Heart Harm
Decades-old documents show researchers were paid to influence scientific thinking, researchers say
September 13, 2016
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Suppressed vaginal immune response makes women more susceptible to RNA viruses
Scientists at the Gladstone Institutes discovered that the vaginal immune system is suppressed in response to RNA viruses, such as Zika. the delayed antiviral immune response allows the virus to remain undetected in the vagina, which can increase the risk of fetal infection during pregnancy.
November 16, 2016
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Super-resolution system reveals mechanics of tiny 'DNA walker'
Researchers have introduced a new type of "super-resolution" microscopy and used it to discover the precise walking mechanism behind tiny structures made of DNA that could find biomedical and industrial applications.
February 10, 2017
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Surface tablets helped to sequence DNA on board the International Space Station
NASA announced today that DNA was successfully sequenced in microgravity for the first time by astronauts on board the International Space Station. the astronauts used Surface tablets from Microsoft to help achieve this historical event.
August 29, 2016
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Syngene introduces easy-to-use powerful NuGenius gel imaging system
Syngene, a world-leading manufacturer of image analysis solutions, is pleased to introduce the powerful, NuGenius gel imaging system. this easy-to-use system quickly generates high quality images of DNA gels and will suit laboratories looking for a sensitive, affordable routine gel imager.
March 17, 2017
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Syngene introduces new Dynamic Fielding feature in GeneSys image capture software
Syngene, a world-leading manufacturer of image analysis solutions, is pleased to introduce a new Dynamic Fielding feature in its GeneSys image capture software. this powerful feature autocorrects for edge effects caused by all lens and lighting in image analysers, providing a consistent image for scientists to accurately quantify DNA and proteins on their gels.
March 17, 2017
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Misc. - T

Tardigrade DNA inserted into human cells gives them X-ray resistance
A study just broke out of Tokyo that says some eyebrow-raising things about water bears and their DNA. First among the revelations is the finding that water bears might not be all that much not-tardigrade at all. Remember that story about the tardigrade genome being about 17% foreign DNA?
September 23, 2016
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Tardigrades can live 30 years in a freezer and survive in space, and now we know why
Scientists discover adaptations to life in extreme environments in the tardigrade genome
September 20, 2016
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Tea tree genome contains clues about how one leaf produces so many flavors
The most popular varieties of tea -- including black tea, green tea, Oolong tea, white tea, and chai -- all come from the leaves of the evergreen shrub Camellia sinensis, otherwise known as the tea tree. Despite tea's cultural and economic significance, relatively little is known about the shrub behind the tea leaves. However, the first draft of the tea tree genome may help explain why tea leaves are so rich in antioxidants and caffeine.
May 1, 2017
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Team nebulizes aphids to knock down gene expression
Researchers are nebulizing soybean aphids with RNA to speed the process of discovering the function of many mystery genes.
March 19, 2017
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Team suggests nanoscale electronic motion sensor as DNA sequencer
Researchers from the National Institute of Standards and Technology (NIST) and collaborators have proposed a design for the first DNA sequencer based on an electronic nanosensor that can detect tiny motions as small as a single atom.
October 3, 2016
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Thank (or blame) your genes for ability to handle java jolt
New genetic link to caffeine metabolism found
August 25, 2016
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The FDA Just Greenlit the First Consumer DNA Tests for Disease Risk
At times, DNA testing can feel more like horoscopes than science. In many cases, we just don't know enough about a gene to say what it means for our health. for this reason, the Food and Drug Administration has sought to protect consumers by preventing DNA testing companies from telling them whether or not they're are at risk for a certain disease. Until now.
April 6, 2017
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The first genome data from ancient Egyptian mummies
Ancient Egyptians were most closely related to ancient populations from the Near East
May 30, 2017
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The keys to a major process in DNA repair
For the first time, researchers describe in its totality the mechanisms by which DNA damaged by UV radiation is repaired, and how the proteins involved in this process cooperate to ensure its efficiency. this work opens new perspectives not only in the fight against cancer but also in combating certain bacterial infections.
August 03, 2016
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The quinoa genome could help scientists get it out of the health food aisle
It's the first step to bringing the super grain to the masses
February 8, 2017
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Therapy flags DNA typos to rev cancer-fighting T cells
Disabled spell-checker identifies patients who may benefit from immune therapy
June 9, 2017
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Thousands of rare cancer-related gene mutations found
Innovative research, published in PLOS Computational Biology this week, explains how thousands of "previously ignored genetic mutations" may contribute to the growth of malignant tumors. Using a new statistical approach, scientists find new patterns in proteins.
April 21, 2017
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'Three-parent baby' boy healthy so far
Three other embryos created by technique had wrong chromosome count
October 19, 2016
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This Machine Lets your Smartphone Analyze Dna
There's An App for That?
January 19, 2017
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To produce biopharmaceuticals on demand, just add water
Freeze-dried cellular components can be rehydrated to churn out useful proteins
September 23, 2016
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Today's East Asians are very genetically similar to their ancient ancestors
This tells us more about ancient culture
February 1, 2017
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Tools of Undiagnosed Diseases Network help unravel mystery of rare genetic disease
Arriving at Duke six years ago at the age of three, the youngster had mild developmental delays and physical characteristics that included a large body and large head circumference. a genetic analysis showed mutation of a specific gene, known as ASXL2, which had never been singled out as causing disease.
September 29, 2016
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Tracking down water pollution through DNA of algae
The degree of pollution of rivers resulting from human activities is assessed using different biotic indices. the latter reflect the ecological status of a river based on the quantity and diversity of organisms selected as bioindicators, due to their ecological preferences and tolerance to pollution. this is the case of diatoms, algae consisting of a single cell surrounded by a silica skeleton, recommended by researchers as one of the ideal bioindicators for rivers and lakes.
April 18, 2017
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Transcription factor Foxn1 and preserving immune function in later life
Researchers use new experimental models and analytical tools to investigate genes regulated by Foxn1, becoming the first to identify the DNA sequence bound by the transcription factor. Among the hundreds of genes whose expression is regulated by Foxn1 are genes essential to attract precursor cells in the blood to the thymus, that commit precursor cells to become T cells, and that provide the molecular machinery which allows T cell selection to best serve an individual.
August 22, 2016
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TSRI scientists tackle decades-old challenge by re-creating primordial RNA world
Scientists at the Scripps Research Institute (TSRI) have taken a big step toward the laboratory re-creation of the "RNA world," which is generally believed to have preceded modern life forms based on DNA and proteins.
August 17, 2016
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Misc. - U

Uncovering a 'smoking gun' in age-related disease
For the first time, researchers reveal a causal link between RNA splicing and aging
December 5, 2016
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Unexplained neurodevelopmental disorder linked to harmful mutations in SON gene
A neurodevelopmental disorder for which there was no known cause has been linked to SON, a gene that is involved in essential mechanisms a cell uses to translate DNA into protein, as well as in DNA replication and cell division.
August 18, 2016
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Understanding X-chromosome silencing in humans
Researchers have discovered new insights into how one of the two X-chromosomes is silenced during the development of female human embryos and also in lab-grown stem cells. X-chromosome silencing is essential for proper development and these findings are important for understanding how the activity of the X-chromosome is regulated to ensure the healthy development of human embryos.
December 14, 2016
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UTI testing technology cuts screening time to four hours
Researchers using DNA sequencing to profile antibiotic resistance in infection have achieved a turnaround time from 'sample to answer' of less than four hours for urinary tract infections (UTIs).
September 23, 2016
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UVA researcher develops new way to track genes inside living cells
For Mazhar Adli, the little glowing dots dancing about on the computer screen are nothing less than the fulfillment of a dream. Those fluorescent dots, moving in real time, are set to illuminate our understanding of the human genome, cancer and other genetic diseases in a way never before possible.
April 13, 2017
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Misc. - V

Variation in 'junk' DNA leads to trouble
Changes linked to unstable genomes, cancer and other defects
August 30, 2016
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Viral protein transforms as it measures out DNA
To generate swarms of new viral particles, a virus hijacks a cell into producing masses of self-assembling cages that are then loaded with the genetic blueprint for the next infection. But the picture of how that DNA is loaded into those viral cages, or capsids, was blurry, especially for two of the most common types of DNA virus on earth, bacterial viruses and human herpesvirus.
January 31, 2017
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Virus-like elements within human genome linked to development of lupus and Sjogren's syndrome
Researchers at Hospital for Special Surgery (HSS) have uncovered a potential genetic trigger of systemic autoimmune disease. the study, the culmination of more than 10 years of research and published online in the journal Arthritis & Rheumatology in June, discovered virus-like elements within the human genome linked to the development of two autoimmune diseases: lupus and Sjogren's syndrome.
June 28, 2016
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Visualizing the genome: First 3-D structures of active DNA created
Scientists have determined the first 3-D structures of intact mammalian genomes from individual cells, showing how the DNA from all the chromosomes intricately folds to fit together inside the cell nuclei.
March 13, 2017
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Misc. - W

Watching the passage of knotted DNA slip through nanopores
How can long DNA filaments, which have convoluted and highly knotted structure, manage to pass through the tiny pores of biological systems? Scientists used computer simulations to investigate the options available to the genetic material in such situations.
March 28, 2017
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Water forms 'spine of hydration' around DNA
Water is the Earth's most abundant natural resource, but it's also something of a mystery due to its unique solvation characteristics -- that is, how things dissolve in it.
May 25, 2017
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Was the secret spice in primal gene soup a thickener?
A little goo will do to get RNA and DNA to progress toward self-replication. Could some abundant ingredient have helped the precursors of genes become life molecules? another indicator that little drama may have been necessary in chemical evolution.
October 10, 2016
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Watching RNA fold
New technology takes a nucleotide-resolution snapshot of RNA folding during synthesis
November 1, 2016
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What's a knot -- and what's not -- in genomic mapping
Computational modeling of genome mapping in nanochannels helps untangle the physics of DNA knots
April 11, 2017
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What's Behind the Gluten-Free Trend?
Not that many years ago, the letters "GF" on a restaurant menu would likely have puzzled many people. No longer.
September 16, 2016
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Whole-exome sequencing may routinely miss detecting some disease-causing genes, say researchers
Whole-exome DNA sequencing -- a technology that saves time and money by sequencing only protein-coding regions and not the entire genome -- may routinely miss detecting some genetic variations associated with disease, according to Penn State researchers who have developed new ways to identify such omissions.
April 24, 2017
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Whitehead Institute scientists develop novel method for profiling mitochondrial metabolites
Whitehead Institute scientists have developed a method to quickly isolate and systematically measure metabolite concentrations within the cellular organelles known as mitochondria, often referred to as the "powerhouses of the cell." Prior attempts at such measurements have yielded unreliable results, either by taking too long to isolate mitochondria or by contaminating mitochondrial metabolites with contents from other cellular components.
August 31, 2016
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Wurzburg researchers discover long-suspected third RNA binding protein
Small regulatory RNA molecules are vital for salmonella and other bacteria potentially harmful to humans: this RNA type controls gene activity and allows bacteria to quickly adjust to changing conditions of living and stress as are typical during an infection, for example, when entering the blood stream or inside human cells.
October 17, 2016
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Misc. - Y

Yale researchers develop new system to simultaneously edit multiple genes
A Yale research team has designed a system to modify, or edit, multiple genes in the genome simultaneously, while also minimizing unintended effects. the gene-editing "toolbox" provides a user-friendly solution that scientists can apply to research on cancer and other disciplines, the researchers said.
July 26, 2016
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Youthful DNA in old age
The DNA of young people is regulated to express the right genes at the right time. with the passing of years, the regulation of the DNA gradually gets disrupted, which is an important cause of aging. a study of over 3,000 people shows that this is not true for everyone: there are people whose DNA appears youthful despite their advanced years.
September 22, 2016
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